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Height of Women, Twinning and Breast Cancer: Epidemiological Evidence of a Relationship

Published online by Cambridge University Press:  01 August 2014

John D.H. Doherty
John D.H. Doherty*
Affiliation:
Medical Service, Food and Agriculture Organization of the United Nations, Rome, Italy
*
Medical Service, Food and Agriculture Organization of the United Nations, Via delle Terme di Caracalla, 00100 Rome, Italy

Abstract

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A comparison was made of the stature of women, twinning rates, and breast cancer mortality for 32 countries. As height increased, so did twinning and breast cancer mortality (P < 0.005). Dizygotic twinning and breast cancer increased sharply with the mean height of the female population. With due caution in drawing causal inferences when uncontrolled confounding variables are present, it is suggested that these findings are an evolutionary consequence of the high mortality found in twin pregnancy.

Keywords

Twinning ratesHeight of womenBreast cancerGonadotrophinsPerinatal mortality
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 37 , Issue 3-4 , October 1988 , pp. 263 - 275
Copyright
Copyright © The International Society for Twin Studies 1988

References

REFERENCES

1. Allen, G (1981): Errors of Weinberg's difference method. Prog Clin Biol Res 69A: 71–74.Google ScholarPubMed
2. Anderson, WJR (1956): Stillbirth and neonatal mortality in twin pregnancy. J Obstet Gynaec Br Emp 63: 205–215.Google Scholar
3. Armitage, P., Berry, G (1987): “Statistical Methods in Medicai Research, 2nd Ed” Oxford: Blackwell Scientific Publications.Google Scholar
4. Armstrong, B, Doll, R (1975): Environmental factors and cancer incidence and mortality in different countries with special reference to dietary practices. Int J Cancer 15: 617–631.Google Scholar
5. Baird, D (1945): The influence of social and economic factors on stillbirths and neonatal deaths. J Obstet Gynaec 52: 339–366.Google Scholar
6. Baird, D (1949): Social faeton in obstetrics. Lancet I: 1079–1083.Google Scholar
7. Bassi, A (1812): “Il Pastore Ben Istruito.” Milano: De Stefania. Quoted by Gedda & Brenci [29], original not seen.Google Scholar
8. Bertillon, M (1874): Des combinaisons de sexe dans les grossesses gémellaires (doubles ou triples), de leur cause et de leur caractère ethnique. Bull Soc Anthrop Paris 9: 267–290.Google Scholar
9. Botting, BJ, Davies, IM, Macfarlane, AJ (1987): Recent trends in the incidence of multiple births and associated mortality. Arch Dis Child 62: 941–950.Google Scholar
10. Bulmer, MG (1959): Twinning rate in Europe during the war. Br Med J 1: 29–36.Google Scholar
11. Bulmer, MG (1960): The Twinning rate in Europe and Africa. Ann Hum Genet 24: 121–125.CrossRefGoogle ScholarPubMed
12. Bulmer, MG (1970): “The Biology of Twinning in Man.” Oxford: Clarendon Press.Google Scholar
13. Bulmer, MG (1976): Is Weinberg's method valid? Acta Genet Med Gemellol 25: 25–28.CrossRefGoogle ScholarPubMed
14. Campbell, DM, Campbell, AJ, MacGillivray, I (1974): Maternal characteristics of women having twin pregnancies. J Biosoc Sci 6: 463–470.Google Scholar
15. Cawley, RH, McKeown, T, Record, RG (1954): Parental stature and birth weight. Am J Hum Genet 6: 448–456.Google Scholar
16. Cawley, RH, McKeown, T, Record, RG (1954): Influence of the prenatal environment on post-natal growth. Brit J Prev Soc Med 8: 66–69.Google Scholar
17. Clarke, J (1788): Observations on some causes of the excess of the mortality of males above that of females. Philos Trans R Soc London 76: 344–364.Google Scholar
