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14 - Voltage-dependent sodium currents in hair cells of the inner ear

Published online by Cambridge University Press:  08 August 2009

By
Julian R. A. Wooltorton ,
Karen M. Hurley ,
Hong Bao  and
Ruth A. Eatock
Edited by
James R. Pomerantz
Julian R. A. Wooltorton
Affiliation:
Department of Clinical Studies at New Bolton Center School of Veterinary Medicine 382 West Street Road Kennett Square, PA 19348
Karen M. Hurley
Affiliation:
Department of Clinical Studies at New Bolton Center School of Veterinary Medicine 382 West Street Road Kennett Square, PA 19348
Hong Bao
Affiliation:
Section of Neurobiology, College of Natural Sciences The University of Texas at Austin Austin, TX 78712
Ruth A. Eatock
Affiliation:
Eaton-Peabody Laboratory Department of Otology and Laryngology Harvard Medical School Boston, MA 02114
James R. Pomerantz
Affiliation:
Rice University, Houston
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Summary

Introduction

The hair cell is the mechanosensory cell of the auditory and vestibular organs of the inner ear. Sounds and head movements deflect the hair cells' apical bundles of specialized microvilli, inducing current flow through mechanosensitive ion channels in the bundles. The resulting change in membrane potential – the receptor potential – in turn modulates diverse voltage-gated ion channels in the basolateral membrane. The most numerous channels are potassium (K+)- selective and may be voltage- and/or calcium (Ca2 +)- activated. Flow of current through K+ channels tends to drive the hair cell towards its resting potential, providing negative feedback on the transduction current or, in some cases, amplifying the voltage response through electrical resonance. The properties of hair cell K+ channels have been the focus of many studies, in part because of the opportunity to link diversity in the repertoire of K+ channels to sensory signaling (Fettiplace & Fuchs, 1999). The voltage-gated Ca2 + channels of hair cells have been investigated because of their functional significance as activators of K+ current (e.g., Art & Fettiplace, 1987; Hudspeth & Lewis, 1988) and/or mediators of chemical transmission (e.g., Beutner et al., 2001; Engel et al., 2002; Parsons et al., 1994).

The voltage-gated sodium (Na+) currents of hair cells have only recently attracted significant attention. Because they have fast inactivation kinetics and frequently very negative voltage ranges of inactivation, hair cell Na+ currents can be negligible during standard voltage protocols, so that their distribution is not fully characterized.

Type
Chapter
Information
Topics in Integrative Neuroscience
From Cells to Cognition
 , pp. 385 - 413
Publisher: Cambridge University Press
Print publication year: 2008

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  • Voltage-dependent sodium currents in hair cells of the inner ear
    • By Julian R. A. Wooltorton, Department of Clinical Studies at New Bolton Center School of Veterinary Medicine 382 West Street Road Kennett Square, PA 19348, Karen M. Hurley, Department of Clinical Studies at New Bolton Center School of Veterinary Medicine 382 West Street Road Kennett Square, PA 19348, Hong Bao, Section of Neurobiology, College of Natural Sciences The University of Texas at Austin Austin, TX 78712, Ruth A. Eatock, Eaton-Peabody Laboratory Department of Otology and Laryngology Harvard Medical School Boston, MA 02114
  • Edited by James R. Pomerantz, Rice University, Houston
  • Book: Topics in Integrative Neuroscience
  • Online publication: 08 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511541681.020
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  • Voltage-dependent sodium currents in hair cells of the inner ear
    • By Julian R. A. Wooltorton, Department of Clinical Studies at New Bolton Center School of Veterinary Medicine 382 West Street Road Kennett Square, PA 19348, Karen M. Hurley, Department of Clinical Studies at New Bolton Center School of Veterinary Medicine 382 West Street Road Kennett Square, PA 19348, Hong Bao, Section of Neurobiology, College of Natural Sciences The University of Texas at Austin Austin, TX 78712, Ruth A. Eatock, Eaton-Peabody Laboratory Department of Otology and Laryngology Harvard Medical School Boston, MA 02114
  • Edited by James R. Pomerantz, Rice University, Houston
  • Book: Topics in Integrative Neuroscience
  • Online publication: 08 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511541681.020
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Voltage-dependent sodium currents in hair cells of the inner ear
    • By Julian R. A. Wooltorton, Department of Clinical Studies at New Bolton Center School of Veterinary Medicine 382 West Street Road Kennett Square, PA 19348, Karen M. Hurley, Department of Clinical Studies at New Bolton Center School of Veterinary Medicine 382 West Street Road Kennett Square, PA 19348, Hong Bao, Section of Neurobiology, College of Natural Sciences The University of Texas at Austin Austin, TX 78712, Ruth A. Eatock, Eaton-Peabody Laboratory Department of Otology and Laryngology Harvard Medical School Boston, MA 02114
  • Edited by James R. Pomerantz, Rice University, Houston
  • Book: Topics in Integrative Neuroscience
  • Online publication: 08 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511541681.020
Available formats
×