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13 - Significant Cognitive Decline

Published online by Cambridge University Press:  16 March 2023

By
Claudia Drossel  and
Jacqueline Pachis
Edited by
Stephen Hupp  and
Cara L. Santa Maria
Stephen Hupp
Affiliation:
Southern Illinois University Edwardsville
Cara L. Santa Maria
Affiliation:
Fielding Graduate University, California
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Summary

This chapter describes pseudoscience and questionable ideas related to neurocognitive disorders. The chapter opens by discussing facts that rebut pervasive myths and pseudoscience. Provider barriers to diagnosis and patient education are also considered. The chapter elaborates on the problems associated with persistent searchers for a cure and the hype of pharmacological interventions. The chapter closes by reviewing research-supported approaches.

Keywords

neurocognitive disordersdementiaAlzheimer’sneurodegenerationbiomarkersdisease-slowing agentstertiary preventionmulti-modal interventionscaregiver support
Type
Chapter
Information
Pseudoscience in Therapy
A Skeptical Field Guide
 , pp. 203 - 226
Publisher: Cambridge University Press
Print publication year: 2023

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References

Achterberg, W., Lautenbacher, S., Husebo, B., Erdal, A., & Herr, K. (2019). Pain in dementia. Pain Reports, 5(1), e803–e803. https://doi.org/10.1097/PR9.0000000000000803.Google Scholar
Adelman, R. C. (1998). The Alzheimerization of aging: A brief update. Experimental Gerontology, 33(1), 155–157. https://doi.org/https://doi.org/10.1016/S0531-5565(97)00057-0.CrossRefGoogle ScholarPubMed
Ahmed, R. M., Paterson, R. W., Warren, J. D., Zetterberg, H., O’Brien, J. T., Fox, N. C., Halliday, G. M., & Schott, J. M. (2014). Biomarkers in dementia: Clinical utility and new directions. Journal of Neurology, Neurosurgery & Psychiatry, 85(12), 1426–1434. https://doi.org/10.1136/jnnp-2014-307662.Google Scholar
Alexander, G. C., Knopman, D. S., Emerson, S. S., Ovbiagele, B., Kryscio, R. J., Perlmutter, J. S., & Kesselheim, A. S. (2021). Revisiting FDA approval of aducanumab. The New England Journal of Medicine, 385(9), 769–771. https://doi.org/http://dx.doi.org/10.1056/NEJMp2110468.CrossRefGoogle ScholarPubMed
Alzheimer’s Association. (n.d.). Stages and behaviors: Aggression and anger. www.alz.org/help-support/caregiving/stages-behaviors/agression-anger.Google Scholar
Alzheimer’s Association. (2002). Medications for memory, cognition, and dementia-related behaviors. www.alz.org/alzheimers-dementia/treatments/medications-for-memory.Google Scholar
American Geriatrics Society Beers Criteria® Update Expert Panel. (2019). American Geriatrics Society 2019 updated AGS Beers Criteria® for potentially inappropriate medication use in older adults. Journal of the American Geriatrics Society, 67(4), 674–694. https://doi.org/10.1111/jgs.15767.Google Scholar
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). American Psychiatric Association. https://doi.org/https://doi.org/10.1176/appi.books.9780890425596.Google Scholar
American Psychiatric Association. (2022). Diagnostic and statistical manual of mental disorders, fifth edition, text revision (DSM-5-TR). American Psychiatric Association.Google Scholar
