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65 - Liver transplantation

from Part VII - Transplantation

Published online by Cambridge University Press:  08 January 2010

By
Paolo Muiesan  and
Nigel D. Heaton
Edited by
Mark D. Stringer ,
Keith T. Oldham  and
Pierre D. E. Mouriquand
Paolo Muiesan
Affiliation:
Liver Transplant Surgical Services, Institute of Liver Studies, King's College Hospital, London, UK
Nigel D. Heaton
Affiliation:
Liver Transplant Surgical Services, Institute of Liver Studies, King's College Hospital, London, UK
Mark D. Stringer
Affiliation:
University of Otago, New Zealand
Keith T. Oldham
Affiliation:
Children's Hospital of Wisconsin
Pierre D. E. Mouriquand
Affiliation:
Debrousse Hospital, Lyon
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Summary

Historical aspects

Over the past 40 years, orthotopic liver transplantation (OLT) has evolved from an experimental procedure to a routine treatment of end-stage liver failure in children. The first attempt at pediatric liver transplantation by Thomas Starzl in 1963 was not successful but 4 years later he reported the first survivor. These early liver transplants were in high-risk recipients and hemorrhage, coagulopathy, and poor graft function resulted in significant intraoperative and early postoperative mortality. Prednisolone and azathioprine were the primary immunosuppressive drugs but some regimens included combinations of cyclophosphamide, anti-lymphocyte globulin, splenectomy, total body irradiation, and thymectomy. Despite advances in surgical techniques, 1-year survival after liver transplantation remained poor and by 1978 was only 30%.

The introduction of the immunosuppressant, cyclosporin, into clinical practice in 1979 transformed the outcome after OLT. Cyclosporin acts by blocking lymphocyte production of interleukin-2 and other cytokines thereby reducing the incidence and severity of acute cellular rejection. The combination of cyclosporin and corticosteroids resulted in a marked increase in graft and patient survival and reduced the need for long-term use of high dose steroids with their attendant side effects. The National Institute of Health consensus conference in 1983 concluded that liver transplantation for end-stage liver disease deserved broad application as a therapeutic option rather than an experimental procedure.

The development of newer immunosuppressive drugs, refinements in operative techniques, improved organ preservation and donor management and advances in anesthetic and intensive care have contributed further to improvements in recipient survival.

Type
Chapter
Information
Pediatric Surgery and Urology
Long-Term Outcomes
 , pp. 858 - 883
Publisher: Cambridge University Press
Print publication year: 2006

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References

Starzl, T. E., Marchioro, T. L., Kaulla, K.et al.Homotransplantation of the liver in humans. Surg. Gynecol. Obstet. 1963; 117:659–676.Google ScholarPubMed
National Institutes of Health Consensus Development Conference Statement: Liver Transplantation. June 20–23, 1983. Hepatology 1984; 4 (suppl): 107S–110S.CrossRef
Williams, R., Portmann, B., & Tan, K. C.The Practice of Liver Transplantation. Edinburgh: Churchill Livingstone, 1995.Google Scholar
Grady, O' J. G., Alexander, G. J., Hayllar, K. M., & Williams, R.Early indicators of prognosis in fulminant hepatic failure. Gastroenterology 1989; 97:439–445.CrossRefGoogle Scholar
Corbally, M. T., Rela, M., Heaton, N. D.et al.Orthotopic liver transplantation for acute hepatic failure in children. Transpl. Int. 1994; 7:S104–S107.Google ScholarPubMed
