Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-15T23:21:20.543Z Has data issue: false hasContentIssue false
  • English
  • Français

Obstetric complications and neurological soft signs in male patients with schizophrenia

Published online by Cambridge University Press:  24 June 2014

Giuseppe Bersani ,
Roberta Clemente ,
Simona Gherardelli ,
Francesco Saverio Bersani  and
Giorgiana Manuali
Giuseppe Bersani*
Affiliation:
Department of Medical – Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy
Roberta Clemente
Affiliation:
Department of Medical – Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy
Simona Gherardelli
Affiliation:
Department of Medical – Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy
Francesco Saverio Bersani
Affiliation:
Department of Medical – Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy
Giorgiana Manuali
Affiliation:
Department of Medical – Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy
*
Prof. Giuseppe Bersani, Department of Medical – Surgical Sciences and Biotechnologies, Sapienza University of Rome, via di Torre Argentina 21, 00186 Rome, Italy. Tel: +39 06 4454765; Fax: +39 06 6875237; E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Extract

Bersani G, Clemente R, Gherardelli S, Bersani FS, Manuali G. Obstetric complications and neurological soft signs in male patients with schizophrenia.

Objective: The study investigated the relationship between neurological soft signs (NSS) and obstetric complications (OCs) in patients with schizophrenia.

Methods: Sixty-three male patients with schizophrenia were divided into two subgroups, based on the OCs presence or absence, which were compared in relation to NSS prevalence. After that, a Person's correlation test was performed to explore the correlation between NSS and OCs severity.

Results: The subgroup with OCs showed more NSS, but there were not significant correlations between NSS and OCs severity.

Conclusions: It seems that any OC, without distinction in typology and severity, could unspecifically impair the neurodevelopment and inducing NSS expression. Our findings confirm the hypothesis that neurodevelopment alterations, such as those probably induced by OCs, can contribute to a premorbid brain dysfunctional state expressed by NSS.

