Skip to main content Accessibility help
×
Hostname: page-component-78c5997874-ndw9j Total loading time: 0 Render date: 2024-11-04T17:57:15.471Z Has data issue: false hasContentIssue false

18 - Medical disorders and treatment-resistant depression

from Part IV - Special patient populations

Published online by Cambridge University Press:  25 March 2010

Jay D. Amsterdam
Affiliation:
University of Pennsylvania
Mady Hornig
Affiliation:
University of California, Irvine
Andrew A. Nierenberg
Affiliation:
Harvard Medical School
Get access

Summary

Definition of treatment-resistant depression

To date, there is no established consensus as to the definition of treatment resistant depression (TRD). Nevertheless, a useful pragmatic approach is to define TRD broadly, as the failure of an episode of major depression to respond fully to a treatment known to be effective in major depression. This implies that TRD exists along a continuum rather than as an all-or-none phenomenon with varying degrees of treatment resistance. It ranges from a minimal or zero response to adequate antidepressant treatment (what has been termed treatment-refractory depression by Fawcett, 1994), to the more general problem of partial but incomplete response, where clinically there is some improvement in the patients condition but insufficient to achieve remission. In the literature remission in clinical studies is usually defined as an endpoint score on the Hamilton Rating Scale for Depression (HDRS) of ≤ 7, and possibly in addition, a physician rated Clinical Global Impression-Improvement (CGI-I) score= 1 (i.e. very much improved). When this more rigorous benchmark is applied, only about 30% of patients in clinical trials will actually achieve remission of symptoms at the end of a 6- or 8-week trial of an antidepressant, so the problem of TRD, to one extent or another, is a very substantial one.

Categories of TRD

Given the fact that the population of TRD patients is a heterogeneous one, some stratification is important in both conceptualization and development of treatment approaches.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2001

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×