Starzl, T. E., Demetris, A. J., & Thiel, D.Liver transplantation (1). N. Engl. J. Med. 1989; 321:1014–1022.CrossRefGoogle Scholar
Casavilla, A., Ramirez, C., Shapiro, R.et al.Experience with liver and kidney allografts from non-heart-beating donors. Transplantation 1995; 59:197–203.CrossRefGoogle ScholarPubMed
Bismuth, H. & Houssin, D.Reduced size orthotopic liver graft in hepatic transplantation in children. Surgery 1984; 95:367–370.Google Scholar
Deshpande, R. R., Bowles, M. J., Vilca-Melendez, H.et al.Results of split liver transplantation in children. Ann. Surg. 2002; 236:248–253.CrossRefGoogle ScholarPubMed
Raia, S., Nery, J. R., & Mies, S.Liver transplantation from live donors. Lancet 1989; 2(8661):497.CrossRefGoogle ScholarPubMed
Broelsch, C. E., Whitington, P. F., Emond, J. C.et al.Liver transplantation in children from living related donors. Surgical techniques and results. Ann. Surg. 1991; 214:428–439.CrossRefGoogle ScholarPubMed
Ozawa, K., Vemoto, S., Tanaka, K.et al.An appraisal of pediatric liver transplantation from living relatives. Ann. Surg. 1992; 216:547–553.CrossRefGoogle ScholarPubMed
Reding, R., Goyet, J., V., Delbeke, I.et al.Pediatric liver transplantation with cadaveric or living related donors: comparative results in 90 elective recipients of primary grafts. J. Pediatr. 1999; 134:280–286.CrossRefGoogle ScholarPubMed
Liu, C. L., Fan, S. T., Lo, C. M.et al.Live donor liver transplantation for fulminant hepatic failure in children. Liver. Transpl. 2003; 9:1185–1190.CrossRefGoogle ScholarPubMed
Broering, D. C., Mueller, L., Ganschow, R.et al.Is there still a need for living-related liver transplantation in children?Ann. Surg. 2001; 234:713–721.CrossRefGoogle Scholar
Kilpe, V. E., Krakauer, H., & Wren, R. E.An analysis of liver transplant experience from 37 transplant centers as reported to Medicare. Transplantation 1993; 56:554–561.CrossRefGoogle Scholar
Shaw, B. W. Jr, Wood, R. P., Stratta, R. J., Pillen, T. J., & Langnas, A. N.Stratifying the causes of death in liver transplant recipients. An approach to improving survival. Arch. Surg. 1989; 124:895–900.CrossRefGoogle ScholarPubMed
Busuttil, R. W., Seu, P., Millis, J. M.et al.Liver transplantation in children. Ann. Surg. 1991; 213:48–57.CrossRefGoogle ScholarPubMed
Otte, J. B., Ville de Goyet, J., Sokal, E.et al.Size reduction of the donor liver is a safe way to alleviate the shortage of size-matched organs in pediatric liver transplantation. Ann. Surg. 1990; 211:146–157.CrossRefGoogle ScholarPubMed
Broelsch, C. E., Emond, J. C., Thistlethwaite, J. R.et al.Liver transplantation, including the concept of reduced-size liver transplants in children. Ann. Surg. 1988; 208:410–420.CrossRefGoogle ScholarPubMed
Andrews, W. S., Wanek, E., Fyock, B., Gray, S., & Benser, M.Pediatric liver transplantation: a 3-year experience. J. Pediatr. Surg. 1989; 24:77–82.CrossRefGoogle ScholarPubMed
Fridell, J. A., Jain, A., Reyes, J.et al.Causes of mortality beyond 1 year after primary pediatric liver transplant under tacrolimus. Transplantation 2002; 74:1721–1724.CrossRefGoogle ScholarPubMed
Shaw, B. W. Jr., Wood, R. P., Stratta, R. J., Pillen, T. J., & Langnas, A. N.Stratifying the causes of death in liver transplant recipients. An approach to improving survival. Arch. Surg. 1989; 24:895–900.CrossRefGoogle Scholar
Bilik, R., Yellen, M., & Superina, R. A.Surgical complications in children after liver transplantation. J. Pediatr. Surg. 1992; 27:1371–1375.CrossRefGoogle ScholarPubMed
Farmer, D. G., Yersiz, H., Ghobrial, R. M.et al.Early graft function after pediatric liver transplantation: comparison between in situ split liver grafts and living-related liver grafts. Transplantation 2001; 72:1795–1802.CrossRefGoogle ScholarPubMed
