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Chapter 10 - Traumatic Brain Injury and Psychogenic Nonepileptic Seizures

Published online by Cambridge University Press:  10 August 2021

By
David K. Chen  and
W. Curt LaFrance
Edited by
Marco Mula
Marco Mula
Affiliation:
St George's Hospital Medical School, University of London
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Summary

Psychogenic nonepileptic seizures (PNES) are paroxysms of altered sensory, cognitive, and/or motor manifestations with or without alteration of consciousness that may resemble epileptic seizures, but do not originate from epileptiform brain activity. One framework conceives PNES as arising from a biopsychosocial, multifactorial etiologic model. An unexpectedly high co-occurrence rate of PNES and mild traumatic brain injury (mTBI) has been reported. A causal relationship may be possible in many cases. In applying the biopsychosocial framework, this review discusses how TBI may subserve contributing roles as Predisposing, Precipitating, and Perpetuating factors in the development of PNES.

Keywords

Psychogenic Nonepileptic seizuresTraumatic brain injuryNetwork disorderFunctional connectivityBiopsychosocial modelPredisposing factorsPrecipitating factorsPerpetuating factors
Type
Chapter
Information
Post-traumatic Epilepsy , pp. 140 - 148
Publisher: Cambridge University Press
Print publication year: 2021

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References

American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5). Washington, DC : American Psychiatric Association, 2013.Google Scholar
Bowman, ES, Markand, ON. Psychodynamics and psychiatric diagnoses of pseudoseizure subjects. Am J Psychiatry 1996;153:57–63.Google Scholar
LaFrance Jr, WC, Bjønaes, H. Chapter 28. Designing Treatment Plans Based on Etiology of Psychogenic Noenpileptic Seizures. In: LaFrance Jr, WC, Schachter, SC, editors. Gates and Rowan’s Nonepileptic Seizures. 4th ed. New York: Cambridge University Press; 2018. p. 283–99.Google Scholar
LaFrance, WC Jr. , Devinsky, O. Treatment of nonepileptic seizures. Epilepsy Behav 2002;3(5 Supplement 1): S19–23.CrossRefGoogle ScholarPubMed
LaFrance, WC Jr, Barry, JJ. Update on treatments of psychological nonepileptic seizures. Epilepsy Behav 2005;7:364–74.Google Scholar
Reuber, M. The etiology of psychogenic non-epileptic seizures: toward a biopsychosocial model. Neurol Clin 2009;27:909–24.Google Scholar
Popkirov, S, Carson, AJ, Stone, J. Scared or scarred: Could ‘dissociogenic’ lesions predispose to nonepileptic seizures after head trauma? Seizure 2018;8:127–32.Google Scholar
Benbadis, SR, Allen Hauser, W. An estimate of the prevalence of psychogenic non-epileptic seizures. Seizure 2000;9:280–1.CrossRefGoogle ScholarPubMed
Frost, RB, Farrer, TJ, Primosch, M, Hedges, DW. Prevalence of traumatic brain injury in the general adult population: a meta-analysis. Neuroepidemiology 2013;40:154–9.CrossRefGoogle ScholarPubMed
Salinsky, M, Storzbach, D, Goy, E, Evrard, C. Traumatic brain injury and psychogenic seizures in veterans. J Head Trauma Rehabil 2015;30:E65–70.CrossRefGoogle ScholarPubMed
Hudak, AM, Trivedi, K, Harper, CR, et al. Evaluation of seizure-like episodes in survivors of moderate and severe traumatic brain injury. J Head Trauma Rehabil 2004;19:290–5.CrossRefGoogle ScholarPubMed
Annegers, JF, Hauser, WA, Coan, SP, Rocca, WA. A population-based study of seizures after traumatic brain injuries. N Engl J Med 1998;338:20–4.Google Scholar
Blennow, K, Brody, DL, Kochanek, PM, et al. Traumatic brain injuries. Nat Rev Dis Primers 2016;17;2:16084.CrossRefGoogle Scholar
