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Chapter 9 - Life and death in the germ line

Apoptosis and the origins of DNA damage in human spermatozoa

from Section 3 - Reproductive biology and cryobiology

Published online by Cambridge University Press:  04 February 2011

By
R. J. Aitken  and
B. J. Curry
Edited by
Jacques Donnez  and
S. Samuel Kim
Jacques Donnez
Affiliation:
Université Catholique de Louvain, Belgium
S. Samuel Kim
Affiliation:
University of Kansas
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Summary

This chapter focuses specifically on how apoptosis affects sperm quality and function, and the implications of this process for both embryonic development and the health and well-being of the offspring. DNA damage in human spermatozoa has been correlated with poor fertilization and impaired embryonic development to the blastocyst stage as well as with the incidence of subsequent miscarriage. Human infertility is a complex multifactorial condition that is strongly impacted by genetic factors that assisted reproductive technology (ART) will ensure are passed onto the progeny. Spermiogenesis is a key event in the etiology of DNA damage in the male germ line. DNA damage in human spermatozoa appears to have its origins in the testes and is associated with oxidative stress. Spermatozoa possess several variants of the prolactin receptor and respond to the presence of this hormone with the stimulation of PI3 kinase/Akt phosphorylation and the prolongation of sperm survival.
Type
Chapter
Information
Principles and Practice of Fertility Preservation , pp. 101 - 113
Publisher: Cambridge University Press
Print publication year: 2011

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