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Chapter 16 - Placental Size, Shape, and Umbilical Cord Abnormalities

from Section 6 - Other Pathologic Processes

Published online by Cambridge University Press:  03 September 2018

By
Raymond W. Redline
Edited by
Raymond W. Redline ,
Theonia K. Boyd  and
Drucilla J. Roberts
Raymond W. Redline
Affiliation:
Case Western Reserve University, Ohio
Theonia K. Boyd
Affiliation:
Harvard Medical School, Boston
Drucilla J. Roberts
Affiliation:
Harvard Medical School, Boston
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Placental and Gestational Pathology , pp. 157 - 180
Publisher: Cambridge University Press
Print publication year: 2017

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References

Fried, AM. Distribution of the bulk of the normal placenta. Review and classification of 800 cases by ultrasonography. Am J Obstet Gynecol. 1978;132:675–80.Google Scholar
Pathak, S, Hook, E, Hackett, G, et al. Cord coiling, umbilical cord insertion and placental shape in an unselected cohort delivering at term: relationship with common obstetric outcomes. Placenta. 2010;31:963–8.CrossRefGoogle Scholar
Salafia, CM, Misra, DP, Yampolsky, M, et al. Allometric metabolic scaling and fetal and placental weight. Placenta. 2009;30:355–60.Google Scholar
Salafia, CM, Zhang, J, Miller, RK, et al. Placental growth patterns affect birth weight for given placental weight. Birth Defects Res A Clin Mol Teratol. 2007;79:281–8.Google Scholar
Salafia, CM, Zhang, J, Charles, AK, et al. Placental characteristics and birthweight. Paediatr Perinat Epidemiol. 2008;22:229–39.CrossRefGoogle ScholarPubMed
Salafia, CM, Yampolsky, M, Shlakhter, A, et al. Variety in placental shape: when does it originate? Placenta. 2012;33:164–70.Google Scholar
Redline, RW, Patterson, P. Patterns of placental injury: correlations with gestational age, placental weight, and clinical diagnosis. Arch Pathol Lab Med. 1994;118:698–701.Google Scholar
Naeye, RL. Do Placental Weights Have Clinical Significance? Hum Pathol. 1987;18:387–91.Google Scholar
Yong, PJ, von Dadelszen, P, McFadden, DE, et al. Placental weight in pregnancies with trisomy confined to the placenta. J Obstet Gynaecol Can. 2009;31:605–10.CrossRefGoogle ScholarPubMed
Sawady, J, Mercer, BM, Wapner, RJ, et al. The National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network Beneficial Effects of Antenatal Repeated Steroids study: impact of repeated doses of antenatal corticosteroids on placental growth and histologic findings. Am J Obstet Gynecol. 2007;197:281 e1–8.Google Scholar
McNamara, H, Hutcheon, JA, Platt, RW, et al. Risk factors for high and low placental weight. Paediatr Perinat Epidemiol. 2014;28:97–105.CrossRefGoogle ScholarPubMed
Williams, LA, Evans, SF, Newnham, JP. Prospective cohort study of factors influencing the relative weights of the placenta and the newborn infant. BMJ. 1997;314:1864–8.Google Scholar
Wallace, JM, Horgan, GW, Bhattacharya, S. Placental weight and efficiency in relation to maternal body mass index and the risk of pregnancy complications in women delivering singleton babies. Placenta. 2012;33:611–8.Google Scholar
McCowan, LM, Becroft, DM. Beckwith-Wiedemann syndrome, placental abnormalities, and gestational proteinuric hypertension. Obstet Gynecol. 1994;83:813–7.Google Scholar
Leon-Garcia, SM, Roeder, HA, Nelson, KK, et al. Maternal obesity and sex-specific differences in placental pathology. Placenta. 2016;38:33–40.Google Scholar
Eskild, A, Romundstad, PR, Vatten, LJ. Placental weight and birthweight: does the association differ between pregnancies with and without preeclampsia? Am J Obstet Gynecol. 2009;201:595 e1–5.Google Scholar
Salafia, C. Why placental shape and vasculature matter. ObGyn News. 2016;51:6–7.Google Scholar
