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Canine leptospirosis in stray and sheltered dogs: a systematic review

Published online by Cambridge University Press:  21 June 2022

Anna Cecília Trolesi Reis Borges Costa ,
Raisa Abreu Bragança Colocho ,
Carine Rodrigues Pereira ,
Andrey Pereira Lage Open the ORCID record for Andrey Pereira Lage [Opens in a new window] ,
Marcos Bryan Heinemann  and
Elaine Maria Seles Dorneles Open the ORCID record for Elaine Maria Seles Dorneles [Opens in a new window]
Anna Cecília Trolesi Reis Borges Costa
Affiliation:
Departamento de Medicina Veterinária, Universidade Federal de Lavras, Lavras, Minas Gerais, Brazil
Raisa Abreu Bragança Colocho
Affiliation:
Departamento de Ciências da Saúde, Universidade Federal de Lavras, Lavras, Minas Gerais, Brazil
Carine Rodrigues Pereira
Affiliation:
Departamento de Medicina Veterinária, Universidade Federal de Lavras, Lavras, Minas Gerais, Brazil
Andrey Pereira Lage
Affiliation:
Departamento de Medicina Veterinária Preventiva, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Marcos Bryan Heinemann
Affiliation:
Departamento de Medicina Veterinária Preventiva e Saúde Animal, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, São Paulo, Brazil
Elaine Maria Seles Dorneles*
Affiliation:
Departamento de Medicina Veterinária, Universidade Federal de Lavras, Lavras, Minas Gerais, Brazil
*
Author for correspondence: Elaine Maria Seles Dorneles, E-mail: [email protected]
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Abstract

The aim of this systematic review was to investigate the prevalence of leptospirosis among stray and sheltered dogs worldwide. Six databases were searched, which resulted in the retrieval of 476 articles. Sixty articles were selected for analysis according to 10 quality criteria. Among the selected papers, 26 papers [43.4% (26/60)] met five of the 10 quality criteria established, 10 papers [16.7% (10/60)] met three criteria, nine papers [15.0% (9/60)] met four criteria, six papers [10.0% (6/60)] met six criteria, four papers [6.7% (4/60)] met eight criteria, and three papers [5.0% (3/60)] met nine of the 10 criteria, whereas two papers [1.7% (1/60)] met two and seven [1.7% (1/60)] criteria. Publications originated mainly from the Americas [45.0% (27/60)] and in the last 16 years (2003–2019) [81.7% (49/60)], and most of the sampled dogs were stray dogs [65.0% (39/60)]. The most commonly used diagnostic test for leptospirosis was the microscopic agglutination test [78.4% (47/60)] followed by polymerase chain reaction [21.7% (13/60)], and the most common serovars were Canicola [71.4% (35/49)], Icterohaemorrhagiae [65.3% (32/49)], Grippotyphosa [40.8% (20/49)], and Pomona [40.8% (20/49)]. In conclusion, our results showed that Leptospira spp. are present in unowned dogs worldwide; however, the low-methodological quality of the recovered cross-sectional studies precluded a meta-analysis.

Keywords

Cross-sectionalepidemiologyLeptospiraseroprevalencestreet dogsunowned dogs
Type
Systematic Review
Information
Animal Health Research Reviews , Volume 23 , Issue 1 , June 2022 , pp. 39 - 58
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Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press

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References

Adesiyun, AA, Hull-Jackson, C, Mootoo, N, Halsall, S, Bennett, R, Clarke, NR, Whittington, CU and Seepersadsingh, N (2006) Sero-epidemiology of canine leptospirosis in Trinidad: serovars, implications for vaccination and public health. Journal of Veterinary Medicine, B: Infectious Diseases and Veterinary Public Health 53, 91–99.CrossRefGoogle ScholarPubMed