Sieders, E., Peeters, P. M., TenVergert, E. M.et al.Graft loss after pediatric liver transplantation. Ann. Surg. 2002; 235:125–132.CrossRefGoogle ScholarPubMed
Egawa, H., Shaked, A., Konishi, Y.et al.Arterial ketone body ratio in pediatric liver transplantation. Transplantation 1993; 55:522–526.CrossRefGoogle ScholarPubMed
Mazariegos, G. V., Toole, O' K., Mieles, L. A.et al.Hyperbaric oxygen therapy for hepatic artery thrombosis after liver transplantation in children. Liver. Transpl. Surg. 1999; 5:429–436.CrossRefGoogle ScholarPubMed
Stringer, M. D., Marshall, M. M., Muiesan, P.et al.Survival and outcome after hepatic artery thrombosis complicating pediatric liver transplantation. J. Pediatr. Surg. 2001; 36:888–891.CrossRefGoogle ScholarPubMed
Cheng, Y. F., Chen, C. L., Huang, T. L.et al.3D CT angiography for detection of vascular complications in pediatric liver transplantation. Liver Transpl. 2004; 10:248–252.CrossRefGoogle Scholar
Rela, M., Muiesan, P., Bhatnagar, V.et al.Hepatic artery thrombosis after liver transplantation in children under 5 years of age. Transplantation 1996; 61:1355–1357.CrossRefGoogle ScholarPubMed
Valente, J. F., Alonso, M. H., Weber, F. L., & Hanto, D. W.Late hepatic artery thrombosis in liver allograft recipients is associated with intrahepatic biliary necrosis. Transplantation 1996; 61:61–65.CrossRefGoogle ScholarPubMed
Langnas, A. N., Marujo, W., Stratta, R. J., Wood, R. P., & Shaw, B. W. Jr.Vascular complications after orthotopic liver transplantation. Am. J. Surg. 1991; 161:76–82.CrossRefGoogle ScholarPubMed
Millis, J. M., Seaman, D. S., Piper, J. B.et al.Portal vein thrombosis and stenosis in pediatric liver transplantation. Transplantation 1996; 62:748–754.CrossRefGoogle ScholarPubMed
Buell, J. F., Funaki, B., Cronin, D. C.et al.Long-term venous complications after full-size and segmental pediatric liver transplantation. Ann. Surg. 2002; 236:658–666.CrossRefGoogle ScholarPubMed
Ville de Goyet, J., Clapuyt, P., & Otte, J. B.Extrahilar mesenterico-left portal shunt to relieve extrahepatic portal hypertension after partial liver transplant. Transplantation 1992; 53:231–232.Google ScholarPubMed
Gane, E., Portmann, B., Saxena, R.et al.Nodular regenerative hyperplasia of the liver graft after liver transplantation. Hepatology 1994; 20:88–94.CrossRefGoogle ScholarPubMed
Kling, K., Lau, H., & Colombani, P.Biliary complications of living related pediatric liver transplant patients. Pediatr. Transpl. 2004; 8:178–184.CrossRefGoogle ScholarPubMed
Bhatnagar, V., Dhawan, A., Haider, C.et al.The incidence and management of biliary complications following liver transplantation in children. Transpl. Int. 1995; 8:388–391.CrossRefGoogle ScholarPubMed
Shaked, A., Vargas, J., Csete, M. E.et al.Diagnosis and treatment of bowel perforation following pediatric orthotopic liver transplantation. Arch. Surg. 1993; 128:994–998.CrossRefGoogle ScholarPubMed
Vilca Melendez, H., Vougas, V., Muiesan, P.et al.Bowel perforation after paediatric orthotopic liver transplantation. Transpl. Int. 1998; 11:301–304.CrossRefGoogle ScholarPubMed
Jain, A., Mazariegos, G., Pokharna, R.et al.The absence of chronic rejection in pediatric primary liver transplant patients who are maintained on tacrolimus-based immunosuppression: a long-term analysis. Transplantation 2003; 75:1020–1025.CrossRefGoogle ScholarPubMed
Sher, L. S., Cosenza, C. A., Michel, J.et al.Efficacy of tacrolimus as rescue therapy for chronic rejection in orthotopic liver transplantation: a report of the U.S. Multicenter Liver Study Group. Transplantation 1997; 64:258–263.Google ScholarPubMed
