Skip to main content Accessibility help
×
Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-26T22:44:12.375Z Has data issue: false hasContentIssue false

References

Published online by Cambridge University Press:  15 September 2022

Robert P. Friedland
Affiliation:
University of Louisville School of Medicine
Get access

Summary

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Chapter
Information
Unaging
The Four Factors that Impact How You Age
, pp. 303 - 319
Publisher: Cambridge University Press
Print publication year: 2022

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bernard, C. Lectures on the Phenomena of Life Common to Animals and Plants. Charles C Thomas Publishing; 1974.Google Scholar
Franceschi, C, Garagnani, P, Parini, P, Giuliani, C, Santoro, A. Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol. 2018;14(10):576–90.Google Scholar
Lorch, M. Language and memory disorder in the case of Jonathan Swift: considerations on retrospective diagnosis. Brain. 2006;129(Pt 11):3127–37.CrossRefGoogle Scholar
Antonovsky, A. Health, Stress and Coping. Jossey-Bass Publishing; 1979.Google Scholar
Garmany, A, Yamada, S, Terzic, A. Longevity leap: mind the healthspan gap. NPJ Regen Med. 2021;6(1):57.Google Scholar
North, BJ, Sinclair, DA. The intersection between aging and cardiovascular disease. Circ Res. 2012;110(8):1097–108.Google Scholar
Livingston, G, Huntley, J, Sommerlad, A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396(10248):413–46.Google Scholar
Fratiglioni, L, Marseglia, A, Dekhtyar, S. Ageing without dementia: can stimulating psychosocial and lifestyle experiences make a difference? Lancet Neurol. 2020;19(6):533–43.Google Scholar
Baker, GT, Martin, GR, Molecular and biologic factors in aging: the origins, causes, and prevention of senescence. In Geriatric Medicine, 3rd ed. Cassel, CK, Cohen, HJ, Larson, LB, et al. (eds.), Springer Verlag; 1997, pp. 328,Google Scholar
Rowe, JW, Kahn, RL. Human aging: usual and successful. Science. 1987;237(4811):143–9.Google Scholar
Schott, JM. The neurology of ageing: what is normal? Pract Neurol. 2017;17(3):172–82.Google Scholar
Soldan, A, Pettigrew, C, Albert, M. Cognitive reserve from the perspective of preclinical Alzheimer disease: 2020 update. Clin Geriatr Med. 2020;36(2):247–63.Google Scholar
Klein, RS. On complement, memory, and microglia. N Engl J Med. 2020;382(21):2056–8.Google Scholar
Baudisch, A. Inevitable Aging?: Contributions to Evolutionary-Demographic Theory. Springer; 2008.Google Scholar
Barulli, D, Stern, Y. Efficiency, capacity, compensation, maintenance, plasticity: emerging concepts in cognitive reserve. Trends Cogn Sci. 2013;17(10):502–9.Google Scholar
Gonneaud, J, Bedetti, C, Pichet Binette, A, et al. Association of education with Abeta burden in preclinical familial and sporadic Alzheimer disease. Neurology. 2020;95(11):e1554–64.Google Scholar
Friedland, RP, Fritsch, T, Smyth, KA, et al. Patients with Alzheimer’s disease have reduced activities in midlife compared with healthy control-group members. Proc Natl Acad Sci U S A. 2001;98(6):3440–5.Google Scholar
Mortimer, JA, Borenstein, AR, Gosche, KM, Snowdon, DA. Very early detection of Alzheimer neuropathology and the role of brain reserve in modifying its clinical expression. J Geriatr Psychiatry Neurol. 2005;18(4):218–23.Google Scholar
Ganz, AB, Beker, N, Hulsman, M, et al. Neuropathology and cognitive performance in self-reported cognitively healthy centenarians. Acta Neuropathol Commun. 2018;6(1):64.Google Scholar
Snowdon, D. Aging with Grace: What the Nun Study Teaches Us about Leading Longer, Healthier, and More Meaningful Lives. Bantam; 2002.Google Scholar
Snowdon, DA, Greiner, LH, Mortimer, JA, et al. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA. 1997;277(10):813–7.Google Scholar