Misra, DP, Salafia, CM, Miller, RK, et al. Non-linear and gender-specific relationships among placental growth measures and the fetoplacental weight ratio. Placenta. 2009;30:1052–7.Google Scholar
Lao, TT, Wong, WM. Implications of a high placental ratio in pregnancies with appropriate-for-gestational age neonates. Gynecol Obstet Invest. 2001;52:34–7.Google Scholar
Macdonald, EM, Natale, R, Regnault, TR, et al. Obstetric conditions and the placental weight ratio. Placenta. 2014;35:582–6.Google Scholar
Redline, RW, Boyd, T, Campbell, V, et al. Maternal vascular underperfusion: nosology and reproducibility of placental reaction patterns. Pediatr Dev Pathol. 2004;7:237–49.Google Scholar
Hiden, U, Glitzner, E, Hartmann, M, et al. Insulin and the IGF system in the human placenta of normal and diabetic pregnancies. J Anat. 2009;215:60–8.Google Scholar
Roberts, DJ, Ampola, MG, Lage, JM. Diagnosis of unsuspected fetal metabolic storage disease by routine placental examination. Pediatr Pathol. 1991;11:647–56.Google Scholar
Zalel, Y, Lehavi, O, Schiff, E, et al. Shortened fetal long bones: a possible in utero manifestation of placental function. Prenat Diagn. 2002;22:553–7.Google Scholar
Hutcheon, JA, McNamara, H, Platt, RW, et al. Placental weight for gestational age and adverse perinatal outcomes. Obstet Gynecol. 2012;119:1251–8.Google Scholar
Shehata, F, Levin, I, Shrim, A, et al. Placenta/birthweight ratio and perinatal outcome: a retrospective cohort analysis. BJOG. 2011;118:741–7.Google Scholar
Straughen, J, Divine, G, Perez-Avilan, G, et al. Placental predictors of childhood body size. Placenta. 2016;45:111.Google Scholar
Barker, DJ, Bull, AR, Osmond, C, et al. Fetal and placental size and risk of hypertension in adult life. BMJ. 1990;301:259–62.Google Scholar
Wen, X, Triche, EW, Hogan, JW, et al. Association between placental morphology and childhood systolic blood pressure. Hypertension. 2011;57:48–55.Google Scholar
Risnes, KR, Romundstad, PR, Nilsen, TI, et al. Placental weight relative to birth weight and long-term cardiovascular mortality: findings from a cohort of 31,307 men and women. Am J Epidemiol. 2009;170:622–31.Google Scholar
Kraus, FT, Redline, R, Gersell, DJ, et al. Placental Pathology. Washington, D.C.: American Registry of Pathology; 2004.Google Scholar
Proctor, LK, Toal, M, Keating, S, et al. Placental size and the prediction of severe early-onset intrauterine growth restriction in women with low pregnancy-associated plasma protein-A. Ultrasound Obstet Gynecol. 2009;34:274–82.Google Scholar
Kajantie, E, Thornburg, KL, Eriksson, JG, et al. In preeclampsia, the placenta grows slowly along its minor axis. Int J Dev Biol. 2009;54:469–73.Google Scholar
Endler, M, Saltvedt, S, Papadogiannakis, N. Macroscopic and histological characteristics of retained placenta: A prospectively collected case-control study. Placenta. 2016;41:39–44.Google Scholar
Costantini, D, Walker, M, Milligan, N, et al. Pathologic basis of improving the screening utility of 2-dimensional placental morphology ultrasound. Placenta. 2012;33:845–9.CrossRefGoogle ScholarPubMed
Jauniaux, E, Hempstock, J, Greenwold, N, et al. Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies. Am J Pathol. 2003;162:115–25.Google Scholar
Alwasel, SH, Abotalib, Z, Aljarallah, JS, et al. The breadth of the placental surface but not the length is associated with body size at birth. Placenta. 2012;33:619–22.Google Scholar
Yampolsky, M, Salafia, CM, Misra, DP, et al. Is the placental disk really an ellipse? Placenta. 2013;34:391–3.Google Scholar
Eriksson, JG, Kajantie, E, Thornburg, KL, et al. Mother’s body size and placental size predict coronary heart disease in men. Eur Heart J. 2011;32:2297–303.Google Scholar
Eriksson, JG, Kajantie, E, Osmond, C, et al. Boys live dangerously in the womb. Am J Hum Biol. 2010;22:330–5.Google Scholar