Anand, A., Patience, A. A., Sharma, N., & Khurana, N. (2017). The present and future of pharmacotherapy of Alzheimer’s disease: A comprehensive review. European Journal of Pharmacology, 815, 364–375. https://doi.org/https://doi.org/10.1016/j.ejphar.2017.09.043.Google Scholar
Arvanitakis, Z., Shah, R. C., & Bennett, D. A. (2019). Diagnosis and management of dementia: Review. Journal of the American Medical Association, 322(16), 1589–1599. https://doi.org/10.1001/jama.2019.4782.CrossRefGoogle ScholarPubMed
Ballard, C., & Cream, J. (2005). Drugs used to relieve behavioral symptoms in people with dementia or an unacceptable chemical cosh? International Psychogeriatrics, 17(1), 4–12. https://doi.org/10.1017/S1041610205221026.Google Scholar
Baumgart, M., Snyder, H. M., Carrillo, M. C., Fazio, S., Kim, H., & Johns, H. (2015). Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective. Alzheimer’s & Dementia, 11(6), 718–726. https://doi.org/https://doi.org/10.1016/j.jalz.2015.05.016.CrossRefGoogle ScholarPubMed
Belle, S. H., Burgio, L., Burns, R., Coon, D., Czaja, S. J., Gallagher-Thompson, D., Gitlin, L. N., Klinger, J., Koepke, K. M., Lee, C. C., Martindale-Adams, J., Nichols, L., Schulz, R., Stahl, S., Stevens, A., Winter, L., Zhang, S., & Resources for Enhancing Alzheimer’s Caregiver Health (REACH) II Investigators. (2006). Enhancing the quality of life of dementia caregivers from different ethnic or racial groups: A randomized, controlled trial. Annals of Internal Medicine, 145(10), 727–738. https://doi.org/10.7326/0003-4819-145-10-200611210-00005.Google Scholar
Bernat, J. L., Beresford, H. R., Celesia, G. G., Cranford, R. E., McQuillen, M. P., Pellegrino, T. R., Snyder, R. D. J., Taylor, R. M., & Wichman, A. (1996). Ethical issues in the management of the demented patient: The American Academy of Neurology Ethics and Humanities Subcommittee. Neurology, 46(4), 1180–1183. https://doi.org/10.1212/WNL.46.4.1180.Google Scholar
Biogen. (2021, December 27). Biogen announces reduced price for Aduhelm® to improve access for patients with early Alzheimer’s disease. https://investors.biogen.com/news-releases/news-release-details/biogen-announces-reduced-price-aduhelmr-improve-access-patients.Google Scholar
Birks, J. S., & Harvey, R. J. (2018). Donepezil for dementia due to Alzheimer’s disease. Cochrane Database of Systematic Reviews, 6(6), CD001190. https://doi.org/10.1002/14651858.CD001190.pub3.Google ScholarPubMed
Birt, L., Poland, F., Csipke, E., & Charlesworth, G. (2017). Shifting dementia discourses from deficit to active citizenship. Sociology of Health & Illness, 39(2), 199–211. https://doi.org/https://doi.org/10.1111/1467-9566.12530.CrossRefGoogle ScholarPubMed
Black, B. S., Johnston, D., Leoutsakos, J., Reuland, M., Kelly, J., Amjad, H., Davis, K., Willink, A., Sloan, D., Lyketsos, C., & Samus, Q. M. (2019). Unmet needs in community-living persons with dementia are common, often non-medical and related to patient and caregiver characteristics. International Psychogeriatrics, 31(11), 1643–1654. https://doi.org/10.1017/S1041610218002296.CrossRefGoogle ScholarPubMed
Braus, B. R., Rummans, T. A., Lapid, M. I., Morgan, R. J., Sampson, S. M., Handler, E. M. & Dimsdale, J. E. (2019). Clinicians and cognitive bias: A case of frontotemporal dementia misdiagnosed as conversion disorder. American Journal of Psychiatry, 176(9), 690–693. https://doi.org/10.1176/appi.ajp.2018.18050551.Google Scholar
