Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-24T14:48:00.552Z Has data issue: false hasContentIssue false
  • English
  • Français

Quantitative trait loci analysis of osteochondrosis traits in the elbow joint of pigs

Published online by Cambridge University Press:  30 October 2009

O. F. Christensen ,
M. E. Busch ,
V. R. Gregersen ,
M. S. Lund ,
B. Nielsen ,
R. K. K. Vingborg  and
C. Bendixen
O. F. Christensen*
Affiliation:
Faculty of Agricultural Sciences, Department of Genetics and Biotechnology, Aarhus University, Blichers Allé 20, P.O. BOX 50, DK-8830 Tjele, Denmark
M. E. Busch
Affiliation:
Danish Agriculture and Food Council, Danish Pig Production, Axelborg, Axeltorv 3, DK-1609 Copenhagen V, Denmark
V. R. Gregersen
Affiliation:
Faculty of Agricultural Sciences, Department of Genetics and Biotechnology, Aarhus University, Blichers Allé 20, P.O. BOX 50, DK-8830 Tjele, Denmark
M. S. Lund
Affiliation:
Faculty of Agricultural Sciences, Department of Genetics and Biotechnology, Aarhus University, Blichers Allé 20, P.O. BOX 50, DK-8830 Tjele, Denmark
B. Nielsen
Affiliation:
Danish Agriculture and Food Council, Danish Pig Production, Axelborg, Axeltorv 3, DK-1609 Copenhagen V, Denmark
R. K. K. Vingborg
Affiliation:
Faculty of Agricultural Sciences, Department of Genetics and Biotechnology, Aarhus University, Blichers Allé 20, P.O. BOX 50, DK-8830 Tjele, Denmark
C. Bendixen
Affiliation:
Faculty of Agricultural Sciences, Department of Genetics and Biotechnology, Aarhus University, Blichers Allé 20, P.O. BOX 50, DK-8830 Tjele, Denmark
*
†E-mail: [email protected]
Get access

Abstract

Osteochondrosis is a growth disorder in the cartilage of young animals and is characterised by lesions found in the cartilage and bone. This study identified quantitative trait loci (QTLs) associated with six osteochondrosis lesion traits in the elbow joint of finishing pigs. The traits were: thickening of the cartilage, lesion in the subchondral bone, irregular cartilage surface, fissure under the cartilage, an irregular sagittal central groove and depression of the proximal edge of the radius. The study comprised 7172 finishing pigs from crossing 12 Duroc boars with 600 crossbred Landrace × Large White sows and included 462 single nucleotide polymorphism markers. The results showed 18 QTLs exceeding the 5% genome-wide threshold. The QTLs associated with lesions in the medial part of the condylus humeri (assumed to be the four main osteochondrosis traits) were, in most cases, at common locations, whereas the QTLs associated with depression of the proximal edge of the radius in general were on the same chromosomes but at separate locations. The detected QTLs explain a large part of the genetic variation, which is promising for incorporating osteochondrosis into a breeding programme using marker-assisted selection.