Jauniaux, E, Ramsay, B, Campbell, S. Ultrasonographic investigation of placental morphologic characteristics and size during the second trimester of pregnancy. Am J Obstet Gynecol. 1994;170:130–7.Google Scholar
Eriksson, JG, Gelow, J, Thornburg, KL, et al. Long-term effects of placental growth on overweight and body composition. Int J Pediatr. 2012;2012:324185.Google Scholar
van Abeelen, AF, de Rooij, SR, Osmond, C, et al. The sex-specific effects of famine on the association between placental size and later hypertension. Placenta. 2011;32:694–8.Google Scholar
Barker, DJ, Osmond, C, Thornburg, KL, et al. The lifespan of men and the shape of their placental surface at birth. Placenta. 2011;32:783–7.Google Scholar
Fitzgerald, B, Kingdom, J, Keating, S. Distal villous hypoplasia. Diagn Histopathol. 2012;18 (5):195–200.Google Scholar
Porat, S, Fitzgerald, B, Wright, E, et al. Placental hyperinflation and the risk of adverse perinatal outcome. Ultrasound Obstet Gynecol. 2013;42:315–21.Google Scholar
Raio, L, Ghezzi, F, Cromi, A, et al. The thick heterogeneous (jellylike) placenta: a strong predictor of adverse pregnancy outcome. Prenat Diagn. 2004;24:182–8.Google Scholar
Blackburn, W, Cooley, NR. The Umbilical Cord. In: Stevenson, RE, Hall, JG, Goodman, RM, editors. Human Malformations and Related Anomalies. New York, NY: Oxford University Press; 1993.Google Scholar
Fox, H. Pathology of the Placenta. 2nd ed. London, UK: W. B. Saunders; 1997.Google Scholar
Catanzarite, V, Cousins, L, Daneshmand, S, et al. Prenatally Diagnosed Vasa Previa: A Single-Institution Series of 96 Cases. Obstet Gynecol. 2016;128:1153–61.Google Scholar
Hertig, A. Human Trophoblast. Springfield, IL: C. C. Thomas; 1968.Google Scholar
Benirschke, K, Burton, G, Baergen, RN, editors. Pathology of the Human Placenta. 6th ed. New York, NY: Springer; 2012.Google Scholar
Schwartz, N, Mandel, D, Shlakhter, O, et al. Placental morphologic features and chorionic surface vasculature at term are highly correlated with 3-dimensional sonographic measurements at 11 to 14 weeks. J Ultrasound Med. 2011;30:1171–8.Google Scholar
Yampolsky, M, Salafia, CM, Shlakhter, O, et al. Modeling the variability of shapes of a human placenta. Placenta. 2008;29:790–7.Google Scholar
Ahmed, A, Gilbert-Barness, E. Placenta membranacea: a developmental anomaly with diverse clinical presentation. Pediatr Dev Pathol. 2003;6:201–2.Google Scholar
Greenberg, JA, Sorem, KA, Shifren, JL, et al. Placenta membranacea with placenta increta: a case report and literature review. Obstet Gynecol. 1991;78:512–4.Google Scholar
Heras, JL, Harding, PG, Haust, MD. Recurrent bleeding associated with placenta membranacea partialis: report of a case. Am J Obstet Gynecol. 1982;144:480–2.Google Scholar
Luo, G, Redline, RW. Peripheral insertion of umbilical cord. Pediatr Dev Pathol. 2013;16:399–404.Google Scholar
Raisanen, S, Georgiadis, L, Harju, M, et al. Risk factors and adverse pregnancy outcomes among births affected by velamentous umbilical cord insertion: a retrospective population-based register study. Eur J Obstet Gynecol Reprod Biol. 2012;165:231–4.Google Scholar
Heinonen, S, Ryynanen, M, Kirkinen, P, et al. Elevated midtrimester maternal serum hCG in chromosomally normal pregnancies is associated with preeclampsia and velamentous umbilical cord insertion. Am J Perinatol. 1996;13:437–41.Google Scholar
Heinonen, S, Ryynanen, M, Kirkinen, P, et al. Velamentous umbilical cord insertion may be suspected from maternal serum alpha-fetoprotein and hCG. Br J Obstet Gynaecol. 1996;103:209–13.Google Scholar
Heinonen, S, Ryynanen, M, Kirkinen, P, et al. Perinatal diagnostic evaluation of velamentous umbilical cord insertion: clinical, Doppler, and ultrasonic findings. Obstet Gynecol. 1996;87:112–7.Google Scholar
