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Systematic review and meta-analysis on the role of mitochondrial cytochrome c oxidase in Alzheimer’s disease

Published online by Cambridge University Press:  01 December 2020

Flavio M. Morais ,
Angela M. Ribeiro ,
Fabricio A. Moreira Open the ORCID record for Fabricio A. Moreira [Opens in a new window]  and
Pollyanna V. G. Silva
Flavio M. Morais
Affiliation:
Graduate Program in Neurosciences, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Angela M. Ribeiro
Affiliation:
Graduate Program in Neurosciences, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Fabricio A. Moreira
Affiliation:
Graduate Program in Neurosciences, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Department of Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Pollyanna V. G. Silva*
Affiliation:
Ministerio Público do Estado de Minas Gerais, Belo Horizonte, Brazil
*
Author for correspondence: Pollyanna V. G. Silva, Email: [email protected]
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Abstract

Objective:

The present study was designed to test the hypothesis that there is a reduction in the activity of the enzyme cytochrome c oxidase (Cox) in Alzheimer’s disease (AD).

Methods:

Systematic review of literature and meta-analysis were used with data obtained from the PubMed, Scopus, MEDLINE, Lilacs, Eric and Cochrane. The keywords were Alzheimer’s AND Cox AND mitochondria; Alzheimer’s AND Cox AND mitochondria; Alzheimer’s AND complex IV AND mitochondria. A total of 1372 articles were found, 23 of them fitting the inclusion criteria. The data were assembled in an Excel spreadsheet and analysed using the RevMan software. A random effects model was adopted to the estimative of the effect.

Results:

The data shows a significant decrease in the activity of the Cox AD patients and animal models.

Conclusion:

Cox enzyme may be an important molecular component involved in the mechanisms underlying AD. Therefore, this enzyme may represent a possible new biomarker for the disease as a complementary diagnosis and a new treatment target for AD.

Keywords

Alzheimer’s diseasemitochondriaelectron transport complex IVmeta-analysis
Type
Review Article
Information
Acta Neuropsychiatrica , Volume 33 , Issue 2 , April 2021 , pp. 55 - 64
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Copyright
© Scandinavian College of Neuropsychopharmacology 2020

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