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Nicotine stimulated GtH2 secretion in vivo in male common carp (Cyprinus carpio); Potentiation of GnRH action and possible interaction with dopaminergic system

Published online by Cambridge University Press:  15 May 1998

Tomasz Mikolajczyk ,
Jaroslaw Chyb ,
Miroslawa Sokolowska-Mikolajczyk ,
Bernard Breton ,
Katrien Monden  and
Piotr Epler
Tomasz Mikolajczyk
Affiliation:
Dept of Ichthyobiology & Fisheries, Agricultural Academy of Cracow, ul. Spiczakowa 6, 30149 Cracow-Mydlniki, Poland
Jaroslaw Chyb
Affiliation:
Dept of Ichthyobiology & Fisheries, Agricultural Academy of Cracow, ul. Spiczakowa 6, 30149 Cracow-Mydlniki, Poland
Miroslawa Sokolowska-Mikolajczyk
Affiliation:
Dept of Ichthyobiology & Fisheries, Agricultural Academy of Cracow, ul. Spiczakowa 6, 30149 Cracow-Mydlniki, Poland
Bernard Breton
Affiliation:
Laboratory of Fish Physiology INRA, Campus de Beaulieu, 35042 Rennes, France
Katrien Monden
Affiliation:
Inst. of Zoology, Catholic University of Leuven, Naamsestraat 59, B3000 Leuven, Belgium
Piotr Epler
Affiliation:
Dept of Ichthyobiology & Fisheries, Agricultural Academy of Cracow, ul. Spiczakowa 6, 30149 Cracow-Mydlniki, Poland
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Abstract

Nicotine injected intravenously or on pituitary in vivo stimulated maturational gonadotropin (GtH2) secretion in domperidone (D-2 receptor antagonist) pretreated carps. The effective dose was 1 mg·kg−1 and 100 μg·kg−1, respectively. No stimulatory effects of nicotine were observed in normal (non-treated) carps. When nicotine was injected together with gonadotropin releasing hormone (GnRH) analogs (D-Arg6 sGnRH or D-Ala6 LHRH) a clear potentiation effect of nicotine on GnRH analogs' action was observed. This potentiation was seen even in normal fish where nicotine itself had no effect on GtH2 release. A synergism between nicotine and GnRH analogs appeared when low doses of GnRH analogs were used. In domperidone pretreated fish, this synergism occurred after injection of 1 μg·kg−1 of sGnRHa. In normal fish, the same phenomenon was observed after injection of 5 μg·kg−1 of sGnRHa or 20 μg·kg−1 of LHRHa. Higher doses of GnRH analogs mask this effect. Results confirm previous in vitro findings on the stimulatory action of nicotine on GtH2 secretion. They also indicate a possible synergy between nicotine and GnRH as well as an inhibitory influence of dopamine on nicotine's action.

Keywords

Sex hormonessexual maturityfish physiologyCyprinus carpio
Type
Research Article
Information
Aquatic Living Resources , Volume 11 , Issue 3 , May 1998 , pp. 155 - 161
Copyright
© Elsevier, IRD, Inra, Ifremer, Cemagref, CNRS, 1998

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