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Introduction

Published online by Cambridge University Press:  31 August 2009

Lindley Darden
Lindley Darden
Affiliation:
University of Maryland, College Park
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Summary

This book discusses reasoning strategies for discovery that are exemplified in numerous biological cases. Scientific discovery should be viewed as an extended, piecemeal process with hypotheses undergoing iterative refinement. Construction, evaluation, and revision are tightly connected in ways that philosophers of science have often not recognized, given their neglect of reasoning in hypothesis construction and revision. Examination of historical cases from twentieth-century biology reveals reasoning strategies that could have produced the changes that did occur. Such critically examined reasoning strategies constitute compiled hindsight gleaned from these past episodes. Examples come from the fields of molecular biology, biochemistry, immunology, neuroscience, and evolutionary biology. Making reasoning strategies explicit shows that they are not merely descriptions of unique historical changes or unwarranted overly general prescriptions. They are advisory. They may be of use as metascientific hypotheses in philosophical and historical analyses of scientific reasoning, of use in future empirical and computational biological research, and of use in science education. Hence, one goal of this book is to make explicit reasoning strategies for construction, evaluation, and revision of scientific hypotheses.

Biologists often seek to discover mechanisms. Knowing what is to be discovered aids the extended process of discovery. The examination of the nature and means of representing biological theories aids analysis of reasoning in their discovery. What play the roles of theories in molecular biology, for example, are diagrammatically represented sets of mechanism schemas for such widely found mechanisms as DNA replication, protein synthesis, and many varieties of gene regulation.

Type
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Reasoning in Biological Discoveries
Essays on Mechanisms, Interfield Relations, and Anomaly Resolution
 , pp. 1 - 10
Publisher: Cambridge University Press
Print publication year: 2006

