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43 - Anaphylaxis

from Section 10 - Environmental Emergencies

Published online by Cambridge University Press:  02 November 2023

By
David Convissar
Edited by
Kaushal Shah  and
Jarone Lee
Edited in association with
Clark G. Owyang  and
Benjamin Christian Renne
Kaushal Shah
Affiliation:
Weill Cornell Medical Center, New York
Jarone Lee
Affiliation:
Massachusetts General Hospital, Boston
Clark G. Owyang
Affiliation:
Weill Cornell Medical Center, New York
Benjamin Christian Renne
Affiliation:
Massachusetts General Hospital, Boston
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Summary

Anaphylaxis is a life-threatening allergic syndrome characterized by multiorgan involvement and rapid onset, which can lead to life-threatening airway compromise and cardiovascular collapse. Anaphylaxis is an IgE-mediated (Type I or immediate) hypersensitivity reaction, resulting in mast cell degranulation and release of mediators including histamine and cytokines. The release of these chemical mediators results in a constellation of symptoms within 30 minutes of exposure.

Keywords

allergic reactionanaphylaxisanaphylactoidepinephrineantihistaminesteroids
Type
Chapter
Information
Practical Emergency Resuscitation and Critical Care , pp. 445 - 452
Publisher: Cambridge University Press
Print publication year: 2023

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References

Anchor, J, & Settipane, RA. Appropriate use of epinephrine in anaphylaxis. Am J Emerg Med 2004;22:488–490.CrossRefGoogle ScholarPubMed
Gavalas, M, Sadana, A, & Metcalf, A. Guidelines for the management of anaphylaxis in the emergency department. J Accid Emerg Med 1998;15:96–98.CrossRefGoogle ScholarPubMed
Kanwar, M, Irvin, CB, Frank, JJ, et al. Confusion about epinephrine dosing leading to iatrogenic overdose: a life-threatening problem with a potential solution. Ann Emerg Med 2010;55:341–344.CrossRefGoogle ScholarPubMed
Marx, JA, Hockberger, RS, Walls, RM, et al, eds. Rosen’s Emergency Medicine: Concepts and Clinical Practice, 7th ed. Philadelphia, PA: Mosby Elsevier, 2010.Google Scholar

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  • Anaphylaxis
  • Edited by Kaushal Shah, Weill Cornell Medical Center, New York, Jarone Lee, Massachusetts General Hospital, Boston
  • Edited in association with Clark G. Owyang, Weill Cornell Medical Center, New York, Benjamin Christian Renne, Massachusetts General Hospital, Boston
  • Book: Practical Emergency Resuscitation and Critical Care
  • Online publication: 02 November 2023
  • Chapter DOI: https://doi.org/10.1017/9781009052566.054
Available formats
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  • Anaphylaxis
  • Edited by Kaushal Shah, Weill Cornell Medical Center, New York, Jarone Lee, Massachusetts General Hospital, Boston
  • Edited in association with Clark G. Owyang, Weill Cornell Medical Center, New York, Benjamin Christian Renne, Massachusetts General Hospital, Boston
  • Book: Practical Emergency Resuscitation and Critical Care
  • Online publication: 02 November 2023
  • Chapter DOI: https://doi.org/10.1017/9781009052566.054
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Anaphylaxis
  • Edited by Kaushal Shah, Weill Cornell Medical Center, New York, Jarone Lee, Massachusetts General Hospital, Boston
  • Edited in association with Clark G. Owyang, Weill Cornell Medical Center, New York, Benjamin Christian Renne, Massachusetts General Hospital, Boston
  • Book: Practical Emergency Resuscitation and Critical Care
  • Online publication: 02 November 2023
  • Chapter DOI: https://doi.org/10.1017/9781009052566.054
Available formats
×