Keywords

genetic parameters, osteochondrosis, pigs, QTLs
Type
Full Paper
Information
animal , Volume 4 , Issue 3 , March 2010 , pp. 417 - 424
Copyright
Copyright © The Animal Consortium 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Andersson-Eklund, L, Uhlhorn, H, Lundeheim, N, Dalin, G 2000. Mapping quantitative trait loci for principal components of bone measurements and osteochondrosis scores in a Wild Boar × Large White intercross. Genetical Research 75, 223–230.CrossRefGoogle Scholar
Dewey, CE 1999. Diseases of the nervous and locomotory system. In Diseases of Swine, 8th ed (ed. B Straw, S D’Allaire, WL Mengling and DJ Taylor), pp. 861–882. Iowa State Univ. Press, Ames, IA, USA.Google Scholar
Evans, DM, Cardon, LR 2004. Guidelines for genotyping in genomewide linkage studies: single-nucleotide-polymorphism maps versus microsatellite maps. American Journal of Human Genetics 75, 687–692.Google Scholar
Fernando, RL, Grossman, M 1989. Marker assisted selection using best linear unbiased prediction. Genetics Selection Evolution 21, 467–477.CrossRefGoogle Scholar
Goedegebuure, SA, Rothschild, MF, Christian, LL, Ross, RF 1988. Severity of osteochondrosis in three genetic lines of Duroc swine divergently selected for front leg-weakness. Livestock Production Science 19, 487–498.Google Scholar
Green, P, Falls, K, Crooks, S 1990. Documentation for CRIMAP, version 2.4. Technical report. Washington University School of Medicine, Saint Louis, MO, USA.Google Scholar
Grøndalen, T 1974. Leg weakness in pigs. I. Incidence and relationship to skeletal lesions, feed level, protein and mineral supply, exercise and exterior conformation. Acta Veterinaria Scandinavica 15, 555–573.CrossRefGoogle ScholarPubMed
Guldbrandtsen, B, Labouriau, R 2006. Confirming QTL. In Book of abstracts from 8th World Congress on Genetics Applied to Livestock Production, Belo Horizonte, MG, Brasil. CD Communication 22_726.Google Scholar
Hill, MA, Ruth, GR, Hilley, HD, Hansen, DC 1984. Dyschondroplasias, including osteochondrosis in boars between 25 and 169 days of age: Histologic changes. American Journal of Veterinary Research 45, 903–916.Google Scholar
Jørgensen, B 1995. Effect of different energy and protein levels on leg weakness and osteochondrosis in pigs. Livestock Production Science 41, 171–181.Google Scholar
Jørgensen, B 2000. Osteochondrosis/osteoarthrosis and claw disorders in sows, associated with leg weakness. Acta Veterinaria Scandinavica 41, 123–138.CrossRefGoogle ScholarPubMed
Jørgensen, B, Andersen, S 2000. Genetic parameters for osteochondrosis in Danish Landrace and Yorkshire boars and correlations with leg weakness and production traits. Animal Science 71, 427–434.CrossRefGoogle Scholar
Jørgensen, B, Arnbjerg, J, Aaslyng, M 1995. Patholocical and radiological investigations on osteochondrosis in pigs, associated with leg weakness. Journal of Veterinary Medicine Series A – Physiology, Pathology, Clinical Medicine 42, 489–504.CrossRefGoogle Scholar
Jørgensen, B, Nielsen, B 2005. Genetic parameters for osteochondrosis traits in elbow joints of crossbred pigs and relationship with production traits. Animal Science 81, 319–324.CrossRefGoogle Scholar
Kadarmideen, HN, Schwörer, D, Ilahi, H, Malek, M, Hofer, A 2004. Genetics of osteochondral disease and its relationship with meat quality and quantity, growth, and feed conversion traits in pigs. Journal of Animal Science 82, 3118–3127.Google Scholar
Kincaid, SA, Allhands, RV, Pijanowski, GJ 1985. Chondrolysis associated with cartilage canals of the epiphyseal cartilage of the distal humerus of growing pigs. American Journal of Veterinary Research 46, 726–732.Google Scholar
Lee, GJ, Archibald, AL, Garth, GB, Law, AS, Nicholsen, D, Barr, A, Haley, CS 2003. Detection for quantitative trait loci for locomotion and osteochondrosis-related traits in Large White × Meishan pigs. Animal Science 76, 155–165.Google Scholar
Madsen, P, Jensen, J 2008. A users guide to DMU, version 6, release 4.7. Manual. Faculty of Agricultural Sciences, University of Aarhus, Tjele, Denmark.Google Scholar
Meuwissen, THE, Hayes, BJ, Goddard, ME 2001. Prediction of total genetic value using genome-wide dense marker maps. Genetics 157, 1819–1829.Google Scholar
Nakano, T, Aherne, FX 1988. Involvement of trauma in the pathogenesis of osteochondritis dissecans in swine. Canadian Journal of Veterinary Research 52, 154–155.Google ScholarPubMed
Nakano, T, Brennan, JJ, Aherne, FX 1987. Leg weakness and osteochondrotic bone in swine: a review. Canadian Journal of Animal Science 67, 883–901.CrossRefGoogle Scholar
Palmer, NC 1993. Bones and joints. In Pathology of Domestic Animals, 4th edition (ed. KVF Jubb, PC Kennedy and N Palmer), pp. 1–182. Academic Press, New York.Google Scholar
Piepho, H-P 2001. A quick method for computing approximate thresholds for quantitative trait loci detection. Genetics 157, 425–432.Google Scholar
Reiland, S 1978. Morphology of osteochondrosis and sequelae in pigs. Acta Radiologica, Suppl 358, 45–90.Google Scholar
Sørensen, P, Lund, MS, Guldbrandtsen, B, Jensen, J, Sorensen, D 2003. A comparison of bivariate and univariate QTL mapping in livestock populations. Genetics Selection Evolution 35, 605–622.Google Scholar
Stern, S, Lundeheim, N, Johansson, K, Andersson, K 1995. Osteochondrosis and leg weakness in pigs selected for lean tissue growth rate. Livestock Production Science 44, 45–52.Google Scholar
Vingborg, RKK, Gregersen, VR, Zhan, B, Panitz, F, Høj, A, Sørensen, KK, Madsen, LB, Larsen, K, Hornshøj, H, Wang, X, Bendixen, C 2009. A robust linkage map of the porcine autosomes based on gene-associated SNPs. BMC Genomics 10, 134.Google Scholar
Ytrehus, B, Carlson, CS, Ekman, S 2008. Etiology and pathogenesis of osteochondrosis. Veterinary Pathology 44, 429–448.CrossRefGoogle Scholar
Ytrehus, B, Ekman, S, Carlson, CS, Teige, J, Reinholt, FP 2004. Focal changes in blood supply during normal epiphyseal growth are central in the pathogenesis of osteochondrosis in pigs. Bone 35, 1294–1306.CrossRefGoogle ScholarPubMed
Supplementary material: PDF

Christensen supplementary material

Christensen supplementary material

Download Christensen supplementary material(PDF)
PDF 42.1 KB