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Chapter 6 - Building a Treatment Plan with Novel Treatment and Augmentation Options For Depression

Published online by Cambridge University Press:  19 October 2021

Stephen M. Stahl
Illustrated by
Nancy Muntner
Edited by
Angela Felker
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

Several emerging treatment options for depression have shown promise, especially for patients resistant to treatment with first-line drugs. Described in this chapter are a variety of options that may assist in treating depression, whether as a monotherapy or in combination with another drug of choice. The concept of trimonoamine modulators (TMMs) is introduced to explain the actions of many agents used to augment anti-depressants including lithium, thyroid, and L-methylfolate. Estrogen as a TMM is explained in the following chapter. Various forms of brain stimulation/neuromodulation are also illustrated here, from vagus nerve stimulation (VNS) to transcranial magnetic stimulation (TMS) to deep brain stimulation (DBS). A few new therapeutic approaches to the treatment of depression are also included at the end of the chapter.

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Information
Stahl's Illustrated Antidepressants , pp. 111 - 128
Publisher: Cambridge University Press
Print publication year: 2009

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