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Pharmacological treatment of the newly diagnosed patient with schizophrenia

Published online by Cambridge University Press:  02 January 2018

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The early treatment of newly diagnosed schizophrenia has ramifications for the future psychiatric and social well-being of the patient. Changes in care structures and care delivery mechanisms, in addition to financial constraints and outcome targets, provide an additional incentive to ensuring that any intervention is both successful and cost-effective.

Type
Research Article
Copyright
Copyright © The Royal College of Psychiatrists 1997 

References

Angrist, B. & Shulz, S. C. (eds) (1990) Introduction to the Neuroleptic Non-Responsive Patient: Characterization and Treatment. Washington, DC: American Psychiatric Press.Google Scholar
Bellack, A. S. & Mueser, K. T. (1993) Psychosocial treatment for schizophrenia. Schizophrenia Bulletin, 19, 317336.CrossRefGoogle ScholarPubMed
Birchwood, M., McGorry, P. & Jackson, H. (1997) Early intervention in schizophrenia. British Journal of Psychiatry, 170, 25.CrossRefGoogle ScholarPubMed
Carpenter, W. T. & Carpenter, W. T. Jr. (1996) Maintenance therapy of persons with schizophrenia. Journal of Clinical Psychiatry, 57 (suppl. 9), 1018.Google ScholarPubMed
Casey, D. E. (1996) Extrapyramidal syndromes and new antipsychotic drugs: findings in patients and non-human primate models. British Journal of Psychiatry, 168 (suppl. 29), 3239.CrossRefGoogle Scholar
Crow, T. J., MacMillan, J. F., Johnson, A. L. et al (1986) A randomised controlled trial of prophylactic neuroleptic treatment. British Journal of Psychiatry, 148, 120127.CrossRefGoogle ScholarPubMed
Davis, J. M., Metalon, L., Watanabe, M. D. et al (1994) Depot antipsychotic drugs: place in therapy. Drugs, 47, 741773.CrossRefGoogle ScholarPubMed
Drury, V., Birchwood, M., Cochrane, R. et al (1996a) Cognitive therapy and recovery from acute psychosis: a controlled trial. I: Impact on psychotic symptoms. British Journal of Psychiatry, 169, 593601.CrossRefGoogle Scholar
Drury, V., Birchwood, M., Cochrane, R. et al (1996b) Cognitive therapy and recovery from acute psychosis: a controlled trial. II: Impact on recovery time. British Journal of Psychiatry, 169, 602607.CrossRefGoogle ScholarPubMed
Frances, A. J. & Weiden, P. (1987) Promoting compliance with outpatient drug treatment. Hospital and Community Psychiatry, 38, 11581160.Google ScholarPubMed
Goldberg, T. E., Hyde, T. M., Kleinman, J. E. et al (1993) Course of schizophrenia: neuropsychological evidence for a static encephalopathy. Schizophrenia Bulletin, 19, 797804.CrossRefGoogle ScholarPubMed
Harrison, G., Croudace, T., Mason, P. et al (1996) Predicting the long term outcome of schizophrenia. Psychological Medicine, 26, 697705.CrossRefGoogle Scholar
Hegarty, J. D., Baldessarini, R. J., Tohen, H. et al (1994) One hundred years of schizophrenia: a meta-analysis of the outcome literature. American Journal of Psychiatry, 151, 14091416.Google ScholarPubMed
Helgason, L. (1990) Twenty years' follow-up of first psychiatric presentation for schizophrenia: what could have been prevented? Acta Psychiatrica Scandinavica, 81, 231235.CrossRefGoogle ScholarPubMed
Hogarty, G. E., Anderson, C. M., Resii, D. J. et al (1991) Family psychoeducation, social skills training and maintenance chemotherapy in the aftercare treatment of schizophrenia. II: Two year effects of a controlled trial on relapse and adjustment. Archives of General Psychiatry, 48, 340347.CrossRefGoogle ScholarPubMed
