Book contents
- Frontmatter
- Contents
- Participants
- Declarations of personal interest
- Preface
- SECTION 1 BACKGROUND TO AGEING AND DEMOGRAPHICS
- SECTION 2 BASIC SCIENCE OF REPRODUCTIVE AGEING
- SECTION 3 PREGNANCY: THE AGEING MOTHER AND MEDICAL NEEDS
- SECTION 4 THE OUTCOMES: CHILDREN AND MOTHERS
- 16 What is known about children born to older parents?
- 17 Consequences of changes in reproductive patterns on later health in women: a life course approach
- 18 The outcomes: children and mothers
- SECTION 5 FUTURE FERTILITY INSURANCE: SCREENING, CRYOPRESERVATION OR EGG DONORS?
- SECTION 6 SEX BEYOND AND AFTER FERTILITY
- SECTION 7 REPRODUCTIVE AGEING AND THE RCOG: AN INTERNATIONAL COLLEGE
- SECTION 8 FERTILITY TREATMENT: SCIENCE AND REALITY – THE NHS AND THE MARKET
- SECTION 9 THE FUTURE: DREAMS AND WAKING UP
- SECTION 10 CONSENSUS VIEWS
- Index
18 - The outcomes: children and mothers
from SECTION 4 - THE OUTCOMES: CHILDREN AND MOTHERS
Published online by Cambridge University Press: 05 February 2014
- Frontmatter
- Contents
- Participants
- Declarations of personal interest
- Preface
- SECTION 1 BACKGROUND TO AGEING AND DEMOGRAPHICS
- SECTION 2 BASIC SCIENCE OF REPRODUCTIVE AGEING
- SECTION 3 PREGNANCY: THE AGEING MOTHER AND MEDICAL NEEDS
- SECTION 4 THE OUTCOMES: CHILDREN AND MOTHERS
- 16 What is known about children born to older parents?
- 17 Consequences of changes in reproductive patterns on later health in women: a life course approach
- 18 The outcomes: children and mothers
- SECTION 5 FUTURE FERTILITY INSURANCE: SCREENING, CRYOPRESERVATION OR EGG DONORS?
- SECTION 6 SEX BEYOND AND AFTER FERTILITY
- SECTION 7 REPRODUCTIVE AGEING AND THE RCOG: AN INTERNATIONAL COLLEGE
- SECTION 8 FERTILITY TREATMENT: SCIENCE AND REALITY – THE NHS AND THE MARKET
- SECTION 9 THE FUTURE: DREAMS AND WAKING UP
- SECTION 10 CONSENSUS VIEWS
- Index
Summary
Stephen Hillier: This distribution of age of onset of menopause — you gave a median but there were two populations. Is that statistically significant?
Gita Mishra: Yes. The actual distribution you saw is skewed. That's the observed distribution and it is definitely not a normal distribution. So, we think that distribution fits these data well. It turns out that this skewed distribution is a mixture of two distributions; one distribution is normal with an early age of menopause around 40, and the other one is normal with a mean age around 50. If you simulate these data with normal distribution with these two and you mix it, a third and two-thirds, you get a distribution that fits the observed distribution perfectly.
Stephen Hillier: Perhaps this is a naïve question, but have you tried to relate any of the other factors independently to the two groups to see whether there is any difference?
Gita Mishra: Yes. We found a lot of early factors determine you to be in this [earlier] distribution and there was an interaction. For instance, the mother's age of menopause: if the mother had a very early age menopause the person was more likely to be in the earlier distribution. Weight at 2 years: if a child was lighter at 2 years old then she is more likely to be in the first distribution. And the other thing that was quite surprising was the effect of parental divorce.
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- Information
- Reproductive Ageing , pp. 193 - 198Publisher: Cambridge University PressPrint publication year: 2009