Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-27T22:12:46.304Z Has data issue: false hasContentIssue false
  • English
  • Français

Lateralisation abnormalities in obsessive–compulsive disorder: a line bisection study

Published online by Cambridge University Press:  27 April 2015

Naren Prahlada Rao ,
Rashmi Arasappa ,
Nalini Narayana Reddy ,
Ganesan Venkatasubramanian  and
Janardhan Reddy Y.C.
Naren Prahlada Rao*
Affiliation:
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India Centre for Neuroscience, Indian Institute of Science, Bangalore, Karnataka, India
Rashmi Arasappa
Affiliation:
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
Nalini Narayana Reddy
Affiliation:
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
Ganesan Venkatasubramanian
Affiliation:
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
Janardhan Reddy Y.C.
Affiliation:
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
*
Dr. Naren P Rao, Centre for Neuroscience, Indian Institute of Science, Bangalore, Karnataka, India. Tel: +91 802 293 2518; Fax: +91 802 360 3323; E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

Asymmetry in brain structure and function is implicated in the pathogenesis of psychiatric disorders. Although right hemisphere abnormality has been documented in obsessive–compulsive disorder (OCD), cerebral asymmetry is rarely examined. Therefore, in this study, we examined anomalous cerebral asymmetry in OCD patients using the line bisection task.

Methods

A total of 30 patients with OCD and 30 matched healthy controls were examined using a reliable and valid two-hand line bisection (LBS) task. The comparative profiles of LBS scores were analysed using analysis of covariance.

Results

Patients with OCD bisected significantly less number of lines to the left and had significant rightward deviation than controls, indicating right hemisphere dysfunction. The correlations observed in this study suggest that those with impaired laterality had more severe illness at baseline.

Conclusions

The findings of this study indicate abnormal cerebral lateralisation and right hemisphere dysfunction in OCD patients.

