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Lipomatous muscular ‘dystrophy’ of Piedmontese cattle

Published online by Cambridge University Press:  27 April 2012

E. Biasibetti ,
S. Amedeo ,
A. Brugiapaglia ,
G. Destefanis ,
L. Di Stasio ,
F. Valenza  and
M. T. Capucchio
E. Biasibetti*
Affiliation:
Department of Animal Pathology, Faculty of Veterinary Medicine, University of Torino, via Leonardo da Vinci 44, 10095 Grugliasco (Torino), Italy
S. Amedeo
Affiliation:
Department of Animal Pathology, Faculty of Veterinary Medicine, University of Torino, via Leonardo da Vinci 44, 10095 Grugliasco (Torino), Italy
A. Brugiapaglia
Affiliation:
Department of Animal Science, Faculty of Agriculture, University of Torino, via Leonardo da Vinci 44, 10095 Grugliasco (Torino), Italy
G. Destefanis
Affiliation:
Department of Animal Science, Faculty of Agriculture, University of Torino, via Leonardo da Vinci 44, 10095 Grugliasco (Torino), Italy
L. Di Stasio
Affiliation:
Department of Animal Science, Faculty of Agriculture, University of Torino, via Leonardo da Vinci 44, 10095 Grugliasco (Torino), Italy
F. Valenza
Affiliation:
Department of Animal Pathology, Faculty of Veterinary Medicine, University of Torino, via Leonardo da Vinci 44, 10095 Grugliasco (Torino), Italy
M. T. Capucchio
Affiliation:
Department of Animal Pathology, Faculty of Veterinary Medicine, University of Torino, via Leonardo da Vinci 44, 10095 Grugliasco (Torino), Italy
*
†E-mail: [email protected]
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Abstract

Lipomatous myopathy is a degenerative muscle pathology characterized by the substitution of muscle cells with adipose tissue, sporadically reported in cattle, pigs, and rarely in sheep, horses and dogs. This study investigated the pathology of this myopathy in 40 muscle samples collected from regularly slaughtered Piedmontese cattle living in Piedmont region (Italy). None of the animals showed clinical signs of muscular disease. Muscle specimens were submitted to histological and enzymatic investigations. Gross pathology revealed a different grade of infiltration of adipose tissue, involving multiple or single muscles. The most affected regions were the ventral abdomen and the shoulders, especially the cutaneous muscles and the muscles of the thoracic group. Morphological staining revealed an infiltration of adipose tissue varying in distribution and severity, changes in muscle fibre size and increased number of fibres with centrally located nuclei, suggesting muscle degeneration–regeneration. Necrosis and non-suppurative inflammatory cells were also seen. Furthermore, proliferation of connective tissue and non-specific myopathic changes were present. Chemical and physical characteristics of the affected tissue were also evaluated. The authors discuss about the aetiopathogenesis and classification of this muscle disorder whose histological lesions were similar to those reported in human dystrophies.

Keywords

lipomatous myopathycattlepathologychemical–physical characteristics
Type
Behaviour, welfare and health
Information
animal , Volume 6 , Issue 11 , November 2012 , pp. 1839 - 1847
Copyright
Copyright © The Animal Consortium 2012

