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Individual responses of rodents in modelling of affective disorders and in their treatment: prospective review

Published online by Cambridge University Press:  18 June 2018

Haim Einat ,
Itamar Ezer ,
Nirit Z Kara  and
Catherine Belzung
Haim Einat*
Affiliation:
School of Behavioral Sciences, Tel Aviv-Yaffo Academic College, Tel-Aviv, Israel Dept. of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beersheba, Israel College of Pharmacy, University of Minnesota, Duluth, MN, USA
Itamar Ezer
Affiliation:
School of Behavioral Sciences, Tel Aviv-Yaffo Academic College, Tel-Aviv, Israel
Nirit Z Kara
Affiliation:
School of Behavioral Sciences, Tel Aviv-Yaffo Academic College, Tel-Aviv, Israel Dept. of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beersheba, Israel
Catherine Belzung
Affiliation:
INSERM 930 & Department of Neurosciences, Université François-Rabelais de Tours, France
*
*Author for correspondence: Haim Einat, Professor, School of Behavioral Sciences, Tel Aviv-Yaffo Academic College, 14 Rabenu Yeruham St., Tel-Aviv, Israel. Tel: (972)3 680 2536; Fax: (972)3 6802526; E-mail: [email protected]
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Abstract

Introduction

Lack of good animal models for affective disorders, including major depression and bipolar disorder, is noted as a major bottleneck in attempts to study these disorders and develop better treatments. We suggest that an important approach that can help in the development and use of better models is attention to variability between model animals.

Results

Differences between mice strains were studied for some decades now, and sex differences get more attention than in the past. It is suggested that one factor that is mostly neglected, individual variability within groups, should get much more attention. The importance of individual differences in behavioral biology and ecology was repeatedly mentioned but its application to models of affective illness or to the study of drug response was not heavily studied. The standard approach is to overcome variability by standardization and by increasing the number of animals per group.

Conclusions

Possibly, the individuality of specific animals and their unique responses to a variety of stimuli and drugs, can be helpful in deciphering the underlying biology of affective behaviors as well as offer better prediction of drug responses in patients.

Keywords

affective disorderanimal modelsantidepressantsbipolar disorderdepressionmood stabilisers
Type
Perspective
Information
Acta Neuropsychiatrica , Volume 30 , Issue 6 , December 2018 , pp. 323 - 333
Copyright
© Scandinavian College of Neuropsychopharmacology 2018 

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