Redline, R, Shah, D, Sakar, H, et al. Placental lesions associated with abnormal growth in twins. Pediat and Devel Pathol. 2001;4:473–81.Google Scholar
Costa-Castro, T, Zhao, DP, Lipa, M, et al. Velamentous cord insertion in dichorionic and monochorionic twin pregnancies – Does it make a difference? Placenta. 2016;42:87–92.Google Scholar
Robinson, LK, Jones, KL, Benirschke, K. The nature of structural defects associated with velamentous and marginal insertion of the umbilical cord. Am J Obstet Gynecol. 1983;146:191–3.Google Scholar
Gordon, Z, Eytan, O, Jaffa, AJ, et al. Fetal blood flow in branching models of the chorionic arterial vasculature. Ann N Y Acad Sci. 2007;1101:250–65.Google Scholar
Nordenvall, M, Sandstedt, B, Ulmsten, U. Relationship between placental shape, cord insertion, lobes and gestational outcome. Acta Obstet Gynecol Scand. 1988;67:611–6.Google Scholar
Hasegawa, J, Matsuoka, R, Ichizuka, K, et al. Cord insertion into the lower third of the uterus in the first trimester is associated with placental and umbilical cord abnormalities. Ultrasound Obstet Gynecol. 2006;28:183–6.Google Scholar
Proctor, LK, Fitzgerald, B, Whittle, WL, et al. Umbilical cord diameter percentile curves and their correlation to birth weight and placental pathology. Placenta. 2013;34:62–6.Google Scholar
Redline, RW. Clinical and pathological umbilical cord abnormalities in fetal thrombotic vasculopathy. Hum Pathol. 2004;35:1494–8.Google Scholar
Swank, ML, Garite, TJ, Maurel, K, et al. Vasa previa: diagnosis and management. Am J Obstet Gynecol. 2016;215:223 e1–6.CrossRefGoogle ScholarPubMed
Baergen, RN, Malicki, D, Behling, C, et al. Morbidity, mortality, and placental pathology in excessively long umbilical cords: retrospective study. Pediatr Dev Pathol. 2001;4:144–53.Google Scholar
Rayburn, WF, Beynen, A, Brinkman, DL. Umbilical cord-length and intrapartum complications. Obstet Gynecol. 1981;57:450–2.Google Scholar
Miller, ME, Higginbottom, M, Smith, DW. Short umbilical cord: its origin and relevance. Pediatrics. 1981;67:618–21.Google Scholar
LaMonica, GE, Wilson, ML, Fullilove, AM, et al. Minimum cord length that allows spontaneous vaginal delivery. J Reprod Med. 2008;53:217–9.Google Scholar
Raio, L, Ghezzi, F, Di Naro, E, et al. Prenatal diagnosis of a lean umbilical cord: a simple marker for the fetus at risk of being small for gestational age at birth. Ultrasound Obstet Gynecol. 1999;13:176–80.Google Scholar
Raio, L, Ghezzi, F, Di Naro, E, et al. Altered sonographic umbilical cord morphometry in early-onset preeclampsia. Obstet Gynecol. 2002;100:311–6.Google Scholar
Roche, N, Skurnick, J, Brown, K, et al. Do stillborns with no identifiable pathology have leaner cords than liveborns? J Reprod Med. 2008;53:283–6.Google Scholar
Casola, G, Scheible, W, Leopold, GR. Large umbilical cord: a normal finding in some fetuses. Radiology. 1985;156:181–2.Google Scholar
Moessinger, AC, Blanc, WA, Merone, PA, et al. Umbilical cord length as an index of fetal activity: experimental study and clinical implications. Pediatr Res. 1982;16:109–12.Google Scholar
Georgiadis, L, Keski-Nisula, L, Harju, M, et al. Umbilical cord length in singleton gestations: a Finnish population-based retrospective register study. Placenta. 2014;35:275–80.Google Scholar
Cardoso, LE, Erlich, RB, Rudge, MC, et al. A comparative analysis of glycosaminoglycans from human umbilical arteries in normal subjects and in pathological conditions affecting pregnancy. Lab Invest. 1992;67:588–95.Google Scholar
Mills, JL, Harley, EE, Moessinger, AC. Standards for measuring umbilical cord length. Placenta. 1983;4:423–6.Google Scholar
Downey, A, Hore, K, McAuliffe, FM, et al. Umbilical cord shortening: quantification postdelivery and postfixation. Pediatr Dev Pathol. 2014;17:327–9.CrossRefGoogle ScholarPubMed
