Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-08T06:34:06.386Z Has data issue: false hasContentIssue false

Diagnosis and dimensional pharmacotherapy of challenging behaviour in mental retardation

Published online by Cambridge University Press:  18 September 2015

Summary

Classical psychiatric taxonomy appears to be increasingly inadequate in the diagnostic process of mentally retarded subjects. The reasons for this are the atypical presentation of classical psychiatric disorders, special diagnostic entities like cycloid psychosis and unstable mood disorder and the existence of so-called behavioural phenotypes related to syndromes with a known genetic etiology. In addition, disturbed behaviour may be the result of somatic or neurologic comorbidity and induced to adverse drug events.

Type
Research Article
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1999

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Literatuur

1.Einfeld, SL, Aman, M. Issues in the taxonomy of psychopathology in mental retardation. J Autism dev Disord 1995; 25: 143–67.CrossRefGoogle ScholarPubMed
2.Meins, W. Symptoms of major depression in mentally retarded adults. J Intel Disabil Res 1995; 39: 41–5.CrossRefGoogle ScholarPubMed
3.Verhoeven, WMA, Curfs, LMG, Tuinier, S. Prader-Willi syndrome and cycloid psychoses. J Intel Disabil Res 1998; 42: 455–62.Google ScholarPubMed
4.Bodfish, JW, Crawford, TW, Powell, SB, Golden, RN, Lewis, MH. Compulsions in adults with mental retardation: Prevalence, phenomenology, and comorbidity with stereotypy and self-injury. Am J ment Retard 1995; 100: 183–92.Google ScholarPubMed
5.Clarke, DJ. Prader-Willi syndrome and psychoses. Br J Psychiat 1993; 163: 680–4.CrossRefGoogle ScholarPubMed
6.Dykens, EM. Measuring behavioural phenotypes: Provocations from the ‘new genetics’. Am J ment Retard 1995; 99: 522–32.Google ScholarPubMed
7.Meins, W. Prevalence and risk factors for depressive disorders in adults with intellectual disability. Aust N Z J develop Disabil 1993; 18: 147–56.Google Scholar
8.King, BH, Deantonio, C, McCracken, JT, Forness, SR, Ackerland, V. Psychiatric consultation in severe and profound mental retardation. Am J Psychiat 1994; 151: 1802–8.Google ScholarPubMed
9.Verhoeven, WMA, Tuinier, S. Neuropsychiatric consultation in mentally retarded patients; a clinical report. Eur Psychiat 1997; 12: 242–8.CrossRefGoogle Scholar
10.Zimmerman, AW, Jinnah, HA, Lockhart, PJ. Behavioural neuropharmacology. Ment Retard develop Disabil Res Rev 1998; 4: 2635.3.0.CO;2-V>CrossRefGoogle Scholar
11.Sandman, CA, Thompson, T, Barrett, RP, Verhoeven, WMA, McCubbin, JA, Hetrick, WP. Opiate Blockers. In: Psychotropic medications and developmental disabilities. In: The international Consensus Handbook. Reiss S. and Aman MG. Eds. The OSU Nisonger Center 1998; 291302.Google Scholar
12.Willemsen-Swinkels, SHN, Buitelaar, JK, Nijhof, GJ, Engeland, H van. Failure of naltrexone hydrochloride to reduce self-injurious and autistic behaviour in mentally retarded adults. Arch gen Psychiat 1995; 52: 766–73.CrossRefGoogle ScholarPubMed
13.Casner, JA, Weinheimer, B, Gualtieri Th. Naltrexone and self-injurious behaviour: A retrospective population study. J clin Psychopharmacol 1996; 16: 389–94.CrossRefGoogle ScholarPubMed
14.Verhoeven, WMA, Tuinier, S. The psychopharmacology of challenging behaviours in developmental disabilities. In: Psychiatric and behavioural disorders in mental retardation. Bouras, N, ed. Cambridge: Cambridge University Press, 1999, in press.Google ScholarPubMed
15.Verhoeven, WMA, Tuinier, S, Sijben, AES. Biological and pharmacological aspects of self-injurious behaviour. In: Mental Health Aspects of Mental Retardation, Fletcher, RJ, Dosen, A, eds. Lexington Books, Free Press McMillan Inc., New York 1993; 291324.Google Scholar
16.Kastner, T, Finesmith, R, Walsh, K. Long-term administration of valproic acid in the treatment of affective symptoms in people with mental retardation. J clin Psychopharmacol 1993; 13: 448–51.CrossRefGoogle ScholarPubMed
17.Spoont, MR. Modulatory role of serotonin in neural information processing; implications for human psychopathology. Psychol Bull 1992; 112: 330–50CrossRefGoogle ScholarPubMed
18.Verhoeven, WMA, Tuinier, S. The effect of buspirone on challenging behaviour in mentally retarded patients; an open prospective multiple case study. J intel Disabil Res 1996; 40: 502–8.CrossRefGoogle ScholarPubMed
19.Verhoeven, WMA, Tuinier, S, Curfs, LMG. Psychopathologie en pathogenese van enkele behavioural phenotypes. Acta Neuropsychiat 1998; 10: 87–9.CrossRefGoogle ScholarPubMed
20.Flint, J. Behavioural phenotypes: Conceptual and methodological issues. Am J med Genet (Neuropsychiatric Genetics) 1998; 81: 235–40.3.0.CO;2-V>CrossRefGoogle ScholarPubMed