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Effects of light and food on plasma leptin concentrations in ewes

Published online by Cambridge University Press:  18 August 2016

T. Tokuda ,
T. Matsui  and
H. Yano
T. Tokuda*
Affiliation:
Laboratory of Animal Nutrition, Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto, 606-8502, Japan
T. Matsui*
Affiliation:
Laboratory of Animal Nutrition, Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto, 606-8502, Japan
H. Yano
Affiliation:
Laboratory of Animal Nutrition, Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto, 606-8502, Japan
*
†Present address: Laboratory of Animal Science, Faculty of Life and Environmental Science, Shimane University Matsue-shi, 690-8504, Japan.
‡To whom correspondence should be addressed.
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Abstract

Plasma leptin concentration shows pulsatility and diurnal rhythm in humans. However, there are few reports concerning the 24-h profile of circulating leptin levels in ruminants. Five crossbred ewes were housed in metabolism cages under a 1-h light-dark cycle. The ewes were offered alfalfa hay daily to meet their energy requirement. Blood samples were collected at 15-min intervals for 24 h. Plasma leptin concentrations were determined using a radioimmunoassay and the profile of plasma leptin levels was analysed by the PULSAR algorithmic program for detecting pulse. Plasma leptin concentration changed in a pulsatile fashion. The mean leptin concentration was 2·93 ng/ml. The mean pulse frequency was 4·8 pulses per day and the mean pulse amplitude was 0·67 ng/ml with an average pulse length of 1:13 h. Plasma leptin level was not affected by feeding or lighting cycle. These results indicate that plasma leptin level in sheep shows pulsatility but diurnal rhythm is not exhibited.

Keywords

diurnal variationhydrocortisoneleptinsheep
Type
Growth, development and meat science
Information
Animal Science , Volume 71 , Issue 2 , October 2000 , pp. 235 - 242
Copyright
Copyright © British Society of Animal Science 2000