Klintmalm, G. B., Nery, J. R., Husberg, B. S., Gonwa, T. A., & Tillery, G. W.Rejection in liver transplantation. Hepatology 1989; 10:978–985.CrossRefGoogle ScholarPubMed
Aw, M. M., Taylor, R. M., Verma, A.et al.Basiliximab (Simulect) for the treatment of steroid-resistant rejection in pediatric liver transpland recipients: a preliminary experience. Transplantation 2003; 75:796–799.CrossRefGoogle ScholarPubMed
Cho, J. H., Bhatnagar, V., Andreani, P.et al.Chronic rejection in paediatric liver transplantation. Transpl. Proc. 1997; 29:4520–4533.CrossRefGoogle Scholar
Deen, J. L. & Blumberg, D. A.Infectious disease considerations in pediatric organ transplantation. Semin. Pediatr. Surg. 1993; 2:218–234.Google ScholarPubMed
Rubin, R. H.Prevention of infection in the liver transplant recipient. Liver Transpl. Surg. 1996; 2(5 Suppl 1):89–98.Google ScholarPubMed
Mellon, A., Shepherd, R. W., Faoagali, J. L.et al.Cytomegalovirus infection after liver transplantation in children. J. Gastroenterol. Hepatol. 1993; 8:540–544.CrossRefGoogle ScholarPubMed
Wiesner, R. H., Marin, E., Porayko, M. K.et al.Advances in the diagnosis, treatment, and prevention of cytomegalovirus infection after liver transplantation. Gastroenterol. Clin. North Am. 1993; 22:351–366.Google ScholarPubMed
Stratta, R. J., Shaefer, M. S., Markin, T. S.et al.Cytomegalovirus infection and disease after liver transplantation: an overview. Dig. Dis. Sci. 1992; 37:673–688.CrossRefGoogle ScholarPubMed
Martin, M., Manez, R., Linden, P.et al.A prospective randomized trial comparing sequential ganciclovir-high dose acyclovir to high dose acyclovir for prevention of cytomegalovirus disease in adult liver transplant recipients. Transplantation 1994; 58:779–785.CrossRefGoogle ScholarPubMed
Langnas, A. N., Markin, R. S., Inagaki, M.et al.Epstein–Barr virus hepatitis after liver transplantation. Am. J. Gastroenterol. 1994; 89:1066–1070.Google ScholarPubMed
Michaels, M. G., Green, M., Wald, E. R., & Starzl, T. E.Adenovirus infection in pediatric liver transplant recipients. J. Infect. Dis. 1992; 165:170–174.CrossRefGoogle ScholarPubMed
Green, M.Viral infections and pediatric liver transplantation. Pediatr. Transpl. 2002; 6:20–24.CrossRefGoogle ScholarPubMed
Broliden, K.Parvovirus B19 infection in pediatric solid-organ and bone marrow transplantation. Pediatr. Transpl. 2001; 5:320–330.CrossRefGoogle ScholarPubMed
Gerber, D. A., Green, M., Jaffe, R., Greenberg, D., Mazariegos, G., & Reyes, J.Cryptosporidial infections after solid organ transplantation in children. Pediatr. Transpl. 2000; 4:50–55.CrossRefGoogle ScholarPubMed
Halstead, A. C. & Nanji, A. A.Artificial lowering the serum creatinine levels in the presence of hyperbilirubinemia. J. Am. Med. Assoc. 1984; 251:38–39.CrossRefGoogle Scholar
Abu Elmagd, K., Fung, J. J., Alessiani, M.et al.The effect of graft function on FK 506 plasma levels, dosages and renal function, with particular reference to the liver. Transplantation 1991; 52:71–77.CrossRefGoogle ScholarPubMed
Platz, K. P., Meuller, A. R., & Blumhardt, G.Nephrotoxicity following orthotopic liver transplantation. Transplantation 1994; 58:170–178.CrossRefGoogle ScholarPubMed
Myers, B. D., Ross, J., Newton, L.et al.Cyclosporine-associated chronic nephropathy. N. Engl. J. Med. 1984; 311:699.CrossRefGoogle ScholarPubMed
Hiatt, J. R., Ament, M. E., Berquist, W. E.et al.Pediatric liver transplantation at UCLA. Transpl. Proc. 1987; 19:3282.Google ScholarPubMed
McDiarmid, S. V., Ettenger, R. B., Hawkins, R. A.et al.The impairment of true glomerular filtration rate in long-term cyclosporine treated pediatric allograft recipients. Transplantation 1990; 49:81–85.CrossRefGoogle ScholarPubMed
