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Actinobacillus pleuropneumoniae biofilms: Role in pathogenicity and potential impact for vaccination development

Published online by Cambridge University Press:  07 November 2017

Skander Hathroubi ,
Abraham Loera-Muro ,
Alma L. Guerrero-Barrera ,
Yannick D. N. Tremblay  and
Mario Jacques
Skander Hathroubi
Affiliation:
Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA, USA
Abraham Loera-Muro
Affiliation:
CONACYT-CIBNOR, Centro de Investigaciones Biológicas del Noroeste, SC. Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur, La Paz, BCS, México
Alma L. Guerrero-Barrera
Affiliation:
Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Av. Universidad 940, Colonia Ciudad Universitaria, Aguascalientes, AGS, México
Yannick D. N. Tremblay
Affiliation:
Laboratoire Pathogenèse des Bactéries Anaérobies, Département de Microbiologie, Institut Pasteur, 25 rue du Dr Roux, 75015, Paris, France
Mario Jacques*
Affiliation:
Groupe de recherche sur la maladies infectieuses en production animale, Faculté de Médecine Vétérinaire, Université de Montréal, St-Hyacinthe, QC, Canada
*
*Corresponding author. E-mail: [email protected]
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Abstract

Actinobacillus pleuropneumoniae is a Gram-negative bacterium that belongs to the family Pasteurellaceae. It is the causative agent of porcine pleuropneumonia, a highly contagious respiratory disease that is responsible for major economic losses in the global pork industry. The disease may present itself as a chronic or an acute infection characterized by severe pathology, including hemorrhage, fibrinous and necrotic lung lesions, and, in the worst cases, rapid death. A. pleuropneumoniae is transmitted via aerosol route, direct contact with infected pigs, and by the farm environment. Many virulence factors associated with this bacterium are well characterized. However, much less is known about the role of biofilm, a sessile mode of growth that may have a critical impact on A. pleuropneumoniae pathogenicity. Here we review the current knowledge on A. pleuropneumoniae biofilm, factors associated with biofilm formation and dispersion, and the impact of biofilm on the pathogenesis A. pleuropneumoniae. We also provide an overview of current vaccination strategies against A. pleuropneumoniae and consider the possible role of biofilms vaccines for controlling the disease.

Keywords

Actinobacillus pleuropneumoniaepleuropneumoniabiofilmantimicrobial therapy and vaccine
Type
Review Article
Information
Animal Health Research Reviews , Volume 19 , Issue 1 , June 2018 , pp. 17 - 30
Copyright
Copyright © Cambridge University Press 2017 

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Footnotes

†

Both authors contributed equally to this work

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