Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-28T01:04:33.647Z Has data issue: false hasContentIssue false

Thyroid function and psychiatric disorders

Published online by Cambridge University Press:  18 September 2015

P.J.M. Schoof*
Affiliation:
Deltaziekenhuis, Poortugaal
L. Timmerman
Affiliation:
PAAZ Refaja ziekenhuis, Dordrecht
E.J. Colon
Affiliation:
Deltaziekenhuis, Poortugaal
H.J. Leijnse-Ybema
Affiliation:
hoofd Klinisch Chemisch Laboratorium, Deltaziekenhuis, Poortugaal
*
Deltaziekenhuis, Albrand-waardsedijk 74, 3172 AA Poortugaal

Summary

To answer the question if it is possible for specific psychiatric illnesses to influence the thyroxine-concentration, a group of 376 patients admitted to a psychiatric hospital was studied retrospectively.

13.5% had an elevated thyroxine-concentration and only 0.6% had a low concentration.

Of the group of 145 men, 22.8% was found to have an elevated thyroxine-concentration. In the group of 196 women we found 6.6% to be elevated. A low thyroxine was found in only 0.5% of the women and 0.7% of the men.

In the group with an elevated thyroxine the psychiatric diagnoses of schizophrenia and psychotic disorders NOS are more common (19.6% and 17.4% respectively) than in the group with a normal thyroxine (4.4% and 6.5% respectively).

Type
Research Article
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1991

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Literatuur

1.Peterson, LG, O'Shanick, GJ.: Psychiatric symptoms in endocrine diseases. Endocr Dis 1985; 77: 233–9.Google ScholarPubMed
2.Hall, RCW. Psychiatric effects of thyroid hormone disturbance. Psychosomatics 1983; 24: 718.CrossRefGoogle ScholarPubMed
3.Giannandrea, PF. The depressed hyperthyroid patient. Gen Hosp Psychiat 1987; 9: 71–4.CrossRefGoogle ScholarPubMed
4.Whybrow, PC, Prange, AJ, Treadway, CR. Mental changes accompanying thyroid gland dysfunction. Arch gen Psychiat 1969; 20: 4863.CrossRefGoogle ScholarPubMed
5.Folks, DG. Organic affective disorder and underlying thyrotoxicosis. Psychosomatics 1984; 25: 243–9.CrossRefGoogle ScholarPubMed
6.Feit, H. Thyroid function in the elderly. Clin ger Med 1988; 4: 151–61.Google ScholarPubMed
7.Hurley, JR. Thyroid disease in the elderly. Symposium on Clinical Geriatric Medicine. Med Clin North Am 1983; 67: 497.CrossRefGoogle Scholar
8.Spring, T, Hofier, J, Meyer, J, Huchzermeier, R, Albano, D, Fino, J, Flentge, C, Kirkemo, C, Shipchandler, M, Vaughn, K. The development fluorescence polarization assays for serum thyroxine and unsaturated thyroxine binding proteins. Ann Endocrinol 1983; 44:64a.Google Scholar
9. American Psychiatric Association: Diagnostic and statistical manual of mental disorders, Third Edition, Revised. Washington; DC: American Psychiatric Association 1987.Google Scholar
10.Cohen, KL, Swigar, ME. Thyroid function screening in psychiatric patients. JAMA 1979; 242: 254–7.CrossRefGoogle ScholarPubMed
11.Levy, RP, Jensen, JB, Laus, VG, Agle, DP, Engel, IM. Serum thyroid hormone abnormalities in psychiatric disease. Metabolism 1981; 30: 1060–64.CrossRefGoogle ScholarPubMed
12.Morley, JE, Shafer, RB. Thyroid function screening in new psychiatric admissions. Arch intern Med 1982; 142: 591–3.CrossRefGoogle ScholarPubMed
13.Spratt, DI, Pont, A, Miller, MB, McDougall, IR, Bayer, MF, McLaughlin, WT. Hyperthyroxinemia in patients with acute psychiatric disorders. Am J Med 1982; 73: 41–8.CrossRefGoogle ScholarPubMed
14.Naber, D, Steinbock, H, Greil, W. Effect of short- and long-term neuroleptic treatment on thyroid function. Prog Neuropsychop-harmacol 1980; 4: 199206.CrossRefGoogle Scholar
15.Rinieris, P, Christodoulou, GN, Souvatzoglou, A, Koutras, DA, Stefanis, C. Free-thyroxine index in schizophrenic patients before and after neuroleptic treatment. Neuropsychobiol 1980; 6: 2933.CrossRefGoogle ScholarPubMed
16.Kaplan, MM, Larsen, PR, Crantz, FR. Prevalence of abnormal thyroid function test results in patients with acute medical illnesses. Am J Med 1982; 72: 916.CrossRefGoogle ScholarPubMed
17.Nauman, J, Ceremuzynski, L, Nauman, A. Total and free thyroid hormones and TSH in acute mycardial infarction. Mat med pol. 1979; 40: 212–7.Google Scholar
18.Kolakowska, T, Swigar, ME. Thyroid function in depression and alcohol abuse. Arch gen Psychiat 1977; 34: 984–8.CrossRefGoogle ScholarPubMed
19.Brambilla, F, Guerrini, A, Guastalla, A, Rovere, C, Riggi, F. Neuroendocrine effects of haloperidol therapy in chronic schizophrenia. Psychopharmacol (Berlijn) 1975; 44: 1722.CrossRefGoogle ScholarPubMed
20.Gavin, LA, Rosenthal, M, Cavalier, RR. The diagnostic dilemma of isolated hyperthyroxinemia in acute illness. JAMA. 1979; 242: 251–3.CrossRefGoogle ScholarPubMed