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13 - Platelet receptors: fibrinogen

from PART I - PHYSIOLOGY

Published online by Cambridge University Press:  10 May 2010

Edward F. Plow
Affiliation:
Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio, USA
Thomas A. Haas
Affiliation:
Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio, USA
Tatiana V. Byzova
Affiliation:
Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio, USA
Paolo Gresele
Affiliation:
Università degli Studi di Perugia, Italy
Clive P. Page
Affiliation:
Sackler Institute of Pulmonary Pharmacology and Therapeutics, Guy's, King's and St Thomas' School of Biomedical Sciences, London
Valentin Fuster
Affiliation:
Mount Sinai Medical Center and School of Medicine, New York
Jos Vermylen
Affiliation:
Universiteitsbibliotheek-K.U., Leuven
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Summary

Introduction and historic perspectives

Scientists have always been intrigued by the highly visible reactions. Hence, platelet aggregation and fibrin deposition, the key events in one of the most visually dramatic of biological reactions, thrombus formation, have been the subject of intensive scrutiny for many decades. Evidence for an interplay between these key components of the thrombus had already begun to evolve in the early 1960s. Platelets in plasma derived from patients with afibrinogenemia failed to aggregate or aggregated poorly when stimulated with ADP or epinephrine, but a robust aggregation response occurred upon addition of fibrinogen to the plasma. These observations also were documented in artificially defibrinated and reconstituted plasma. In the 1970s, as investigators became adept at isolating functional platelets, the role of fibrinogen in platelet aggregation was corroborated; and the requirements for an agonist, a divalent cation and fibrinogen to support the aggregation response was documented. By the late 1970s, formal studies, utilizing approaches developed to examine hormone–receptor interactions, to measure the direct interaction of fibrinogen with platelets, were under way. Thus, in the early 1980s, results from multiple laboratories had documented that platelets expressed fibrinogen receptors, capable of binding this plasma protein in a specific and saturable manner. Furthermore, an important functional response, platelet aggregation, could be ascribed to the binding of fibrinogen to the platelet surface.

Type
Chapter
Information
Platelets in Thrombotic and Non-Thrombotic Disorders
Pathophysiology, Pharmacology and Therapeutics
, pp. 188 - 203
Publisher: Cambridge University Press
Print publication year: 2002

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  • Platelet receptors: fibrinogen
    • By Edward F. Plow, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio, USA, Thomas A. Haas, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio, USA, Tatiana V. Byzova, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio, USA
  • Edited by Paolo Gresele, Università degli Studi di Perugia, Italy, Clive P. Page, Valentin Fuster, Jos Vermylen, Universiteitsbibliotheek-K.U., Leuven
  • Book: Platelets in Thrombotic and Non-Thrombotic Disorders
  • Online publication: 10 May 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511545283.014
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  • Platelet receptors: fibrinogen
    • By Edward F. Plow, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio, USA, Thomas A. Haas, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio, USA, Tatiana V. Byzova, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio, USA
  • Edited by Paolo Gresele, Università degli Studi di Perugia, Italy, Clive P. Page, Valentin Fuster, Jos Vermylen, Universiteitsbibliotheek-K.U., Leuven
  • Book: Platelets in Thrombotic and Non-Thrombotic Disorders
  • Online publication: 10 May 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511545283.014
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Platelet receptors: fibrinogen
    • By Edward F. Plow, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio, USA, Thomas A. Haas, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio, USA, Tatiana V. Byzova, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio, USA
  • Edited by Paolo Gresele, Università degli Studi di Perugia, Italy, Clive P. Page, Valentin Fuster, Jos Vermylen, Universiteitsbibliotheek-K.U., Leuven
  • Book: Platelets in Thrombotic and Non-Thrombotic Disorders
  • Online publication: 10 May 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511545283.014
Available formats
×