Brimelow, R. E., Wollin, J. A., Byrne, G. J., & Dissanayaka, N. N. (2019). Prescribing of psychotropic drugs and indicators for use in residential aged care and residents with dementia. International Psychogeriatrics, 31(6), 837–847. https://doi.org/http://dx.doi.org/10.1017/S1041610218001229.Google Scholar
Clevenger, C. K., Cellar, J., Kovaleva, M., Medders, L., & Hepburn, K. (2018). Integrated memory care clinic: Design, implementation, and initial results. Journal of the American Geriatrics Society, 66(12), 2401–2407. https://doi.org/https://doi.org/10.1111/jgs.15528.Google Scholar
Cummings, J., Aisen, P., Apostolova, L. G., Atri, A., Salloway, S., & Weiner, M. (2021). Aducanumab: Appropriate use recommendations. The Journal of Prevention of Alzheimer’s Disease, 8(4), 398–410. https://doi.org/10.14283/jpad.2021.41.Google Scholar
Daly, T., Mastroleo, I., Gorski, D., & Epelbaum, S. (2020). The ethics of innovation for Alzheimer’s disease: The risk of overstating evidence for metabolic enhancement protocols. Theoretical Medicine and Bioethics, 41(5), 223–237. https://doi.org/10.1007/s11017-020-09536-7.CrossRefGoogle ScholarPubMed
Dubois, B., Villain, N., Frisoni, G. B., Rabinovici, G. D., Sabbagh, M., Cappa, S., Bejanin, A., Bombois, S., Epelbaum, S., Teichmann, M., Habert, M.-O., Nordberg, A., Blennow, K., Galasko, D., Stern, Y., Rowe, C. C., Salloway, S., Schneider, L. S., Cummings, J. L., & Feldman, H. H. (2021). Clinical diagnosis of Alzheimer’s disease: Recommendations of the International Working Group. The Lancet Neurology, 20(6), 484–496. https://doi.org/10.1016/S1474-4422(21)00066-1.Google Scholar
Erskine, D., Koss, D., Korolchuk, V. I., Outeiro, T. F., Attems, J., & McKeith, I. (2021). Lipids, lysosomes and mitochondria: Insights into Lewy body formation from rare monogenic disorders. Acta Neuropathologica, 141(4), 511–526. https://doi.org/10.1007/s00401-021-02266-7.Google Scholar
Fisher, J. E., Drossel, C., Yury, C., & Cherup, S. (2007). A contextual model of restraint-free care for persons with dementia. In Sturmey, P. (Ed.), Functional analysis in clinical treatment (pp. 211–237). Academic Press/Elsevier.CrossRefGoogle Scholar
Gill, S. S., Mamdani, M., Naglie, G., Streiner, D. L., Bronskill, S. E., Kopp, A., Shulman, K. I., Lee, P. E., & Rochon, P. A. (2005). A prescribing cascade involving cholinesterase inhibitors and anticholinergic drugs. Archives of Internal Medicine, 165(7), 808–813. https://doi.org/10.1001/archinte.165.7.808.Google Scholar
Gitlin, L. N., Belle, S. H., Burgio, L. D., Czaja, S. J., Mahoney, D., Gallagher-Thompson, D., Burns, R., Hauck, W. W., Zhang, S., Schulz, R., & Ory, M. G. (2003). Effect of multicomponent interventions on caregiver burden and depression: The REACH multisite initiative at 6-month follow-up. Psychology and Aging, 18(3), 361–374. https://doi.org/10.1037/0882-7974.18.3.361.Google Scholar
Goldberg, J. F., & Ernst, C. L. (2018). Managing the side effects of psychotropic medications. 2nd ed. American Psychiatric Association.Google Scholar
Goodman, R. A., Lochner, K. A., Thambisetty, M., Wingo, T. S., Posner, S. F., & Ling, S. M. (2017). Prevalence of dementia subtypes in United States Medicare fee-for-service beneficiaries, 2011–2013. Alzheimer’s & Dementia, 13(1), 28–37. https://doi.org/https://doi.org/10.1016/j.jalz.2016.04.002.Google Scholar
Hamilton, J. M., Landy, K. M., Salmon, D. P., Hansen, L. A., Masliah, E., & Galasko, D. (2012). Early visuospatial deficits predict the occurrence of visual hallucinations in autopsy-confirmed dementia with Lewy bodies. The American Journal of Geriatric Psychiatry, 20(9), 773–781. https://doi.org/https://doi.org/10.1097/JGP.0b013e31823033bc.Google Scholar