Oveisgharan, S, Wilson, RS, Yu, L, Schneider, JA, Bennett, DA. Association of early-life cognitive enrichment with Alzheimer disease pathological changes and cognitive decline. JAMA Neurol. 2020;77(10):1217–24.Google Scholar
Pulido, RS, Munji, RN, Chan, TC, et al. Neuronal activity regulates blood–brain barrier efflux transport through endothelial circadian genes. Neuron. 2020;108(5):937–52.e7.CrossRefGoogle ScholarPubMed
Hobson, P, Lewis, A, Nair, H, Wong, S, Kumwenda, M. How common are neurocognitive disorders in patients with chronic kidney disease and diabetes? Results from a cross-sectional study in a community cohort of patients in North Wales, UK. BMJ Open. 2018;8(12):e023520.Google Scholar
Evans, IEM, Llewellyn, DJ, Matthews, FE, et al. Social isolation, cognitive reserve, and cognition in healthy older people. PLoS One. 2018;13(8):e0201008.Google Scholar
Dafsari, FS, Jessen, F. Depression: an underrecognized target for prevention of dementia in Alzheimer’s disease. Transl Psychiatry. 2020;10(1):160.Google Scholar
Aizenstein, HJ, Nebes, RD, Saxton, JA, et al. Frequent amyloid deposition without significant cognitive impairment among the elderly. Arch Neurol. 2008;65(11):1509–17.Google Scholar
Krystal, H. Integration and Self Healing: Affect, Trauma, Alexithymia. The Analytic Press; 1988.Google Scholar
Erikson, EH. Identity and the Life Cycle. W. W. Norton & Company; 1994.Google Scholar
Wilson, RS, Krueger, KR, Arnold, SE, et al. Loneliness and risk of Alzheimer disease. Arch Gen Psychiatry. 2007;64(2):234–40.Google Scholar
Berry, W. Another Turn of the Crank: Essays. Counterpoint; 1995.Google Scholar
Bennett, DA, Schneider, JA, Tang, Y, Arnold, SE, Wilson, RS. The effect of social networks on the relation between Alzheimer’s disease pathology and level of cognitive function in old people: a longitudinal cohort study. Lancet Neurol. 2006;5(5):406–12.Google Scholar
Wang, HS. Dementia in old age. Contemp Neurol Ser. 1977;15:1527.Google ScholarPubMed
Friedland, RP, Nandi, S. A modest proposal for a longitudinal study of dementia prevention (with apologies to Jonathan Swift, 1729). J Alzheimers Dis. 2013;33(2):313–5.Google Scholar
Cobb, M. The Idea of the Brain: The Past and Future of Neuroscience. Basic Books; 2020.Google Scholar
Fine, I, Park, JM. Blindness and human brain plasticity. Annu Rev Vis Sci. 2018;4:337–56.Google Scholar
Maguire, EA, Nannery, R, Spiers, HJ. Navigation around London by a taxi driver with bilateral hippocampal lesions. Brain. 2006;129(Pt 11):2894–907.Google Scholar
Yong, E. How Brain Scientists Forgot That Brains Have Owners. The Atlantic; 2017.Google Scholar
Bennett, J. On Human Origins, Spirituality and the Meaning of Life. Friesen Press; 2021, p. 235.Google Scholar
Schulte, BPM. John Hughlings Jackson. In Eling, P (ed.), Reader in the History of Aphasia. Benjamins; 1994, pp. 13367.Google Scholar
Jackson, JH. BMJ. 1884;I:662.Google Scholar
Badimon, A, Strasburger, HJ, Ayata, P, et al. Negative feedback control of neuronal activity by microglia. Nature. 2020;586(7829):417–23.CrossRefGoogle ScholarPubMed
Buffington, SA, Di Prisco, GV, Auchtung, TA, et al. Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring. Cell. 2016;165(7):1762–75.Google Scholar
Li, Q, Barres, BA. Microglia and macrophages in brain homeostasis and disease. Nat Rev Immunol. 2018;18(4):225–42.Google Scholar
Vuong, HE, Pronovost, GN, Williams, DW, et al. The maternal microbiome modulates fetal neurodevelopment in mice. Nature. 2020;586(7828):281–6.Google Scholar
Strittmatter, A, Sunde, U, Zegners, D. Life cycle patterns of cognitive performance over the long run. Proc Natl Acad Sci U S A. 2020;117(44):27255–61.Google Scholar
Davidow Hirshbein, L. William Osler and The Fixed Period: conflicting medical and popular ideas about old age. Arch Intern Med. 2001;161(17):2074–8.Google Scholar
Gravitz, L. The forgotten part of memory. Nature. 2019;571(7766):S12S14.Google Scholar
