Skip to main content Accessibility help
×
Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-02T18:50:42.347Z Has data issue: false hasContentIssue false

Chapter 15 - Brain Stem Death and Organ Donation

Published online by Cambridge University Press:  28 April 2020

Peter C. Whitfield
Affiliation:
Derriford Hospital, Plymouth
Jessie Welbourne
Affiliation:
University Hospitals, Plymouth
Elfyn Thomas
Affiliation:
Derriford Hospital, Plymouth
Fiona Summers
Affiliation:
Aberdeen Royal Infirmary
Maggie Whyte
Affiliation:
Aberdeen Royal Infirmary
Peter J. Hutchinson
Affiliation:
Addenbrooke’s Hospital, Cambridge
Get access

Summary

Death is the end point of a process of irreversible and progressive loss of vital organ function leading to certain and irreversible cessation of the characteristics that define life. Perhaps surprisingly, there is no globally accepted definition of what constitutes death, and in the UK, there is no statutory definition. However, successive working parties of the medical Royal Colleges have produced guidance for the diagnosis and confirmation of neurological death and these have been revised more recently to include death after cardiorespiratory arrest.1 The irreversible loss of consciousness with the irreversible loss of the capacity to breathe produced by brain stem death (BSD) is accepted in the UK as the death of the individual and can be diagnosed using clinical tests of brain stem function. Diagnosis of BSD allows the discontinuation of treatment, which is no longer in the patient’s best interest and thereby reduces distress to relatives, carers and positively impacts on the costs of health care. Diagnosing BSD on these ethical, humanitarian and utilitarian grounds also facilitates organ donation when patients and families choose to donate.

Type
Chapter
Information
Traumatic Brain Injury
A Multidisciplinary Approach
, pp. 186 - 196
Publisher: Cambridge University Press
Print publication year: 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Academy of Royal Medical Colleges. A code of practice for the diagnosis and confirmation of death; 2008.Google Scholar
Mollaret, P, Goulon, M. Le coma dépassé. Rev Neurol 1959;101:315.Google Scholar
Anon. A definition of irreversible coma. Report of the ad hoc Committee of the Harvard Medical School to examine the definition of brain death. J Am Med Assoc 1968;205:337–40.Google Scholar
Conference of Medical Royal Colleges and their Faculties (UK). Diagnosis of brain death. Br Med J 1976;2:1187–8.Google Scholar
Manara, AR, Thomas, I, Harding, R. A case for stopping the early withdrawal of life sustaining therapies in patients with devastating brain injuries. J Intensive Care Soc 2016;17(4):295301.Google Scholar
Souter, MJ, Blissitt, PA, Blosser, S, et al. Recommendations for the critical care management of devastating brain injury: prognostication, psychosocial, and ethical management: a position statement for healthcare professionals from the Neurocritical Care Society. Neurocrit Care 2015;23(1):413.Google Scholar
Harvey, D, Butler, J, Groves, J, et al. Management of perceived devastating brain injury after hospital admission: a consensus statement from stakeholder professional organizations. Br J Anaes 2018;120(1):138–45.Google Scholar
Pratt, OW, Bowles, B, Protheroe, RT. Brain stem death testing after thiopental use: a survey of UK neuro critical care practice. Anaesthesia 2006;61:1075–8.CrossRefGoogle ScholarPubMed
Lopez-Navidad, A, Caballero, F, Domingo, P, et al. Early diagnosis of brain death in patients treated with central nervous system depressant drugs. Transplantation 2000;70:131–5.Google ScholarPubMed
Young, GB, Shemie, SD, Doig, CJ. Brief review: the role of ancillary tests in the neurological determination of death. Can J Anesth 2006;53:620–7.Google Scholar
Flowers, WM Jr, Patel, BR. Persistence of cerebral blood flow after brain death. South Med J 2000;93:364–70.Google Scholar
Monteiro, LM, Bollen, CW, van Huffelen, AC, et al. Transcranial Doppler ultrasonography to confirm brain death: a meta-analysis. Intens Care Med 2006;32:1937–44.Google Scholar
Yatim, A, Mercatello, A, Coronel, B, et al. 99 mTc-HMPAO cerebral scintigraphy in the diagnosis of brain death. Transpl Proc 1991;23:2491.Google Scholar
de Tourtchaninoff, M, Hantson, P, Mahieu, P, et al. Brain death diagnosis in misleading conditions. Q J Med 1999;92 :407–14.Google Scholar
Wijdicks, EFM. Brain death worldwide: accepted fact but no global consensus in diagnostic criteria. Neurology 2002;58:20–5.Google Scholar
NICE. Organ donation for transplantation CG135; 2011.Google Scholar
GMC. Treatment and care towards end of life: good practice in decision making; 2010.Google Scholar
Department of Health (UK) Report of the Organ Donation Taskforce. Organs for transplants; 2008.Google Scholar
NHSBT. Taking organ transplantation to 2020: a detailed strategy; 2014.Google Scholar
Intensive Care Society. Guidelines for adult organ and tissue donation. London: Intensive Care Society; 2004.Google Scholar
Shemie, SD, Ross, H, Pagliarello, J, et al. Organ donor management in Canada: recommendations of the forum on medical management to optimise donor organ potential. Can Med Associ J 2006;174:S1330.Google Scholar
NHSBT. Donation after brainstem death (DBD) donor optimisation extended care bundle; 2014.Google Scholar
Koostra, G, Daemen, JHC, Oomen, APA. Categories of non-heart beating donors. Transpl Proc 1995;27:2893–4.Google Scholar
Summers, DM, Watson, CJ, Pettigrew, GJ, et al. Kidney donation after circulatory death (DCD): state of the art. Kidney Int. 2015 Aug;88(2):241–9.CrossRefGoogle ScholarPubMed
Reeb, J, Cybel, M. Ex vivo lung perfusion. Clin Transplant. 2016;30(3):183–94.Google Scholar
Morrissey, PE, Monaco, AP. Donation after circulatory death: current practices, ongoing challenges, and potential improvements Transplantation 2014;97(3):258–64.Google Scholar
Macdonald, PS, Chew, HC, Connellan, M, Dhital, K. Extracorporeal heart perfusion before heart transplantation: the heart in a box. Curr Opin Organ Transplant. 2016; 21(3):336–42Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×