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Lessons to be learnt from meta-analyses of newer versus older antidepressants

Published online by Cambridge University Press:  02 January 2018

Ian Anderson
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Meta-analysis is the use of statistical techniques to analyse the findings of many individual analyses (Glass, 1977). It covers all aspects of the review process involving formulating relevant research questions, searching the literature, assessing the quality of studies and choosing relevant ones, extracting and combining the data (for review see Henry & Wilson, 1992; Wilson & Henry, 1992). Meta-analysis as part of a systematic review has advantages over a narrative review but there are problems in applying it in practice (Box 1).

Type
Research Article
Information
Advances in Psychiatric Treatment , Volume 3 , Issue 1 , January 1997 , pp. 58 - 63
Copyright
Copyright © The Royal College of Psychiatrists 1997 

References

Altman, D. G. (1991) Practical Statistics for Medical Research. London & New York: Chapman and Hall.Google Scholar
Anderson, I. M. & Tomenson, B. M. (1994) The efficacy of selective serotonin reuptake inhibitors in depression: A meta-analysis of studies against tricyclic antidepressants. Journal of Psychopharmacology, 8, 238–249.CrossRefGoogle ScholarPubMed
Anderson, I. M. & Tomenson, B. M.– (1995) Treatment discontinuation with selective serotonin reuptake inhibitors compared to tricyclic antidepressants: A meta-analysis. British Medical Journal, 310, 1433–1438.Google Scholar
Angst, J. & Stabl, M. (1992) Efficacy of moclobemide in different patient groups: A meta-analysis of studies. Psychopharmacology, suppl. 106, S109–S113.Google Scholar
Angst, J., Amrein, R. & Stabl, M. (1995) Moclobemide and tricyclic antidepressants in severe depression: Meta-analysis and prospective studies. Journal of Clinical Psychopharmacology, suppl. 15, 16S–23S.Google Scholar
Beasley, C. M., Dornseif, B. E., Bosomworth, J. C. et al (1991) Fluoxetine and suicide: A meta-analysis of controlled trials of treatment for depression. British Medical Journal, 303, 685–692.Google Scholar
Bech, P. & Cialdella, P. (1992) Citalopram in depression – meta-analysis of intended and unintended effects. International Clinical Psychopharmacology, 6 (suppl. 5), 45–54.Google Scholar
Danish University Antidepressant Group (1993) Moclobemide. A reversible MAO-A-inhibitor showing weaker antidepressant effect than clomipramine in a controlled multicentre study. Journal of Affective Disorders, 28, 105–116.Google Scholar
Davis, J. M., Wang, Z. & Janicak, P. G. (1993) A quantitative analysis of clincal drug trials for the treatment of affective disorders. Psychopharmacology Bulletin, 29, 175–181.Google Scholar
Donovan, S. (1993) The efficacy and tolerability of dothiepin versus serotonin specific reuptake inhibitors in the treatment of depression. European Neuropsychopharmacology, 3, 331–332.CrossRefGoogle Scholar
Einarson, T. R., Arikian, S., Sweeney, S. et al (1995) A model to evaluate the cost-effectiveness of oral therapies in the management of patients with major depression. Clinical Therapeutics, 17, 136–153.CrossRefGoogle Scholar
Glass, G. V. (1977) Integrating findings: The meta-analysis of research. Review of Research in Education, 5, 351–379.Google Scholar
Godlee, F. (1994) The Cochrane Collaboration. British Medical Journal, 309, 969–970.Google Scholar
Hedges, L. V. & Olkin, I. (1985) Statistical Methods for Meta-Analysis. Orlando, FL: Academic Press.Google Scholar
Henry, D. A. & Wilson, A. (1992) Meta-analysis. Part 1: An assessment of its aims, validity and reliability. Medical Journal of Australia, 156, 31–38.Google Scholar
Kasper, S., Fuger, J. & Moller, H.-J. (1992) Comparative efficacy of antidepressants. Drugs, 43, 11–23.Google Scholar
Kerihuel, J. C. & Dreyfus, J. F. (1991) Meta-analyses of the efficacy and tolerability of the tricyclic antidepressant lofepramine. Journal of International Medical Research, 19, 183–201.CrossRefGoogle ScholarPubMed
Moller, H. J. & Haug, G. (1988) Secondary and meta-analysis of the efficacy of non-tricyclic antidepressants. Pharmacopsychiatry, 21, 363–364.CrossRefGoogle ScholarPubMed
Montgomery, S. A. & Kasper, S. (1995) Comparison of compliance between serotonin reuptake inhibitors and tricyclic antidepressants: A meta-analysis. International Clinical Psychopharmacology, 9 (suppl. 4), 33–40.CrossRefGoogle ScholarPubMed
Pande, A. C. & Sayler, M. E. (1993a) Fluoxetine – a clinical and research update: Severity of depression and response to fluoxetine. International Clinical Psychopharmacology, 8, 243–245.Google Scholar
Pande, A. C. & Sayler, M. E.– (1993b) Adverse events and treatment discontinuations in fluoxetine clinical trials. International Clinical Psychopharmacology, 8, 267–269.Google Scholar
Patten, S. B. (1992) The comparative efficacy of trazodone and imipramine in the treatment of depression. Canadian Medical Association Journal, 146, 1177–1182.Google Scholar
Sinclair, J. C. & Bracken, M. B. (1994) Clinically useful measures of effect in binary analyses of randomized trials. Journal of Clinical Epidemiology, 47, 881–889.Google Scholar
Song, F., Freemantle, N., Sheldon, T. A. et al (1993) Selective serotonin reuptake inhibitors: Meta-analysis of efficacy and acceptability. British Medical Journal, 306, 683–687.CrossRefGoogle ScholarPubMed
Wilson, A. & Henry, D. A. (1992) Meta-analysis. Part 2: Assessing the quality of published meta-analyses. Medical Journal of Australia, 156, 173–187.CrossRefGoogle ScholarPubMed
Workman, E. A. & Short, D. D. (1993) Atypical antidepressants versus imipramine in the treatment of major depression: A meta-analysis. Journal of Clinical Psychiatry, 54, 5–12.Google Scholar
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