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References

Albrecht, E, Teuscher, F, Ender, K, Wegner, J 2006. Growth- and breed-related changes of muscle bundle structure in cattle. Journal of Animal Science 84, 2959–2964.Google Scholar
Albrecht, E, Gotoh, T, Ebara, F, Xu, JX, Viergutz, T, Nürnberg, G, Maak, S, Wegner, J 2011. Cellular conditions for intramuscular fat deposition in Japanese Black and Holstein steers. Meat Science 89, 13–20.Google Scholar
Association of Official Analytical Chemists (AOAC) 1970. Official methods of analysis, 11th edition. AOAC, Washington, USA.Google Scholar
Barge, MT, Brugiapaglia, A, Destefanis, G, Mazzocco, P 1993. The influence of muscle type, ethnic group, muscular hypertrophy on the composition of beef meat. Conference at the 39th International Congress of Meat Science and Technology, Calgary, Alberta, Canada, File S5PO2.WP.Google Scholar
Beck, WE, Marchello, JA, Ray, DE 1971. Effects of some pharmacological agents on bovine intramuscular fat deposition. Journal of Animal Science 32, 863–869.Google Scholar
Boccard, R 1981. Facts and reflection on muscular hypertrophy in cattle: double muscling or culard. In Development in Meat Science 2 (ed. R Lawrie), pp. 1–28. Applied Science Publishers Ltd, Ripple Road, Barking, Essex, UK.Google Scholar
Campbell, KP 1995. Three muscular dystrophies: loss of cytoskeleton–extracellular matrix linkage. Cell 80, 675–679.CrossRefGoogle ScholarPubMed
Casanova, G, Jerusalem, F 1979. Myopathology of myotonic dystrophy. A morphometric study. ACTA Neuropathologica 45, 231–240.Google Scholar
CIE 1978. International Commission on Illumination, Recommendations on uniform color spaces, color-difference equations, psychometric color terms. Supplement no.2 to CIE publication no. 15 (E.-1.3.1) 1971/(TC-1.3.) 1978. Bureau de la CIE, Paris, France.Google Scholar
Cook, CF 1963. Variations in certain physical and chemical components of bovine tissue, and methods for identification and measurement of these parameters. PhD Thesis, University of Wisconsin, Madison.Google Scholar
Davis, WC, Hamilton, MJ, Park, YH, Larsen, RA, Wyatt, CR, Okada, K 1990. Ruminant leukocyte differentiation molecules. In MHC, Differentiation antigens and cytokines in animals and birds. Monographs in animal immunology (ed. O Barta), pp. 47–70. BAR-LAB, Blacksburg, VA.Google Scholar
Davis, WC, Marusic, S, Lewin, HA, Splitter, GA, Perryman, LE, McGuire, TC, Gorham, JR 1987. The development and analysis of species specific and cross reactive monoclonal antibodies to leukocyte differentiation antigens and antigens of the major histocompatibility complex for use in the study of the immune system in cattle and other species. Veterinary Immunology and Immunopathology 15, 337–376.Google Scholar
Destefanis, G, Barge, MT, Brugiapaglia, A 1993. Variabilità delle caratteristiche qualitative nella carne di bovini di razza piemontese con ipertrofia muscolare. Zootecnica e nutrizione animale 19, 117–183.Google Scholar
Destefanis, G, Barge, MT, Brugiapaglia, A 1994. pH, colour and water holding capacity in muscles of young bulls differing for ethnic group. In Conference at the 40th International Congress of Meat Science and Technology, Aia, Oland, File S-IVA.25.Google Scholar
Dubowitz, V, Sewry, CA 2007. Muscle biopsy: a practical approach, 3rd edition. Saunders, Philadelphia, USA.Google Scholar
Fontana, G 1963. Lipomatous muscular dystrophy in cattle. Graduate Thesis, Annali Della Facoltà Di Medicina Veterinaria, Università di Pisa 16, 267pp.Google Scholar
George, MH, Morgan, JB, Glock, RD, Tatum, JD, Schmidt, GR, Sofos, JN, Cowman, GL, Smith, GC 1995. Injection-site lesions: incidence, tissue histology, collagen concentration, and muscle tenderness in beef rounds. Journal of Animal Science 73, 3510–3518.Google Scholar
Goedegebuure, SA, Hartman, W, Hoebe, HP 1983. Dystrophy of the diaphragmatic muscles in adult Meuse-Rhine-Yssel cattle: electromyographical and histological findings. Veterinary Pathology 20, 32–48.Google Scholar
Guarda, F, Castagnaro, M 2002. Muscoli scheletrici. In Trattato di anatomia patologica veterinaria (ed. F Guarda and G Mandelli), pp. 91–113. UTET Publishing, Torino, Italy.Google Scholar