Keywords

neurodevelopmentneurological soft signsobstetric complicationsschizophrenia
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 24 , Issue 6 , December 2012 , pp. 344 - 348
Copyright
Copyright © Cambridge University Press 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Heinrichs, RW, Zakzanis, KK.Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 1998;12: 426–445.CrossRefGoogle ScholarPubMed
2.Cocchi, L, Bosisio, F, Berchtold, A et al. Visuospatial encoding deficits and compensatory strategies in schizophrenia revealed by eye movement analysis during a working memory task. Acta Neuropsychiatrica 2009;21: 75–83.CrossRefGoogle ScholarPubMed
3.De Wilde, OM, Bour, LJ, Dingermans, PM, Koelman, JHTM, Linszen, DH.A meta-analysis of the P50 studies in patients with schizophrenia and relatives: differences in methodology between research groups. Schizophr Res 2007;97: 137–151.CrossRefGoogle ScholarPubMed
4.Yamada, M, Yukawa, E, Taketani, F, Matsuura, T, Hara, Y.Multifocal visual-evoked potentials in patients with schizophrenia during treatment. Acta Neuropsychiatrica 2011;23: 31–34.CrossRefGoogle ScholarPubMed
5.Buchanan, RW, Heinrichs, DW.The neurological evaluation scale (NES): a structured instrument for the assessment of neurological signs in schizophrenia. Psychiatry Res 1989;27: 335–350.CrossRefGoogle Scholar
6.Ota, M, Obu, S, Sato, N, Mizukami, K, Asada, T. Progressive brain changes in schizophrenia: a 1-year follow-up study of diffusion tensor imaging. Acta Neuropsychiatrica 2009;21: 301–307.CrossRefGoogle Scholar
7.Marcus, J, Hans, SL, Lewow, E, Wilkinson, L, Burack, CM.Neurological findings in high risk children: childhood assessment and 5-year follow up. Schizophr Bull 1985;11: 85–100.CrossRefGoogle Scholar
8.Gupta, S, Andreasen, NC, Arndt, S et al. Neurological soft signs in neuroleptic-naïve and neuroleptic treated schizophrenic patients and in normal comparison subjects. Am J Psychiatry 1995;152: 191–196.Google ScholarPubMed
9.Bersani, G, Clemente, R, Gherardelli, S, Pancheri, P.Deficit of executive functions in schizophrenia: relationship to neurological soft signs and psychopathology. Psychopathology 2004;37: 118–123.CrossRefGoogle ScholarPubMed
10.Tsuang, MT, Gilberson, MW, Faraone, SV.The genetics of schizophrenia: current knowledge and future directions. Schizophr Res 1991;4: 157–171.CrossRefGoogle ScholarPubMed
11.Tsuang, MT, Faraone, SV.The concept of target features in schizophrenia research. Acta Psychiatr Scand Suppl 1999;395: 2–11.CrossRefGoogle ScholarPubMed
12.Mohr, F, Hubmann, W, Cohen, R et al. Neurological soft signs in schizophrenia: assessment and correlates. Eur Arch Psychiatry Clin Neurosci 1996;246: 240–248.CrossRefGoogle ScholarPubMed
13.Cuesta, MJ, Peralta, V, De Leon, J.Neurologicalfrontal signs and neuropsychological deficits in schizophrenic patients. Schizophr Res 1996;20: 15–20.CrossRefGoogle ScholarPubMed
14.Merriam, AE, Kay, SR, Opler, LA, Kushner, SF, Van Praag, HM.Neurological signs and the positive-negative dimension in schizophrenia. Biol Psychiatry 1990;28: 181–192.CrossRefGoogle ScholarPubMed
15.Flashman, LA, Flaum, M, Gupta, S, Andreasen, NC.Soft signs and neuropsychological performance in schizophrenia. Am J Psychiatry 1996;153: 526–532.Google ScholarPubMed
16.Arango, C, Bartko, JJ, Gold, JM, Buchannan, RW.Prediction of neuropsychological performance by neurological signs in schizophrenia. Am J Psychiatry 1999;156: 1349–1357.CrossRefGoogle ScholarPubMed
17.Sanders, RD, Schuepbach, D, Goldstein, G, Haas, GL, Sweeney, JA, Keshavan, MS.Relationships between cognitive and neurological performance in neuroleptic-naïve psychosis. J Neuropsychiatry Clin Neurosci 2004;16: 480–487.CrossRefGoogle ScholarPubMed
18.Breslau, N, Chilcoat, HD, Johnson, EO, Andreski, P, Lucia, VC.Neurologic soft signs and low birthweight: their association and neuropsychiatric implications. Biol Psychiatry 2000;47: 71–79.CrossRefGoogle ScholarPubMed
19.Hediger, ML, Overpeck, MD, Ruan, WJ, Troendle, JF.Birthweight and gestational age effects on motor and social development. Pediatr Perinatol Epidemiol 2002;16: 33–46.CrossRefGoogle ScholarPubMed
20.Lewis, SW, Murray, RM.Obstetric complications, neurodevelopment deviance, and risk of schizophrenia. J Psychiatr Res 1987; 21: 413–421.CrossRefGoogle Scholar
21.Bersani, G, Taddei, I, Manuali, G.Severity of obstetric complications and risk of adult schizophrenia in male patients: a case-control study. J Matern Fetal Neonatal Med 2003;14: 35–38.Google ScholarPubMed
22.Cannon, M, Jones, PB, Murray, RM.Obstetric complications and schizophrenia: historical and meta-analytic review. Am J Psychiat 2002;159: 1080–1092.CrossRefGoogle ScholarPubMed
23.Geddes, JR, Lawrie, SM.Obstetric complications and schizophrenia: a meta-analysis. Br J Psychiatry 1995;167: 786–793.CrossRefGoogle ScholarPubMed