Inoue, K., Nakajima, T. & Kato, N. (1986) A longitudinal study of schizophrenia in adolescence. I: The one to three year outcome. Japanese Journal of Psychiatry and Neurology, 40, 143151.Google ScholarPubMed
Johnstone, E. C., Crow, T. J., Johnson, A. L. et al (1986) The Northwick Park Study of first episodes of schizophrenia. I: Presentation of the illness and problems relating to admission. British Journal of Psychiatry, 148, 115120.CrossRefGoogle ScholarPubMed
Kane, J. M. & Marder, S. R. (1993) Psychopharmacological treatment of schizophrenia. Schizophrenia Bulletin, 19, 287302.CrossRefGoogle ScholarPubMed
Kapur, S. & Remington, G. (1996) Serotonin-dopamine interaction and its relevance to schizophrenia. American Journal of Psychiatry, 153, 466476.Google ScholarPubMed
Kuipers, E. (1996) The management of difficult to treat patients with schizophrenia, using non-drug therapies. British Journal of Psychiatry, 169 (suppl. 31), 4151.CrossRefGoogle Scholar
Lo, W. H. & Lo, T. (1977) A ten-year follow-up study of Chinese schizophrenics in Hong Kong. British Journal of Psychiatry, 131, 6366.CrossRefGoogle ScholarPubMed
Loebel, A. D., Lieberman, J. A., Alvir, J. M. J. et al (1992) Duration of psychosis and outcome in first-episode schizophrenia. American Journal of Psychiatry, 149, 11831188.Google ScholarPubMed
Malhotra, A. K., Litman, R. E. & Pickar, D. (1993) Adverse effects of antipsychotic drugs. Drug Safety, 9, 429436.CrossRefGoogle ScholarPubMed
Marder, S. R. (1994) Risperidone in the treatment of schizophrenia. American Journal of Psychiatry, 151, 825835.Google ScholarPubMed
McGlashan, T. H. & Johannessen, J. O. (1996) Early detection and intervention with schizophrenia: rationale. Schizophrenia Bulletin, 22, 201222.CrossRefGoogle ScholarPubMed
Moscarelli, M., Capri, S. & Neri, L. (1991) Cost evaluation of chronic schizophrenic patients during the first three years after first contact. Schizophrenia Bulletin, 17, 421426.CrossRefGoogle ScholarPubMed
Opjordsmoen, S. (1991) Long-term clinical outcome of schizophrenia with special reference to gender differences. Acta Psychiatrica Scandinavica, 83, 307313.CrossRefGoogle ScholarPubMed
Rabiner, C. J., Wegner, J. T. & Kane, J. M. (1986) Outcome study of first episode psychosis: relapse rates after 1 year. American Journal of Psychiatry, 143, 11551158.Google ScholarPubMed
Szymanski, S. R., Cannon, T. D., Gallacher, F. et al (1996) Course and treatment response in first episode and chronic schizophrenia. American Journal of Psychiatry, 153, 519525.Google ScholarPubMed
Thara, R., Henrietta, M., Joseph, A. et al (1994) Ten-year course of schizophrenia – the Madras longitudinal study. Acta Psychiatrica Scandinavica, 90, 329336.CrossRefGoogle ScholarPubMed
Thompson, C. (1994) The use of high-dose antipsychotic medication. British Journal of Psychiatry, 164, 448458.CrossRefGoogle ScholarPubMed
Wagstaff, A. J. & Bryson, H. M. (1995) Clozapine: a review of its pharmacological properties and therapeutic use in patients with schizophrenia who are unresponsive to or intolerant of classical antipsychotic agents. CNS Drugs, 4, 370400.CrossRefGoogle Scholar
Wyatt, R. J. (1991) Neuroleptics and the natural course of schizophrenia. Schizophrenia Bulletin, 17, 325351.CrossRefGoogle ScholarPubMed
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