Fishman, E. Risk of developing dementia at older ages in the United States. Demography. 2017;54(5):1897–919.Google Scholar
Association Association. Alzheimer’s disease facts and figures. Alzheimer’s Association Report. Alzheimer’s Association, March 10, 2020. doi: https://doi.org/10.1002/alz.12068.Google Scholar
Kalaria, RN, Maestre, GE, Arizaga, R, et al. Alzheimer’s disease and vascular dementia in developing countries: prevalence, management, and risk factors. Lancet Neurol. 2008;7(9):812–26.Google Scholar
Barnes, LL. Alzheimer disease in African American individuals: increased incidence or not enough data? Nat Rev Neurol. 2022;18(1):56–62.Google Scholar
Engstrom, EJ, Burgmair, W, Weber, MM. Emil Kraepelin’s “self-assessment”: clinical autography in historical context. Hist Psychiatry. 2002;13(49 Pt 1): 89119.Google Scholar
Freyhan, FA, Woodford, RB, Kety, SS. Cerebral blood flow and metabolism in psychoses of senility. J Nerv Ment Dis. 1951;113(5):449–56.Google Scholar
Katzman, R. Editorial: The prevalence and malignancy of Alzheimer disease. A major killer. Arch Neurol. 1976;33(4):217–8.Google Scholar
Friedland, RP, Chapman, MR. The role of microbial amyloid in neurodegeneration. PLoS Pathog. 2017;13(12):e1006654.Google Scholar
Friedland, RP. Mechanisms of molecular mimicry involving the microbiota in neurodegeneration. J Alzheimers Dis. 2015;45(2):349–62.Google Scholar
Ayres, JS. The biology of physiological health. Cell. 2020;181(2):250–69.Google Scholar
Ayres, JS, Schneider, DS. Tolerance of infections. Annu Rev Immunol. 2012;30:271–94.Google Scholar
Espay, A, Stecher, B. Brain Fables: The Hidden History of Neurodegenerative Diseases and a Blueprint to Conquer Them. Cambridge University Press; 2020, pp. 111–23.Google Scholar
Levine, DA, Gross, AL, Briceno, EM, et al. Association between blood pressure and later-life cognition among black and white individuals. JAMA Neurol. 2020;77(7):810–9.Google Scholar
Frisoni, GB, Molinuevo, JL, Altomare, D, et al. Precision prevention of Alzheimer’s and other dementias: anticipating future needs in the control of risk factors and implementation of disease-modifying therapies. Alzheimers Dement. 2020;16(10):1457–68.Google Scholar
Xu, W, Tan, L, Wang, HF, et al. Education and risk of dementia: dose-response meta-analysis of prospective cohort studies. Mol Neurobiol. 2016;53(5):3113–23.Google Scholar
Fink, HA, Linskens, EJ, MacDonald, R, et al. Benefits and harms of prescription drugs and supplements for treatment of clinical Alzheimer-type dementia. Ann Intern Med. 2020;172(10):656–68.Google Scholar
Kurlawala, Z, Roberts, JA, McMillan, JD, Friedland, RP. Diazepam toxicity presenting as a dementia disorder. J Alzheimers Dis. 2018;66(3):935–8.Google Scholar
Friedland, RP. “Normal”-pressure hydrocephalus and the saga of the treatable dementias. JAMA. 1989;262(18):2577–81.Google Scholar
Ohnmacht, J, May, P, Sinkkonen, L, Kruger, R. Missing heritability in Parkinson’s disease: the emerging role of non-coding genetic variation. J Neural Transm (Vienna). 2020;127(5):729–48.Google Scholar
Kummer, BR, Diaz, I, Wu, X, et al. Associations between cerebrovascular risk factors and Parkinson disease. Ann Neurol. 2019;86(4):572–81.Google Scholar
Ingre, C, Roos, PM, Piehl, F, Kamel, F, Fang, F. Risk factors for amyotrophic lateral sclerosis. Clin Epidemiol. 2015;7:181–93.Google Scholar
Einstein, A. On the Method of Theoretical Physics. Lecture delivered at Oxford, June 10, 1933.Google Scholar
Gorelick, PB, Scuteri, A, Black, SE, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42(9):2672–713.CrossRefGoogle ScholarPubMed
Gu, Y, Gutierrez, J, Meier, IB, et al. Circulating inflammatory biomarkers are related to cerebrovascular disease in older adults. Neurol Neuroimmunol Neuroinflamm. 2019;6(1):e521.Google Scholar
