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18 - The outcomes: children and mothers

from SECTION 4 - THE OUTCOMES: CHILDREN AND MOTHERS

Published online by Cambridge University Press:  05 February 2014

Susan Bewley
Affiliation:
St Thomas’s Hospital, London
William Ledger
Affiliation:
University of New South Wales, Sydney
Dimitrios Nikolaou
Affiliation:
Chelsea and Westminster Hospital, London
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Summary

Stephen Hillier: This distribution of age of onset of menopause — you gave a median but there were two populations. Is that statistically significant?

Gita Mishra: Yes. The actual distribution you saw is skewed. That's the observed distribution and it is definitely not a normal distribution. So, we think that distribution fits these data well. It turns out that this skewed distribution is a mixture of two distributions; one distribution is normal with an early age of menopause around 40, and the other one is normal with a mean age around 50. If you simulate these data with normal distribution with these two and you mix it, a third and two-thirds, you get a distribution that fits the observed distribution perfectly.

Stephen Hillier: Perhaps this is a naïve question, but have you tried to relate any of the other factors independently to the two groups to see whether there is any difference?

Gita Mishra: Yes. We found a lot of early factors determine you to be in this [earlier] distribution and there was an interaction. For instance, the mother's age of menopause: if the mother had a very early age menopause the person was more likely to be in the earlier distribution. Weight at 2 years: if a child was lighter at 2 years old then she is more likely to be in the first distribution. And the other thing that was quite surprising was the effect of parental divorce.

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Reproductive Ageing , pp. 193 - 198
Publisher: Cambridge University Press
Print publication year: 2009

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