Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-20T11:29:21.736Z Has data issue: false hasContentIssue false

6 - Science and Technology of Novel Ultrananocrystalline Diamond (UNCD™) Scaffolds for Stem Cell Growth and Differentiation for Developmental Biology and Biological Treatment of Human Medical Conditions

Published online by Cambridge University Press:  08 July 2022

By
Bing Shi  and
Orlando Auciello
Edited by
Orlando Auciello
Orlando Auciello
Affiliation:
University of Texas, Dallas
Get access

Summary

Biomaterials are being investigated to produce platform as scaffolds for cell/tissue growth and differentiation/regeneration. Cell-materials, chemical and biological interactions enable the application of more functional materials in the area of bioengineering, providing a pathway to novel treatment of humans suffering from tissue/organ damage and facing limitation of donation organs. Many studies were done on the tissue/organ regeneration. Development of new scaffolds for cell/tissue regeneration is a key R&D field. This chapter focuses on describing R&D on the novel ultrananocrystalline diamond (UNCD) film as a unique biomaterial for scaffolds for developmental biology. Recent research showed that cells grown on the surface of UNCD-coated culture dishes are similar to cell culture dishes with little retardation, indicating UNCD films have no or little inhibition on cell proliferation and are potentially appealing as substrate/scaffold materials. The mechanisms of cell adhesion on UNCD surfaces are proposed based on the experimental results. The comparisons of cell cultures on diamond-powder-seeded culture dishes and on UNCD-coated dishes with matrix-assisted laser desorption/ionization - time-of-flight mass spectroscopy (MALDI-TOF MS) and X-ray photoelectron spectroscopy (XPS) analyses provided valuable data to support the mechanisms proposed to explain the adhesion and proliferation of cells on the surface of UNCD scaffolds.

Keywords

Ultrananocrystalline Diamond (UNCD)chemicaltreated surfacescaffoldgrowembryonic cellsdifferentiationotherhuman cells
Type
Chapter
Information
Ultrananocrystalline Diamond Coatings for Next-Generation High-Tech and Medical Devices , pp. 175 - 196
Publisher: Cambridge University Press
Print publication year: 2022