Szaflarski, JP, LaFrance, WC Jr. Psychogenic nonepileptic seizures (PNES) as a network disorder – evidence from neuroimaging of functional (psychogenic) neurological disorders. Epilepsy Curr 2018;18:211–16.Google Scholar
Alnæs, D, Kaufmann, T, Doan, NT, et al. Association of heritable cognitive ability and psychopathology with white matter properties in children and adolescents. JAMA Psychiatry 2018;75:287–95.Google Scholar
Von Der Heide, RJ, Skipper, LM, Klobusicky, E, Olson, IR. Dissecting the uncinate fasciculus: disorders, controversies and a hypothesis. Brain 2013;136: 1692–707.Google Scholar
Niogi, SN, Mukherjee, P, Ghajar, J, et al. Extent of microstructural white matter injury in postconcussive syndrome correlates with impaired cognitive reaction time: a 3 T diffusion tensor imaging study of mild traumatic brain injury. Am J Neuroradiol. 2008;29:967–73.Google Scholar
Lee, S, Allendorfer, JB, Gaston, TE, et al. White matter diffusion abnormalities in patients with psychogenic non-epileptic seizures. Brain Res 2015;1620:169–76.Google Scholar
Hernando, KA, Szaflarski, JP, Ver Hoef, LW, Lee, S, Allendorfer, JB. Uncinate fasciculus connectivity in patients with psychogenic nonepileptic seizures: A preliminary diffusion tensor tractography study. Epilepsy Behav 2015, 5:68–73.CrossRefGoogle Scholar
Reuber, M, Kral, T, Kurthen, M, Elger, CE. New-onset psychogenic seizures after intracranial neurosurgery. Acta Neurochir (Wien) 2002;44:901–7.Google Scholar
Asadi-Pooya, AA, Asadollahi, M, Tinker, J, Nei, M, Sperling, MR. Post-epilepsy surgery psychogenic nonepileptic seizures. Epilepsia 2016;57:1691–6.Google Scholar
Ney, GC, Barr, WB, Napolitano, C, Decker, R, Schaul, N. New-onset psychogenic seizures after surgery for epilepsy. Arch Neurol 1998;5:726–30.Google Scholar
Glosser, G, Roberts, D, Glosser, DS. Nonepileptic seizures after resective epilepsy surgery. Epilepsia 1999;40:1750–4.Google Scholar
Budisavljevic, S, Kawadler, JM, Dell’Acqua, F, et al. Heritability of the limbic networks. Soc Cogn Affect Neurosci 2016;11:746–57.CrossRefGoogle ScholarPubMed
Lebel, C, Gee, M, Camicioli, R, Wieler, M, Martin, W, Beaulieu, C. Diffusion tensor imaging of white matter tract evolution over the lifespan. Neuroimage 2012;60:340–52.Google Scholar
Greicius, MD, Krasnow, B, Reiss, AL, Menon, V. Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci U S A 2003;100:253–8.Google Scholar
Ham, TE, Bonnelle, V, Hellyer, P, et al. The neural basis of impaired self-awareness after traumatic brain injury. Brain 2014;137:586–97.Google Scholar
Bonnelle, V, Ham, TE, Leech, R, et al. Salience network integrity predicts default mode network function after traumatic brain injury. Proc Natl Acad Sci U S A 2012;109:4690–5.CrossRefGoogle ScholarPubMed
Knyazeva, MG, Jalili, M, Frackowiak, RS, Rossetti, AO. Psychogenic seizures and frontal disconnection: EEG synchronisation study. J Neurol Neurosurg Psychiatry 2011;82:505–11.CrossRefGoogle ScholarPubMed
Reuber, M, Brown, RJ. Understanding psychogenic nonepileptic seizures-Phenomenology, semiology and the Integrative Cognitive Model. Seizure 2017;4:199–205.Google Scholar
van der Kruijs, SJ, Jagannathan, SR, Bodde, NM, et al. Resting-state networks and dissociation in psychogenic non-epileptic seizures. J Psychiatr Res 2014;54:126–33.Google Scholar
Ding, J, An, D, Liao, W, Wu, G, Xu, Q, Zhou, D, Chen, H. Abnormal functional connectivity density in psychogenic non-epileptic seizures. Epilepsy Res 2014;108:1184–94.Google Scholar
Ding, JR, An, D, Liao, W, et al. Altered functional and structural connectivity networks in psychogenic non-epileptic seizures. PLoS One 2013;8:e63850.Google Scholar