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References

Ahima, R. S., Prabakaran, D., Montzoros, C., Qu, D., Lowell, B., Maratos-Flier, E. and Flier, J. S. 1996. Role of leptin in the neuroendocrine response to fasting. Nature 382: 250–252.Google Scholar
Barb, C. R. 1999. The brain-pituitary-adipocyte axis: role of leptin in modulating neuroendocrine function. Journal of Animal Science 77: 1249–1257.Google Scholar
Bergman, E. N., Reulein, S. S. and Corlett, R. E. 1989. Effects of obesity on insulin sensitivity and responsiveness in sheep. American Journal of Physiology 257: E772–E781.Google Scholar
Bocquier, F., Bonnet, M., Faulconnier, Y., Guerre-Millo, M., Martin, P. and Chilliard, Y. 1998. Effects of photoperiod and feeding level on perirenal adipose tissue metabolic activity and leptin synthesis in the ovariectomized ewe. Reproduction, Nutrition, Development 38: 489–498.Google Scholar
Bornstein, S. R., Uhlmann, K., Haiden, A., E-Bornstein, M. and Scherbaum, W. A. 1997. Evidence for novel peripheral action of leptin as a metabolic signal to the adrenal gland. Diabetes 46: 1235-1238.Google Scholar
Caro, J. F., Sinha, M. K., Kolaczynski, J. W., Zhang, P. L. and Considine, R. V. 1996. Leptin: the tale of an obesity gene. Diabetes 45: 1455-1462.Google Scholar
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P. , Marco, C. C., McKee, L. J., Bauer, T. L. and Caro, J. F. 1996. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New England Journal of Medicine 334: 292–295.Google Scholar
De Vos, P., Saladin, R., Auwerx, J. and Staels, B. 1995. Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. Journal of Biological Chemistry 270: 15958–15961.Google Scholar
Frajblat, M., Beam, S. W. and Butler, W. R. 1998. Plasma leptin concentrations and first postpartum ovulation in dairy cows differing in energy balance. Journal of Animal Science 76:/Journal of Dairy Science 81: (joint suppl.) 231.Google Scholar
Guillaume, V., Conte-Devolx, B., Magnan, E., Boudouresque, F., Grino, M., Cataldi, M., Muret, L., Priou, A., Figaroli, J. C. and Oliver, C. 1992. Effect of chronic active immunization with antiarginine vasopressin on pituitary-adrenal function in sheep. Endocrinology 130: 3007–3014.CrossRefGoogle ScholarPubMed
Hardie, L. J., Rayner, D. V., Holmes, S. and Trayhurn, P. 1996. Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zuker (fa/fa) rats as measured by ELISA. Biochemical and Biophysical Research Communications 223: 660–665.Google Scholar
Havel, P. J., Kasim-Karakas, S., Dubuc, G. R., Mueller, W. and Phinney, S. D. 1996. Gender differences in plasma leptin concentrations. Nature Medicine 2: 949–950.Google Scholar
Houseknecht, K. L., Baile, C. A., Matteri, R. L. and Spurlock, M. E. 1998. The biology of leptin: a review. Journal of Animal Science 76: 1405-1420.Google Scholar
Jenkins, A. B., Markovic, T. P., Fleury, A. and Campbell, L. V. 1997. Carbohydrate intake and short-term regulation of leptin in humans. Diabetrogia 40: 348–351.Google Scholar
Licinio, J., Mantzoros, C., Negrao, A. B., Cizza, G., Wong, M. L., Bongiorno, P. B., Chrousos, G. P., Karp, B., Allan, C., Flier, J. S. and Gold, P. W. 1997. Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nature Medicine 3: 1029–1033.Google Scholar
Merriam, G. R. and Wachter, K. W. 1982. Algolithms for the study of episodic hormone secretion. American Journal of Physiology 6: E310–E318.Google Scholar
Minton, J. E., Bindel, D. J., Drouillard, J. S., Titgemeyer, E. C., Grieger, D. M. and Hill, C. M. 1998. Serum leptin is associated with carcass traits in finishing cattle. Journal of Animal Science 76:/Journal of Dairy Science 81: (joint suppl.) 231.Google Scholar
Mueller, W. M., Gregoire, F. M., Stanhope, K. L., Mobbs, C. V., Mizuno, T. M., Warden, C. H., Stern, J. S. and Havel, P. J. 1998. Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes. Endocrinology 139: 551–558.Google Scholar
Ostlund, R. E. Jr, Wang, J. W., Klein, S. and Gingerrich, R. 1996. Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. Journal of Clinical Endocrinology and Metabolism 81: 3909–3913.Google Scholar
Pickavance, L., Tadayyon, M., Williams, G. and Vernon, R. G. 1998. Lactation suppresses diurnal of serum leptin. Biochemical and Biophysical Research Communications 248: 196–199.CrossRefGoogle ScholarPubMed
Rosenbaum, M., Nicolson, M., Hirsch, J., Heymsfield, S. B., Gallagher, D., Chu, F. and Leibel, R. L. 1996. Effects of gender, body composition, and menopause on plasma concentrations of leptin. Journal of Clinical Endocrinology and Metabolism 81: 3424–3427.Google Scholar
Ross, J. P. and Kitts, W. D. 1973. Relationship between postprandial plasma volatile fatty acids, glucose and insulin level in sheep fed different feeds. Journal of Nutrition 103: 488–493.Google Scholar
Saad, M. F., Riad-Gabriel, M. G., Khan, A., Sharma, A., Michael, R., Jinagouda, S. D., Boyadjian, R. and Steil, G. M. 1998. Diurnal and ultradian rhythmicity of plasma leptin: effects of gender and adiposity. Journal of Clinical Endocrinology and Metabolism 83: 453–459.Google Scholar
Saladin, R. P., De Vos, P., Guerre-Millo, M., Leturque, A., Girard, J., Staels, B. and Auwerx, J. 1995. Transient increase in obese gene expression after food intake or insulin administration. Nature 377: 527–529.CrossRefGoogle ScholarPubMed
Schoeller, D. A., Cella, L. K., Sinha, M. K. and Caro, J. F. 1997. Entrainment of the diurnal rhythm of plasma leptin to meal timing. Journal of Clinical Investigation 100: 1882–1887.Google Scholar
Sinha, M. K., Sturis, J., Ohannesian, J., Magosin, S., Stephens, T., Heiman, M. L., Polonsky, K. S. and Caro, J. F. 1996. Ultradian oscillations of leptin secretion in humans. Biochemical and Biophysical Research Communications 228: 733–738.Google Scholar
Slieker, L. J., Sloop, K. W., Surface, P. L., Kriauciunas, A., LaQuier, F., Manetta, J., Bue-Valleskey, J. and Stephens, T. W. 1996. Regulation of expression of od mRNA and protein by glucocorticoids and cAMP. Journal of Biological Chemistry 271: 5301–5304.CrossRefGoogle Scholar
Statistical Analysis Systems Institute. 1985. SAS user’s guide: statistics, version 5 edition. Statistical Analysis Systems Institute Inc., Cary, NC.Google Scholar
Weigle, D. S., Duell, P. B., Connor, W. E., Steiner, R. A., Soules, M. R. and Kuijper, J. L. 1997. Effect of fasting, refeeding, and dietary fat restriction on plasma leptin levels. Journal of Clinical Endocrinology and Metabolism 82: 561–565.Google Scholar