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Chapter 1 - Neurobiology of Depression

Published online by Cambridge University Press:  19 October 2021

Stephen M. Stahl
Illustrated by
Nancy Muntner
Edited by
Angela Felker
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

Depression can affect every aspect of life. A patient undergoing a major depressive episode who receives treatment with any antidepressant will often experience symptomatic improvement. However, oftentimes treatment does not reach the goal of remission (complete cessation of all symptoms of depression) until several different pharmacotherapies have been utilized, possibly in combination. Understanding the neurobiology underlying depressive symptomatology may allow clinicians the opportunity to treat the symptoms specifically, based upon brain mechanisms and the interplay among genes, circuits and symptoms. This chapter focuses on the neurobiology of depression, and offers a review of the three monoamines hypothetically linked not only to the symptoms of a major depressive episode, but also to the treatment of those symptoms.

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Information
Stahl's Illustrated Antidepressants , pp. 1 - 40
Publisher: Cambridge University Press
Print publication year: 2009

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