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Chapter 34 - Osteoporosis and Other Metabolic Bone Disorders

from Section III - Care of the Elderly by Organ System

Published online by Cambridge University Press:  30 June 2022

Jan Busby-Whitehead
Affiliation:
University of North Carolina, Chapel Hill
Samuel C. Durso
Affiliation:
The Johns Hopkins University, Maryland
Christine Arenson
Affiliation:
Thomas Jefferson University, Philadelphia
Rebecca Elon
Affiliation:
The Johns Hopkins University School of Medicine
Mary H. Palmer
Affiliation:
University of North Carolina, Chapel Hill
William Reichel
Affiliation:
Georgetown University Medical Center
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Summary

Age-related changes in bone metabolism are reviewed as well as the impact of age-related diseases on bone health. Current guidelines for osteoporosis screening and treatment are provided. Management of other metabolic bone disorders of older adults is detailed, including the conditions of osteomalacia, hyperparathyroidism, Paget ’s disease, and renal osteodystrophy.

Type
Chapter
Information
Reichel's Care of the Elderly
Clinical Aspects of Aging
, pp. 418 - 424
Publisher: Cambridge University Press
Print publication year: 2022

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References

Siris, ES, Adler, R, Bilezikian, J, et al. The clinical diagnosis of osteoporosis: A position statement from the National Bone Health Alliance Working Group. Osteoporosis International. 2014; 25:14391443.CrossRefGoogle ScholarPubMed
US Preventive Services Task Force. Screening for osteoporosis: US Preventive Services Task Force recommendation statement. JAMA. 2018; 319:25212531.Google Scholar
Crandall, CJ, Ensrud, KE. Osteoporosis screening in younger postmenopausal women. JAMA. 2020; 323:367368.CrossRefGoogle ScholarPubMed
National Osteoporosis Foundation. Clinician’s Guide to Prevention and Treatment of Osteoporosis. Washington, DC: National Osteoporosis Foundation, 2014.Google Scholar
Blake, GM, Fogelman, I. Role of dual-energy x-ray absorptiometry in the diagnosis and treatment of osteoporosis. J Clin Densitom. 2007; 10:102110.Google Scholar
Parveen, B, Parveen, A, Vohora, D. Biomarkers of osteoporosis: An update. Endocrine, Metabolic, and Immune Disorders – Drug Targets. 2019; 19:895912.Google Scholar
Anderson, JJB, Kruszka, B, Delaney, JAC, et al. Calcium intake from diet and supplements and the risk of coronary artery calcification and its progression among older adults: 10-year follow-up of the multi-ethnic study of atherosclerosis. J Am Heart Assoc. 2016; 5(10):113.Google Scholar
Bouillon, R, Marcocci, C, Carmeliet, G, et al. Skeletal and extraskeletal actions of vitamin D: Current evidence and outstanding questions. Endocrine Reviews. 2019; 40(4):11091151.Google Scholar
Yao, P, Bennett, D, Mafham, M, et al. Vitamin D and calcium for the prevention of fracture: A systematic review and meta-analysis. JAMA Network Open. 2019; 2(12):114.CrossRefGoogle ScholarPubMed
Camacho, PM, Petak, SM, Binkley, N, et al., American Association of Clinical Endocrinologists/American College of Endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis. Endocr Pract. 2020; 26:564570.Google Scholar
Barrionuevo, P, Kapoor, E, Asi, N, et al. Efficacy of pharmacologic therapies for the prevention of fractures in postmenopausal women: A network meta-analysis. J Clin Endocrinol Metab. 2019; 104(5):16231630.Google Scholar
Shoback, D, Rose, CJ, Black, DM. Pharmacological management of osteoporosis in postmenopausal women: An endocrine society guideline update. J Clin Endocrinol Metab. 2020; 105:587594.Google Scholar
Black, DM, Geiger, EJ, Eastell, R, et al. Atypical femur fracture risk versus fragility fracture prevention with bisphosphonates. N Engl J Med. 2020; 383:743753.CrossRefGoogle ScholarPubMed
Aljohani, S, Fliefel, R, Ihbe, J, et al. What is the effect of anti-resorptive drugs (ARDS) on the development of medication-related osteonecrosis of the jaw (MRONJ) in osteoporosis patients? A systematic review. J Oral Maxiollofac Surg. 2017; 45:14931502.Google ScholarPubMed
Watson, SL, Weeks, BK, Weis, LJ, et al. High-intensity resistance and impact training improves bone mineral density and physical function in postmenopausal women with osteopenia and osteoporosis: The LIFTMOR randomized controlled trial. JBMR. 2017; 33(2):211220.Google Scholar
Zhu, CY, Sturgeon, C, Yeh, MW. Diagnosis and management of primary hyperparathyroidism. JAMA. 2020; 323:11861187.Google Scholar
Stephen, AE, Mannstadt, M, Hodin, RA. Indications for surgical management of hyperparathyroidism, a review. JAMA Surgery. 2017; 152(9):878882.Google Scholar
Ralston, SH, Corral-Gudino, L, Cooper, C, et al. Diagnosis and management of Paget’s disease of bone in adults: A clinical guideline. JBMR. 2019; 34:579604.CrossRefGoogle ScholarPubMed
Tan, A, Goodman, K, Walker, A, et al. Long-term randomized trial of intensive versus symptomatic management in Paget’s disease of bone: The PRISM-EZ Study. J Bone Miner Res. 2017; 32:11651173.Google Scholar
Kettler, M, Block, GA, Evenepoel, P, et al. Executive summary of the 2017 KDIGO chronic kidney disease-mineral and bone disorder guideline update: What’s changed and why it matters. Kidney International. 2017; 92:2636.Google Scholar

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