Tonomura, S, Ihara, M, Kawano, T, et al. Intracerebral hemorrhage and deep microbleeds associated with cnm-positive Streptococcus mutans: a hospital cohort study. Sci Rep. 2016;6:20074.Google Scholar
Tonomura, S, Ihara, M, Friedland, RP. Microbiota in cerebrovascular disease: a key player and future therapeutic target. J Cereb Blood Flow Metab. 2020;40(7):1368–80.Google Scholar
Tang, WH, Wang, Z, Levison, BS, et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med. 2013;368(17):1575–84.Google Scholar
Gajdusek, DC, Gibbs, CJ, Alpers, M. Experimental transmission of a kuru-like syndrome to chimpanzees. Nature. 1966;209(5025):794–6.Google Scholar
Friedland, RP, Petersen, RB, Rubenstein, R. Bovine spongiform encephalopathy and aquaculture. J Alzheimers Dis. 2009;17(2):277–9.Google Scholar
Stern, RA, Riley, DO, Daneshvar, DH, et al. Long-term consequences of repetitive brain trauma: chronic traumatic encephalopathy. 2011;3(10 Suppl 2):S460–7.Google Scholar
Darwin, C, Origin of Species, second British edition; 1860, p. 3.Google Scholar
Leshem, A, Liwinski, T, Elinav, E. Immune-microbiota interplay and colonization resistance in infection. Mol Cell. 2020;78(4):597613.Google Scholar
Differding, MK, Mueller, NT. Human milk bacteria: seeding the infant gut? Cell Host Microbe. 2020;28(2):151–3.Google Scholar
Liu, Q, Liu, Q, Meng, H, et al. Staphylococcus epidermidis contributes to healthy maturation of the nasal microbiome by stimulating antimicrobial peptide production. Cell Host Microbe. 2020;27(1):68–78 e5.Google Scholar
Faraco, G, Hochrainer, K, Segarra, SG, et al. Dietary salt promotes cognitive impairment through tau phosphorylation. Nature. 2019;574(7780):686–90.Google Scholar
Kimura, I, Miyamoto, J, Ohue-Kitano, R, et al. Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice. Science. 2020;367(6481): eaaw8429.Google Scholar
D’Aquila, P, Carelli, LL, De Rango, F, Passarino, G, Bellizzi, D. Gut microbiota as important mediator between diet and DNA methylation and histone modifications in the host. Nutrients. 2020;12(3):597.Google Scholar
Finlay, BB, CFIR Humans, & the Microbiome: Are noncommunicable diseases communicable? Science. 2020;367(6475):250–1.Google Scholar
Glowacki, RWP, Martens, EC. In sickness and health: effects of gut microbial metabolites on human physiology. PLoS Pathog. 2020;16(4):e1008370.CrossRefGoogle ScholarPubMed
Itzhaki, RF. A turning point in Alzheimer’s disease: microbes matter. J Alzheimers Dis. 2019;72(4):977–80.CrossRefGoogle ScholarPubMed
Dominy, SS, Lynch, C, Ermini, F, et al. Porphyromonas gingivalis in Alzheimer’s disease brains: evidence for disease causation and treatment with small-molecule inhibitors. Sci Adv. 2019;5(1):eaau3333.Google Scholar
O’Keefe, SJ, Li, JV, Lahti, L, et al. Fat, fibre and cancer risk in African Americans and rural Africans. Nat Commun. 2015;6:6342.Google Scholar
Kohler, W. Dynamics in Psychology, Retention and Recall. Liveright Publishing Corp.; 1940, pp. 115–6.Google Scholar
Friedland, RP, McMillan, JD, Kurlawala, Z. What are the molecular mechanisms by which functional bacterial amyloids influence amyloid beta deposition and neuroinflammation in neurodegenerative disorders? Int J Mol Sci. 2020;21(5):1652.Google Scholar
Kowalski, K, Mulak, A. Brain–gut–microbiota axis in Alzheimer’s disease. J Neurogastroenterol Motil. 2019;25(1):4860.Google Scholar
Kim, S, Kwon, SH, Kam, TI, et al. Transneuronal propagation of pathologic α-synuclein from the gut to the brain models Parkinson’s disease. Neuron. 2019;103(4):627–641.e7.Google Scholar
Xue, QL. The frailty syndrome: definition and natural history. Clin Geriatr Med. 2011;27(1):115.Google Scholar
Claesson, MJ, Jeffery, IB, Conde, S, et al. Gut microbiota composition correlates with diet and health in the elderly. Nature. 2012;488(7410):178–84.Google Scholar
Friedland, RP, Haribabu, B. The role for the metagenome in the pathogenesis of COVID-19. EBioMedicine. 2020;61:103019.Google Scholar
