Skip to main content Accessibility help
×
Hostname: page-component-cd9895bd7-jkksz Total loading time: 0 Render date: 2024-12-26T09:25:29.494Z Has data issue: false hasContentIssue false

Chapter 12 - Recognition, Management, and Prevention of Delirium

from Section II - Geriatric Syndromes

Published online by Cambridge University Press:  30 June 2022

Jan Busby-Whitehead
Affiliation:
University of North Carolina, Chapel Hill
Samuel C. Durso
Affiliation:
The Johns Hopkins University, Maryland
Christine Arenson
Affiliation:
Thomas Jefferson University, Philadelphia
Rebecca Elon
Affiliation:
The Johns Hopkins University School of Medicine
Mary H. Palmer
Affiliation:
University of North Carolina, Chapel Hill
William Reichel
Affiliation:
Georgetown University Medical Center
Get access

Summary

Delirium is a serious neuropsychiatric condition characterized by an acute change in cognition and attention that affects a significant proportion of hospitalized older adults and is associated with significant morbidity and mortality. Prevention of delirium is an important part of the care of hospitalized older adults. The Hospital Elder Life Program is a multicomponent intervention that has been shown to reduce the incidence of delirium. As many cases of delirium are overlooked, its diagnosis is important and can be achieved using the Confusion Assessment Method, which relies on four cardinal features of delirium: acute onset, inattention, altered level of consciousness, and disorganized thinking. The etiology of delirium is often multifactorial with contributions from predisposing factors (such as sensory impairment, chronic illness, and cognitive impairment) and precipitating factors (such as infection, polypharmacy, or illness). Once diagnosed, delirium should be evaluated with a thorough history, complete physical, medication review, and targeted tests in an effort to identify these factors. Management should focus on addressing the noted precipitating and predisposing factors with limited use of low-dose antipsychotic medications in patients at risk of self-harm.

Type
Chapter
Information
Reichel's Care of the Elderly
Clinical Aspects of Aging
, pp. 129 - 138
Publisher: Cambridge University Press
Print publication year: 2022

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ryan, DJ, O’Regan, NA, Caoimh, RO, Clare, J, O’Connor, M, Leonard, M, et al. Delirium in an adult acute hospital population: Predictors, prevalence and detection. BMJ Open. 2013 (Jan. 7);3(1):e001772.Google Scholar
Dasgupta, M. Prognosis of delirium in hospitalized elderly: Worse than we thought. Geriatric Psychiatry. 2013 (May); 29(5):497505.CrossRefGoogle ScholarPubMed
Kiely, DK, Marcantonio, ER, Inouye, SK, Shaffer, ML, Bergmann, MA, Yang, FM, et al. Persistent delirium predicts greater mortality. J Am Geriatr Soc. 2009 (Jan.); 57(1):5561.CrossRefGoogle ScholarPubMed
George, J, Bleasdale, S, Singleton, S. Causes and prognosis of delirium in elderly patients admitted to a district general hospital. Age Ageing. 1997 (Nov.); 26(6):423427.Google Scholar
Leslie, DL, Inouye, SK. The importance of delirium: economic and societal costs. J Am Geriatr Soc. 2011 (Nov.); 59(2):241243.CrossRefGoogle ScholarPubMed
Inouye, SK, Westendorp, RG, Saczynski, JS. Delirium in elderly people. Lancet. 2014 (Mar. 8); 383(9920):911922.CrossRefGoogle ScholarPubMed
Williams, ST. Pathophysiology of encephalopathy and delirium. Journal of Clinical Neurophysiology. 2013; 30(5):435437.CrossRefGoogle ScholarPubMed
Maldonado, J. Delirium pathophysiology: An update hypothesis of the etiology of acute brain failure. Int J Geriatr Psychiatry. 2018 (Nov.); 33(11):14281457.Google Scholar
Morrison, RS, Magaziner, J, Gilbert, M, Koval, KJ, McLaughlin, MA, Orosz, G, et al. Relationship between pain and opioid analgesics on the development of delirium following hip fracture. J Gerontol A Biol Sci Med Sci. 2003 (Jan.); 58(1):7681.Google Scholar
Inouye, SK. Delirium in older persons. NEJM. 2006 (Mar.); 354:11571165.Google Scholar
Rudolph, JL, Jones, RN, Levkoff, SE, Rockett, C, Inouye, SK, Sellke, FW, et al. Derivation and validation of a preoperative prediction rule for delirium after cardiac surgery. Circulation. 2009 (Jan. 20); 119(2):229236.Google Scholar
Kennedy, M, Enander, RA, Tadiri, SP, Wolfe, RE, Shapiro, NI, Marcantonio, ER. Delirium risk prediction, healthcare use and mortality of elderly adults in the emergency department. J Am Geriatr Soc. 2014 (Mar.); 62(3):462469.Google Scholar
Inouye, SK, Zhang, Y, Jones, RN, Kiely, DK, Yang, F, Marcantonio, ER. Risk factors for delirium at discharge: Development and validation of a predictive model. Arch Intern Med. 2007 (Jul. 9); 167(13):14061413.Google Scholar
Inouye, SK. A multicomponent intervention to prevent delirium in hospitalized older patients. NEJM. 1999 (Mar. 4); 340(9):669676.Google Scholar
Inouye, SK, Rubin, FH, Wierman, HR, Supiano, MA, Fenlon, K. No shortcuts for delirium prevention. J Am Geriatr Soc. 2010 (May); 58(5):998999.CrossRefGoogle ScholarPubMed
Marcantonio, ER. Reducing delirium after hip fracture: A randomized trial. J Am Geriatr Soc. 2001 (May); 49(5):516522.CrossRefGoogle ScholarPubMed
Gorsch, MNJ. Pharmacologic prevention of postoperative delirium. Z Gerontol Geriatri. 2014; 47(2):105.Google Scholar
Inouye, SK, van Dyck, CH, Alessi, CA, Balkin, S, Siegal, AP, Horwitz, RI. Clarifying confusion: The Confusion Assessment Method – A new method for detection of delirium. Ann Intern Med. 1990 (Dec. 15); 113(12):941948.Google Scholar
Flaherty, JH, Little, MO. Matching the environment to patients with delirium: Lessons learned from the delirium room, a restraint-free environment for older hospitalized adults with delirium. J Am Geriatr Soc. 2013; 59:295300.Google Scholar
Lonergan, E, Britton, AM, Luxenberg, J, Wyller, T. Antipsychotics for delirium. Cochrane Database Syst Rev. 2007 (Apr. 18); 2:CD005594.Google Scholar
Girard, T, et al. Haloperidol and ziprasidone for the treatment of delirium in critical illness. NEJM. 2018 (Dec. 27); 379(26): 25062516.CrossRefGoogle ScholarPubMed
Mo, Yoonson, Scheer, C, Abdallah, G. Emerging role of melatonin and melatonin receptor agonists in sleep and delirium in intensive care unit patients. J Intensive Care Med. 2016 (Aug.); 31(7) 451455.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×