Adler, B (2015) Leptospira and Leptospirosis, 1st Edn, Berlin Heidelberg: Springer-Verlag.CrossRefGoogle ScholarPubMed
Adler, B and de la Peña Moctezuma, A (2010) Leptospira and leptospirosis. Veterinary Microbiology 140, 287–296.Google ScholarPubMed
Baraitareanu, S, Gurau, MR and Danes, D (2014) Survey of Leptospira spp. in captive street dogs housed in shelters. Advances in Environmental Technology and Biotechnology, 193–197. ISBN: 978-960-474-384-1.Google Scholar
Baraitareanu, S, Stanca, LE, Gurau, MR and Danes, D (2019) Research on the Leptospira infection prevalence in stray dogs in a Romanian shelter. Revista Romana de Medicina Veterinara 29, 37–41.Google Scholar
Batista, CdSA, Azevedo, SSd, Alves, CJ, Vasconcellos, SA, Morais, ZMd, Clementino, IJ, Lima, FDS and Araújo Neto, JOd (2004) Soroprevalência de leptospirose em cães errantes da cidade de Patos, Estado da Paraíba, Brasil. Brazilian Journal of Veterinary Research and Animal Science 41, 131–136.CrossRefGoogle Scholar
Belay, ED, Kile, JC, Hall, AJ, Barton-Behravesh, C, Parsons, MB, Salyer, S and Walke, H (2017) Zoonotic disease programs for enhancing global health security. Emerging Infectious Diseases 23, S65–S70. doi:10.3201/eid2313.170544.CrossRefGoogle ScholarPubMed
Belitardo, DR, Freitas, JCD and Müller, EE (2000) Prevalence of leptospirosis in animals from biologic science center of Londrina State University. Semina: Ciências Agrárias 21, 19–25.Google Scholar
Benacer, D, Thong, KL, Ooi, PT, Souris, M, Lewis, JW, Ahmed, AA and Mohd Zain, SN (2017) Serological and molecular identification of Leptospira spp. in swine and stray dogs from Malaysia. Tropical Biomedicine 34, 89–97.Google ScholarPubMed
Benitez, A, Rodrigues, GG, Gonçalves, DD, Burke, JC, Alves, LA, Müller, EE and Freitas, JCd (2010) Leptospirosis in stray dogs found in university campus: serological evaluation and urine direct exam. Semina: Ciências Agrárias 31, 191–196.Google Scholar
Blazius, RD, Romão, PR, Blazius, EM and da Silva, OS (2005) Occurrence of Leptospira spp. seropositive stray dogs in Itapema, Santa Catarina, Brazil. Cadernos de Saude Publica 21, 1952–1956.Google Scholar
Bloch, KV and Coutinho, EDSF (2009) Fundamentos da pesquisa epidemiológica. In Medronho, RDA (ed.), Epidemiologia, 2nd Edn, São Paulo: Editora Atheneu, pp. 173–180.Google Scholar
Blum Domínguez, SC, Chi Dzib, MY, Maldonado Velázquez, MG, Nuñez Oreza, LA, Gómez Solano, MI, Caballero Poot, RI and Tamay Segovia, P (2013) Detection of reactive canines to Leptospira in Campeche city, Mexico. Revista Argentina de Microbiología 45, 34–38.Google Scholar
Cabral, FGDS and Savalli, C (2020) Sobre a relação humano-cão. Psicologia USP 31, e190109. https://doi.org/10.1590/0103-6564e190109.CrossRefGoogle Scholar
Chetta, M, Vicari, D, Agnello, S, Percipalle, M, Ferrantelli, V and Vitale, M (2014) Canine leptospirosis cases and molecular screening for Leptospira interrogans infection. Pakistan Veterinary Journal 34, 260–262.Google Scholar
Chou, C, Yeh, T, Lu, Y, Shih, W, Chang, C, Chien, C, Liu, S, Wu, H, Tsai, F, Huang, H and Liao, M (2014) Prevalence of zoonotic pathogens by molecular detection in stray dogs in central Taiwan. Thai Journal of Veterinary Medicine 44, 363–375.Google Scholar
Cortez-Aguirre, GR, Jiménez-Coello, M, Gutiérrez-Blanco, E and Ortega-Pacheco, A (2018) Stray dog population in a city of Southern Mexico and its impact on the contamination of public areas. Veterinary Medicine International 2018, 2381583.CrossRefGoogle Scholar
