Book contents
- Frontmatter
- Dedication
- Contents
- Contents
- Contributors
- Foreword to the First Edition
- Preface to the Sixth Edition
- Acknowledgements
- Chapter 1 The normal lung: histology, embryology, development, aging and function
- Chapter 2 Lung specimen handling and practical considerations
- Chapter 3 Congenital abnormalities and pediatric lung diseases, including neoplasms
- Chapter 4 Pulmonary bacterial infections
- Chapter 5 Pulmonary viral infections
- Chapter 6 Pulmonary mycobacterial infections
- Chapter 7 Pulmonary mycotic infections
- Chapter 8 Pulmonary parasitic infections
- Chapter 9 Acute lung injury
- Chapter 10 Interstitial lung diseases
- Chapter 11 Metabolic and inherited connective tissue disorders involving the lung
- Chapter 12 Hypersensitivity pneumonitis
- Chapter 13 Sarcoidosis
- Chapter 14 Occupational lung disease
- Chapter 15 Eosinophilic lung disease
- Chapter 16 Drug- and therapy-induced lung injury
- Chapter 17 Chronic obstructive pulmonary disease and diseases of the airways
- Chapter 18 Pulmonary vascular pathology
- Chapter 19 Pulmonary vasculitis and pulmonary hemorrhage syndromes
- Chapter 20 The pathology of lung transplantation
- Chapter 21 The lungs in connective tissue disease
- Chapter 22 Benign epithelial neoplasms and tumor-like proliferations of the lung
- Chapter 23 Pulmonary pre-invasive disease
- Chapter 24 Epidemiological and clinical aspects of lung cancer
- Chapter 25 Lung cancer staging
- Chapter 26 Immunohistochemistry in the diagnosis of pulmonary tumors
- Chapter 27 Adenocarcinoma of the lung
- Chapter 28 Squamous cell carcinoma of the lung
- Chapter 29 Large cell carcinoma and adenosquamous carcinoma of the lung
- Chapter 30 Salivary gland neoplasms of the lung
- Chapter 31 Neuroendocrine tumors and other neuroendocrine proliferations of the lung
- Chapter 32 Sarcomatoid carcinomas and variants
- Chapter 33 Mesenchymal and miscellaneous neoplasms
- Chapter 34 Pulmonary lymphoproliferative diseases
- Chapter 35 Metastases involving the lungs
- Chapter 36 Diseases of the pleura
- Index
- References
Chapter 19 - Pulmonary vasculitis and pulmonary hemorrhage syndromes
Published online by Cambridge University Press: 05 June 2014
- Frontmatter
- Dedication
- Contents
- Contents
- Contributors
- Foreword to the First Edition
- Preface to the Sixth Edition
- Acknowledgements
- Chapter 1 The normal lung: histology, embryology, development, aging and function
- Chapter 2 Lung specimen handling and practical considerations
- Chapter 3 Congenital abnormalities and pediatric lung diseases, including neoplasms
- Chapter 4 Pulmonary bacterial infections
- Chapter 5 Pulmonary viral infections
- Chapter 6 Pulmonary mycobacterial infections
- Chapter 7 Pulmonary mycotic infections
- Chapter 8 Pulmonary parasitic infections
- Chapter 9 Acute lung injury
- Chapter 10 Interstitial lung diseases
- Chapter 11 Metabolic and inherited connective tissue disorders involving the lung
- Chapter 12 Hypersensitivity pneumonitis
- Chapter 13 Sarcoidosis
- Chapter 14 Occupational lung disease
- Chapter 15 Eosinophilic lung disease
- Chapter 16 Drug- and therapy-induced lung injury
- Chapter 17 Chronic obstructive pulmonary disease and diseases of the airways
- Chapter 18 Pulmonary vascular pathology
- Chapter 19 Pulmonary vasculitis and pulmonary hemorrhage syndromes
- Chapter 20 The pathology of lung transplantation
- Chapter 21 The lungs in connective tissue disease
- Chapter 22 Benign epithelial neoplasms and tumor-like proliferations of the lung
- Chapter 23 Pulmonary pre-invasive disease
- Chapter 24 Epidemiological and clinical aspects of lung cancer
- Chapter 25 Lung cancer staging
- Chapter 26 Immunohistochemistry in the diagnosis of pulmonary tumors
- Chapter 27 Adenocarcinoma of the lung
- Chapter 28 Squamous cell carcinoma of the lung
- Chapter 29 Large cell carcinoma and adenosquamous carcinoma of the lung
- Chapter 30 Salivary gland neoplasms of the lung
- Chapter 31 Neuroendocrine tumors and other neuroendocrine proliferations of the lung
- Chapter 32 Sarcomatoid carcinomas and variants
- Chapter 33 Mesenchymal and miscellaneous neoplasms
- Chapter 34 Pulmonary lymphoproliferative diseases
- Chapter 35 Metastases involving the lungs
- Chapter 36 Diseases of the pleura
- Index
- References
Summary
Introduction
Vasculitis is defined generically as inflammation of a vessel. Hemorrhage is defined generically as the escape of blood from vessels. Were pulmonary vasculitis and pulmonary hemorrhage so directly connected that inflammation of blood vessels led to rupture and then hemorrhage, the classification of the vasculitic and hemorrhagic syndromes would be considerably easier. However, inflamed vessels may leak or not leak; inflammation in vessels may have great or little clinical or pathophysiological significance; and hemorrhage may be due to trauma, vascular anomalies, pulmonary hypertension, or a bleeding diathesis in the absence of inflammation or vascular necrosis.
There are many schemes for classifying vasculitis. One can classify vasculitis by organ involvement, etiology, histology, size of blood vessel, immunological parameters, cellular mediation, or associated systemic disease. Various categorizations are given in Table 1.
In this chapter we separate the large and complex topic into three major groups: antineutrophil cytoplasmic antibody (ANCA)-associated diseases; pulmonary hemorrhage syndromes; and idiopathic vasculitides that rarely affect the lung. Many other entities, including but not limited to pulmonary infections, interstitial lung diseases such as sarcoidosis/necrotizing sarcoid granulomatosis and Langerhans cell histiocytosis, pulmonary hypertension, drugs, transplantation, radiation, systemic processes including connective tissue disease and inflammatory bowel disease, and malignancies, especially lymphoproliferative disorders such as lymphomatoid granulomatosis, cause pulmonary vasculitis and/or hemorrhage. These entities are discussed elsewhere in this text.
- Type
- Chapter
- Information
- Spencer's Pathology of the Lung , pp. 711 - 766Publisher: Cambridge University PressPrint publication year: 2000