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Maternal Plasma Concentrations of Insulin-Like Growth Factor-I (IGF-I) and Human Placental Lactogen (hPL) in Twin Pregnancies

Published online by Cambridge University Press:  01 August 2014

R.R. Kazer ,
E.R. Cheng ,
T.G. Unterman  and
R.P. Glick
R.R. Kazer*
Affiliation:
Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Illinois
E.R. Cheng
Affiliation:
Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Illinois
T.G. Unterman
Affiliation:
Department of Medicine, Northwestern University Medical School, Chicago, Illinois
R.P. Glick
Affiliation:
Department of Neurosurgery, University of Illinois College of Medicine, and Veterans Administration West Side Medical Center, and Cook County Hospital, Chicago, Illinois
*
Center for Assisted Reproduction, Northwestern Medical Faculty Foundation, Inc., 680 North Lake Shore Drive, Suite 810, Chicago IL 60611, USA

Abstract

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Maternal plasma IGF-I and hPL concentrations were examined in 10 singleton pregnancies and in 11 twin gestations near term. hPL concentrations were higher in the twin pregnancies (14.4 ± 2.4 μg/1 vs 6.9 ± 0.9 μg/1, P < 0.02). In contrast, plasma IGF-I concentrations were similar in the singleton and twin pregnancies (533 ± 45 μg/1 vs 572 ± 60 μg/1, respectively). IGF-I concentrations failed to correlate with hPL concentrations in either group separately or when all subjects were considered together. These data do not support the hypothesis that maternal IGF-I secretion is an hPL-dependent process.

Keywords

TwinsInsulin-like growth factor-IHuman placental lactogen
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 40 , Issue 3-4 , October 1991 , pp. 383 - 387
Copyright
Copyright © The International Society for Twin Studies 1991

References

REFERENCES

1. Daughaday, WH, Trivedi, B, Winn, HN, Yan, H (1990): Hypersomatotropism in pregnant women as measured by a human liver radioreceptor assay. J Clin Endocrinol Metab 70:215–221.Google Scholar
2. Frankenne, F, Closset, J, Gomez, F, Scippo, ML, Smal, J, Hennen, G (1988): The physiology of growth hormones (GHs) in pregnant women and partial characterization of the placental GH variant. J Clin Endocrinol Metab 66:1171–1180.Google Scholar
3. Furlanetto, RW, Underwood, LE, Van Wyk, JJ, D'Ercole, AJ (1977): Estimation of somatomedin-C levels in normals and patients with pituitary disease by radioimmunoassay. J Clin Invest 60: 648–657.Google Scholar
4. Furlanetto, RW, Underwood, LE, Van Wyk, JJ, Handwerger, S (1978): Serum immunoreactive somatomedin-C is elevated late in pregnancy. J Clin Endocrinol Metab 47:695–698.CrossRefGoogle ScholarPubMed
5. Giudice, LC, Farrell, EM, Pham, H, Lamson, G, Rosenfeld, RG (1990): Insulin-like growth factor binding proteins (IGF-BPS) in serum during pregnancy and the puerperium: Depletion of IGF-BP-3 by endogenous pregnancy-associated protease actibity (Abstract). Program of the 72nd Annual Meeting of the Endocrine Society, Atlanta, Georgia, p 71.Google Scholar
6. Kaplan, SL, Grumbach, MM (1964): Studies of a human and simian placental hormone with growth hormone-like and prolactin-like activities. J Clin Endocrinol Metab 24:80–89.CrossRefGoogle ScholarPubMed
7. Kazer, RR, Unterman, TG, Glick, RP (1990): An abnormality of the growth hormone/insulin-like growth factor-I axis in women with polycystic ovary syndrome. J Clin Endocrinol Metab 71;958–962.Google Scholar
8. Spellacy, WN, Buhi, WC, Birk, SA (1978): Human placental lactogen levels in multiple pregnancies. Obstet Gynecol 52:210–215.Google Scholar