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2 - Discovering Mechanisms in Neurobiology: The Case of Spatial Memory with Carl F. Craver

Published online by Cambridge University Press:  31 August 2009

Lindley Darden
Lindley Darden
Affiliation:
University of Maryland, College Park
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Summary

INTRODUCTION

This chapter is about discovery in neurobiology; more specifically, it is about the discovery of mechanisms. The search for mechanisms is widespread in contemporary neurobiology, and, understandably, the character of this product shapes the process by which mechanisms are discovered. Analyzing mechanisms and their characteristic organization reveals constraints on their discovery. These constraints reflect, at least in part, what it is to have a plausible description of a mechanism. These constraints also highlight varieties of evidence that both guide and delimit the construction, evaluation, and revision of such plausible descriptions.

The central example in the following discussion is the continuing discovery of the mechanism of spatial memory. Spatial memory, roughly speaking, is the ability to learn to navigate through a novel environment. The mechanism of spatial memory is multilevel, and recently an integrated sketch of the mechanism at each of these levels has started to emerge. Even though this sketch is far from complete at this time, the example offers a glimpse at the kinds of constraints that are delimiting and guiding this gradual and piecemeal discovery process.

This chapter opens with an analysis of mechanisms, discussing their components and their characteristic spatial, temporal, and multilevel organization. Mechanisms are often discovered gradually and piecemeal. The second section introduces conventions for constructing incomplete and abstract descriptions of mechanisms (namely, the mechanism sketch and the mechanism schema) and for describing the constraints under which the gradual and piecemeal discovery of these sketches and schemata proceeds.

Type
Chapter
Information
Reasoning in Biological Discoveries
Essays on Mechanisms, Interfield Relations, and Anomaly Resolution
 , pp. 40 - 64
Publisher: Cambridge University Press
Print publication year: 2006