Costa, F, Hagan, JE, Calcagno, J, Kane, M, Torgerson, P, Martinez-Silveira, MS, Stein, C, Abela-Ridder, B and Ko, AI (2015) Global morbidity and mortality of leptospirosis: a systematic review. PLoS Neglected Tropical Diseases 9, e0003898.CrossRefGoogle ScholarPubMed
Cruz-Romero, A, Romero-Salas, D, Aguirre, CA, Aguilar-Domínguez, M and Bautista-Piña, C (2013) Frequency of canine leptospirosis in dog shelters in Veracruz, Mexico. African Journal of Microbiology Research 7, 1518–1521.Google Scholar
Desvars, A, Naze, F, Vourc'h, G, Cardinale, E, Picardeau, M, Michault, A and Bourhy, P (2012) Similarities in Leptospira serogroup and species distribution in animals and humans in the Indian Ocean Island of Mayotte. American Journal of Tropical Medicine and Hygiene 87, 134–140.CrossRefGoogle ScholarPubMed
Desvars, A, Naze, F, Benneveau, A, Cardinale, E and Michault, A (2013) Endemicity of leptospirosis in domestic and wild animal species from Reunion Island (Indian Ocean). Epidemiology and Infection 141, 1154–1165.CrossRefGoogle Scholar
Dharanesh, CD, Suryanarayan, T, Veeregowda, BM, Rathnamma, D, Gajendragad, MR, Prabhudas, K and Yathiraj, S (2009) Seroprevalence of leptospirosis in dogs from Bangalore. Indian Journal of Animal Sciences 79, 159–160.Google Scholar
Ellis, WA (2010) Control of canine leptospirosis in Europe: time for a change? Veterinary Record 167, 602–605.CrossRefGoogle ScholarPubMed
Ellis, WA (2015) Animal leptospirosis. In Adler, B (ed.), Leptospira and Leptospirosis. Current Topics Microbiology and Immunology, 1st Edn. Berlin Heidelberg: Springer-Verlag, pp. 99–137.Google Scholar
FAO (2014) Dog Population Management – Report of the FAO/WSPA/IZSAM Expert Meeting – Banna, Italy, 14–19 March 2011, 6, Rome: Food and Agriculture Organization of the United Nations.Google Scholar
Farrington, NP and Sulzer, KR (1982) Canine leptospirosis in Puerto Rico. International Journal of Zoonoses 9, 45–50.Google ScholarPubMed
Feng, T, Chou, C, Yeh, T, Su, Y, Lu, Y, Shih, W, Chiang, C, Chang, C, Liu, S, Wu, H, Huang, H and Liao, M (2015) Molecular prevalence of zoonotic pathogens in pet and stray dogs in southern Taiwan. Thai Journal of Veterinary Medicine 45, 509–522.Google Scholar
Fonzar, UJV and Langoni, H (2012) Geographic analysis on the occurrence of human and canine leptospirosis in the city of Maringá, state of Paraná, Brazil. Revista da Sociedade Brasileira de Medicina Tropical 45, 100–105.CrossRefGoogle ScholarPubMed
Gagnier, JJ, Riley, D, Altman, DG, Moher, D, Sox, H and Kienle, G and CARE Group (2013) The CARE guidelines: consensus-based clinical case reporting guideline development. Deutsches Ärzteblatt International 110, 603–608.Google ScholarPubMed
Goh, SH, Ismail, R, Lau, SF, Megat Abdul Rani, PA, Mohd Mohidin, TB, Daud, F, Bahaman, AR, Khairani-Bejo, S, Radzi, R and Khor, KH (2019) Risk factors and prediction of leptospiral seropositivity among dogs and dog handlers in Malaysia. International Journal of Environmental Research and Public Health 16, 1499. doi:10.3390/ijerph16091499.CrossRefGoogle ScholarPubMed
Gonçalez, CC, Paes, AC, Langoni, H, da Silva, RC, Greca, H, Camossi, LG, Guimarães, FF and Ullmann, LS (2010) Antibodies to Leptospira spp., Toxoplasma gondii, and Neospora caninum in mongrel dogs kept in private kennel. Arquivo Brasileiro de Medicina Veterinária e Zootecnia 62, 1011–1014.CrossRefGoogle Scholar
Hafemann, DCM, Merlini, LS, Gonçalves, DD, Fortes, MS, Navarro, IT, Chiderolli, RT, Freitas, JC, Gonçalves, APP, Rosa, G and Sposito, PH (2018) Detection of anti-Leptospira spp., anti-Brucella spp., and anti-Toxoplasma gondii antibodies in stray dogs. Semina: Ciências Agrárias 39, 167–176.Google Scholar
