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A Mathematical Model of Alzheimer's Disease and the Apoe Gene

Published online by Cambridge University Press:  29 August 2014

Angus Macdonald  and
Delme Pritchard
Angus Macdonald*
Affiliation:
Heriot-Watt University, Edinburgh
Delme Pritchard*
Affiliation:
Heriot-Watt University, Edinburgh
*
Department of Actuarial Mathematics and Statistics, Heriot-Watt UniversityEdinburgh EH14 4AS, United Kingdom.
Department of Actuarial Mathematics and Statistics, Heriot-Watt UniversityEdinburgh EH14 4AS, United Kingdom.
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Abstract

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Alzheimer's disease (AD) accounts for a significant proportion of long-term care costs. The recent discovery that the ε4 allele of the ApoE gene indicates a predisposition to earlier onset of AD raises questions about the potential for adverse selection in long-term care insurance, about long-term care costs in general, and about the potential effects on costs of gene therapy, or better targetted treatments for AD. This paper describes a simple Markov model for AD, and the estimation of the transition intensities from the medical and epidemiological literature.

Keywords

Alzheimer's DiseaseApolipoprotein E GeneGeneticsMarkov Models
Type
Articles
Information
ASTIN Bulletin: The Journal of the IAA , Volume 30 , Issue 1 , May 2000 , pp. 69 - 110
Copyright
Copyright © International Actuarial Association 2000

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