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References

Barinaga, M. (1999), “New Clues to How Neurons Strengthen Their Connections,” Science 284: 1755–1757.CrossRefGoogle ScholarPubMed
Bechtel, William and Richardson, Robert C. (1993), Discovering Complexity: Decomposition and Localization as Strategies in Scientific Research. Princeton, NJ: Princeton University Press.Google Scholar
Bogen, James and Woodward, J. (1988), “Saving the Phenomena,” Philosophical Review 97: 303–352.CrossRefGoogle Scholar
Chapuis, N., Durup, M., and Thinus-Blanc, C. (1987), “The Role of Exploratory Experience in a Shortcut in Golden Hamsters (Mesocricetus auratus),” Animal Learning and Behavior 15: 174–178.CrossRefGoogle Scholar
Craver, Carl F. (1998), Neural Mechanisms: On the Structure, Function, and Development of Theories in Neurobiology. Doctoral dissertation, Department of History and Philosophy of Science, University of Pittsburgh, Pittsburgh, PA.Google Scholar
Craver, Carl F. (2001), “Role Functions, Mechanisms, and Hierarchy,” Philosophy of Science 68: 53–74.CrossRefGoogle Scholar
Darden, Lindley (1991), Theory Change in Science: Strategies from Mendelian Genetics. New York: Oxford University Press.Google Scholar
Darden, Lindley (1992), “Strategies for Anomaly Resolution,” in Giere, Ronald (ed.), Cognitive Models of Science. Minnesota Studies in the Philosophy of Science, v. 15. Minneapolis, MN: University of Minnesota Press, pp. 251–273.Google Scholar
Darden, Lindley (1996), “Generalizations in Biology: Essay Review of K. Schaffner's Discovery and Explanation in Biology and Medicine,” Studies in History and Philosophy of Science 27: 409–419.CrossRefGoogle Scholar
Darden, Lindley and Michael Cook (1994), “Reasoning Strategies in Molecular Biology: Abstractions, Scans, and Anomalies,” in Hull, David, Forbes, Mickey, and Burian, Richard M. (eds.), PSA 1994, v. 2. East Lansing, MI: Philosophy of Science Association, pp. 179–191.Google Scholar
Engert, E. and Bonhoeffer, T. (1999), “Dendritic Spine Changes Associated with Hippocampal Long-Term Synaptic Plasticity,” Nature 399: 66–70.CrossRefGoogle ScholarPubMed
Frey, U., and Morris, R. G. (1998), “Synaptic Tagging: Implications for Late Maintenance of Hippocampal Long-Term Potentiation,” Trends in Neuroscience 21: 181–188.CrossRefGoogle ScholarPubMed
Hacking, Ian (1988), “On the Stability of the Laboratory Sciences,” Journal of Philosophy 85: 507–514.CrossRefGoogle Scholar
Hacking, Ian (1992), “The Self-Vindication of the Laboratory Sciences,” in Pickering, A. (ed.), Science as Practice and Culture. Chicago, IL: University of Chicago Press, pp. 29–64.CrossRefGoogle Scholar
Hebb, D. O. (1949), The Organization of Behavior. New York: Wiley.Google Scholar
Kuno, M. (1995), The Synapse: Function, Plasticity, and Neurotrophism. Oxford: Oxford University Press.Google Scholar
Lederberg, Joshua S. (1995), “Notes on Systematic Hypothesis Generation and Application to Disciplined Brainstorming,” in Working Notes: Symposium: Systematic Methods of Scientific Discovery. AAAI Spring Symposium Series. American Association for Artificial Intelligence, Stanford, CA: Stanford University, pp. 97–98.Google Scholar
Machamer, Peter, Darden, Lindley, and Craver, Carl F. (2000), “Thinking about Mechanisms,” Philosophy of Science 67: 1–25.CrossRefGoogle Scholar
Maletic-Savatic, M., Malinow, R., and Svoboda, K. (1999), “Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity,” Science 283: 1923–1926.CrossRefGoogle ScholarPubMed
Malinow, R. (1998), “Silencing the Controversy in LTP?” Neuron 21: 1226–1227.CrossRefGoogle ScholarPubMed
McHugh, T. J., Blum, K. I., Tsien, J. Z., Tonegawa, S., and Wilson, M. A. (1996), “Impaired Hippocampal Representation of Space in CA1-Specific NMDARI Knockout Mice,” Cell 87: 1339–1349.CrossRefGoogle Scholar
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., and O'Keefe, J. (1982), “Place Navigation Impaired in Rats with Hippocampal Lesions,” Nature 297: 681–683.CrossRefGoogle ScholarPubMed
O'Keefe, J. and Dostrovsky, J. (1971), “The Hippocampus as a Spatial Map: Preliminary Evidence from Unit Activity in the Freely Moving Rat,” Brain Research 34: 171–175.CrossRefGoogle ScholarPubMed
Olton, D. S. and Samuelson, R. J. (1976), “Remembrances of Places Passed: Spatial Memory in Rats,” Journal of Experimental Psychology: Animal Behavior Processes 2: 97–116.Google Scholar
Rottenberg, A., Mayford, M., Hawkins, R. D., Kandel, E. R., and Muller, R. U. (1996), “Mice Expressing Activated CaMKII Lack Low Frequency LTP and Do Not Form Stable Place Cells in the CA1 Region of the Hippocampus,” Cell 87: 1351–1361.CrossRefGoogle Scholar
Roush, W. (1997), “New Knockout Mice Point to Molecular Basis of Memory,” Science 275: 32–33.CrossRefGoogle Scholar
Schaffner, Kenneth (1993), Discovery and Explanation in Biology and Medicine. Chicago, IL: University of Chicago Press.Google Scholar
Scoville, W. B. and Millner, B. (1957), “Loss of Recent Memory after Bilateral Hippocampal Lesions,” Journal of Neurology, Neurosurgery, and Psychiatry 20: 11–20.CrossRefGoogle ScholarPubMed
Sherry, D. and S. Healy (1998), “Neural Mechanisms of Spatial Representation,” in Healy, S. (ed.), Spatial Representation in Animals. Oxford: Oxford University Press, pp. 133–157.Google Scholar
Shi, S., Hayashi, Y., Petralia, R. S., Zaman, S. H., Wenthold, R., Svoboda, K., and Malinow, R. (1999), “Rapid Spine Delivery and Redistribution of AMPA Receptors after Synaptic NMDA Receptor Activation,” Science 284: 1811–1816.CrossRefGoogle ScholarPubMed
Skipper, Robert (1999), “Selection and the Extent of Explanatory Unification,” Philosophy of Science (Supplement) 66: S196–S209.CrossRefGoogle Scholar
Stevens, C. F. (1996), “Spatial Learning and Memory: The Beginning of a Dream,” Cell 87: 1147–1148.CrossRefGoogle Scholar
Tolman, E. (1948), “Cognitive Maps in Rats and Men,” Psychological Review 55: 189–208.CrossRefGoogle ScholarPubMed
Tolman, E. and Honzick, C.(1930), “Introduction and Removal of Reward and Maze Performance in Rats,” University of California Publications in Psychology 4: 257–275.Google Scholar
Tsien, J. Z., Chen, D. E., Gerber, D., Tom, C., Mercer, E., Anderson, D., Mayford, M., and Kandel, E. R. (1996a), “Subregion- and Cell Type-Restricted Gene Knockout in Mouse Brain,” Cell 87: 1317–1326.CrossRefGoogle Scholar
Tsien, J. Z., Huerta, P. T., and Tonegawa, S. (1996b), “The Essential Role of Hippocampal CA1 NMDA Receptor-Dependent Synaptic Plasticity in Spatial Memory,” Cell 87: 1327–1338.CrossRefGoogle Scholar
Wilson, M. A. and McNaughton, B. (1993), “Dynamics of the Hippocampal Ensemble Code for Space,” Science 261: 1055–1058.CrossRefGoogle ScholarPubMed
Zola-Morgan, S. and Squire, L. (1993), “Neuroanatomy of Memory,” Annual Review of Neuroscience 16: 547–563.CrossRefGoogle Scholar

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