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Chapter 36 - Modafinil/armodafinil in the treatment of excessive daytime sleepiness

from Section 4 - Therapy of Excessive Sleepiness

Published online by Cambridge University Press:  04 February 2011

By
Renee Monderer  and
Michael J. Thorpy
Edited by
Michael J. Thorpy  and
Michel Billiard
Michael J. Thorpy
Affiliation:
Sleep-Wake Disorders Center, Montefiore Medical Center, Bronx, NY, USA
Michel Billiard
Affiliation:
Guide Chauliac Hospital, Montpellier, France
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Summary

This chapter reviews the therapeutic efficacy, tolerability and mode of action of modafinil and armodafinil for approved and off-label treatment of excessive sleepiness. The American Academy of Sleep Medicine (AASM) recommends modafinil as standard treatment for residual excessive sleepiness in treated obstructive sleep apnea (OSA) patients. Both modafinil and armodafinil appear to be effective treatments for residual sleepiness in patients with OSA despite continuous positive airway pressure (CPAP) treatment. Armodafinil significantly improves speed of memory, episodic secondary memory, and power of attention. Currently, modafinil and armodafinil are widely used for sleepiness associated with narcolepsy. Armodafinil has recently been approved for the treatment of daytime sleepiness in patients with narcolepsy, shift work disorder (SWD), and sleepiness associated with treated OSA. Modafinil has been used for sleepiness or fatigue in Parkinson's disease, multiple sclerosis, depression, and chronic fatigue syndrome, as well as other neurological and psychiatric disorders.

Keywords

agingAlzheimer's diseasedementiaolder adultsnappingexcessive daytime sleepinessdepression
Type
Chapter
Information
Sleepiness
Causes, Consequences and Treatment
 , pp. 408 - 420
Publisher: Cambridge University Press
Print publication year: 2011

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