Alexander, M, Turnbaugh, PJ. Deconstructing mechanisms of diet–microbiome–immune interactions. Immunity. 2020;53(2):264–76.CrossRefGoogle ScholarPubMed
Wene-Batu, P, Bisimwa, G, Baguma, M, et al. Long-term effects of severe acute malnutrition during childhood on adult cognitive, academic and behavioural development in African fragile countries: the Lwiro cohort study in Democratic Republic of the Congo. PLoS One. 2020;15(12):e0244486.CrossRefGoogle Scholar
Slade, K, Plack, CJ, Nuttall, HE. The effects of age-related hearing loss on the brain and cognitive function. Trends Neurosci. 2020;43(10):810–21.Google Scholar
Knopman, DS, Roberts, RO. Healthy young hearts sharper older minds make. Ann Neurol. 2013;73(2):151–2.Google Scholar
Llewellyn, DJ, Langa, KM, Friedland, RP, Lang, IA. Serum albumin concentration and cognitive impairment. Curr Alzheimer Res. 2010;7(1):91–6.Google Scholar
Chrischilles, E, Schneider, K, Wilwert, J, et al. Beyond comorbidity: expanding the definition and measurement of complexity among older adults using administrative claims data. Med Care. 2014;52(Suppl 3):S7584.Google Scholar
Nesse, RM. Why We Get Sick: The New Science of Darwinian Medicine. Vintage; 1996.Google Scholar
Lasselin, J. Back to the future of psychoneuroimmunology: studying inflammation-induced sickness behavior. Brain Behav Immun Health. 2021;18:100379.Google Scholar
Song, H, Sieurin, J, Wirdefeldt, K, et al. Association of stress-related disorders with subsequent neurodegenerative diseases. JAMA Neurol. 2020;77(6):700–9.Google Scholar
Krystal, H. The aging survivor of the holocaust. Integration and self-healing in posttraumatic states. J Geriatr Psychiatry. 1981;14(2):165–89.Google Scholar
Zhou, XL, Wang, LN, Wang, J, Shen, XH, Zhao, X. Effects of exercise interventions for specific cognitive domains in old adults with mild cognitive impairment: a protocol of subgroup meta-analysis of randomized controlled trials. Medicine (Baltimore). 2018;97(48):e13244.Google Scholar
Bissell, MJ. Asking the question of why. Cell. 2020;181(3):503–6.Google Scholar
Farrer, LA, Cupples, LA, Haines, JL, et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA. 1997;278(16):1349–56.Google Scholar
Scheltens, P, Blennow, K, Breteler, MM, et al. Alzheimer’s disease. Lancet. 2016;388(10043):505–17.Google Scholar
Tran, TTT, Corsini, S, Kellingray, L, et al. APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer’s disease pathophysiology. FASEB J. 2019;33(7):8221–31.Google Scholar
Konijnenberg, E, Tomassen, J, den Braber, A, et al. Onset of preclinical Alzheimer disease in monozygotic twins. Ann Neurol. 2021;89(5):987–1000.Google Scholar
Daviglus, ML, Bell, CC, Berrettini, W, et al. NIH State-of-the-Science Conference statement: preventing Alzheimer’s disease and cognitive decline. NIH Consens State Sci Statements. 2010;27(4):130.Google Scholar
Daviglus, ML, Plassman, BL, Pirzada, A, et al. Risk factors and preventive interventions for Alzheimer disease: state of the science. Arch Neurol. 2011;68(9):1185–90.Google Scholar
National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Health Sciences Policy; Committee on Preventing Dementia and Cognitive Impairment. Preventing Cognitive Decline and Dementia: A Way Forward. Downey, A, Stroud, C, Landis, S, Leshner, AI (eds.), National Academies Press; 2017.Google Scholar
Yu, JT, Xu, W, Tan, CC, et al. Evidence-based prevention of Alzheimer’s disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials. J Neurol Neurosurg Psychiatry. 2020; 91(11):1201–9.Google Scholar
Friedland, RP, Brayne, C. What does the pediatrician need to know about Alzheimer disease? J Dev Behav Pediatr. 2009;30(3):239–41.Google Scholar
Hurley, D. Grandma’s experiences leave a mark on your genes. Discover. 2015; June 25.Google Scholar