Hart, L and Yamamoto, M (2016) Dogs as helping partners and companions for humans. In Serpell, J (ed.), The Domestic Dog: Its Evolution, Behavior and Interactions with People, Cambridge: Cambridge University Press, pp. 247–270. doi:10.1017/9781139161800.013.CrossRefGoogle Scholar
Hughes, J and Macdonald, DW (2013) A review of the interactions between free-roaming domestic dogs and wildlife. Biological Conservation 157, 341–351.CrossRefGoogle Scholar
IBGE, Instituto Brasileiro de Geografia e Estatística (2013) População de animais de estimação no Brasil [online], Available at: https://www.gov.br/agricultura/pt-br/assuntos/camaras-setoriais-tematicas/documentos/camaras-tematicas/insumos-agropecuarios/anos-anteriores/ibge-populacao-de-animais-de-estimacao-no-brasil-2013-abinpet-79.pdf/view [accessed 10/23/2020].Google Scholar
Ivana, S, Bogdan, AT, Ipate, I, Andreescu, N, Chiurciu, C, Chiurciu, V, Caplan, DM, Bărăităreanu, S, Țogoe, I and Popescu, AN (2010) Biodiversity of the germs involved in the human and animal leptospirosis in stray dog of Bucharest temporally adopted by the community. Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Veterinary Medicine 67, 82–86.Google Scholar
Jackman, J and Rowan, A (2007) Free-roaming dogs in developing countries: the benefits of capture, neuter, and return programs. The State of the Animals IV, 55–78.Google Scholar
Jimenez-Coello, M, Vado-Solis, I, Cárdenas-Marrufo, MF, Rodríguez-Buenfil, JC and Ortega-Pacheco, A (2008) Serological survey of canine leptospirosis in the tropics of Yucatan Mexico using two different tests. Acta Tropica 106, 22–26.CrossRefGoogle ScholarPubMed
Jimenez-Coello, M, Ortega-Pacheco, A, Guzman-Marin, E, Guiris-Andrade, DM, Martinez-Figueroa, L and Acosta-Viana, KY (2010) Stray dogs as reservoirs of the zoonotic agents Leptospira interrogans, Trypanosoma cruzi, and Aspergillus spp. in an urban area of Chiapas in southern Mexico. Vector Borne and Zoonotic Diseases 10, 135–141.CrossRefGoogle Scholar
Jittapalapong, S, Sittisan, P, Sakpuaram, T, Kabeya, H, Maruyama, S and Inpankaew, T (2009) Coinfection of Leptospira spp. and Toxoplasma gondii among stray dogs in Bangkok, Thailand. Southeast Asian Journal of Tropical Medicine and Public Health 40, 247–252.Google ScholarPubMed
Jung, BY, Song, YK, Choi, JS, Lee, KW, Ha, TY, Yoon, SS, Kweon, CH and Park, CK (2008) Seroprevalence of leptospirosis in animals in Korea. Veterinary Record 163, 28–29.Google ScholarPubMed
Khamesipour, F, Doosti, A, Emadi, MF and Awosile, B (2014) Detection of Brucella sp. and Leptospira sp. in dogs using conventional polymerase chain reaction. Bulletin of the Veterinary Institute in Pulawy 58, 527–531.CrossRefGoogle Scholar
Khor, KH, Tan, WX, Lau, SF, Mohd Azri, R, Rozanaliza, R, Siti, KB and Abdul Rani, B (2016) Seroprevalence and molecular detection of leptospirosis from a dog shelter. Tropical Biomedicine 33, 276–284.Google ScholarPubMed
Kumar, A, Sinha, DK, Chaudhury, P, Shankar, H and Srivastava, SK (2009) Comparative studies on seroepidemiology of canine leptospirosis by microagglutination test (MAT) and recombinant lip L32 ELISA. Indian Journal of Animal Sciences 79, 1089–1094.Google Scholar
Kurilung, A, Keeratipusana, C, Suriyaphol, P, Hampson, DJ and Prapasarakul, N (2019) Genomic analysis of Leptospira interrogans serovar Paidjan and Dadas isolates from carrier dogs and comparative genomic analysis to detect genes under positive selection. BMC Genomics 20, 168.CrossRefGoogle ScholarPubMed
Lau, SF, Wong, JY, Khor, KH, Roslan, MA, Abdul Rahman, MS, Bejo, SK, Radzi, R and Bahaman, AR (2017) Seroprevalence of leptospirosis in working dogs. Topics in Companion Animal Medicine 32, 121–125.CrossRefGoogle ScholarPubMed
