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Antimicrobial resistance in Mannheimia haemolytica: prevalence and impact

Published online by Cambridge University Press:  02 December 2020

Brent Credille Open the ORCID record for Brent Credille [Opens in a new window]
Brent Credille*
Affiliation:
Food Animal Health and Management Program, Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
*
Author for correspondence: Brent Credille, Food Animal Health and Management Program, Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA. E-mail: [email protected]
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Abstract

Bovine respiratory disease (BRD) is the most common cause of morbidity and mortality in North American beef cattle. In recent years, isolation of strains of Mannheimia haemolytica that are resistant to multiple different classes of antimicrobials has become commonplace. New research would suggest that the routine use of antimicrobials by some cattle operations might be driving emerging resistance patterns, with the majority of the spread observed due to propagation of strains of M. haemolytica that have acquired integrative conjugative elements. To date, there is little information evaluating the impact of antimicrobial resistance on clinical outcome in cattle with BRD.

Keywords

Antimicrobial resistancebovine respiratory diseaseMannheimia haemolytica
Type
Special issue: Papers from Bovine Respiratory Disease Symposium
Information
Animal Health Research Reviews , Volume 21 , Issue 2 , December 2020 , pp. 196 - 199
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Copyright
Copyright © The Author(s), 2020. Published by Cambridge University Press