Chang, KT, Keating, S, Costa, S, et al. Third-trimester stillbirths: correlative neuropathology and placental pathology. Pediatr Dev Pathol. 2011;14:345–52.Google Scholar
Strong, TH Jr., Jarles, DL, Vega, JS, et al. The umbilical coiling index. Am J Obstet Gynecol. 1994;170:29–32.Google Scholar
Peng, HQ, Levitin-Smith, M, Rochelson, B, et al. Umbilical cord stricture and overcoiling are common causes of fetal demise. Pediatr Dev Pathol. 2006;9:14–9.Google Scholar
Machin, GA, Ackerman, J, Gilbert-Barness, E. Abnormal umbilical cord coiling is associated with adverse perinatal outcomes. Pediatr Dev Pathol. 2000;3:462–71.Google Scholar
de Laat, MW, Franx, A, Bots, ML, et al. Umbilical coiling index in normal and complicated pregnancies. Obstet Gynecol. 2006;107:1049–55.Google Scholar
Ernst, LM, Minturn, L, Huang, MH, et al. Gross patterns of umbilical cord coiling: Correlations with placental histology and stillbirth. Placenta. 2013;34:583–8.Google Scholar
Lacro, RV, Jones, KL, Benirschke, K. The umbilical cord twist: origin, direction, and relevance. Am J Obstet Gynecol. 1987;157:833–8.Google Scholar
Rana, J, Ebert, GA, Kappy, KA. Adverse perinatal outcome in patients with an abnormal umbilical coiling index. Obstet Gynecol. 1995;85:573–7.Google Scholar
Degani, S, Lewinsky, RM, Berger, H, et al. Sonographic estimation of umbilical coiling index and correlation with Doppler flow characteristics. Obstet Gynecol. 1995;86:990–3.Google Scholar
Cromi, A, Ghezzi, F, Durig, P, et al. Sonographic umbilical cord morphometry and coiling patterns in twin-twin transfusion syndrome. Prenat Diagn. 2005;25:851–5.Google Scholar
Sun, Y, Arbuckle, S, Hocking, G, et al. Umbilical cord stricture and intrauterine fetal death. Pediatr Pathol Lab Med. 1995;15:723–32.Google Scholar
French, AE, Gregg, VH, Newberry, Y, et al. Umbilical cord stricture: a cause of recurrent fetal death. Obstet Gynecol. 2005;105:1235–9.Google Scholar
Rodriguez, JI, Marino-Enriquez, A, Suarez-Aguado, J, et al. Umbilical cord stricture is not a genetic anomaly: a study in twins. Pediatr Dev Pathol. 2008;11:363–9.Google Scholar
de Laat, MW, Nikkels, PG, Franx, A, et al. The Roach muscle bundle and umbilical cord coiling. Early Hum Dev. 2007;83:571–4.Google Scholar
Georgiou, HM, Rice, GE, Walker, SP, et al. The effect of vascular coiling on venous perfusion during experimental umbilical cord encirclement. Am J Obstet Gynecol. 2001;184:673–8.Google Scholar
Skulstad, SM, Kiserud, T, Rasmussen, S. Degree of fetal umbilical venous constriction at the abdominal wall in a low-risk population at 20–40 weeks of gestation. Prenat Diagn. 2002;22:1022–7.Google Scholar
Blickstein, I, Varon, Y, Varon, E. Implications of differences in coiling indices at different segments of the umbilical cord. Gynecol Obstet Invest. 2001;52:203–6.Google Scholar
de Laat, MW, van der Meij, JJ, Visser, GH, et al. Hypercoiling of the umbilical cord and placental maturation defect: associated pathology? Pediatr Dev Pathol. 2007;10:293–9.Google Scholar
Redline, RW. Cerebral palsy in term infants: a clinicopathologic analysis of 158 medicolegal case reviews. Pediatr Dev Pathol. 2008;11:456–64.Google Scholar
Weber, MA, Sau, A, Maxwell, DJ, et al. Third trimester intrauterine fetal death caused by arterial aneurysm of the umbilical cord. Pediatr Dev Pathol. 2007;10:305–8.Google Scholar
Bendon, RW, Tyson, RW, Baldwin, VJ, et al. Umbilical cord ulceration and intestinal atresia: a new association? Am J Obstet Gynecol. 1991;164:582–6.Google Scholar
Ichinose, M, Takemura, T, Andoh, K, et al. Pathological analysis of umbilical cord ulceration associated with fetal duodenal and jejunal atresia. Placenta. 2010;31:1015–8.Google Scholar
Qureshi, F, Jacques, SM. Marked segmental thinning of the umbilical cord vessels. Arch Pathol Lab Med. 1994;118:826–30.Google Scholar