Hellmuth, J., Rabinovici, G. D., & Miller, B. L. (2019). The rise of pseudomedicine for dementia and brain health. Journal of the American Medical Association, 321(6), 543–544. https://doi.org/10.1001/jama.2018.21560.Google Scholar
Howard, R., Burns, A., & Schneider, L. (2020). Antipsychotic prescribing to people with dementia during COVID-19. The Lancet Neurology, 19(11), 892–892. https://doi.org/10.1016/S1474-4422(20)30370-7.CrossRefGoogle ScholarPubMed
Hupp, S., & Tolin, D. (in press). Science-based therapy. Cambridge University Press.Google Scholar
James, B. D., Power, M. C., Gianattasio, K. Z., Lamar, M., Oveisgharan, S., Shah, R. C., Marquez, D. X., Barnes, L. L., & Bennett, D. A. (2020). Characterizing clinical misdiagnosis of dementia using Medicare claims records linked to Rush Alzheimer’s Disease Center (RADC) cohort study data. Alzheimer’s & Dementia, 16(S10), e044880. https://doi.org/https://doi.org/10.1002/alz.044880.Google Scholar
Jansen, W. J., Ossenkoppele, R., Tijms, B. M., Fagan, A. M., Hansson, O., Klunk, W. E., van der Flier, W. M., Villemagne, V. L., Frisoni, G. B., Fleisher, A. S., Lleó, A., Mintun, M. A., Wallin, A., Engelborghs, S., Na, D. L., Chételat, G., Molinuevo, J. L., Landau, S. M., Mattsson, N., … Zetterberg, H. (2018). Association of cerebral amyloid-β aggregation with cognitive functioning in persons without dementia. JAMA Psychiatry, 75(1), 84–95. https://doi.org/10.1001/jamapsychiatry.2017.3391.Google Scholar
Joling, K. J., Ten Koppel, M., van Hout, H. P. J., Onwuteaka-Philipsen, B. D., Francke, A. L., Verheij, R. A., Twisk, J. W. R., & van Marum, R. J. (2021). Psychotropic drug prescription rates in primary care for people with dementia from recorded diagnosis onwards.International Journal of Geriatric Psychiatry, 36(3), 443–451. https://doi.org/https://doi.org/10.1002/gps.5442.Google Scholar
Kahn, R. S. (1965). Comments. In Lawton, M. P., & Lawton, F. G. (Eds.), Mental impairment in the aged; Proceedings. Philadelphia Geriatric Center.Google Scholar
Khoury, R., & Ghossoub, E. (2019). Diagnostic biomarkers of Alzheimer’s disease: A state-of-the-art review. Biomarkers in Neuropsychiatry, 1, 100005. https://doi.org/10.1016/j.bionps.2019.100005.Google Scholar
Larson, E. B., & Stroud, C. (2021). Meeting the challenge of caring for persons living with dementia and their care partners and caregivers: A report from the National Academies of Sciences, Engineering, and Medicine. Journal of the American Medical Association, 325(18), 1831–1832. https://doi.org/10.1001/jama.2021.4928.CrossRefGoogle ScholarPubMed
Lilienfeld, S. O., Ritschel, L. A., Lynn, S. J., Cautin, R. L., & Latzman, R. D. (2014). Why ineffective psychotherapies appear to work: A taxonomy of causes of spurious therapeutic effectiveness. Perspectives on Psychological Science, 9(4), 355–387. https://doi.org/10.1177/1745691614535216.Google Scholar
Lourida, I., Hannon, E., Littlejohns, T. J., Langa, K. M., Hyppönen, E., Kuzma, E., & Llewellyn, D. J. (2019). Association of lifestyle and genetic risk with incidence of dementia. Journal of the American Medical Association, 322(5), 430–437. https://doi.org/10.1001/jama.2019.9879.CrossRefGoogle ScholarPubMed