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

OrthoInfo. Homepage. http://orthoinfo.aaos.org.Google Scholar
Langer, R. and Vacanti, J. P., “Tissue engineering,” Science, vol. 260, p. 920, 1993.Google Scholar
Vacanti, J. P. and Langer, R., “Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation,” Lancet, vol. 354 (S1), p. 132, 1999.CrossRefGoogle ScholarPubMed
Stupp, S. I., “Biomaterials: introduction for annual review of materials research,” Ann. Rev. Mater. Res., vol. 31, 2001.CrossRefGoogle Scholar
Clevers, H., Loh, K. M., and Nusse, R., “An integral program for tissue renewal and regeneration: with signaling and stem cell control,” Science, vol. 346, (6205), 2014.CrossRefGoogle ScholarPubMed
Kotton, D. N. and Morrisey, E. E., “Lung regeneration: mechanisms, applications and emerging stem cell populations,” Nat. Med., vol. 20, p. 822, 2014.CrossRefGoogle ScholarPubMed
Wagers, A. J., “The stem cell niche in regenerative medicine,” Cell Stem Cell, vol. 10 (4), p. 362, 2012.Google Scholar
Peppas, N. A. and Langer, R., “New challenges in biomaterials,” Science, vol. 263, p. 1715, 1994.Google Scholar
Peters, M. C., Isenberg, B. C., Rowley, J. A., and Mooney, D. J., “Release from alginate enhances the biological activity of vascular endothelial growth factor,” J. Biomat. Sci Polymer Edi., vol. 9 (12), p. 1267, 1998.Google Scholar
Thomson, L. A., Law, F. C., Rushton, N., and Franks, J., “Biocompatibility of diamond-like carbon coating,” Biomaterials, vol. 12, p. 37, 1991.Google Scholar
Clem, W. C., Chowdhury, S., Catledge, S. A., et al., “Mesenchymal stem cell interaction with ultra-smooth nanostructured diamond for wear resistant orthopedic implants,” Biomaterials, vol. 29, p. 3461, 2008.Google Scholar
Shi, B., Jin, Q., Chen, L., et al., “Cell growth on different types of ultrananocrystalline diamond thin films,” J. Funct. Biomed. Mater., vol. 3, p. 588, 2012.Google ScholarPubMed
Duailibi, S. E., Duailibi, M. T., Ferreira, L. M., et al., “Tooth, tissue engineering: the influence of hydrophilic surface on nanocrystalline diamond films for human dental stem cells,” Tissue Eng., vol. A19, p. 2537, 2013.CrossRefGoogle Scholar
Taylor, A. C., Vagaska, B., Edgington, R., et al., “Biocompatibility of nanostructured boron doped diamond for the attachment and proliferation of human neural stem cells,” J. Neural. Eng., vol. 12, p. 066016, 2015.Google Scholar
Chen, Y. C., Lee, D. C., Hsiao, C. Y., et al., “The effect of ultrananocrystalline diamond films on the proliferation and differentiation of neural stem cells,” Biomaterials, vol. 30, p. 3428, 2009.Google Scholar
Chen, Y. C., Lee, D. C., Tsai, T. Y., et al., “Induction and regulation of differentiation in neural stem cells on ultra-nanocrystalline diamond films,” Biomaterials, vol. 31, p. 5575, 2010.Google Scholar
Taylor, A., “Diamond for stem cell biotechnology,” PhD thesis, University College London, 2016.Google Scholar
Nistor, P. A., May, P. W., Tamagnini, F., Randall, A. D., and Caldwell, M. A., “Long-term culture of pluripotent stem-cell-derived human neurons on diamond: a substrate for neurodegeneration research and therapy,” Biomaterials, vol. 61, p. 139, 2015.Google Scholar
Specht, C. G., Williams, O. A., Jackman, R. B., and Schoepfer, R.. “Ordered growth of neurons,” Biomaterials, vol. 25, p. 4073, 2004.CrossRefGoogle ScholarPubMed
May, P. W., Regan, E. M., Taylor, A., Uney, J., Dick, A. D., and McGeehan, J.. “Spatially controlling neuronal adhesion on CVD diamond,” Diam. Relat. Mater., vol. 23, p. 100, 2012.Google Scholar
Edgington, R. J., Thalhammer, A., Welch, J. O., et al., “Patterned neuronal networks using nanodiamonds and the effect of varying nanodiamond properties on neuronal adhesion and outgrowth,” J. Neural Eng., vol. 10, p. 056022, 2013.Google Scholar
Thalhammer, A., Edgington, R. J., Cingolani, L. A., Schoepfer, R., and Jackman, R. B., “The use of nanodiamond monolayer coatings to promote the formation of functional neuronal networks,” Biomaterials, vol. 31, p. 2097, 2010.CrossRefGoogle ScholarPubMed
Ojovan, S. M., McDonald, M., Rabieh, N., et al., “Nanocrystalline diamond surfaces for adhesion and growth of primary neurons, conflicting results and rational explanation,” Front. Neuroeng., vol. 7, p. 17, 2014.CrossRefGoogle ScholarPubMed
Tong, W., Tran, P. A., Turnley, A. M., et al., “The influence of sterilization on nitrogen-included ultrananocrystalline diamond for biomedical applications,” Mater. Sci. Eng. C Mater. Biol. Appl., vol. 61, p. 324, 2016.CrossRefGoogle ScholarPubMed
Ariano, P., Budnyk, O., Dalmazzo, S., et al., “On diamond surface properties and interactions with neurons,” Eur. Phys. J. E., vol. 30, p. 149, 2009.Google Scholar
Bendali, A., Agnes, C., Meffert, S., et al., “Distinctive glial and neuronal interfacing on nanocrystalline diamond,” PLoS One, vol. 9 (3), p. e92562, 2014.Google Scholar
Steinmuller-Nethl, D., Kloss, F. R., Najam-Ul-HAq, M., et al., “Strong binding of bioactive BMP-2 to nanocrystalline diamond by physisorption,” Biomaterials, vol. 27, p. 4547, 2006.Google Scholar
Grausova, L., Kromka, A., Burdikova, Z., et al., “Enhanced growth and osteogenic differentiation of human osteoblast-like cells on boron-doped nanocrystalline, diamond thin films,” PLoS One, vol. 6, 2011.Google Scholar