18. Collins, R (1835): “A Practical Treatise on Midwifery.” London: Longman, Rees, Orme, Browne, Green and Longman.Google Scholar
19. Corney, G, Seedburgh, D, Thompson, B, Campbell, DM, MacGillivray, I, Timlin, D (1979): Maternal height and twinning. Ann Hum Genet 43: 55–59.Google Scholar
20. Corney, G, Seedburgh, D, Thompson, B, Campbell, DM, MacGillivray, I, Timlin, D (1981): Multiple and singleton pregnancy: differences between mothers as well as offspring. Prog Clin Biol Res 69A: 107–114.Google Scholar
21. Das, K (1934): Twin pregnancy (a demographic and ethnic study). J Obst Gyn Brit Emp 41: 227–255.Google Scholar
22. Dean, G, Keane, T (1972): An investigation of the high twinning rate in the Republic of Ireland. Brit J Prev Soc Med 26: 186–192.Google Scholar
23. Doherty, JDH (1988): Perinatal mortality in twins, Australia, 1973-1980: I. Acta Genet Med Gemellol 37: 313–319.Google Scholar
24. Doherty, JDH (1988): Fertility, fecundity and twinning. Acta Genet Med Gemellol 37: 119–125.Google Scholar
25. Doherty, JDH, Lancaster, PAL (1986): The secular trend of twinning in Australia, 1853-1982. Acta Genet Med Gemellol 35: 61–76.Google Scholar
26. Eriksson, A (1962): Variations in the human twinning rate. Acta Genet Basel 12: 242–250.Google Scholar
27. Eriksson, AW, Eskola, MR, Fellman, JO (1976): Retrospective studies on the twinning rate in Scandinavia. Acta Genet Med Gemellol 25: 29–35.Google Scholar
28. Eveleth, PB, Tanner, JM (1976): “Worldwide Variation in Human Growth.” Cambridge: Cambridge University Press.Google Scholar
29. Gedda, L, Brenci, G (1965): Human monozygotic and plurizygotic multiple births: heredity and hormone action. Acta Genet Med Gemellol 14 (2): 109–129.Google Scholar
30. Gemzel, C, Roos, P (1966): Pregnancies following treatment with human gonadotropins. Am J Obstet Gynecol 94: 480–496.Google Scholar
31. Gittelsohn, AM, Milham, S (1965): Observations on twinning in New York State. Brit J Prev Soc Med 19: 8–17.Google Scholar
32. Gray, GE, Pike, MC, Henderson, BE (1979): Breast cancer incidence and mortality rates in different countries in relation to known risk factors and dietary practices. Br J Cancer 39: 1–7.Google Scholar
33. Greulich, WW (1930): The incidence of human multiple births. Amer Nat 64: 142–153.CrossRefGoogle Scholar
34. Guttmacher, AF (1953): The incidence of multiple births in man and some of the other unipara. Obstet Gynec 2: 22–35.Google ScholarPubMed
35. Hamlet, GWD (1935): Human twinning in the United States: racial frequencies, sex ratios and geographical variations. Genetics 20: 250–258.Google Scholar
36. Hémon, D, Berger, C, Lazar, P (1979): The etiology of human dizygotic twinning with special reference to spontaneous abortions. Acta Genet Med Gemellol 28: 253–258.Google ScholarPubMed
37. Imaizumi, Y, Inouye, E (1979): Analysis of multiple birth rates in Japan. I. Secular trend, maternal age effect and geographical variation in twinning rates. Acta Genet Med Gemellol 28: 107–124.Google Scholar
38. James, WH (1979): Is Weinberg's differential rule valid? Acta Genet Med Gemellol 28: 69–71.Google ScholarPubMed
39. James, WH (1982): Second survey of secular trends in twinning rates. J Biosoc Sci 14: 481–497.CrossRefGoogle ScholarPubMed
40. James, WH (1984): Twins (letter). N Engl J Med 311: 58.Google Scholar
41. Kamimura, K (1976): Epidemiology of twin births from a climatic point of view. Brit J Prev Soc Med 30: 175–179.Google Scholar
42. Knibbs, GH (1917): The mathematical theory of population. Appendix A. Volume 1. “Census of the Commonwealth of Australia.” Melbourne: Government Printer.Google Scholar