24.Verdoux, H, Geddes, JR, Takei, N et al. Obstetric complications and age at onset in schizophrenia: an international collaborative meta-analysis of individualpatient data. Am J Psychiat 1997;154: 1220–1227.Google Scholar
25.Mrad, A, Mechri, A, Slama, H, Mokni, S, Letaief, M, Gha, L.Correlations between obstetric complications and neurological soft signs in Tunisian patients with schizophrenia. Psychiatry Clin Neurosci 2010;64: 645–648.CrossRefGoogle ScholarPubMed
26.Boks, MP, Selten, JP, Leask, S, Castelein, S, Van Den Bosch, RJ.Negative association between a history of obstetric complications and the number of neurological soft signs in first-episode schizophrenic disorder. Psychiatry Res 2007;149: 273–277.CrossRefGoogle ScholarPubMed
27.O'Callaghan, E, Gibson, T, Colohan, H et al. Risk of schizophrenia in adult born after obstetric complications, and their association with early onset of illness: a controlled study. Br Med J 1992;305: 1256–1259.CrossRefGoogle ScholarPubMed
28.AAVV. Diagnostic criteria from DSM IV TR, 4th edn. Washington DC: American Psychiatric Association, 2002.Google Scholar
29.First, MB, Donovan, S, Frances, A et al. Nosology of chronic mood disorders. Psychiatr Clin North Am 1996;19: 29–39.CrossRefGoogle ScholarPubMed
30.Buchanan, RW, Heinrichs, DW.The Neurological Evaluation Scale (NES): a structured instrument for the assessment of neurological signs in schizophrenia. Psychiatry Res 1989;27: 335–350.CrossRefGoogle Scholar
31.Lewis, SW, Murray, RM.Obstetric complications, neurodevelopment deviance, and risk of schizophrenia. J Psychiatr Res 1987;21: 413–421.CrossRefGoogle Scholar
32.Parnas, J, Schulsinger, F, Teasdale, TW, Schulsinger, H, Feldman, PM, Mednick, SA.Perinatal complications and clinical outcome within the schizophrenia spectrum. Br J Psychiatry 1982;140: 416–420.CrossRefGoogle ScholarPubMed
33.Chen, EYH, Lam, LCW, Chen, RYL, Nguyen, DGH.Neurological signs, age, and illness duration in schizophrenia. J Nerv Ment Dis 1996;184: 339–345.CrossRefGoogle ScholarPubMed
34.Lane, A, Colgan, K, Moynihan, F et al. Schizophrenia and neurological soft signs: gender differences in clinical correlates and antecedent factors. Psychiatry Res 1996;64: 105–114.CrossRefGoogle ScholarPubMed
35.Cantor-Graae, E, Mcneil, TF, Rickler, KC et al. Are neurological abnormalities in well discordant monozygotic co-twins of schizophrenic subjects the result of perinatal trauma? Am J Psychiatry 1994;151: 1194–1199.Google ScholarPubMed
36.Boks, MP, Selten, JP, Leask, S, Castelein, S, Van Den Bosch, RJ.Negative association between a history of obstetric complications and the number of neurological soft signs in first-episode schizophrenic disorder. Psychiatry Res 2007;149: 273–277.CrossRefGoogle ScholarPubMed
37.O'Callaghan, E, Gibson, T, Colohan, H et al. Risk of schizophrenia in adult born after obstetric complications, and their association with early onset of illness: a controlled study. Br Med J 1992;305: 1256–1259.CrossRefGoogle ScholarPubMed
38.Boks, MP, Selten, JP, Leask, S, Castelein, S, Van Den Bosch, RJ.Negative association between a history of obstetric complications and the number of neurological soft signs in first-episode schizophrenic disorder. Psychiatry Res 2007;149: 273–277.CrossRefGoogle ScholarPubMed
39.Goldstein, JM, Seidman, LJ, Santangelo, S, Knapp, PH, Tsuang, MT.Are schizophrenic men at higher risk for developmental deficits than schizophrenic women? Implications for adult neuropsychological functions. J Psychiatr Res 1994;28: 483–498.CrossRefGoogle ScholarPubMed
40.Peralta, V, De Jalon, EG, Campos, MS, Basterra, V, Sanchez-Torres, A, Cuesta, MJ.Risk factors, pre-morbid functioning and episode correlates of neurological soft signs in drug-naive patients with schizophrenia-spectrum disorders. Psychol Med 2010;22: 1–11.Google Scholar
41.Heuser, M, Thomann, PA, Essig, M, Bachmann, S, Schröder, J.Neurological signs and morphological cerebral changes in schizophrenia: an analysis of NSS subscales in patients with first episode psychosis. Psychiatry Res 2011;192: 69–76.CrossRefGoogle ScholarPubMed
42.Gupta, S, Andreasen, NC, Arndt, S et al. Neurological soft signs in neuroleptic-naive and neuroleptic-treated schizophrenic patients and in normal comparison subjects. Am J Psychiatry 1995;152: 191–196.Google ScholarPubMed
43.Bersani, G, Gherardelli, S, Clemente, R et al. Neurological soft signs in schizophrenic patients treated with conventional and atypical antipsychotic. J Clin Psychopharmacol 2005;25: 372–375.CrossRefGoogle Scholar
44.Walshe, M, Mcdonald, C, Boydell, J et al. Long-term maternal recall of obstetric complications in schizophrenia research. Psychiatry Res 2011;187: 335–340.CrossRefGoogle ScholarPubMed
45.Hidalgo, BR, Zandio, M, Zarzuela, A.Validità of maternal recall of obstetric complications in mothers of patients with schizophrenia spectrum disorders and their healthy siblings. Schizophr Res 2011;126: 308–309.Google Scholar