Gilbert, J, Knight, R. Dirt Is Good: The Advantage of Germs for Your Child’s Developing Immune System. St. Martin’s Press; 2017.Google Scholar
Norton, S, Matthews, FE, Barnes, DE, Yaffe, K, Brayne, C. Potential for primary prevention of Alzheimer’s disease: an analysis of population-based data. Lancet Neurol. 2014;13(8):788–94.Google Scholar
Kovari, E, Herrmann, FR, Bouras, C, Gold, G. Amyloid deposition is decreasing in aging brains: an autopsy study of 1,599 older people. Neurology. 2014;82(4):326–31.Google Scholar
Wu, YT, Beiser, AS, Breteler, MMB, et al. The changing prevalence and incidence of dementia over time: current evidence. Nat Rev Neurol. 2017;13(6):327–39.Google Scholar
United States Census Bureau. Current Population Survey (CPS). 2021; December 14.Google Scholar
Krell-Roesch, J, Syrjanen, JA, Bezold, J, et al. Physical activity and trajectory of cognitive change in older persons: Mayo Clinic Study of Aging. J Alzheimers Dis. 2021;79(1):377–88.Google Scholar
Wilson, EO. Biophilia. Harvard University Press; 1984.Google Scholar
Borenstein, A, Mortimer, J. Alzheimer’s Disease: Life Course Perspectives on Risk Reduction. Academic Press; 2016.Google Scholar
Jung, MS, Chung, E. Television viewing and cognitive dysfunction of Korean older adults. Healthcare (Basel). 2020;8(4):547.Google Scholar
Kehler, DS, Hay, JL, Stammers, AN, et al. A systematic review of the association between sedentary behaviors with frailty. Exp Gerontol. 2018;114:112.Google Scholar
Takagi, H, Hari, Y, Nakashima, K, Kuno, T, Ando, T, Group, A. Meta-analysis of the relation of television-viewing time and cardiovascular disease. Am J Cardiol. 2019;124(11):1674–83.Google Scholar
Gallucci, M, Mazzarolo, AP, Focella, L, et al. ‘Camminando e leggendo … “Ricordo” (walking and reading … I remember): prevention of frailty through the promotion of physical activity and reading in people with mild cognitive impairment. Results from the TREDEM Registry. J Alzheimers Dis. 2020;77(2):689–99.Google Scholar
Smyth, KA, Fritsch, T, Cook, TB, et al. Worker functions and traits associated with occupations and the development of AD. Neurology. 2004;63(3):498503.Google Scholar
Budson, AE, O’Connor, MK. Seven Steps to Managing Your Memory: What’s Normal, What’s Not, and What to Do About It. Oxford University Press; 2017.Google Scholar
Kornfield, J. A Path with Heart: A Guide through the Perils and Promises of Spiritual Life. Bantam; 1993.Google Scholar
James, W. The Selected Letters of William James. Anchor Books; 1993.Google Scholar
Schanche, E, Vollestad, J, Visted, E, et al. The effects of mindfulness-based cognitive therapy on risk and protective factors of depressive relapse: a randomized wait-list controlled trial. BMC Psychol. 2020;8(1):57.Google Scholar
Barusch, AS. Love Stories of Later Life: A Narrative Approach to Understanding Romance. Oxford University Press; 2008.Google Scholar
Gunak, MM, Billings, J, Carratu, E, et al. Post-traumatic stress disorder as a risk factor for dementia: systematic review and meta-analysis. Br J Psychiatry. 2020;217(5):600–8.Google Scholar
Barthelemy, NR, Liu, H, Lu, W, et al. Sleep deprivation affects tau phosphorylation in human cerebrospinal fluid. Ann Neurol. 2020;87(5):700–9.Google Scholar
Cascella, M, Bimonte, S, Barbieri, A, et al. Dissecting the mechanisms and molecules underlying the potential carcinogenicity of red and processed meat in colorectal cancer (CRC): an overview on the current state of knowledge. Infect Agent Cancer. 2018;13:3.Google Scholar
Aune, D, Keum, N, Giovannucci, E, et al. Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: systematic review and dose–response meta-analysis of prospective studies. BMJ. 2016;353:i2716.Google Scholar
School of Public Health UoW. The Anti-Inflammatory Lifestyle. School of Medicine and Public Health, University of Wisconsin-Madison, 2018, p. 12.Google Scholar