43. Komai, T, Fukuoka, G (1936): Frequency of multiple births among the Japanese and related peoples. Amer J Phys Anthrop 21: 433–447.CrossRefGoogle Scholar
44. Lazar, P, Hemon, D, Berger, C (1978): Twinning rate and reproduction failure. In Nance, WE, Allen, G, Parisi, P (eds) “Twin Research.” New York: Alan R Liss, pp 125–132.Google Scholar
45. Lin, TM, Chen, KP, MacMahon, B (1971): Epidemological characteristics of cancer of the breast in Taiwan. Cancer 27: 1497–1504.Google Scholar
46. Logan, WPD (1982): “Cancer Mortality by Occupation and Social Class 1851-1971.” IARC Scientific Publications No 36. Studies on Medicai and Populatkms Subjects. Lyon: International Agency for Research on Cancer, pp 63–66.Google Scholar
47. Lyle, KC (1980): Female breast cancer: distribution, risk factors and effect of steroid contraception. Obstet Gynec Survey 35 (7): 413–427.Google Scholar
48. MacArthur, JW (1942): Relations of body size to litter size and to the incidence of fratemal twins. J Hered 33: 87–91.Google Scholar
49. MacGillivray, I (1970): The changing incidence of twinning in Scotland in 1939-1968. Acta Genet Med Gemellol 19: 26–29.CrossRefGoogle ScholarPubMed
50. Martin, NG, El Beaini, JL, Olsen, ME, Bhatnagar, AS, Macourt, D (1984): Gonadotropa levels in mothers who have had two sets of DZ twins. Acta Genet Med Gemellol 33: 131–139.Google Scholar
51. McArthur, N (1952): The frequency of monovular and binovular twin births in Italy 1949-1950. Acta Genet Med Gemellol 2: 11–17.Google Scholar
52. McKeown, T, Record, RG (1954): Influence of pre-natal environment on correlation between birth weight and parental height. Am J Hum Genet 6: 457–463.Google Scholar
53. McKeown, T, Record, RG (1954): Influence of maternal size and parity on onset of labour in multiple pregnancy in man. J Endocrin 11: 160–164.Google Scholar
54. Meredith, HV (1971): Worldwide somatic comparisons among contemporary human groups of adult females. Am J Phys Anthrop 34: 89–132.CrossRefGoogle ScholarPubMed
55. Milham, S (1964): Pituitary gonadotrophin and dizygotic twinning. Lancet 2: 566.Google Scholar
56. Millis, J (1959): The frequency of twinning in poor Chinese in the maternity hospital Singapore. Ann Hum Genet 23: 171–174.CrossRefGoogle ScholarPubMed
57. Morton, NE (1962): Genetics of interracial crosses in Hawaii. Eugen Q 9: 23–24.Google Scholar
58. Nylander, PPS (1971) Ethnic differences in twinning rates in Nigeria. J Biosoc Sci 3: 151–157.Google Scholar
59. Nylander, PPS (1971): Biosocial aspects of multiple births. J Biosoc Sci Suppl 3: 29–38.Google Scholar
60. Nylander, PPS (1974): Pituitary gonadotropins and multiple births in Nigeria. Acta Genet Med Gemellol Suppl 22: 198–201.Google Scholar
61. Nylander, PPS (1981): The factors that influence twinning rates. Acta Genet Med Gemellol 30: 189–202.Google Scholar
62. Nylander, PPS, Corney, G (1969): Placentation and zygosity of twins in Ibadan, Nigeria. Ann Hum Genet 33: 31–40.Google Scholar
63. Parisi, P, Caperna, G (1982): Twinning rates, fertility and industrialization: A secular study. In: “Human Genetics, Part A: The Unfolding Genome.” New York: Alan R Liss, pp 375–394.Google Scholar
64. Pollard, GN (1969): Multiple births in Australia, 1944-1963. J Biosoc Sci I: 389–404.Google Scholar
65. Renkonen, KO (1967): Is Weinberg's differential rule defective? Ann Hum Genet 30: 277–280.Google Scholar
66. Shipley, PW, Wray, JA, Hecheter, HH, Arellano, MG, Borhani, NO (1967): Frequency of twinning in California, its relationship to maternal age, parity and race. Am J Epidemiol 85: 147–156.Google Scholar