Li, R, Li, Y, An, D, Gong, Q, Zhou, D, Chen, H. Altered regional activity and inter-regional functional connectivity in psychogenic non-epileptic seizures. Sci Rep 2015;5:11635.Google Scholar
Cretton, A, Brown, RJ, LaFrance, WC Jr., Aybek, S. What does neuroscience tell us about the conversion model of functional neurological disorders? J Neuropsychiatry Clin Neurosci. 2019:32:24–32.Google Scholar
Li, R, Liu, K, Ma, X, et al. Altered functional connectivity patterns of the insular subregions in psychogenic nonepileptic seizures. Brain Topogr 2015;28:636–45.Google Scholar
Nelson, LD, Temkin, NR, Dikmen, S, et al. Recovery after mild traumatic brain injury in patients presenting to US Level I Trauma Centers: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) study. JAMA Neurology 2019:76:1049–59.Google Scholar
Voon, V, Cavanna, AE, Coburn, K, Sampson, S, Reeve, A, LaFrance, WC Jr. Functional neuroanatomy and neurophysiology of functional neurological disorders (conversion disorder). J Neuropsychiatry Clin Neurosci 2016;28:168–9.CrossRefGoogle ScholarPubMed
Sergent, C, Dehaene, S. Neural processes underlying conscious perception: experimental findings and a global neuronal workspace framework. J Physiol Paris 2004;98:374–84.Google Scholar
Harvey, AG, Bryant, RA. Acute stress disorder after mild traumatic brain injury. J Nerv Ment Dis 1998;186:333–7.CrossRefGoogle ScholarPubMed
Harvey, AG, Bryant, RA. Two-year prospective evaluation of the relationship between acute stress disorder and posttraumatic stress disorder following mild traumatic brain injury. Am J Psychiatry 2000;157:626–8.Google Scholar
Salinsky, M, Evrard, C, Storzbach, D, Pugh, MJ. Psychiatric comorbidity in veterans with psychogenic seizures. Epilepsy Behav 2012;25:345–9.Google Scholar
Rosenberg, HJ, Rosenberg, SD, Williamson, PD, Wolford, GL 2nd. A comparative study of trauma and posttraumatic stress disorder prevalence in epilepsy patients and psychogenic nonepileptic seizure patients. Epilepsia 2000;41:447–52.Google Scholar
Spencer, RJ, Drag, LL, Walker, SJ, Bieliauskas, LA. Self-reported cognitive symptoms following mild traumatic brain injury are poorly associated with neuropsychological performance in OIF/OEF veterans. J Rehabil Res Dev 2010;47:521–30.CrossRefGoogle ScholarPubMed
Lippa, SM, Pastorek, NJ, Benge, JF, Thornton, GM. Postconcussive symptoms after blast and nonblast-related mild traumatic brain injuries in Afghanistan and Iraq war veterans. J Int Neuropsychol Soc 2010;16:856–66.Google Scholar
Fiszman, A, Alves-Leon, SV, Nunes, RG, D’Andrea, I, Figueira, I. Traumatic events and posttraumatic stress disorder in patients with psychogenic nonepileptic seizures: a critical review. Epilepsy Behav 2004;5:818–25.Google Scholar
Stone, J, Carson, A, Aditya, H, et al. The role of physical injury in motor and sensory conversion symptoms: a systematic and narrative review. J Psychosom Res 2009;66:383–90.CrossRefGoogle ScholarPubMed
Pareés, I, Kojovic, M, Pires, C, et al. Physical precipitating factors in functional movement disorders. J Neurol Sci 2014;338(1–2):174–7.CrossRefGoogle ScholarPubMed
Whelan-Goodinson, R, Ponsford, J, Johnston, L, Grant, F. Psychiatric disorders following traumatic brain injury: their nature and frequency. J Head Trauma Rehabil 2009;24:324–32.Google Scholar
Hibbard, MR, Bogdany, J, Uysal, S, et al. Axis II psychopathology in individuals with traumatic brain injury. Brain Inj 2000;14:45–61.Google Scholar
LaFrance, WC Jr, Deluca, M, Machan, JT, Fava, JL. Traumatic brain injury and psychogenic nonepileptic seizures yield worse outcomes. Epilepsia 2013;54:718–25.Google Scholar

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