Macpherson, CNL, Meslin, FX and Wandeler, AI (2000) Dogs, Zoonoses and Public Health. Wallingford, Oxon, UK: CABI Publishing.CrossRefGoogle Scholar
Mamak, N, Ozkanlar, Y, Kazim-Borku, M and Yilmaz-Imren, H (2014) Detection of antibodies against Leptospira spp. and Listeria monocytogenes, and intestinal parasite eggs in Kangal dogs. Revista Cientifica de la Facultad de Ciencias Veterinarias de la Universidad del Zulia 24, 18–23.Google Scholar
Manić, M, Prokić, N, Gojković, K, Đorić, G, Vasić, A, Marić, J, Vojinović, D and Đuričić, B (2014) Seroprevalence of some infectious diseases in stray dogs in the wider territory of Leskovac city. Arhiv Veterinarske Medicine 7, 19–27.Google Scholar
Mbilo, C, Coetzer, A, Bonfoh, B, Angot, A, Bebay, C, Cassamá, B, De Benedictis, P, Ebou, MH, Gnanvi, C, Kallo, V, Lokossou, RH, Manjuba, C, Mokondjimobe, E, Mouillé, B, Mounkaila, M, Ndour, APN, Nel, L, Olugasa, BO, Pato, P, Pyana, PP, Rerambyath, GA, Roamba, RC, Sadeuh-Mba, SA, Suluku, R, Suu-Ire, RD, Tejiokem, MC, Tetchi, M, Tiembre, I, Traoré, A, Voupawoe, G and Zinsstag, J (2020) Dog rabies control in West and Central Africa: a review. Acta Tropica 224, 105459.CrossRefGoogle ScholarPubMed
Medina, AZ, Guerra, BM and Veliz, N (2010) Serological study of leptospirosis in canines from a shelter in the state of Aragua. Revista de la Facultad de Ciencias Veterinarias, Universidad Central de Venezuela 51, 93–97.Google Scholar
Meira, CD, Wenceslau, AA, Carvalho, FS, Albuquerque, GR and Dias, RC (2011) Molecular diagnosis of leptospirosis in blood of dogs naturally infected. Revista Brasileira de Medicina Veterinaria 33, 7–11.Google Scholar
Mérien, F, Amouriaux, P, Perolat, P, Baranton, G and Saint Girons, I (1992) Polymerase chain reaction for detection of Leptospira spp. in clinical samples. Journal of Clinical Microbiology 30, 2219–2224.CrossRefGoogle ScholarPubMed
Miotto, BA, Guilloux, AGA, Tozzi, BF, Moreno, LZ, Da Hora, AS, Dias, RA, Heinemann, MB, Moreno, AM, de Souza Filho, AF, Lilenbaum, W and Hagiwara, MK (2018) Prospective study of canine leptospirosis in shelter and stray dog populations: identification of chronic carriers and different Leptospira species infecting dogs. PLoS ONE 13, e0200384. doi:10.1371/journal.pone.0200384.CrossRefGoogle ScholarPubMed
Mohammed, H, Nozha, C, Hakim, K and Abdelaziz, F (2011) Leptospira: morphology, classification and pathogenesis. Journal of Bacteriology and Parasitology 2, 120. doi:10.4172/2155-9597.1000120.CrossRefGoogle Scholar
Myburgh, JG, Posnett, SJ and Lawrence, JV (1993) Serological survey for canine leptospirosis in the Pretoria area. Journal of the South African Veterinary Association 64, 37–38.Google ScholarPubMed
OIE and World Organization for Animal Health (2021) Leptospirosis, Chapter 3.1.12 in Manual of Diagnostic Tests and Vaccines for Terrestrial Animals 2021 [online]. Available at: https://www.oie.int/en/what-we-do/standards/codes-and-manuals/terrestrial-manual-online-access/ [accessed 25/08/2021].Google Scholar
Ojha, KC, Singh, DK, Kaphle, K, Shah, Y and Pant, DK (2018) Sero-prevalence of leptospirosis and differentiation in blood parameters between positive and negative cases in dogs of Kathmandu valley. Transactions of the Royal Society of Tropical Medicine and Hygiene 112, 378–382.CrossRefGoogle ScholarPubMed
Oliveira, ST, Messick, JB, Biondo, AW, dos Santos, AP, Stedile, R, Dalmolin, ML, Guimaraes, AMD, Mohamed, AS, Riediger, IN and Gonzalez, FHD (2012) Exposure to Leptospira spp. in sick dogs, shelter dogs and dogs from an endemic area: points to consider. Acta Scientiae Veterinariae 40, 1–7.Google Scholar