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References

Allchin, Douglas (2002), “Error Types,” Perspectives on Science 9: 38–58.CrossRefGoogle Scholar
Baker, Jason M. (2005), “Adaptive Speciation: The Role of Natural Selection in Mechanisms of Geographic and Non-geographic Speciation,” in Carl F. Craver and Lindley Darden (eds.), Special Issue: “Mechanisms in Biology,” Studies in History and Philosophy of Biological and Biomedical Sciences 36: 303–326.CrossRefGoogle ScholarPubMed
Bechtel, William (1984), “Reconceptualizations and Interfield Connections: The Discovery of the Link Between Vitamins and Coenzymes,” Philosophy of Science 51: 265–292.CrossRefGoogle Scholar
Bechtel, William (1986), “Introduction: The Nature of Scientific Integration,” in Bechtel, W. (ed.), Integrating Scientific Disciplines. Dordrecht: Nijhoff, pp. 3–52.CrossRefGoogle Scholar
Bechtel, William and Abrahamsen, Adele (2005), “Explanation: A Mechanist Alternative,” in Carl F. Craver and Lindley Darden (eds.), Special Issue: “Mechanisms in Biology,” Studies in History and Philosophy of Biological and Biomedical Sciences 36: 421–441.CrossRefGoogle ScholarPubMed
Bechtel, William and Richardson, Robert C. (1993), Discovering Complexity: Decomposition and Localization as Strategies in Scientific Research. Princeton, NJ: Princeton University Press.Google Scholar
Bogen, James (2005), “Regularities and Causality; Generalizations and Causal Explanations,” in Carl F. Craver and Lindley Darden (eds.), Special Issue: “Mechanisms in Biology,” Studies in History and Philosophy of Biological and Biomedical Sciences 36: 397–420.CrossRefGoogle ScholarPubMed
Brandon, Robert (1985), “Grene on Mechanism and Reductionism: More Than Just a Side Issue,” in Asquith, Peter and Kitcher, Philip (eds.), PSA 1984, v. 2. East Lansing, MI: Philosophy of Science Association, pp. 345–353.Google Scholar
Buchanan, Bruce (1982), “Mechanizing the Search for Explanatory Hypotheses,” in Asquith, Peter and Nickles, Thomas (eds.), PSA 1982, v. 2. East Lansing, MI: Philosophy of Science Association, pp. 129–146.Google Scholar
Buchanan, Bruce (1985), “Steps Toward Mechanizing Discovery,” in Schaffner, K. (ed.), Logic of Discovery and Diagnosis in Medicine. Berkeley, CA: University of California Press, pp. 94–114.Google Scholar
Burian, Richard M. (1996a), “Underappreciated Pathways Toward Molecular Genetics as Illustrated by Jean Brachet's Cytochemical Embryology,” in Sarkar, S. (ed.), The Philosophy and History of Molecular Biology: New Perspectives. Dordrecht: Kluwer, pp. 67–85.CrossRefGoogle Scholar
Craver, Carl F. (2001), “Role Functions, Mechanisms, and Hierarchy,” Philosophy of Science 68: 53–74.CrossRefGoogle Scholar
Craver, Carl F. (2002a), “Structures of Scientific Theories,” in Machamer, P. K. and Silberstein, M. (eds.), Blackwell Guide to the Philosophy of Science. Oxford, UK: Blackwell, pp. 55–79.Google Scholar
Craver, Carl F. (2002b), “Interlevel Experiments, Multilevel Mechanisms in the Neuroscience of Memory,” Philosophy of Science (Supplement) 69: S83–S97.Google Scholar
Craver, Carl F. (2003), “The Making of a Memory Mechanism,” Journal of the History of Biology 36: 153–195.CrossRefGoogle ScholarPubMed
Craver, Carl F. (2005), “Beyond Reduction: Mechanisms, Multifield Integration, and the Unity of Neuroscience,” in Carl F. Craver and Lindley Darden (eds.), Special Issue: “Mechanisms in Biology,” Studies in History and Philosophy of Biological and Biomedical Sciences 36: 373–397.CrossRefGoogle ScholarPubMed
Darden, Lindley (1991), Theory Change in Science: Strategies from Mendelian Genetics. New York: Oxford University Press.Google Scholar
Darden, Lindley (2001), “Discovering Mechanisms: A Computational Philosophy of Science Perspective,” in Jantke, Klaus P. and Shinohara, Ayumi (eds.), Discovery Science (Proceedings of the 4th International Conference, DS2001). New York: Springer-Verlag, pp. 3–15.CrossRefGoogle Scholar
Dobzhansky, Theodosius (1937), Genetics and the Origin of Species. New York: Columbia University Press.Google Scholar
Elliott, Kevin (2004), “Error as Means to Discovery,” Philosophy of Science 71: 174–197.CrossRefGoogle Scholar
Glennan, Stuart S. (1996), “Mechanisms and the Nature of Causation,” Erkenntnis 44: 49–71.CrossRefGoogle Scholar
Glennan, Stuart S. (2002), “Rethinking Mechanistic Explanation,” Philosophy of Science (Supplement) 69: S342–S353.Google Scholar
Glennan, Stuart S. (2005), “Modeling Mechanisms,” in Carl F. Craver and Lindley Darden (eds.), Special Issue: “Mechanisms in Biology,” Studies in History and Philosophy of Biological and Biomedical Sciences 36: 443–464.CrossRefGoogle ScholarPubMed