Thompson, M. E., Shapiro, A. P., Johnsen, A. M.et al.The contrasting effects of cyclosporin-A and azathioprine on arterial blood pressure and renal function following cardiac transplantation. Int. J. Cardiol. 1986; 11:219–229.CrossRefGoogle ScholarPubMed
Weidle, P. J. & Vlasses, P. H.Systemic hypertension associated with cyclosporin. A review. Drug Intel. Clin. Pharm. 1988; 22:443–450.CrossRefGoogle ScholarPubMed
Textor, S. C.De novo hypertension after liver transplantation. Clinical conference. Am. J. Hypertens. 1993; 22:257–267.Google Scholar
Egawa, H., Esquivel, C. O., So, S. K.et al.FK 506 conversion therapy in paediatric liver transplantation. Transplantation 1994; 57:1169–1173.CrossRefGoogle Scholar
Epstein, M.Calcium antagonists and renal protection. Kidney Int. 1992; 41:S66–S72.Google Scholar
Textor, S. C., Schwartz, L., Augustine, J.et al.Hypertension after transplantation; Hemodynamic and renal effects of labetalol and nifedipine monotherapy. (Abstr.) Am. J. Hypertens. 1992; 5:8A.Google Scholar
Ghosh, P., Evans, D. B., Tomlinson, S. A., & Calne, R. Y.Plasma lipids following renal transplantation. Transplantation 1973; 15:521–523.Google ScholarPubMed
Kobashigawa, J. A., Katznelson, S., Laks, H.et al.Effect of pravastatin on outcomes after cardiac transplantation. N. Engl. J. Med. 1995; 333:621–627.CrossRefGoogle ScholarPubMed
Sindhi, R.Sirolimus in pediatric transplant recipients. Transpl. Proc. 2003; 35(3 Suppl.):113S–114S.CrossRefGoogle ScholarPubMed
Yamamoto, S. & Kato, R.Hair growth-stimulating effects of cyclosporin A and tacrolimus, potent immunosuppressants. Skin. Pharmacol. 1994; 7:101–104.Google ScholarPubMed
Dyall-Smith, D., Trowell, H., & Dyall-Smith, M. L.Benign human papillomavirus infection in renal transplant recipients. J. Am. Acad. Dermatol. 1989; 21:167–179.Google Scholar
Ingelfinger, J. R., Grupe, W. E., Topor, M., & Levey, R. H.Warts in a pediatric renal transplant population. Int. J. Dermatol. 1991; 30:785–789.Google Scholar
Yuan, Z. F., Davis, A., Macdonald, K., & Bailey, R. R.Use of acitretin for the skin complications in renal transplant recipients. N. Z. Med. J. 1995; 108:255–256.Google ScholarPubMed
Plevak, D. J., Southorn, P. A., Narr, B. J.et al.Intensive care unit experience in the Mayo liver transplant program: the first 100 cases. Mayo Clin. Proc. 1989; 64:433–445.CrossRefGoogle ScholarPubMed
Bruijn, K. M., Klompmaker, I. J., Sloof, M. J. H.et al.Cyclosporin neurotoxicity late after liver transplantation. Transplantation 1989; 47:575–576.Google ScholarPubMed
European FK506 Multicentre Liver Study Group. Randomised trial comparing tacrolimus (FK506) and cyclosporin in prevention of liver allograft rejection. Lancet 1994; 344:423–428.CrossRef
US Multicentre FK506 Liver Study Group A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression in liver transplantation. N. Engl. J. Med. 1994; 331:1110–1115.CrossRef
Lopez, O. L., Estol, C., Colina, I., Quirogga, J., lmvertarza, O. C., & Thiel, D. H.Neurological complications after liver retransplantation. Hepatology 1992; 16:162–166.CrossRefGoogle ScholarPubMed
Bennett, M. W. R., Webster, N. R., & Sadek, S. A.Alterations in plasma magnesium concentrations during liver transplantation. Transplantation 1993; 56:859–861.CrossRefGoogle ScholarPubMed
Adams, D. H., Gunson, B., Honigsberger, L.et al.Neurological complications following liver transplantation. Lancet 1987; 1:949–951.CrossRefGoogle ScholarPubMed
Noll, R. B. & Kulkarni, R.Complex visual hallucinations and cyclosporin. Arch. Neurol. 1984; 41:329–330.CrossRefGoogle Scholar
