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Biochemical and Genetic Variables Associated with Mothers of G1-Trisomy Affected Children*

Published online by Cambridge University Press:  01 August 2014

Julius Kerkay ,
Steven Zsako ,
James E. Cotton  and
Arnold R. Kaplan
Julius Kerkay*
Affiliation:
Department of Chemistry, Cleveland State University, Cleveland, Ohio, USA
Steven Zsako
Affiliation:
Department of Medicine, Euclid Clinic Foundation, Euclid, Ohio, USA
James E. Cotton
Affiliation:
Laboratory of Medical Genetics, Ohio Mental Health and Mental Retardation Research Center, Cleveland Psychiatric Institute, Cleveland, Ohio, USA
Arnold R. Kaplan
Affiliation:
Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Nebraska, USA
*
Department of Chemistry, Cleveland State University, Cleveland, Ohio 44115, USA

Abstract

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The significant differences in biochemical and chromosomal characteristics, and familial history observed between group of mothers who gave birth to children affected with G1-trisomy (Down's syndrome) and their age-matched controls, indicate that these three maternal variables, in addition to the well known variable of maternal age, are associated with etiology of the aneuploidy. Since attempts to find statistical correlation between these chromosomal and biochemical variables failed, it is believed that these three are unrelated, but very possible etiological factors.

Riassunto

RIASSUNTO

Le significative differenze in caratteristiche biochimiche e cromosomiche e nelle anamnesi familiari riscontrate fra madri di bambini affetti da trisomia G1 (sindrome di Down) e un gruppo di controllo, indicano che queste tre variabili materne (oltre alla ben nota variabile dell'età materna) sono associate all'eziologia dell'aneuploidia. Essendo falliti i tentativi di trovare una correlazione statistica fra queste variabili cromosomiche e biochimiche, si ritiene che si possa trattare di fattori eziologici non collegati.

Résumé

RÉSUMÉ

Les différences significatives remarquées vis à vis de quelques caractéristiques biochimiques et chromosomiques, ainsi que dans l'histoire familiale, entre mères d'enfants atteints de trisomie G1 (syndrome de Down) et contrôles, indiquent que ces trois variables maternelles (en plus de la variable de l'âge maternel) sont associées à l'étiologie de l'aneuploïdie. Ces variables chromosomiques et biochimiques ne paraissant pas corrélées, il est possible qu'il s'agisse de trois facteurs étiologiques non associés.

Zusammenfassung

ZUSAMMENFASSUNG

Einige biochemische und Chromosomenmerkmale sowie die Familienanamnese weisen erhebliche Unterschiede auf bei den Müttern von Kindern mit G1-Trisomie (Downsches Syndrom) und bei einer Kontrollgruppe. Diese Unterschiede sprechen dafür, dass diese drei mütterlichen Variablen (Abgesehen von der bekannten Variablen des Alters der Muttter) mit der Aetiologie der Aneuploidie in Verbindung stehen. Nachdem die Versuche, eine statistische Korrelation zwischen diesen Chromosomen- und biochemischen Variablen zu finden, fehlschlugen, nimmt man an, dass es sich um voneinander unabhängige ätiologische Faktoren handelt.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 24 , Issue 3-4 , 07-10 1975 , pp. 239 - 244
Copyright
Copyright © The International Society for Twin Studies 1975

Footnotes

*

These studies were supported by research grants from the Euclid Clinic Research Foundation and from the U.S. Public Health Service National Institutes of Health (MH 07820-01 and GRS 05563), and by the State of Ohio Department of Mental Hygiene and Correction, Division of Mental Hygiene.

References

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