Gutmann, E, Zelena, J 1962. Morphological changes in the denervated Muscle (ed. E Gutmann). Publishing House Czechoslovakia Academic Science, Prague.Google Scholar
Gutierrez, M, Forster, FI, McConnell, SA, Cassidy, JP, Pollock, JM, Bryson, DG 1999. The detection of CD2+, CD4+, CD8+, and WC1+ T lymphocytes, B cells and macrophages in fixed and paraffin embedded bovine tissue using a range of antigen recovery and signal amplification techniques. Veterinary Immunology and Immunopathology 71, 321–334.Google Scholar
Hanset, R, Michaux, C, Dessy-Doize, C, Burtonboy, G 1982. Studies on the 7th rib cut in double muscled and conventional cattle. Anatomical, histological and biochemical aspects. In Muscle hypertrophy of genetic origin and its use to improve beef production (ed. JWB King and F Menissier), pp. 341–349. Martinus Nijhoff, The Hague, The Netherlands.Google Scholar
Hartman, L, Shorland, FB 1957. The fatty acid composition of lipids in the muscle and fatty tissues of loin mutton chops. Journal of the Science of Food and Agriculture 8, 428–432.Google Scholar
Hovenier, R, Brascamp, EW, Kanis, EV, Van der Werf, JH, Wassenberg, AP 1993. Economic values of optimum traits: the example of meat quality in pigs. Journal of Animal Science 71, 1429–1433.CrossRefGoogle ScholarPubMed
Link, BA, Cassens, RG, Bray, RW, Kowalczyk, T 1967. Fatty degeneration of bovine longissimus. Journal of Animal Science 26, 694–700.Google Scholar
Jeffrey, M, Hopper, SA, Bradley, R 1985. Kyphosis in Jersey calves. Veterinary Record 117, 608–610.CrossRefGoogle ScholarPubMed
Kambadur, R, Sharma, M, Smith, TP, Bass, JJ 1997. Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle. Genome Research 7, 910–916.Google Scholar
Kobayashi, M, Nakamura, A, Hasegawa, D, Fujita, M, Orima, H, Takeda, S 2009. Evaluation of dystrophic dog pathology by fat-suppressed T2-weighted imaging. Muscle Nerve 40, 815–826.Google Scholar
Lepetit, J, Culioli, J 1994. Mechanical properties of meat. Meat Science 36, 203–237.Google Scholar
Marcato, S, Rosmini, R, Bazzo, R 2002. Sistema locomotore: muscoli. In Patologia sistematica veterinaria (ed. S Marcato), pp. 1095–1158. Edagricole, Bologna, Italy.Google Scholar
Marchello, JA, Brown, JT, Ray, DE 1971. Effect of probing and alcohol injection of muscle on subsequent intramuscular fat deposition. Journal of Animal Science 32, 62–67.Google Scholar
Marden, FA, Connolly, AM, Siegel, MJ, Rubin, DA 2005. Compositional analysis of muscle in boys with Duchenne muscular dystrophy using MR imaging. Skeletal Radiology 34, 140–148.Google Scholar
Mason, DY, Cordell, JL, Tse, AGD, van Dongen, JJM, van Noesel, JM, Micklem, K, Pulford, KAF, Valensi, F, Comans-Bitter, WM, Borst, J, Gatter, KC 1991. The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells. Journal of Immunology 147, 2474–2482.CrossRefGoogle ScholarPubMed
McGavin, MD, Baynes, ID 1969. A congenital progressive ovine muscular dystrophy. Veterinary Pathology 6, 513–524.Google Scholar
Nadaj-Pakleza, A, Lusakowska, A, Sułek-Piątkowska, A, Krysa, W, Rajkiewicz, M, Kwieciński, H, Kamińska, A 2011. Muscle pathology in myotonic dystrophy: light and electron microscopic investigation in eighteen patients. Folia Morphologica 70, 121–129.Google Scholar
Swatland, HJ, Kieffer, NM 1974. Fetal development of the double muscled condition in cattle. Journal of Animal Science 38, 752–757.CrossRefGoogle ScholarPubMed
Sewry, CA 2010. Muscular dystrophies: an update on pathology and diagnosis. Acta Neuropathologica 120, 343–358.Google Scholar
Shelton, GD, Engvall, E 2002. Muscular dystrophies and other inherited myopathies. Veterinary Clinics of North America: Small Animal Practice 32, 103–124.Google Scholar
Tatum, JD, Gronewald, KW, Seideman, SC, Lamm, WD 1990. Composition and quality of beef from steers sired by Piedmontese, Gelbvieh and Red Angus bulls. Journal of Animal Science 68, 1049–1160.Google Scholar
Valentine, BA 2007. Skeletal muscle. In Pathologic basis of veterinary disease (ed. MD Mc Gavin and JF Zachary), pp. 973–1041. Mosby Publishing, Saint Louis, USA.Google Scholar
Van Vleet, JF, Valentine, BA 2007. Muscle and tendon. In Pathology of domestic animals (ed. Jub, Kennedy and Palmer), pp. 185–281. M. Grant Maxie Publishing, Edinburgh, UK.Google Scholar