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Karl Landsteiner: Father of Blood Grouping and Immunochemistry

Published online by Cambridge University Press:  01 August 2014

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It was on June 25, 1943 that the world lost a great mind and a great medical scientist, when Dr. Karl Landsteiner succumbed to the effects of a heart attack that had overtaken him two days before while he was actively at work in his laboratory. He had just passed his seventy-fifth birthday of a lifetime devoted to fundamental research. Shortly before his death he had completed the second edition of his classic book, “The Specificity of Serological Reactions”, and he had also published almost 350 scientific papers describing the results of his pioneering investigations. This year is the centenary of the birth of Karl Landsteiner, and it seems fitting at this time to pay tribute to this genius and benefactor of mankind by reviewing some of his great discoveries.

Of Dr. Landsteiner's discoveries, the one that has captivated the popular imagination the most is his discovery of the A-B-O blood groups, frequently called the Landsteiner blood groups in his honor. At the beginning of the present century, it was recognized that bloods from animals of different species could be distinguished from one another by their serological reactions. For this reason, the use of animal blood for transfusions to human beings was abandoned, but the frequent serious reactions that followed transfusions of blood from one human being to another still remained unexplained. Landsteiner then tested the blood of workers in his laboratory by mixing serum taken from one individual with the red cells of others. He found that instead of the weak or negative reactions that might have been expected, in some combinations strong agglutination of the red cells occurred, while in other combinations no effect was apparent.

Type
Other
Copyright
Copyright © The International Society for Twin Studies 1968

References

Landsteiner, K. (1945). The Specificity of Serological Reactions. Reprinted by Dover Publ. Inc., New York 1962.Google Scholar
Speiser, P. (1961). Karl Landsteiner, Entdecker der Blutgruppen. Biographie eines Nobelpreisträger aus der Wiener Medizinischen Schule. Brüder Hollinke, Wien.Google Scholar
Wiener, A. S. (1943). Karl Landsteiner. Scientific Monthly, 67: 280283.Google Scholar
Wiener, A. S. (1968). Karl Landsteiner and the History of the Rh-Hr Blood Types. (In press).Google Scholar
Landsteiner, Karl (18681943). J. Immun., 38: 116, 1944.Google Scholar
Landsteiner, Karl (18681943). Obituary Notices of Fellows of the Royal Society. 5:295324.Google Scholar
Selected Contributions to the Literature of the Blood Groups and Immunology. Vol. I. The A-B-O System. Blood Transfusion Division, U. S. Army Medical Research Lab., Fort Knox, Kentucky, 1966.Google Scholar