Hanson, Norwood Russell (1958), Patterns of Discovery. Cambridge: Cambridge University Press.Google Scholar
Hanson, Norwood Russell ([1961]1970), “Is There a Logic of Scientific Discovery?” in Feigl, H. and Maxwell, G. (eds.), Current Issues in the Philosophy of Science. New York: Holt, Rinehart and Winston, 1961. Reprinted in Brody, B. (ed.), Readings in the Philosophy of Science. Englewood Cliffs, NJ: Prentice Hall, pp. 620–633.Google Scholar
Harré, Rom (1970), The Principles of Scientific Thinking. Chicago, IL: University of Chicago Press.CrossRefGoogle Scholar
Harré, Rom and Madden, E. H. (1975), Causal Powers: A Theory of Natural Necessity. Totowa, NJ: Rowman and Littlefield.Google Scholar
Holyoak, Keith J. and Thagard, Paul (1995), Mental Leaps: Analogy in Creative Thought. Cambridge, MA: MIT Press.Google Scholar
Kleiner, Scott A. (1993), The Logic of Discovery: A Theory of the Rationality of Scientific Research. Dordrecht: Kluwer.CrossRefGoogle Scholar
Machamer, Peter (1998), “Galileo's Machines, His Mathematics and His Experiments,” in Machamer, Peter (ed.), Cambridge Companion to Galileo. Cambridge: Cambridge University Press, pp. 53–79.CrossRefGoogle Scholar
Machamer, Peter (2004), “Activities and Causation: The Metaphysics and Epistemology of Mechanisms,” International Studies in the Philosophy of Science 18: 27–39.CrossRefGoogle Scholar
Machamer, Peter, Darden, Lindley, and Craver, Carl F (2000), “Thinking About Mechanisms,” Philosophy of Science 67: 1–25.CrossRefGoogle Scholar
Machamer, Peter and Woody, Andrea (1994), “A Model of Intelligibility in Science: Using Galileo's Balance as a Model for Understanding the Motion of Bodies,” Science and Education 3: 215–244.CrossRefGoogle Scholar
Marcum, James A. (2002), “From Heresy to Dogma in Accounts of Opposition to Howard Temin's DNA Provirus Hypothesis,” History and Philosophy of the Life Sciences 24: 165–192.CrossRefGoogle ScholarPubMed
Nickles, Thomas (1980c), “Introductory Essay: Scientific Discovery and the Future of Philosophy of Science,” in Nickles, Thomas (ed.), Scientific Discovery, Logic, and Rationality. Dordrecht: Reidel, pp. 1–59.CrossRefGoogle Scholar
Popper, Karl R. (1965), The Logic of Scientific Discovery. New York: Harper Torchbooks.Google Scholar
Rudge, David W. (1999), “Taking the Peppered Moth with a Grain of Salt,” Biology & Philosophy 14: 9–37.CrossRefGoogle Scholar
Schaffner, Kenneth (1974a), “Logic of Discovery and Justification in Regulatory Genetics,” Studies in the History and Philosophy of Science 4: 349–385.CrossRefGoogle Scholar
Skipper, Robert A. Jr. (1999), “Selection and the Extent of Explanatory Unification,” Philosophy of Science 66 (Proceedings): S196–S209.CrossRefGoogle Scholar
Skipper, Robert A. Jr. (2001), “The Causal Crux of Selection,” in Behavioral and Brain Sciences 24: 556.Google Scholar
Skipper, Robert A. Jr., and Millstein, Roberta L. (2005), “Thinking about Evolutionary Mechanisms: Natural Selection,” in Carl F. Craver and Lindley Darden (eds.), Special Issue: “Mechanisms in Biology,” Studies in History and Philosophy of Biological and Biomedical Sciences 36: 327–347.CrossRefGoogle ScholarPubMed
Thagard, Paul (1992), Conceptual Revolutions. Princeton, NJ: Princeton University Press.Google Scholar
Thagard, Paul (2003), “Pathways to Biomedical Discovery,” Philosophy of Science 70: 235–254.CrossRefGoogle Scholar
Wimsatt, William (1972), “Complexity and Organization,” in Schaffner, Kenneth F. and Cohen, Robert S. (eds.), PSA 1972, Proceedings of the Philosophy of Science Association. Dordrecht: Reidel, pp. 67–86.Google Scholar
Wimsatt, William (1987), “False Models as Means to Truer Theories,” in Nitecki, Matthew and Hoffman, Antoni (eds.), Neutral Models in Biology. New York: Oxford University Press, pp. 23–55.Google Scholar

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  • Introduction
  • Lindley Darden, University of Maryland, College Park
  • Book: Reasoning in Biological Discoveries
  • Online publication: 31 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511498442.002
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To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

  • Introduction
  • Lindley Darden, University of Maryland, College Park
  • Book: Reasoning in Biological Discoveries
  • Online publication: 31 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511498442.002
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Introduction
  • Lindley Darden, University of Maryland, College Park
  • Book: Reasoning in Biological Discoveries
  • Online publication: 31 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511498442.002
Available formats
×