Labarrere, C, Sebastiani, M, Siminovich, M, et al. Absence of Wharton’s jelly around the umbilical arteries: an unusual cause of perinatal mortality. Placenta. 1985;6:555–9.Google Scholar
Collins, JH, Collins, CL, Collins, CC. Umbilical Cord Accidents 2010. pregnancyinst.com/UmbilicalCordAccidents2.pdfGoogle Scholar
Sentilhes, L, Vivet-Lefebure, A, Patrier, S, et al. Umbilical artery aneurysm in a severe growth-restricted fetus with normal karyotype. Prenat Diagn. 2007;27:1059–61.Google Scholar
Wang, G, Bove, KE, Stanek, J. Pathological evidence of prolonged umbilical cord encirclement as a cause of fetal death. Am J Perinatol. 1998;15:585–8.Google Scholar
King, EL, Redline, RW, Smith, SD, et al. Myocytes of chorionic vessels from placentas with meconium associated vascular necrosis exhibit apoptotic markers. Hum Pathol. 2004;35:412–7.Google Scholar
Froehlich, LA, Fujikura, T. Significance of a single umbilical artery. Report from the collaborative study of cerebral palsy. Am J Obstet Gynecol. 1966;94:274–9.Google Scholar
Khong, TY, George, K. Chromosomal abnormalities associated with a single umbilical artery. Prenat Diagn. 1992;12:965–8.Google Scholar
Murphy-Kaulbeck, L, Dodds, L, Joseph, KS, et al. Single umbilical artery risk factors and pregnancy outcomes. Obstet Gynecol. 2010;116:843–50.Google Scholar
Martinez-Frias, ML, Bermejo, E, Rodriguez-Pinilla, E, et al. Does single umbilical artery (SUA) predict any type of congenital defect? Clinical-epidemiological analysis of a large consecutive series of malformed infants. Am J Med Genet A. 2008;146A:15–25.Google Scholar
Battarbee, AN, Palatnik, A, Ernst, LM, et al. Association of Isolated Single Umbilical Artery With Small for Gestational Age and Preterm Birth. Obstet Gynecol. 2015;126:760–4.Google Scholar
Dolkart, LA, Reimers, FT, Kuonen, CA. Discordant umbilical arteries: ultrasonographic and Doppler analysis. Obstet Gynecol. 1992;79:59–63.Google Scholar
Raio, L, Ghezzi, F, di Naro, E, et al. In-utero characterization of the blood flow in the Hyrtl anastomosis. Placenta. 2001;22:597–601.Google Scholar
Gamzu, R, Zalel, Y, Jacobson, JM, et al. Type II single umbilical artery (persistent vitelline artery) in an otherwise normal fetus. Prenat Diagn. 2002;22:1040–3.Google Scholar
Bourke, WG, Clarke, TA, Mathews, TG, et al. Isolated single umbilical artery–the case for routine renal screening. Arch Dis Child. 1993;68:600–1.Google Scholar
Fortune, DW, Ostor, AG. Angiomyxomas of the umbilical cord. Obstet Gynecol. 1980;55:375–8.Google Scholar
Kilicdag, EB, Kilicdag, H, Bagis, T, et al. Large pseudocyst of the umbilical cord associated with patent urachus. J Obstet Gynaecol Res. 2004;30:444–7.Google Scholar
Schaefer, IM, Manner, J, Faber, R, et al. Giant umbilical cord edema caused by retrograde micturition through an open patent urachus. Pediatr Dev Pathol. 2010;13:404–7.Google Scholar
Sepulveda, W, Gutierrez, J, Sanchez, J, et al. Pseudocyst of the umbilical cord: prenatal sonographic appearance and clinical significance. Obstet Gynecol. 1999;93:377–81.Google Scholar
Yavner, DL, Redline, RW. Angiomyxoma of the umbilical cord with massive cystic degeneration of Wharton’s jelly. Arch Pathol Lab Med. 1989;113:935–7.Google Scholar
Jauniaux, E, De Munter, C, Vanesse, M, et al. Embryonic remnants of the umbilical cord: morphologic and clinical aspects. Hum Pathol. 1989;20:458–62.Google Scholar
Vougiouklakis, T, Mitselou, A, Zikopoulos, K, et al. Ruptured hemangioma of the umbilical cord and intrauterine fetal death, with review data. Pathol Res Pract. 2006;202:537–40.Google Scholar
Daniel-Spiegel, E, Weiner, E, Gimburg, G, et al. The association of umbilical cord hemangioma with fetal vascular birthmarks. Prenat Diagn. 2005;25:300–3.Google Scholar

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