Di Martini, A., Pajer, K., Trzepacz, P., Fung, J., Starzi, T., & Tringali, R.Psychiatric morbidity in liver transplant patients. Transpl. Proc. 1991; 23:3179–3180.Google Scholar
Penn, I.The changing patterns of posttransplant malignancies. Transpl. Proc. 1991; 23:1101–1103.Google Scholar
Penn, I.Cancers complicating organ transplantation. (Editorial) N. Engl. J. Med. 1990; 323:1767–1769.CrossRefGoogle ScholarPubMed
Penn, I.Why do immunosuppressed patients develop cancer?Crit. Rev. Oncogen. 1989; 1:27–52.Google ScholarPubMed
Lee, E. S., Locker, J., Nalesnik, M.et al.The association of Epstein-Barr virus with smooth-muscle tumors occurring after organ transplantation. N. Engl. J. Med. 1995; 332:19–25.CrossRefGoogle ScholarPubMed
Brichard, B., Smets, F., Sokal, E.et al.Unusual evolution of an Epstein–Barr virus-associated leiomyosarcoma occurring after liver transplantation. Pediatr. Transpl. 2001; 5:365–369.CrossRefGoogle ScholarPubMed
Jain, A., Nalesnik, M., Reyes, J.et al.Posttransplant lymphoproliferative disorders in liver transplantation: a 20-year experience. Ann. Surg. 2002; 236:429–436.CrossRefGoogle ScholarPubMed
Morgan, G. & Superina, R. A.Lymphoproliferative disease after pediatric liver transplantation. J. Pediatr. Surg. 1994; 29:1192–1196.CrossRefGoogle ScholarPubMed
Malatack, J. F., Gartner, J. C., Urbach, A. H., & Zitelli, B. J.Orthotopic liver transplantation, Epstein–Barr virus, cyclosporine, and lymphoproliferative disease: a growing concern. J. Pediatr. 1991; 118:667–675.CrossRefGoogle ScholarPubMed
Ho, M., Miller, G., Atchinson, R. W.et al.Epstein–Barr virus infections and DNA hybridization studies in posttransplantation lymphoma and lymphoproliferative lesions: the role of primary infection. J. Infect. Dis. 1985; 152:876–886.CrossRefGoogle ScholarPubMed
Cohen, J.Epstein–Barr virus lymphoproliferative disease associated with acquired immunodeficiency. Medicine 1991; 70:137–160.CrossRefGoogle ScholarPubMed
Oertel, S. H., Anagnostopoulos, I., Bechstein, W. O.et al.Treatment of posttransplant lymphoproliferative disorder with the anti-CD20 monoclonal antibody rituximab alone in an adult after liver transplantation: a new drug in therapy of patients with posttransplant lymphoproliferative disorder after solid organ transplantation?Transplantation 2000; 69:430–432.CrossRefGoogle Scholar
Serinet, M. O., Jacquemin, E., Habes, D., Debray, D., Fabre, M., & Bernard, O.Anti-CD20 monoclonal antibody (Rituximab) treatment for Epstein–Barr virus-associated, B-cell lymphoproliferative disease in pediatric liver transplant recipients. J. Pediatr. Gastroenterol. Nutr. 2002; 34:389–393.CrossRefGoogle ScholarPubMed
Benkerrou, M., Durandy, A., & Fischer, A.Therapy for transplant-related lymphoproliferative diseases. Hematol. Oncol. Clin. North Am. 1993; 7:467–475.CrossRefGoogle ScholarPubMed
Abu-Elmagd, K., Bronsther, O., Jain, A.et al.Recent advances in hepatic transplantation at the University of Pittsburgh. Clin. Transpl. 1993; 137–152.Google ScholarPubMed
Jain, A., Mazariegos, G., Kashyap, R.et al.Pediatric liver transplantation in 808 consecutive children: 20-years experience from a single center. Transpl. Proc. 2002; 34:1955–1957.CrossRefGoogle ScholarPubMed
Sudan, D. L., Shaw, B. W. Jr, & Langnas, A. N.Causes of late mortality in pediatric liver transplant recipients. Ann. Surg. 1998; 227:289–295.CrossRefGoogle ScholarPubMed
Vogt, D. P., Henderson, J. M., Carey, W. D., Barnes, D.The long-term survival and causes of death in patients who survive at least 1 year after liver transplantation. Surgery 2002; 132:775–780.CrossRefGoogle ScholarPubMed