Ortega-Pacheco, A, Colin-Flores, RF, Gutiérrez-Blanco, E and Jiménez-Coello, M (2008) Frequency and type of renal lesions in dogs naturally infected with Leptospira species. Annals of the New York Academy of Sciences 1149, 270–274.CrossRefGoogle ScholarPubMed
Patino, CM and Ferreira, JC (2018) Internal and external validity: can you apply research study results to your patients? Journal Brasileiro de Pneumologia 44, 183.CrossRefGoogle ScholarPubMed
Paz, GSD, Rocha, KS, Lima, MS, Jorge, EM, Pantoja, JCF, Moraes, Ccgd and Langoni, H (2015) Seroprevalence for brucellosis and leptospirosis in dogs from Belém and Castanhal, State of Pará, Brazil. Acta Amazonica, 45, 265–270.CrossRefGoogle Scholar
Pesavento, PA and Murphy, BG (2014) Common and emerging infectious diseases in the animal shelter. Veterinary Pathology 51, 478–491.CrossRefGoogle ScholarPubMed
Polachini, CO and Fujimori, K (2015) Leptospirose canina e humana, uma possível transmissão conjuntival no Município de São Paulo, Estado de São Paulo, Brasil. Revista Pan-Amazônica de Saúde 6, 59–65.CrossRefGoogle Scholar
Rivera Flores, A, Roa Riol, MdlÁ, Ordóñez Badillo, ML and Peña Moctezuma, Adl (1999) Seroprevalence of leptospirosis in stray dogs in northern Mexico City. Veterinaria México 30, 105–107.Google Scholar
Roach, JM, van Vuuren, M and Picard, JA (2010) A serological survey of antibodies to Leptospira species in dogs in South Africa. Journal of the South African Veterinary Association 81, 156–159.CrossRefGoogle ScholarPubMed
Rodríguez, AL, Ferro, BE, Varona, MX and Santafé, M (2004) Exposure to Leptospira in stray dogs in the city of Cali. Biomedica: Revista del Instituto Nacional de Salud 24, 291–295.CrossRefGoogle ScholarPubMed
Ryu, E (1975) An investigation of canine antileptospiral antibodies in Japan. International Journal of Zoonoses 2, 16–34.Google ScholarPubMed
Samir, A, Soliman, R, El-Hariri, M, Abdel-Moein, K and Hatem, ME (2015) Leptospirosis in animals and human contacts in Egypt: broad range surveillance. Revista da Sociedade Brasileira de Medicina Tropical 48, 272–277.CrossRefGoogle ScholarPubMed
Scanziani, E, Origgi, F, Giusti, AM, Iacchia, G, Vasino, A, Pirovano, G, Scarpa, P and Tagliabue, S (2002) Serological survey of leptospiral infection in kennelled dogs in Italy. Journal of Small Animal Practice 43, 154–157.CrossRefGoogle ScholarPubMed
Schuller, S, Francey, T, Hartmann, K, Hugonnard, M, Kohn, B, Nally, JE and Sykes, J (2015) European Consensus statement on leptospirosis in dogs and cats. Journal of Small Animal Practice 56, 159–179.CrossRefGoogle ScholarPubMed
Sedgwick, P (2014) Cross sectional studies: advantages and disadvantages. BMJ 348, g2276.CrossRefGoogle ScholarPubMed
Senthil, NR, Palanivel, KM and Rishikesavan, R (2013) Seroprevalence of leptospiral antibodies in canine population in and around Namakkal. Journal of Veterinary Medicine 2013, 971810.CrossRefGoogle ScholarPubMed
Siam, MA, Karim, AMA, Hamed, OM and Zakaria, A (1973) The possible role of stray dogs and cats in the epidemiology of some bacterial human pathogens in Egypt. Zentralblatt für Veterinärmedizin. Reihe B 20, 409–414.CrossRefGoogle ScholarPubMed
Silva, ERDDFS, Castro, V, Prianti, MDG, Gonçalves, LMF, Sobrinho, EPC Jr, Drumond, KO and Mineiro, ALBB (2017) Occurrence of antibodies against Leptospira spp. in dogs from Teresina, Piauí, Brazil. Brazilian Journal of Veterinary Research and Animal Science 54, 88–91.CrossRefGoogle Scholar