McClellan, M., Brown, N., Califf, R. M., & Warner, J. J. (2019). Call to action: Urgent challenges in cardiovascular disease: A presidential advisory from the American Heart Association. Circulation, 139(9), e44–e54. https://doi.org/doi:10.1161/CIR.0000000000000652.CrossRefGoogle ScholarPubMed
McCurry, S., & Drossel, C. (2011). Treating dementia in context: A step-by-step guide to working with individuals and families. American Psychological Association.Google Scholar
McKeith, I. G., Boeve, B. F., Dickson, D. W., Halliday, G., Taylor, J.-P., Weintraub, D., Aarsland, D., Galvin, J., Attems, J., Ballard, C. G., Bayston, A., Beach, T. G., Blanc, F., Bohnen, N., Bonanni, L., Bras, J., Brundin, P., Burn, D., Chen-Plotkin, A., … Kosaka, K. (2017). Diagnosis and management of dementia with Lewy bodies. Fourth Consensus Report of the DLB Consortium, 89(1), 88–100. https://doi.org/10.1212/wnl.0000000000004058.Google ScholarPubMed
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer’s disease. Report of the NINCDS‐ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology, 34(7), 939–939. https://doi.org/10.1212/wnl.34.7.939.Google Scholar
McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack Jr., C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., Mohs, R. C., Morris, J. C., Rossor, M. N., Scheltens, P., Carrillo, M. C., Thies, B., Weintraub, S., & Phelps, C. H. (2011). The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s & Dementia, 7(3), 263–269. https://doi.org/10.1016/j.jalz.2011.03.005.Google Scholar
McShane, R., Westby, M. J., Roberts, E., Minakaran, N., Schneider, L., Farrimond, L. E., Maayan, N., Ware, J., & Debarros, J. (2019). Memantine for dementia. Cochrane Database of Systematic Reviews, 3(3), CD003154. https://doi.org/10.1002/14651858.CD003154.pub6.Google Scholar
Nasreddine, Z. S., Phillips, N. A., Bédirian, V., Charbonneau, S., Whitehead, V., Collin, I., Cummings, J. L., & Chertkow, H. (2005). The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment. Journal of the American Geriatrics Society, 53(4), 695–699. https://doi.org/https://doi.org/10.1111/j.1532-5415.2005.53221.x.CrossRefGoogle Scholar
Nelson, P. T., Dickson, D. W., Trojanowski, J. Q., Jack, C. R., Boyle, P. A., Arfanakis, K., Rademakers, R., Alafuzoff, I., Attems, J., Brayne, C., Coyle-Gilchrist, I. T. S., Chui, H. C., Fardo, D. W., Flanagan, M. E., Halliday, G., Hokkanen, S. R. K., Hunter, S., Jicha, G. A., Katsumata, Y., … Schneider, J. A. (2019). Limbic-predominant age-related TDP-43 encephalopathy (LATE): Consensus working group report. Brain, 142(6), 1503–1527. https://doi.org/10.1093/brain/awz099.CrossRefGoogle ScholarPubMed
Nichols, L. O., Martindale-Adams, J., Burns, R., Graney, M. J., & Zuber, J. (2011). Translation of a dementia caregiver support program in a health care system – REACH VA. Archives of Internal Medicine, 171(4), 353–359. https://doi.org/10.1001/archinternmed.2010.548.CrossRefGoogle Scholar
O’Brien, J., Taylor, J. P., Ballard, C., Barker, R. A., Bradley, C., Burns, A., Collerton, D., Dave, S., Dudley, R., Francis, P., Gibbons, A., Harris, K., Lawrence, V., Leroi, I., McKeith, I., Michaelides, M., Naik, C., O’Callaghan, C., Olsen, K., … Ffytche, D. (2020). Visual hallucinations in neurological and ophthalmological disease: Pathophysiology and management. Journal of Neurology, Neurosurgery & Psychiatry, 91(5), 512–519. https://doi.org/10.1136/jnnp-2019-322702.Google Scholar