Heinrich, G., Grogler, T., Rosiwal, S. M., and Singer, R. F., “CVD diamond coated titanium alloys for biomedical and aerospace applications,” Surf. Coat. Technol, vol. 94(5), p. 514, 1997.Google Scholar
Parizek, M., Douglas, T. E. L., Novotna, K., et al., “Nanofibrous poly (lactide-co-glycolide) membranes loaded with diamond nanoparticles as promising substrates for bone tissue engineering,” Int. J. Nanomed., vol. 7, p. 5873, 2012.Google Scholar
Rezek, B., Michalikova, L., Ukraintsev, E., Kromka, A., and Kalbacova, M., “Micro-pattern guided adhesion of osteoblasts on diamond surfaces,” Sensors, vol. 9, p. 3549, 2009.Google Scholar
Grausova, L., Kromka, A., Bacakova, L., et al., “Bone and vascular endothelial cells in cultures on nanocrystalline diamond films,” Diam. Relat. Mater., vol. 17, p. 1405, 2008.CrossRefGoogle Scholar
Amaral, M., Dias, A. G., Gomes, P. S., et al., “Nanocrystalline diamond: in vitro biocompatibility assessment by MG63 and human bone marrow cells cultures,” J. Biomed. Mater. Res. A, vol. 87a, p. 91, 2008.Google Scholar
Yang, L., Sheldon, B. W., and Webster, T. J., “The impact of diamond nanocrystallinity on osteoblast functions,” Biomaterials, vol. 30, p. 3458, 2009.Google Scholar
Chong, K. F., Loh, K. P., Vedula, S. R. K., et al., “Cell adhesion properties on photochemically functionalized diamond,” Langmuir, vol. 23, p. 5615, 2007.CrossRefGoogle ScholarPubMed
Amaral, M., Gomes, P. S., Lopes, M. A., et al., “Cytotoxicity evaluation of nanocrystalline diamond coatings by fibroblast cell cultures,” Acta Biomaterialia, vol. 5, p. 755, 2009.Google Scholar
Huang, H. J., Chen, M., Bruno, P., et al. “Ultrananocrystalline diamond thin films functionalized with therapeutically active collagen networks,” J. Phys. Chem. B, vol. 113, p. 2966, 2009.Google Scholar
Chen, Y. C., Tsai, C. Y., Lee, C.Y, and Lin, I. N., “In vitro and in vivo evaluation of ultrananocrystalline diamond as an encapsulation layer for implantable microchips,” Acta Biomaterialia, vol. 10, p. 2187, 2014.CrossRefGoogle Scholar
Lechleitner, T., Klauser, F., Seppi, T., et al., “The surface properties of nanocrystalline diamond and nanoparticulate diamond powder and their suitability as cell growth support surfaces,” Biomaterials, vol. 29, p. 4275, 2008.CrossRefGoogle ScholarPubMed
Rezek, B., Ukraintsev, E., Kratka, M., et al. “Epithelial cell morphology and adhesion on diamond films deposited and chemically modified by plasma processes,” Biointerphases, vol. 9, p. 031012, 2014.Google Scholar
Auciello, O., and Sumant, A. V., “Status review of the science and technology of ultrananocrystalline diamond films and application to multifunctional devices,” Diam. Relat. Mater., vol. 19, p. 699, 2010.Google Scholar
Carlisle, J. A., Gruen, D. M., Auciello, O., and Xiao, X., “A method to grow pure nanocrystalline diamond films at low temperatures and high deposition rates,” US Patent #7,556,982, 2009.Google Scholar
Naguib, N., Birrell, J., Elam, J., Carlisle, J. A., and Auciello, O., “A method to grow carbon thin films consisting entirely of diamond grains 3–5 nm in size and high-energy grain boundaries,” US Patent #7,128,8893, 2006.Google Scholar
Gruen, D. M., Krauss, A. R., Auciello, O., and Carlisle, J. A., “N-type doping of NCD films with nitrogen and electrodes made therefrom,” US patent #6,793,849 B1, 2004.Google Scholar
Krauss, A. R., Gruen, D. E., Pellin, M. J., and Auciello, O., “Ultrananocrystalline diamond cantilever wide dynamic range acceleration/vibration/pressure sensor,” US patent #6,422,077, 2002.Google Scholar
Gerbi, J. E., Auciello, O., Birrell, J., et al., “Electrical contacts to ultrananocrystalline diamond,” App. Phy. Lett., vol. 83, p. 2001, 2003.Google Scholar
Bhattacharyya, S., Auciello, O., Birrell, J., et al., “Synthesis and characterization of highly-conducting nitrogen-doped ultrananocrystalline diamond films,” App. Phy. Lett., vol. 79, p. 1441, 2001.Google Scholar
Hajra, M., Hunt, C. E., Ding, M., et al., “Effect of gases on the field emission properties of ultrananocrystalline diamond-coated silicon field emitter arrays,” J. App. Phy., vol. 94, p. 4079, 2003.Google Scholar
Nemanich, R. J., Glass, J. T., and Lucovsky, G., “Raman scattering characterization of carbon bonding in diamond and diamond like thin films,” J. Vac. Sci. Technol., vol. A6, p. 1783, 1988.Google Scholar
Shi, B., Jin, Q., Chen, L., and Auciello, O., “Fundamentals of ultrananocrystalline diamond (UNCD) thin films as biomaterials for developmental biology: embryonic fibroblasts growth on the surface of (UNCD) films,” Diam. Relat. Mater., vol. 18, p. 596, 2009.Google Scholar
Liu, C., Xiao, X., Wang, J., et al., “Dielectric properties of hydrogen-incorporated chemical vapor deposited diamond thin films,” J. Appl. Phys., vol. 102 (7), p. 074115/1-7, 2007.Google Scholar
Thomas, B. D., Owens, M. S., Butler, J. E., and Spiro, C., “Production and characterization of smooth, hydrogen-terminated diamond C(100),” Appl. Phy. Lett., vol. 65 (23), p. 2957, 1994.CrossRefGoogle Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×