Enders, G. Gut: The Inside Story of Our Body’s Most Underrated Organ. Greystone Books; 2018.Google Scholar
Shaikh, FY, Sears, CL. Messengers from the microbiota. Science. 2020;369(6510):1427–8.Google Scholar
Swaminathan, S, Dehghan, M, Raj, JM, et al. Associations of cereal grains intake with cardiovascular disease and mortality across 21 countries in Prospective Urban and Rural Epidemiology study: prospective cohort study. BMJ. 2021;372:m4948.Google Scholar
Glenn, AJ, Lo, K, Jenkins, DJA, et al. Relationship between a plant-based dietary portfolio and risk of cardiovascular disease: findings from the Women’s Health Initiative Prospective Cohort Study. J Am Heart Assoc. 2021;10(16):e021515.Google Scholar
Kaplan, A, Zelicha, H, Meir, AY, et al. The effect of a high-polyphenol Mediterranean diet (GREEN-MED) combined with physical activity on age-related brain atrophy: the DIRECT PLUS randomized controlled trial. Am J Clin Nutr. 2022. doi: 10.1093/ajcn/nqac001.Google Scholar
Keenan, TD, Agron, E, Mares, JA, et al. Adherence to a Mediterranean diet and cognitive function in the Age-Related Eye Disease Studies 1 & 2. Alzheimers Dement. 2020;16(6):831–42.Google Scholar
Harari, Y. Homo Deus: A Brief History of Tomorrow. Harper; 2017.Google Scholar
Yin, J, Zhu, Y, Malik, V, et al. Intake of sugar-sweetened and low-calorie sweetened beverages and risk of cardiovascular disease: a meta-analysis and systematic review. Adv Nutr. 2021;12(1):89101.Google Scholar
Chong, CP, Shahar, S, Haron, H, Din, NC. Habitual sugar intake and cognitive impairment among multi-ethnic Malaysian older adults. Clin Interv Aging. 2019;14:1331–42.Google Scholar
United Brain Association. How sugar affects the brain. Available from: https://unitedbrainassociation.org/2020/06/28/how-sugar-affects-the-brain/.Google Scholar
Charisis, S, Ntanasi, E, Yannakoulia, M, et al. Diet inflammatory index and dementia incidence: a population-based study. Neurology. 2021;97(24):e2381–91.Google Scholar
Shishtar, E, Rogers, GT, Blumberg, JB, Au, R, Jacques, PF. Long-term dietary flavonoid intake and risk of Alzheimer disease and related dementias in the Framingham Offspring Cohort. Am J Clin Nutr. 2020;112(2):343–53.Google Scholar
Neelakantan, N, Seah, JYH, van Dam, RM. The effect of coconut oil consumption on cardiovascular risk factors: a systematic review and meta-analysis of clinical trials. Circulation. 2020;141(10):803–14.Google Scholar
Seshadri, S, Beiser, A, Selhub, J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer’s disease. N Engl J Med. 2002;346(7):476–83.Google Scholar
Blacher, E, Bashiardes, S, Shapiro, H, et al. Potential roles of gut microbiome and metabolites in modulating ALS in mice. Nature. 2019;572(7770):474–80.Google Scholar
Green, KN, Steffan, JS, Martinez-Coria, H, et al. Nicotinamide restores cognition in Alzheimer’s disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J Neurosci. 2008;28(45):11500–10.Google Scholar
Liebler, DC. The role of metabolism in the antioxidant function of vitamin E. Crit Rev Toxicol. 1993;23(2):147–69.Google Scholar
Chen, F, Du, M, Blumberg, JB, et al. Association among dietary supplement use, nutrient intake, and mortality among US adults: a cohort study. Ann Intern Med. 2019;170(9):604–13.Google Scholar
Kirichenko, TV, Sukhorukov, VN, Markin, AM, et al. Medicinal plants as a potential and successful treatment option in the context of atherosclerosis. Front Pharmacol. 2020;11:403.Google Scholar
Fiala, M, Liu, PT, Espinosa-Jeffrey, A, et al. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer’s disease patients are improved by bisdemethoxycurcumin. Proc Natl Acad Sci U S A. 2007;104(31):12849–54.Google Scholar
Yamasaki, TR, Ono, K, Ho, L, Pasinetti, GM. Gut microbiome-modified polyphenolic compounds inhibit alpha-synuclein seeding and spreading in alpha-synucleinopathies. Front Neurosci. 2020;14:398.Google Scholar