O’Donnell, B. F., Drachman, D. A., Barnes, H. J., Peterson, K. E., Swearer, J. M., & Lew, R. A. (1992). Incontinence and troublesome behaviors predict institutionalization in dementia. Topics in geriatrics, 5(1), 45–52. https://doi.org/10.1177/002383099200500108.Google Scholar
Olson, N. L., & Albensi, B. C. (2021). Dementia-friendly “design”: Impact on COVID-19 death rates in long-term care facilities around the world. Journal of Alzheimer’s Disease, 81, 427–450. https://doi.org/10.3233/JAD-210017.CrossRefGoogle ScholarPubMed
Postuma, R. B., Gagnon, J.-F., Vendette, M., Desjardins, C., & Montplaisir, J. Y. (2011). Olfaction and color vision identify impending neurodegeneration in rapid eye movement sleep behavior disorder. Annals of Neurology, 69(5), 811–818. https://doi.org/https://doi.org/10.1002/ana.22282.CrossRefGoogle ScholarPubMed
Powell, T. (2019). Dementia reimagined: Building a life of joy and dignity from beginning to end. Avery.Google Scholar
Renn, B. N., Asghar-Ali, A. A., Thielke, S., Catic, A., Martini, S. R., Mitchell, B. G., & Kunik, M. E. (2018). A systematic review of practice guidelines and recommendations for discontinuation of cholinesterase inhibitors in dementia. The American Journal of Geriatric Psychiatry, 26(2), 134–147. https://doi.org/https://doi.org/10.1016/j.jagp.2017.09.027.Google Scholar
Roebuck-Spencer, T. M., Glen, T., Puente, A. E., Denney, R. L., Ruff, R. M., Hostetter, G., & Bianchini, K. J. (2017). Cognitive screening tests versus comprehensive neuropsychological test batteries: A National Academy of Neuropsychology education paper. Archives of Clinical Neuropsychology, 32(4), 491–498. https://doi.org/10.1093/arclin/acx021.Google Scholar
Ruangritchankul, S., Chantharit, P., Srisuma, S., & Gray, L. C. (2021). Adverse drug reactions of acetylcholinesterase inhibitors in older people living with dementia: A comprehensive literature review. Therapeutics and Clinical Risk Management, 17, 927–949. https://doi.org/10.2147/TCRM.S323387.Google Scholar
Rubino, A., Sanon, M., Ganz, M. L., Simpson, A., Fenton, M. C., Verma, S., Hartry, A., Baker, R. A., Duffy, R. A., Gwin, K., & Fillit, H. (2020). Association of the US Food and Drug Administration antipsychotic drug boxed warning with medication use and health outcomes in elderly patients with dementia. JAMA Network Open, 3(4), e203630–e203630. https://doi.org/10.1001/jamanetworkopen.2020.3630.Google Scholar
Salzman, T., Sarquis-Adamson, Y., Son, S., Montero-Odasso, M., & Fraser, S. (2022). Associations of multidomain interventions with improvements in cognition in mild cognitive impairment: A systematic review and meta-analysis. JAMA Network, 5(5), e226744. https://doi.org/10.1001/jamanetworkopen.2022.6744.CrossRefGoogle ScholarPubMed
Saredakis, D., Collins-Praino, L. E., Gutteridge, D. S., Stephan, B. C. M., & Keage, H. A. D. (2019). Conversion to MCI and dementia in Parkinson’s disease: A systematic review and meta-analysis. Parkinsonism & Related Disorders, 65, 20–31. https://doi.org/10.1016/j.parkreldis.2019.04.020.Google Scholar
Scales, K., Zimmerman, S., & Miller, S. J. (2018). Evidence-based nonpharmacological practices to address behavioral and psychological symptoms of dementia. Gerontologist, 58(S1), S88–S102. https://doi.org/10.1093/geront/gnx167.Google Scholar
Schulz, R., Burgio, L., Burns, R., Eisdorfer, C., Gallagher-Thompson, D., Gitlin, L. N., & Mahoney, D. F. (2003). Resources for enhancing Alzheimer’s caregiver health (REACH): Overview, site-specific outcomes, and future directions. The Gerontologist, 43(4), 514–520. https://doi.org/10.1093/geront/43.4.514.Google Scholar