McDiarmid, S., Busuttil, R. W., Goss, J.et al.Causes of late graft dysfunction, retransplantation (RE-TX) and death after pediatric (OLT) orthotopic liver transplantation. (Abstract). Liver Transpl. Surg. 1997; 30:1397.Google Scholar
Kerkar, N., Hadzic, N., Davies, E. T.et al.De-novo autoimmune hepatitis after liver transplantation. Lancet 1998; 35:409–413.CrossRefGoogle Scholar
Deshpande, R. R., Rela, M., Girlanda, R.et al.Long-term outcome of liver retransplantation in children. Transplantation 2002; 74:1124–1130.CrossRefGoogle ScholarPubMed
Shaw, B. W., Gordon, R. D., Iwatsuki, S.et al.Hepatic transplantation. Transpl. Proc. 1985; 17:264–271.Google Scholar
Esquivel, C. O., Koneru, B., Todo, S.et al.Is multiple organ failure a contraindication for liver transplantation in children?Transpl. Proc. 1987; 19 (Suppl. 3): 47–48.Google ScholarPubMed
Muller, M. J., Lautz, H. U., Plogmann, B., Burger, M., Korber, J., & Schmidt, F. W.Energy expenditure and substrate oxidation in patients with cirrhosis: The impact of cause, clinical staging and nutritional state. Hepatology 1992; 15:782–794.CrossRefGoogle ScholarPubMed
Pikul, J., Sharpe, M. D., Lowndes, R., & Chent, C. N.Degree of preoperative malnutrition is predictive of postoperative morbidity and mortality in liver transplant recipients. Transplantation 1994; 57:469–472.CrossRefGoogle ScholarPubMed
Bucuvalas, J. C., Cutlield, W., Horn, J., & Balistreri, W. F.Resistance to the growth promoting and metabolic effects of GH in children with chronic liver disease. J. Pediatr. 1990; 117:397–402.CrossRefGoogle ScholarPubMed
Becht, M. B., Pedersen, S. H., Ryckman, F. C., & Balistreri, W. F.Growth and nutritional management of pediatric patients after orthotopic liver transplantation. Gastroenterol. Clin. North Am. 1993; 22:367–380.Google ScholarPubMed
Renz, J. F., Roos, M., Rosenthal, P.et al.Posttransplantation growth in pediatric liver recipients. Liver Transpl. 2001; 7:1040–1055.CrossRefGoogle ScholarPubMed
Urbach, A. H., Gartner, J. C., & Malatac, J. J.Linear growth following pediatric liver transplantation. Am. J. Dis. Child. 1987; 141:547–549.Google ScholarPubMed
Sarna, S., Sipila, I., Jaianko, H., Laine, J., & Holmberg, C.Factors affecting growth after pediatric liver transplantation. Transpl. Proc. 1994; 26:161–164.Google ScholarPubMed
Diemen-Steenvoorde, R. & Donckerwoicke, R. A.et al.Growth and sexual maturation in children after kidney transplantation. Acta Paediatr. Scand. Suppl. 1988; 343:109–117.Google ScholarPubMed
Holt, R. I., Baker, A. J., & Miell, J. P.The pathogenesis of growth failure in pediatric liver disease. J. Hepatol. 1997; 27:413–423.CrossRefGoogle Scholar
Wehrenberg, W. B., Janowski, B. A., Piedring, A. W., Cullier, F., & Jones, K. L.Giucocorticoids: potent inhibitors and stimulators of growth hormone secretion. Endocrinology 1990; 126:3200–3203.CrossRefGoogle Scholar
Hehir, D. J., Jenkins, R. L., & Bistrian, B. R.Nutrition in patients undergoing orthotopic liver transplant. J. Parenter. Enteral. Nutr. 1985; 9:695–700.CrossRefGoogle ScholarPubMed
Ryckman, F. R., Fisher, R. A., Pedersen, S. H., & Balistreri, W. F.Liver transplantation in children. Semin. Pediatr. Surg. 1992; 1:162–172.Google ScholarPubMed
Munoz, S. J.Nutritional therapies in liver disease. Semin. Liver Dis. 1991; 11:278–291.CrossRefGoogle ScholarPubMed
Moreno, L. A., Gottrand, F., Hoden, S.et al.Improvement of nutritional status in cholestatic children with supplemental nocturnal enteral nutrition. J. Pediatr. Gastroenterol. Nutr. 1991; 12:213–216.CrossRefGoogle ScholarPubMed
Zaloga, G. P. & MacGregor, D. A.What to consider when choosing enteral or parenteral nutrition: is the guideline still “if the gut works, use it”?J. Crit. Ill 1990; 5:1180–1200.Google Scholar
