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Chapter 5 - Monoamine Oxidase Inhibitors (MAOIs) and Tricyclic Antidepressants (TCAs)

Published online by Cambridge University Press:  19 October 2021

Stephen M. Stahl
Illustrated by
Nancy Muntner
Edited by
Angela Felker
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

This chapter reviews the classical antidepressants known as monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs). The focus here is on mechanisms of action of these particular classes. The aim of this chapter is to familiarize the reader with these “old-fashioned” but quite powerful options for treating depression.

SSRI: selective serotonin reuptake inhibitors. NDRI: norepinephrine dopamine reuptake inhibitors. SNRI: serotonin norepinephrine reuptake inhibitors. SDA: serotonin dopamine antagonists. α 2 antagonist: alpha 2 antagonists. NRI: selective norepinephrine reuptake inhibitors. TCA: tricyclic antidepressants. SARI: serotonin 2A antagonist/reuptake inhibitors. MAOI: monoamine oxidase inhibitors. 5HT1A: serotonin 1A partial agonists. BZ: benzodiazepines. DPA: dopamine partial agonists. MTHF: L-5-methyl-tetrahydrofolate. T3/T4: thyroid hormone. ECT: electroconvulsive therapy. IPT: interpersonal therapy. VNS: vagus nerve stimulation.

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Chapter
Information
Stahl's Illustrated Antidepressants , pp. 97 - 110
Publisher: Cambridge University Press
Print publication year: 2009

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