Singh-Manoux, A., Dugravot, A., Fournier, A., Abell, J., Ebmeier, K., Kivimäki, M., & Sabia, S. (2017). Trajectories of depressive symptoms before diagnosis of dementia: A 28-year follow-up study. JAMA Psychiatry, 74(7), 712–718. https://doi.org/10.1001/jamapsychiatry.2017.0660.Google Scholar
Spiegl, K., Luttenberger, K., Graessel, E., Becker, L., Scheel, J., & Pendergrass, A. (2021). Predictors of institutionalization in users of day care facilities with mild cognitive impairment to moderate dementia. BMC Health Services Research, 21(1), 1009. https://doi.org/10.1186/s12913-021-07017-8.Google Scholar
Stokes, L., Combes, H., & Stokes, G. (2015). The dementia diagnosis: A literature review of information, understanding, and attributions. Psychogeriatrics, 15(3), 218–225. https://doi.org/https://doi.org/10.1111/psyg.12095.CrossRefGoogle ScholarPubMed
Suen, Y. N., Wong, S. M. Y., Hui, C. L. M., Chan, S. K. W., Lee, E. H. M., Chang, W. C., & Chen, E. Y. H. (2019). Late-onset psychosis and very-late-onset-schizophrenia-like-psychosis: An updated systematic review. International Review of Psychiatry, 31(5/6), 523–542. https://doi.org/10.1080/09540261.2019.1670624.CrossRefGoogle ScholarPubMed
Tjia, J., Lemay, C. A., Bonner, A., Compher, C., Paice, K., Field, T., Mazor, K., Hunnicutt, J. N., Lapane, K. L., & Gurwitz, J. (2017). Informed family member involvement to improve the quality of dementia care in nursing homes. Journal of the American Geriatrics Society, 65(1), 59–65. https://doi.org/10.1111/jgs.14299.CrossRefGoogle ScholarPubMed
U.S. Food and Drug Administration. (2021, June 7). FDA grants accelerated approval for Alzheimer’s drug. www.fda.gov/news-events/press-announcements/fda-grants-accelerated-approval-alzheimers-drug.Google Scholar
van Wijngaarden, E., Manna, A., & Anne-Mei, T. (2019). ‘The eyes of others’ are what really matters: The experience of living with dementia from an insider perspective. PLoS One, 14(4). https://doi.org/10.1371/journal.pone.0214724.CrossRefGoogle ScholarPubMed
Wilson, R. S., Leurgans, S. E., Boyle, P. A., & Bennett, D. A. (2011). Cognitive decline in prodromal Alzheimer disease and mild cognitive impairment. Archives of Neurology, 68(3), 351–356. https://doi.org/10.1001/archneurol.2011.31.Google Scholar
Yamada, Y., Vlachova, M., Richter, T., Finne-Soveri, H., Gindin, J., van der Roest, H., Denkinger, M. D., Bernabei, R., Onder, G., & Topinkova, E. (2014). Prevalence and correlates of hearing and visual impairments in European nursing homes: Results from the SHELTER study. Journal of the American Medical Directors Association, 15(10), 738–743. https://doi.org/https://doi.org/10.1016/j.jamda.2014.05.012.Google Scholar
Yumoto, A., & Suwa, S. (2021). Difficulties and associated coping methods regarding visual hallucinations caused by dementia with Lewy bodies. Dementia, 20(1), 291–307. https://doi.org/10.1177/1471301219879541.CrossRefGoogle ScholarPubMed

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Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

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Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

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Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

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