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MODELLING HYDROGEN CLEARANCE FROM THE RETINA

Part of: Physiological, cellular and medical topics

Published online by Cambridge University Press:  25 January 2018

D. E. FARROW Open the ORCID record for D. E. FARROW [Opens in a new window] ,
G. C. HOCKING Open the ORCID record for G. C. HOCKING [Opens in a new window] ,
S. J. CRINGLE Open the ORCID record for S. J. CRINGLE [Opens in a new window]  and
D.-Y. YU
D. E. FARROW*
Affiliation:
Mathematics and Statistics, Murdoch University, Murdoch WA 6150, Australia email [email protected], [email protected]
G. C. HOCKING
Affiliation:
Mathematics and Statistics, Murdoch University, Murdoch WA 6150, Australia email [email protected], [email protected]
S. J. CRINGLE
Affiliation:
Lions Eye Institute, 2 Verdun St, Nedlands WA 6009, Australia email [email protected], [email protected]
D.-Y. YU
Affiliation:
Lions Eye Institute, 2 Verdun St, Nedlands WA 6009, Australia email [email protected], [email protected]
*
✉[email protected]
Rights & Permissions [Opens in a new window]

Abstract

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The human retina is supplied by two vascular systems: the highly vascular choroidal, situated behind the retina; and the retinal, which is dependent on the restriction that the light path must be minimally disrupted. Between these two circulations, the avascular retinal layers depend on diffusion of metabolites through the tissue. Oxygen supply to these layers may be threatened by diseases affecting microvasculature, for example diabetes and hypertension, which may ultimately cause loss of sight.

An accurate model of retinal blood flow will therefore facilitate the study of retinal oxygen supply and, hence, the complications caused by systemic vascular disease. Here, two simple models of the blood flow and exchange of hydrogen with the retina are presented and compared qualitatively with data obtained from experimental measurements. The models capture some interesting features of the exchange and highlight effects that will need to be considered in a more sophisticated model and in the interpretation of experimental results.

Keywords

mathematical modelhydrogen clearanceadvection/diffusion

MSC classification

Primary: 92C50: Medical applications (general)
Type
Research Article
Information
The ANZIAM Journal , Volume 59 , Issue 3 , January 2018 , pp. 281 - 292
Copyright
© 2018 Australian Mathematical Society 

References

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