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References

Apley, MD (2003) Susceptibility testing for bovine respiratory and enteric disease. The Veterinary Clinics of North America. Food Animal Practice 19, 625–646.CrossRefGoogle ScholarPubMed
Avra, TD, Abell, KM, Shane, DD, Theurer, ME, Larson, RL and White, BJ (2017) A retrospective analysis of risk factors associated with bovine respiratory disease treatment failure in feedlot cattle. Journal of Animal Science 95, 1521–1527.Google ScholarPubMed
Clawson, ML, Murray, RW, Sweeney, MT, Apley, MD, Dedonder, KD, Capik, SF, Larson, RL, Lubbers, BV, White, BJ, Kalbfleisch, TS, Schuller, G, Dickey, AM, Harhay, GP, Heaton, MP, Chitko-McKown, CG, Brichta-Harhay, DM, Bono, JL and Smith, TP (2016) Genomic signatures of Mannheimia haemolytica that associate with the lungs of cattle with respiratory disease, an integrative conjugative element, and antibiotic resistance genes. BMC Genomics 17, 982.CrossRefGoogle ScholarPubMed
Crosby, S, Credille, B, Giguere, S and Berghaus, R (2018) Comparative efficacy of enrofloxacin to that of tulathromycin for the control of bovine respiratory disease and prevalence of antimicrobial resistance in Mannheimia haemolytica in calves at high risk of developing bovine respiratory disease. Journal of Animal Science 96, 1259–1267.CrossRefGoogle ScholarPubMed
Klima, CL, Alexander, TW, Read, RR, Gow, SP, Booker, CW, Hannon, S, Sheedy, C, McAllister, TA and Selinger, LB (2011) Genetic characterization and antimicrobial susceptibility of Mannheimia haemolytica isolated from the nasopharynx of feedlot cattle. Veterinary Microbiology 149, 390–398.CrossRefGoogle ScholarPubMed
Klima, CL, Alexander, TW, Hendrick, S and McAllister, TA (2014a) Characterization of Mannheimia haemolytica isolated from feedlot cattle that were healthy or treated for bovine respiratory disease. Canadian Journal of Veterinary Research 78, 38–45.Google Scholar
Klima, CL, Zaheer, R, Cook, SR, Booker, CW, Hendrick, S, Alexander, TW and Mcallister, TA (2014b) Pathogens of bovine respiratory disease in North American feedlots conferring multidrug resistance via integrative conjugative elements. Journal of Clinical Microbiology 52, 438–448.CrossRefGoogle Scholar
Lubbers, BV and Hanzlicek, GA (2013) Antimicrobial multidrug resistance and coresistance patterns of Mannheimia haemolytica isolated from bovine respiratory disease cases – a three-year (2009–2011) retrospective analysis. Journal of Veterinary Diagnostic Investigation 25, 413–417.CrossRefGoogle Scholar
Lubbers, BV and Turnidge, J (2015) Antimicrobial susceptibility testing for bovine respiratory disease: getting more from diagnostic results. Veterinary Journal 203, 149–154.CrossRefGoogle ScholarPubMed
Magstadt, DR, Schuler, AM, Coetzee, JF, Krull, AC, O'Connor, AM, Cooper, VL and Engelken, TJ (2018) Treatment history and antimicrobial susceptibility results for Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni isolates from bovine respiratory disease cases submitted to the Iowa State University Veterinary Diagnostic Laboratory from 2013 to 2015. Journal of Veterinary Diagnostic Investigation 30, 99–104.CrossRefGoogle ScholarPubMed
McClary, DG, Loneragan, GH, Shryock, TR, Carter, BL, Guthrie, CA, Corbin, MJ and Mechor, GD (2011) Relationship of in vitro minimum inhibitory concentrations of tilmicosin against Mannheimia haemolytica and Pasteurella multocida and in vivo tilmicosin treatment outcome among calves with signs of bovine respiratory disease. Journal of the American Veterinary Medical Association 239, 129–135.CrossRefGoogle ScholarPubMed
Noyes, NR, Benedict, KM, Gow, SP, Booker, CW, Hannon, SJ, McAllister, TA and Morley, PS (2015) Mannheimia haemolytica in feedlot cattle: prevalence of recovery and associations with antimicrobial use, resistance, and health outcomes. Journal of Veterinary Internal Medicine 29, 705–713.CrossRefGoogle ScholarPubMed
Snyder, E, Credille, B, Berghaus, R and Giguere, S (2017) Prevalence of multi drug antimicrobial resistance in isolated from high-risk stocker cattle at arrival and two weeks after processing. Journal of Animal Science 95, 1124–1131.Google ScholarPubMed
Snyder, ER, Alvarez-Narvaez, S and Credille, BC (2019) Genetic characterization of susceptible and multi-drug resistant Mannheimia haemolytica isolated from high-risk stocker calves prior to and after antimicrobial metaphylaxis. Veterinary Microbiology 235, 110–117.CrossRefGoogle ScholarPubMed
Tennant, TC, Ives, SE, Harper, LB, Renter, DG and Lawrence, TE (2014) Comparison of tulathromycin and tilmicosin on the prevalence and severity of bovine respiratory disease in feedlot cattle in association with feedlot performance, carcass characteristics, and economic factors. Journal of Animal Science 92, 5203–5213.CrossRefGoogle ScholarPubMed
Watts, JL, Yancey, RJ Jr., Salmon, SA and Case, CA (1994) A 4-year survey of antimicrobial susceptibility trends for isolates from cattle with bovine respiratory disease in North America. Journal of Clinical Microbiology 32, 725–731.CrossRefGoogle ScholarPubMed
Welsh, RD, Dye, LB, Payton, ME and Confer, AW (2004) Isolation and antimicrobial susceptibilities of bacterial pathogens from bovine pneumonia: 1994–2002. Journal of Veterinary Diagnostic Investigation 16, 426–431.CrossRefGoogle ScholarPubMed
Woolums, AR, Karisch, BB, Frye, JG, Epperson, W, Smith, DR, Blanton, J Jr., Austin, F, Kaplan, R, Hiott, L, Woodley, T, Gupta, SK, Jackson, CR and McClelland, M (2018) Multidrug resistant Mannheimia haemolytica isolated from high-risk beef stocker cattle after antimicrobial metaphylaxis and treatment for bovine respiratory disease. Veterinary Microbiology 221, 143–152.CrossRefGoogle ScholarPubMed
Wozniak, RA and Waldor, MK (2010) Integrative and conjugative elements: mosaic mobile genetic elements enabling dynamic lateral gene flow. Nature Reviews Microbiology 8, 552–563.CrossRefGoogle ScholarPubMed