Bower, R. H., Talamini, M. A., Sax, H. C., Hamilton, F., & Fischer, J. E.Postoperative enteral versus parenteral nutrition: a randomized controlled trial. Arch. Surg. 1986; 121:1040–1045.CrossRefGoogle Scholar
Kudsk, K. A., Croce, M. A., Fabian, T. C.et al.Enteral versus parenteral feeding: effects on septic morbidity after blunt and penetrating abdominal trauma. Ann. Surg. 1992; 215:503–513.CrossRefGoogle ScholarPubMed
Moore, F. A., Feliciano, D. V., Andrassy, R. J.et al.Early enteral feeding compared with parenteral reduces postoperative septic complications: The results of a meta-analysis. Ann. Surg. 1992; 216:172–183.CrossRefGoogle ScholarPubMed
Chin, S. E., Shepherd, R. W., Thomas, B. J.et al.The nature of malnutrition in children with end-stage liver disease awaiting orthotopic liver transplantation. Am. J. Clin. Nutr. 1992; 56:164–168.CrossRefGoogle ScholarPubMed
Holt, R. I., Broide, E., Buchanan, C. R.et al.Orthotopic liver transplantation reverses the adverse nutritional changes of end-stage liver disease in children. Am. J. Clin. Nutr. 1997; 65:534–542.CrossRefGoogle ScholarPubMed
Spolidoro, J. V., Berquist, W. E., & Pehiivanoglu, E . Growth acceleration in children after orthotopic liver transplantation. J. Pediatr. 1988; l12:41–44.CrossRefGoogle Scholar
Bucuvalas, J. C., Horn, J. A., Carisson, L.et al.Growth hormone insensitivity associated with elevated circulating growth hormone binding protein in children with Alagille Syndrome and short stature. J. Clin. Endocrinol. Metabol. 1994; 76:1477–1482.Google Scholar
Starzl, T. E., Koep, L. J., Schroter, G. P. J.et al.The quality of life after liver transplantation. Transpl. Proc. 1979; 11:252–256.Google ScholarPubMed
Zitelli, B. J., Miller, J. W., Gartner, J. C.et al.Changes in lifestyle after liver transplantation. Pediatrics 1988; 82:173–180.Google ScholarPubMed
Zitelli, B. J., Gartner, J. C., Malatack, J. J.et al.Pediatric liver transplantation: patient evaluation and selection, infectious complications, and life-style after transplantation. Transpl. Proc. 1987; 4:3309–3316.Google Scholar
Wayman, K. I., Cox, K. L., & Esquivel, C. O.Neurodevelopmental outcome of young children with extrahepatic biliary atresia 1 year after liver transplantation. J. Pediatr. 1997; 131:894–898.CrossRefGoogle ScholarPubMed
Tornqvist, J., Broeck, N., Finkenauer, C.et al.Long-term psychosocial adjustment following pediatric liver transplantation. Pediatr. Transpl. 1999; 3:115–125.CrossRefGoogle ScholarPubMed
Stone, R. D., Beasley, P. J., Treacy, S. J.et al.Children and families can achieve normal psychological adjustment and a good quality of life following pediatric liver transplantation: a long-term study. Transpl. Proc. 1997; 29:1571–1572.CrossRefGoogle Scholar
Zamberlan, K. E.Quality of life in school-age children following liver transplantation. Maternal–Child Nurs. J. 1992; 20:167–229.Google ScholarPubMed
Schulz, K. H., Hofmann, K., Sander, S.et al.Comparison of quality of life and family stress in families of children with living-related liver transplants versus families of children who received a cadaveric liver. Transpl. Proc. 2001; 33:1496–1497.CrossRefGoogle ScholarPubMed
Gold, L. M., Kirkpatrick, B. S., Fricker, F. J., & Zitelli, B. J.Psychosocial issues in pediatric organ transplantation. The parent's perspective. Pediatrics 1986; 77:738–744.Google Scholar
Penn, I., Bunch, D., Olenik, D.et al.Psychiatric experience with patients receiving renal and hepatic transplants. Semin. Psychiatry 1971; 3:133–144.Google ScholarPubMed

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