Keywords

asymmetrylateralityline bisectionobsessive–compulsive disorderright hemisphere
Type
Short Communications
Information
Acta Neuropsychiatrica , Volume 27 , Issue 4 , August 2015 , pp. 242 - 247
Check for updates
Copyright
© Scandinavian College of Neuropsychopharmacology 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Crow, TJ. The ‘big bang’ theory of the origin of psychosis and the faculty of language. Schizophr Res 2008;102:31–52.CrossRefGoogle ScholarPubMed
2.Wheeler, RE, Davidson, RJ, Tomarken, AJ. Frontal brain asymmetry and emotional reactivity: a biological substrate of affective style. Psychophysiology 1993;30:82–89.CrossRefGoogle ScholarPubMed
3.Bradshaw, JL, Sheppard, DM. The neurodevelopmental frontostriatal disorders: evolutionary adaptiveness and anomalous lateralization. Brain Lang 2000;73:297–320.CrossRefGoogle ScholarPubMed
4.Kuelz, AK, Hohagen, F, Voderholzer, U. Neuropsychological performance in obsessive-compulsive disorder: a critical review. Biol Psychol 2004;65:185–236.CrossRefGoogle ScholarPubMed
5.Rao, NP, Reddy, YC, Kumar, KJ, Kandavel, T, Chandrashekar, CR. Are neuropsychological deficits trait markers in OCD? Prog Neuropsychopharmacol Biol Psychiatry 2008;32:1574–1579.CrossRefGoogle ScholarPubMed
6.Abramovitch, A, Abramowitz, JS, Mittelman, A. The neuropsychology of adult obsessive–compulsive disorder: a meta-analysis. Clin Psychol Rev 2013;33:1163–1171.CrossRefGoogle ScholarPubMed
7.Radua, J, Mataix-Cols, D. Voxel-wise meta-analysis of grey matter changes in obsessive–compulsive disorder. Br J Psychiatry 2009;195:393–402.CrossRefGoogle ScholarPubMed
8.Rotge, J-Y, Guehl, D, Dilharreguy, Bet al. Provocation of obsessive–compulsive symptoms: a quantitative voxel-based meta-analysis of functional neuroimaging studies. J Psychiatry Neurosci 2008;33:405–412.Google ScholarPubMed
9.Yazgan, MY, Peterson, B, Wexler, BE, Leckman, JF. Behavioral laterality in individuals with Gilles de la Tourette’s syndrome and basal ganglia alterations: a preliminary report. Biol Psychiatry 1995;38:386–390.CrossRefGoogle ScholarPubMed
10.Morton, BE. Two-hand line-bisection task outcomes correlate with several measures of hemisphericity. Brain Cogn 2003;51:305–316.CrossRefGoogle ScholarPubMed
11.Cohen, LJ, Hollander, E, Stein, DJ. The neuropsychiatry of OCD. In: Hollander E, Stein DJ editors. Obsessive-compulsive disorders: diagnosis, etiology, treatment. New York: Dekker, 1997. p. 75–88.Google Scholar
12.Peterson, B, Leckman, J, Lombroso, Pet al. Environmental risk and protective factors. In: James F. Leckman, Donald J. Cohen, editors. Tourette’s syndrome–tics, obsessions, compulsions: developmental psychopathology and clinical care. New York: Wiley, 1999. p. 213–229.Google Scholar
13.Nelson, E, Early, TS, Haller, JW. Visual attention in obsessive-compulsive disorder. Psychiatry Res 1993;49:183–196.CrossRefGoogle ScholarPubMed
14.Maril, S, Hermesh, H, Gross-Isseroff, R, Tomer, R. Spatial attention and neural asymmetry in obsessive-compulsive disorder. Psychiatry Res 2007;153:189–193.CrossRefGoogle ScholarPubMed
15.Rao, NP, Arasappa, R, Reddy, NN, Venkatasubramanian, G, Gangadhar, BN. Antithetical asymmetry in schizophrenia and bipolar affective disorder: a line bisection study. Bipolar Disord 2010;12:221–229.CrossRefGoogle ScholarPubMed
16.Bowers, D, Heilman, KM. Pseudoneglect: effects of hemispace on a tactile line bisection task. Neuropsychologia 1980;18:491–498.CrossRefGoogle ScholarPubMed
17.Schenkenberg, T, Bradford, DC, Ajax, ET. Line bisection and unilateral visual neglect in patients with neurologic impairment. Neurology 1980;30:509–517.CrossRefGoogle ScholarPubMed
18.Sheehan, DV, Lecrubier, Y, Sheehan, KHet al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998;59(Suppl. 20):22–33.Google ScholarPubMed
19.Goodman, WK, Price, LH, Rasmussen, SAet al. The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry 1989;46:1006–1011.CrossRefGoogle ScholarPubMed
20.Guy, W, Bonato, RR. Clinical global impressions. In: Guy W, Bonato RR, editors. Manual for the ECDEU Assessment Battery. National Institute of Mental Health, Chevy Chase (Md), 1970.Google Scholar
21.Folstein, MF, Folstein, SE, McHugh, PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–198.CrossRefGoogle ScholarPubMed
22.Oldfield, RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 1971;9:97–113.CrossRefGoogle ScholarPubMed
23.Schenkenberg, T, Bradford, D, Ajax, E. Line bisection and unilateral visual neglect in patients with neurologic impairment. Neurology 1980;30:509.CrossRefGoogle ScholarPubMed
24.Jewell, G, McCourt, ME. Pseudoneglect: a review and meta-analysis of performance factors in line bisection tasks. Neuropsychologia 2000;38:93–110.CrossRefGoogle ScholarPubMed
25.Siviero, MO, Rysovas, EO, Juliano, Y, Del Porto, JA, Bertolucci, PH. Eye-hand preference dissociation in obsessive-compulsive disorder and dyslexia. Arq Neuropsiquiatr 2002;60:242–245.CrossRefGoogle ScholarPubMed
26.Menzies, L, Williams, GB, Chamberlain, SRet al. White matter abnormalities in patients with obsessive-compulsive disorder and their first-degree relatives. Am J Psychiatry 2008;165:1308–1315.CrossRefGoogle ScholarPubMed
27.Koprivova, J, Horacek, J, Tintera, Jet al. Medial frontal and dorsal cortical morphometric abnormalities are related to obsessive-compulsive disorder. Neurosci Lett 2009;464:62–66.CrossRefGoogle ScholarPubMed
28.Nakao, T, Nakagawa, A, Yoshiura, Tet al. A functional MRI comparison of patients with obsessive-compulsive disorder and normal controls during a Chinese character Stroop task. Psychiatry Res 2005;139:101–114.CrossRefGoogle ScholarPubMed
29.Wexler, BE, Goodman, WK. Cerebral laterality, perception of emotion, and treatment response in obsessive-compulsive disorder. Biol Psychiatry 1991;29:900–908.CrossRefGoogle ScholarPubMed
30.He, W, Chai, H, Zhang, Y, Yu, S, Chen, W, Wang, W. Line bisection performance in patients with generalized anxiety disorder and treatment-resistant depression. Int J Med Sci 2010;7:224–231.CrossRefGoogle ScholarPubMed
31.Varnava, A, Halligan, PW. Influence of age and sex on line bisection: a study of normal performance with implications for visuospatial neglect. Aging NeuropsycholCogn 2007;14:571–585.CrossRefGoogle ScholarPubMed