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A Genetic Study of Erythrocyte Arginine-tRNA Synthetase Activity in Man

Published online by Cambridge University Press:  01 August 2014

Sylvia A. McCune
Affiliation:
Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
P. L. Yu
Affiliation:
Department of Medical Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA
Walter E. Nance
Affiliation:
Department of Human Genetics, Medical College of Virginia, Richmond, Virginia, USA

Abstract

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To search for evidence of genetic variation among the aminoacyl-tRNA synthetases, a semi-automated assay procedure employing a Technicon Auto Analyzer was used to measure erythrocyte arginine-tRNA synthetase activity in samples obtained from normal human twins of various ages. Variation in enzyme activity within the older DZ twins was five times that of the MZ twins suggesting the existence of genetically determined variation in enzyme activity. Higher enzyme activity was observed in newborn DZ unlike-sexed twins than in like-sexed twins of either zygosity. Possible explanations for this observation are discussed.

Type
Research Article
Copyright
Copyright © The International Society for Twin Studies 1977

References

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