Noguchi-Shinohara, M, Yuki, S, Dohmoto, C, et al. Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline. PLoS One. 2014;9(5):e96013.Google Scholar
Holland, TM, Agarwal, P, Wang, Y, et al. Dietary flavonols and risk of Alzheimer dementia. Neurology. 2020;94(16):e1749–56.Google Scholar
de Cabo, R, Mattson, MP. Effects of intermittent fasting on health, aging, and disease. N Engl J Med. 2019;381(26):2541–51.Google Scholar
Metchnikoff, E. On the present state of the question of immunity and infectious diseases, Nobel Lecture, December 11, 1908.Google Scholar
Shah, J. Heart Health: A Guide to the Tests and Treatments You Really Need. Rowman & Littlefield Publishers; 2019.Google Scholar
Friedland, RP, Lerner, AJ, Hedera, P, Brass, EP. Encephalopathy associated with bismuth subgallate therapy. Clin Neuropharmacol. 1993;16(2):173–6.Google Scholar
Maher, RL, Hanlon, J, Hajjar, ER. Clinical consequences of polypharmacy in elderly. Expert Opin Drug Saf. 2014;13(1):5765.Google Scholar
Wastesson, JW, Morin, L, Tan, ECK, Johnell, K. An update on the clinical consequences of polypharmacy in older adults: a narrative review. Expert Opin Drug Saf. 2018;17(12):1185–96.Google Scholar
Chew, ML, Mulsant, BH, Pollock, BG, et al. Anticholinergic activity of 107 medications commonly used by older adults. J Am Geriatr Soc. 2008;56(7):1333–41.Google Scholar
de Ropp, RS. The New Prometheans. Delacorte; 1972, p. 80.Google Scholar
Brauer, CA, Coca-Perraillon, M, Cutler, DM, Rosen, AB. Incidence and mortality of hip fractures in the United States. JAMA. 2009;302(14):1573–9.Google Scholar
Fleminger, S, Oliver, DL, Lovestone, S, Rabe-Hesketh, S, Giora, A. Head injury as a risk factor for Alzheimer’s disease: the evidence 10 years on; a partial replication. J Neurol Neurosurg Psychiatry. 2003;74(7):857–62.Google Scholar
Harvard Health Publishing. Chiropractic neck adjustments linked to stroke. Available from: www.health.harvard.edu/heart-health/chiropractic-neck-adjustments-linked-to-stroke.Google Scholar
Iaccarino, L, La Joie, R, Lesman-Segev, OH, et al. Association between ambient air pollution and amyloid positron emission tomography positivity in older adults with cognitive impairment. JAMA Neurol. 2021;78(2):197207.Google Scholar
Niu, H, Qu, Y, Li, Z, et al. Smoking and risk for Alzheimer disease: a meta-analysis based on both case–control and cohort study. J Nerv Ment Dis. 2018;206(9):680–5.Google Scholar
Hamburg, MA, Collins, FS. The path to personalized medicine. N Engl J Med. 2010; 363(4):301–4. Erratum in N Engl J Med. 2010; 363(11):1092.Google Scholar
Sampson, TR, Challis, C, Jain, N, et al. A gut bacterial amyloid promotes alpha-synuclein aggregation and motor impairment in mice. Elife. 2020;9 :e53111.Google Scholar
Wargo, JA. Modulating gut microbes. Science. 2020;369(6509):1302–3.Google Scholar
Palmqvist, S, Tideman, P, Cullen, N, et al. Prediction of future Alzheimer’s disease dementia using plasma phospho-tau combined with other accessible measures. Nat Med. 2021; 27(6):1034–42.Google Scholar
Brookmeyer, R, Abdalla, N. Estimation of lifetime risks of Alzheimer’s disease dementia using biomarkers for preclinical disease. Alzheimers Dement. 2018;14(8):981–8.Google Scholar
Kosinski, M. Facial recognition technology can expose political orientation from naturalistic facial images. Sci Rep. 2021;11(1):100. Erratum in Sci Rep. 2021;11(1):23228.Google Scholar
Efron, R. The duration of the present. Ann NY Acad Sci. 1967;138(2):713–29.Google Scholar
Csikszentmihalyi, M. Flow: The Psychology of Optimal Experience. Harper Perennial Modern Classics; 2008.Google Scholar
James, W. What is an emotion? Mind. 1884:188205.Google Scholar
Seelye, KQ. Christina Crosby, 67, dies; feminist scholar wrote of becoming disabled. NY Times. 2021; January 26.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×