Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-24T18:07:09.310Z Has data issue: false hasContentIssue false

Case 10 - A 50-Year-Old Woman with a Discrete Area of Leukoplakia That on In-Office Punch Biopsy Showed VIN 3

Published online by Cambridge University Press:  19 November 2021

By
Sarah M. Page-Ramsey
Edited by
Todd R. Jenkins ,
Lisa Keder ,
Abimola Famuyide ,
Kimberly S. Gecsi  and
David Chelmow
Todd R. Jenkins
Affiliation:
University of Alabama, Birmingham
Lisa Keder
Affiliation:
Ohio State University School of Medicine, Columbus
Abimola Famuyide
Affiliation:
Mayo Clinic, Rochester
Kimberly S. Gecsi
Affiliation:
Medical College of Wisconsin
David Chelmow
Affiliation:
Virginia Commonwealth University School of Medicine
Get access

Summary

A 50-year-old postmenopausal woman, gravid 2, para 2, is referred for evaluation after her primary physician noted a vulvar lesion during a recent well woman examination. The patient reports a remote history of abnormal Pap smear for which she underwent an excisional procedure 15 years ago with normal follow-up cytology. Her last menstrual cycle was three years ago and she is not on hormone replacement. She is regularly sexually active with one male partner. She has smoked cigarettes for the past 30 years. An in-office biopsy of the lesion was performed.

Keywords

vulvar dysplasiawide local excisionhigh grade dysplasia
Type
Chapter
Information
Surgical Gynecology
A Case-Based Approach
 , pp. 26 - 28
Publisher: Cambridge University Press
Print publication year: 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Committee Opinion No. 675: Management of vulvar intraepithelial neoplasia. Obstet Gynecol 2016; 128: e178–82. Erratum in: Obstet Gynecol 2017; 129: 209.Google Scholar
Jin, C, Liang, S. Differentiated vulvar intraepithelial neoplasia: a brief review of clinicopathologic features. Arch Pathol Lab Med 2019; 143: 768–71.CrossRefGoogle ScholarPubMed
Bornstein, J, Bogliatto, F, Haefner, HK, et al. The 2015 International Society for the Study of Vulvovaginal Disease (ISSVD) Terminology of Vulvar Squamous Intraepithelial Lesions. Obstet Gynecol 2016; 127: 264–8.CrossRefGoogle Scholar
Van Seters, M, Van Beurden, M, De Craen, AJM. Is the assumed natural history of vulvar intraepithelial neoplasia III based on enough evidence? A systematic review of 3322 published patients. Gynecol Oncol 2005; 97: 645–51.CrossRefGoogle ScholarPubMed
Modesitt, SC, Waters, AB, Walton, L, Fowler, WC, Van Le, L. Vulvar intraepithelial neoplasia III: occult cancer and the impact of margin status on recurrence. Obstet Gynecol 1998; 92: 962–6.Google Scholar
Lawrie, TA, Nordin, A, Chakrabarti, M, et al. Medical and surgical interventions for the treatment of usual-type vulval intraepithelial neoplasia. Cochrane Database Syst Rev 2016; 2016(1): CD011837.Google ScholarPubMed
Van Seters, M, Van Beurden, M, Ten Kate, FJW, et al. Treatment of vulvar intraepithelial neoplasia with topical imiquimod. N Engl J Med 2008; 358(14): 1465–73.CrossRefGoogle ScholarPubMed
Mathiesen, O, Buus, SK, Cramers, M. Topical imiquimod can reverse vulvar intraepithelial neoplasia: a randomised, double-blinded study. Gynecol Oncol 2007; 107(2): 219–22.Google Scholar
Satmary, W, Holschneider, CH, Brunette, LL, Natarajan, S. Vulvar intraepithelial neoplasia: risk factors for recurrence. Gynecol Oncol 2018; 148(1): 126–31.Google Scholar
Jones, RW, Rowan, DM, Stewart, AW. Vulvar intraepithelial neoplasia: aspects of the natural history and outcome in 405 women. Obstet Gynecol 2005; 106(6): 1319–26.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×