67. Short, RV (1984): Testis size, ovulatkm rate and breast cancer. In Ryder, OA, Byrd, ML (eds) “One Medicine.” Berlin: Springer-Verlag.Google Scholar
68. Soma, H, Takayama, M, Kiyokawa, T, Akaeda, T, Tokoro, K (1975): Serum gonadotropin levels in Japanese women. Obstet Gynec 46: 311–312.Google Scholar
69. Strandskov, HH (1945): Plural birth frequencies in the total, the “white” and the “colored” US populations. Amer J Phys Anthrop NS 3: 49–55.CrossRefGoogle Scholar
70. Tanner, JM (1962): “Growth at Adolescence, 2nd Ed.” Oxford: Blackwell.Google Scholar
71. Tchouriloff, M (1877): Sur la statistique des naissances gémellaires et leur rapport avec la taille. Bull Soc Anthrop Paris 12: 440–446.Google Scholar
72. Thomson, AM, Barron, SL (1983): Perinatal mortality. In Barron, SL, Thomson, AM (eds) “Obstetrical Epidemiology.” London: Academic Press, pp 347–397.Google Scholar
73. Thomson, AM, Thomson, W (1949): Lambing in relation to the diet of the pregnant ewe. Br J Nutr 2: 290–305.Google Scholar
74. Torgersen, J (1951): Hereditary and environmental factors in twinning. Am J Phys Anthrop 9: 441–454.CrossRefGoogle ScholarPubMed
75. United Nations (1983): “Demographic Yearbook 1981. Thirty Third Issue.” New York: United Nations, pp 805–809.Google Scholar
76. Van Der Spuy, ZM, Steer, Pj, McCusker, M, Steele, SJ, Jacobs, HS (1988): Outcome of pregnancy in underweight women after spontaneous and induced ovulation. Br Med J 296: 962–965.Google Scholar
77. Veit, G (1855): Beiträge zur Geburtshilflichen Statistik. Monatschr Gynäk Frauenkrankh 6: 101–132.Google Scholar
78. Waard, F de (1975): Breast cancer incidence and nutritional status with particular reference to body weight and height. Cancer Res 35: 3351–3356.Google Scholar
79. Waard, F de, Bannders-van Halewijn, EA (1974): A prospective study in general practice on breast cancer risk in postmenopausal women. Int J Cancer 14: 153–160.Google Scholar
80. Waard F, de, Cornelis, JP, Aoki, K, Yoshida, M (1977): Breast cancer incidence according to weight and height in two cities in the Netherlands and in Aichi Prefecture, Japan. Cancer 40: 1269–1275.Google Scholar
81. Wallace, LR (1948): The growth of lambs before and after birth in relation to the level of nutrition. J Agric Sci Part I 38 (2): 93–153; Part III 38 (4): 25-401.CrossRefGoogle Scholar
82. Wallace, LR (1951): Flushing of ewes. NZ J Agric 83: 377–380.Google Scholar
83. Waterhouse, JAH (1950): Twinning in twin pedigrees. Brit J Soc Med 4: 197–216.Google Scholar
84. Waterhouse, J, Correa, P, Muir, C, Powell, J (eds) (1976): “Cancer Incidence in Five Continents, Volume III.” IARC: Lyon.Google Scholar
85. Wei, PY, Lin, CC (1967): Incidence of twin births among the Chinese in Taiwan. Am J Obst Gynec 98: 881–884.Google Scholar
86. Weinberg, W (1901): Beiträge zur Physiologie und Pathologie der Mehrlingsgeburten beim Menschen. Pflügers Archiv Gesamte Physiol Menschen Tiere 88: 346–430.Google Scholar
87. World Bank (1980): “World Development Report 1980”. New York: Oxford University Press, pp 152–153.Google Scholar
88. World Health Organization (1985): “World Health Statistics Annual 1985.” Geneva: WHO, pp 460–464.Google Scholar
89. World Health Organization (1985): “Energy and Protein Requirements”. Report of a joint FAO/WHO/UNU expert consultation. Technical report series No 724. Geneva: WHO, p 85.Google Scholar
90. Wyshak, G (1984): Health characteristic of mothers of twins. Acta Genet Med Gemellol 33: 141–145.Google Scholar
91. Wyshak, G, Honeyman, MS, Flannery, JT, Beck, AS (1983): Cancer in mothers of dizygotic twins. J Natl Cancer Inst 70: 593–599.Google Scholar