Book contents
- Uncommon Causes of Stroke
- Uncommon Causes of Stroke
- Copyright page
- Contents
- List of Contributors
- Preface
- PART I: INFECTIOUS AND INFLAMMATORY CONDITIONS
- PART II: HEREDITARY AND GENETIC CONDITIONS AND MALFORMATIONS
- PART III: VASCULAR CONDITIONS OF THE EYES, EARS, AND BRAIN
- PART IV: DISORDERS INVOLVING ABNORMAL COAGULATION
- PART V: SYSTEMIC DISORDERS THAT ALSO INVOLVE THE CEREBROVASCULAR SYSTEM
- 43 MICROSCOPIC POLYANGIITIS AND POLYARTERITIS NODOSA
- 44 CHURG-STRAUSS SYNDROME
- 45 SYSTEMIC LUPUS ERYTHEMATOSUS
- 46 RHEUMATOID ARTHRITIS AND CEREBROVASCULAR DISEASE
- 47 HYPERVISCOSITY AND STROKE
- 48 CALCIUM, HYPERCALCEMIA, MAGNESIUM, AND BRAIN ISCHEMIA
- 49 STROKE AND SUBSTANCE ABUSE
- 50 CANCER AND PARANEOPLASTIC STROKES
- 51 KOHLMEIER-DEGOS’ DISEASE (MALIGNANT ATROPHIC PAPULOSIS)
- 52 STROKE IN PATIENTS WHO HAVE INFLAMMATORY BOWEL DISEASE
- 53 SWEET’S SYNDROME (ACUTE FEBRILE NEUTROPHILIC DERMATOSIS)
- 54 NEPHROTIC SYNDROME AND OTHER RENAL DISEASES AND STROKE
- 55 EPIDERMAL NEVUS SYNDROME
- 56 SNEDDON’S SYNDROME
- 57 MITOCHONDRIAL AND METABOLIC CAUSES OF STROKE
- 58 BONE DISORDERS AND CEREBROVASCULAR DISEASES
- 59 SCLERODERMA
- PART VI: NONINFLAMMATORY DISORDERS OF THE ARTERIAL WALL
- PART VII: VENOUS OCCLUSIVE CONDITIONS
- PART VIII: VASOSPASTIC CONDITIONS AND OTHER MISCELLANEOUS VASCULOPATHIES
- PART IX: OTHER MISCELLANEOUS CONDITIONS
- Index
47 - HYPERVISCOSITY AND STROKE
from PART V: - SYSTEMIC DISORDERS THAT ALSO INVOLVE THE CEREBROVASCULAR SYSTEM
Published online by Cambridge University Press: 06 January 2010
Book contents
- Uncommon Causes of Stroke
- Uncommon Causes of Stroke
- Copyright page
- Contents
- List of Contributors
- Preface
- PART I: INFECTIOUS AND INFLAMMATORY CONDITIONS
- PART II: HEREDITARY AND GENETIC CONDITIONS AND MALFORMATIONS
- PART III: VASCULAR CONDITIONS OF THE EYES, EARS, AND BRAIN
- PART IV: DISORDERS INVOLVING ABNORMAL COAGULATION
- PART V: SYSTEMIC DISORDERS THAT ALSO INVOLVE THE CEREBROVASCULAR SYSTEM
- 43 MICROSCOPIC POLYANGIITIS AND POLYARTERITIS NODOSA
- 44 CHURG-STRAUSS SYNDROME
- 45 SYSTEMIC LUPUS ERYTHEMATOSUS
- 46 RHEUMATOID ARTHRITIS AND CEREBROVASCULAR DISEASE
- 47 HYPERVISCOSITY AND STROKE
- 48 CALCIUM, HYPERCALCEMIA, MAGNESIUM, AND BRAIN ISCHEMIA
- 49 STROKE AND SUBSTANCE ABUSE
- 50 CANCER AND PARANEOPLASTIC STROKES
- 51 KOHLMEIER-DEGOS’ DISEASE (MALIGNANT ATROPHIC PAPULOSIS)
- 52 STROKE IN PATIENTS WHO HAVE INFLAMMATORY BOWEL DISEASE
- 53 SWEET’S SYNDROME (ACUTE FEBRILE NEUTROPHILIC DERMATOSIS)
- 54 NEPHROTIC SYNDROME AND OTHER RENAL DISEASES AND STROKE
- 55 EPIDERMAL NEVUS SYNDROME
- 56 SNEDDON’S SYNDROME
- 57 MITOCHONDRIAL AND METABOLIC CAUSES OF STROKE
- 58 BONE DISORDERS AND CEREBROVASCULAR DISEASES
- 59 SCLERODERMA
- PART VI: NONINFLAMMATORY DISORDERS OF THE ARTERIAL WALL
- PART VII: VENOUS OCCLUSIVE CONDITIONS
- PART VIII: VASOSPASTIC CONDITIONS AND OTHER MISCELLANEOUS VASCULOPATHIES
- PART IX: OTHER MISCELLANEOUS CONDITIONS
- Index
Summary
The association of elevated hematocrit and fibrinogen levels with increased stroke risk has led to continued interest in hemorheologic factors and their role in the development of vascular disease and acute stroke. Viscosity increases logarithmically at the lowest shear rates and this effect is magnified at higher hematocrit levels. Fibrinogen may play a causal role in ischemic stroke through several mechanisms. The most prominent of these is its essential role in thrombosis, both as the substrate for fibrin clot formation and as a facilitator of platelet aggregation. The risk of stroke in sickle cell disease (SCD) varies according to genotype and is highest in patients with homozygous SS. Plasma hyperviscosity syndromes are treated by plasmapheresis (plasma exchange) to remove the paraproteins and thereby reduce hyperviscosity and hypervolemia. Newer techniques of cell centrifugation, plasma separation, and filtration may also be useful.
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- Uncommon Causes of Stroke , pp. 347 - 356Publisher: Cambridge University PressPrint publication year: 2008
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