Book contents
- Frontmatter
- Contents
- List of Contributors
- Preface
- 1 The microbiological investigation of sudden unexpected death in infancy
- 2 An overview of childhood lymphomas
- 3 Assessment of the brain in the hospital consented autopsy
- 4 The value of immunohistochemistry as a diagnostic aid in gynaecological pathology
- 5 The role of the pathologist in the diagnosis of cardiomyopathy: a personal view
- 6 Metastatic adenocarcinoma of unknown origin
- 7 Immune responses to tumours: current concepts and applications
- 8 Post-mortem imaging – an update
- 9 Understanding the Human Tissue Act 2004
- 10 The Multidisciplinary Team (MDT) meeting and the role of pathology
- 11 Drug induced liver injury
- Index
- References
4 - The value of immunohistochemistry as a diagnostic aid in gynaecological pathology
Published online by Cambridge University Press: 06 January 2010
- Frontmatter
- Contents
- List of Contributors
- Preface
- 1 The microbiological investigation of sudden unexpected death in infancy
- 2 An overview of childhood lymphomas
- 3 Assessment of the brain in the hospital consented autopsy
- 4 The value of immunohistochemistry as a diagnostic aid in gynaecological pathology
- 5 The role of the pathologist in the diagnosis of cardiomyopathy: a personal view
- 6 Metastatic adenocarcinoma of unknown origin
- 7 Immune responses to tumours: current concepts and applications
- 8 Post-mortem imaging – an update
- 9 Understanding the Human Tissue Act 2004
- 10 The Multidisciplinary Team (MDT) meeting and the role of pathology
- 11 Drug induced liver injury
- Index
- References
Summary
INTRODUCTION
In recent years there has been a rapidly expanding literature investigating the value of immunohistochemistry as a diagnostic aid in gynaecological pathology [1]–[3]. The aim of this review is to provide a critical appraisal of the uses of immunohistochemistry in diagnostic gynaecological pathology that pathologists will find of practical value in their routine day-to-day practice. The value of immunohistochemical prognostic factors in various gynaecological malignancies is not covered since, although there is an extensive literature on this subject, little has found a role in routine pathological practice. Before detailing the uses of immunohistochemistry as a diagnostic aid in gynaecological pathology, several points are stressed: (a) most cases do not require immunohistochemistry, which should be reserved for those cases where there is genuine diagnostic confusion; (b) the results of immunohistochemistry should always be carefully interpreted in the context of the morphology; (c) no antibody is totally specific; and (d) in general, panels of antibodies should be used rather than relying on a single antibody. In this review I will detail what I consider to be useful applications of immunohistochemistry in gynaecological pathology site-by-site in the female genital tract.
OVARY AND PERITONEUM
ANTIBODIES OF VALUE IN DISTINGUISHING BETWEEN PRIMARY AND METASTATIC ADENOCARCINOMA
The histological distinction between a primary ovarian adenocarcinoma and a metastatic adenocarcinoma may be difficult. In some cases of metastatic adenocarcinoma the presence of a primary neoplasm elsewhere is known, but in other instances an ovarian metastasis is the first manifestation of an adenocarcinoma.
- Type
- Chapter
- Information
- Progress in Pathology , pp. 73 - 100Publisher: Cambridge University PressPrint publication year: 2007
References
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