Smith, LM, Hartmann, S, Munteanu, AM, Dalla Villa, P, Quinnell, RJ and Collins, LM (2019) The effectiveness of dog population management: a systematic review. Animals (Basel) 9, 1020.CrossRefGoogle ScholarPubMed
Thakur, M (2014) Sero-prevalence of leptospiral infection in canine population of Kathmandu valley. Nepalese Journal of Agricultural Sciences 12, 67–73.Google Scholar
Thiermann, AB (1980) Canine leptospirosis in Detroit. American Journal of Veterinary Research 41, 1659–1661.Google ScholarPubMed
Thrusfield, M (2007) Veterinary Epidemiology, 3rd Edn, Oxford, UK: Blackwell Science Ltd.Google Scholar
Tuemmers, C, Lüders, C, Rojas, C, Serr, M, Espinoza, R and Castillo, C (2013) Prevalencia de leptospirosis en perros vagos capturados en la ciudad de Temuco, 2011. Revista Chilena de Infectología 30, 252–257.Google Scholar
Vandenbroucke, JP, von Elm, E, Altman, DG, Gøtzsche, PC, Mulrow, CD, Pocock, SJ, Poole, C, Schlesselman, JJ and Egger, M and STROBE Initiative (2007) Strengthening the reporting of observational studies in epidemiology (STROBE): explanation and elaboration. PLoS Medicine 4, e297–e297.CrossRefGoogle ScholarPubMed
Vicari, D, Percipalle, M, Concetta, LM, Li Vecchi, L, Curro, V, Vitale, M and Vicenzo, F (2007) Evidencia de leptospirosis canina en las perreras de Sicilia según el método de RCP. Revista Cubana de Medicina Tropical 59, 61–62.Google Scholar
Villanueva, SYAM, Baterna, RA, Cavinta, LL, Yanagihara, Y, Gloriani, NG and Yoshida, Si (2018) Seroprevalence of leptospirosis among water buffaloes, pigs, and dogs in selected areas in the Philippines, 2007 to 2008. Acta Medica Philippina 52, 109–117.CrossRefGoogle Scholar
Vojinović, D, Bogićević, N, Vasić, A, Manić, M, Elezović Radovanović, ME, Rogožarski, D, Marić, J and Valčić, M (2015) Seroepidemiological survey of leptospiral infection in stray dogs in Serbia. Turkish Journal of Veterinary and Animal Sciences 39, 719–723.CrossRefGoogle Scholar
Weekes, CC, Everard, COR and Levett, PN (1997) Seroepidemiology of canine leptospirosis on the island of Barbados. Veterinary Microbiology 57, 215–222.CrossRefGoogle ScholarPubMed
WSPA, World Society for the Protection of Animals (2011) Working with strays: a humane alternative [online]. Available at: at http://www.wspa-usa.org/wspaswork/dogs/companionanimals/ahumanealternative.html [accessed 08/04/2020].Google Scholar
Yasuda, PH, Santa Rosa, CA, Myers, DM and Yanaguita, RM (1980a) The isolation of leptospires from stray dogs in the city of Sao Paulo, Brazil. International Journal of Zoonoses 7, 131–134.Google Scholar
Yasuda, PH, Santa Rosa, CA and Yanaguita, RM (1980b) Variação sazonal na prevalência de leptospirose em cães de rua da cidade de São Paulo, Brasil. Revista de Saúde Pública 14, 589–596.CrossRefGoogle Scholar
Zaidi, S, Bouam, A, Bessas, A, Hezil, D, Ghaoui, H, Ait-Oudhia, K, Drancourt, M and Bitam, I (2018) Urinary shedding of pathogenic Leptospira in stray dogs and cats, Algiers: a prospective study. PLoS ONE 13, e0197068.CrossRefGoogle ScholarPubMed
Zhang, Z, Khederzadeh, S and Li, Y (2020) Deciphering the puzzles of dog domestication. Zoological Research 41, 97–104.Google ScholarPubMed
Ziehl-Quirós, EC, García-Aguilar, MC and Mellink, E (2017) Colony-level assessment of Brucella and Leptospira in the Guadalupe fur seal, Isla Guadalupe, Mexico. Diseases of Aquatic Organisms 122, 185–193.CrossRefGoogle ScholarPubMed
Zwijnenberg, RJG, Smythe, LD, Symonds, ML, Dohnt, MF and Toribio, JALML (2008) Cross-sectional study of canine leptospirosis in animal shelter populations in mainland Australia. Australian Veterinary Journal 86, 317–323.CrossRefGoogle ScholarPubMed
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