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Genetic diversity at the FMR1 locus in the Indonesian population

Published online by Cambridge University Press:  26 July 2016

Sultana M. H. FARADZ ,
M. Z. PATTIIHA ,
D. A. LEIGH ,
M. JENKINS ,
J. LEGGO ,
M. F. BUCKLEY  and
J. J. A. HOLDEN
Sultana M. H. FARADZ
Affiliation:
Molecular and Cytogenetics Unit, South Eastern Area Laboratory Services, Sydney, Australia Faculty of Medicine, Diponegoro University, Semarang, Indonesia Cytogenetics and DNA Research Laboratory, Ongwanada Resource Center and Dept of Psychiatry, Queen's University, Kingston, Canada
M. Z. PATTIIHA
Affiliation:
Dept of Internal Medicine, Ternate General Hospital, Ternate, Maluku, Indonesia
D. A. LEIGH
Affiliation:
Molecular and Cytogenetics Unit, South Eastern Area Laboratory Services, Sydney, Australia Current address: Pre-implantation Genetic Diagnosis Laboratory, Sydney IVF, Sydney.
M. JENKINS
Affiliation:
Dept of Public Health and Community Medicine, University of Melbourne, Parkville, Australia
J. LEGGO
Affiliation:
Cytogenetics and DNA Research Laboratory, Ongwanada Resource Center and Dept of Psychiatry, Queen's University, Kingston, Canada
M. F. BUCKLEY
Affiliation:
Molecular and Cytogenetics Unit, South Eastern Area Laboratory Services, Sydney, Australia School of Pathology, University of New South Wales, Sydney, Australia
J. J. A. HOLDEN
Affiliation:
Cytogenetics and DNA Research Laboratory, Ongwanada Resource Center and Dept of Psychiatry, Queen's University, Kingston, Canada
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Abstract

We report an analysis of allelic diversity at short tandem repeat polymorphisms within the fragile XA locus in 1069 male volunteers from twelve Indonesian sub-populations. An odd numbered allele of DXS548 was found at high frequency in all Indonesian populations. Greater allelic diversity was identified at the loci under study than has been previously reported for an Asian population. These differences distinguish the Indonesian population from all previously reported Asian, European and African populations. A high frequency of small premutation alleles, 4/120 (3.3%, 95% CI 0.9–8.3%), was identified in the Moluccan population of Hiri Island.

Type
Research Article
Information
Annals of Human Genetics , Volume 64 , Issue 4 , July 2000 , pp. 329 - 339
Copyright
University College London 2000

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