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10 - Head and neck tumors

from Part II - Head and neck

Published online by Cambridge University Press:  08 January 2010

By
Robert Ord  and
Rui Fernandes
Edited by
Mark D. Stringer ,
Keith T. Oldham  and
Pierre D. E. Mouriquand
Robert Ord
Affiliation:
Department of Oral and Maxillo Facial Surgery, University of Maryland, Baltimore, MD, USA
Rui Fernandes
Affiliation:
Department of Oral and Maxillo Facial Surgery, University of Maryland, Baltimore, MD, USA
Mark D. Stringer
Affiliation:
University of Otago, New Zealand
Keith T. Oldham
Affiliation:
Children's Hospital of Wisconsin
Pierre D. E. Mouriquand
Affiliation:
Debrousse Hospital, Lyon
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Summary

Malignant tumors: an introduction

Childhood cancer is fortunately rare. In the USA, 129.5 cases per million of white children and 104.1 cases per million of black children under the age of 15 years develop a cancer, only 5% of which occur in the head and neck. Pediatric head and neck malignancies represent a spectrum of histological types, which are totally different from those found in adults. In adult patients, squamous cell carcinoma accounts for over 90% of head and neck cancers if facial skin cancers are excluded. In pediatric patients, the majority of malignancies consist of small, blue, round cell tumors (neuroblastoma, peripheral neuroendocrine tumor, Ewing's sarcoma, non-Hodgkin's lymphoma, and soft tissue sarcomas). If central nervous system and hematological malignancies are excluded, then retinoblastomas, rhabdomyosarcomas and neuroblastomas are the most common cancers. Below the age of 3 years, retinoblastomas are the most common, followed by rhabdomyosarcomas and neuroblastomas; from 3 to 11 years, rhabdomyosarcomas are the most common, followed by lymphomas, while from 12 to 21 years this order is reversed.

Recent advances in molecular biology have led to increased understanding of the role of chromosomal changes, suppressor genes, and oncogenes in the etiology of these neoplasms. In addition, electron microscopy, histochemical staining, identification of cell markers, immunofluorescence, etc., have enabled better tumor typing and classification. In the clinical arena, multimodal therapy incorporating surgery, radiation and chemotherapy has increased long-term survival.

Type
Chapter
Information
Pediatric Surgery and Urology
Long-Term Outcomes
 , pp. 117 - 132
Publisher: Cambridge University Press
Print publication year: 2006

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References

Young, J. L., Ries, L. G., Silverberg, E.et al.Cancer incidence survival and mortality for children younger than age 15 years. Cancer 1986; 58:598–602.3.0.CO;2-C>CrossRefGoogle ScholarPubMed
Cunningham, M. J., Myers, E. N., Bluestone, C. D.Malignant tumors of the head and neck in children: a twenty-year review. Int J Pediat Otorhinolaryngol 1987; 13:279–292.CrossRefGoogle ScholarPubMed
Robinson, L. D., Rightmire, J., Smith, R. J. M.Head and neck malignancies in children: an age-incidence study. Laryngoscope 1988; 98:11–13.CrossRefGoogle ScholarPubMed
Jaffe, N., Toth, B. B., Moar, R. E.et al.Dental and maxillofacial abnormalities in long term survivors of childhood cancer: effects of treatment with chemotherapy and radiation to the head and neck. Pediatrics 1984; 73:816–823.Google ScholarPubMed
Paulino, A. C., Simon, J. H., Zhen, W., Wen, B. C.Long-term effects in children treated with radiotherapy for head and neck rhabdomyosarcomas. Int. J. Radiat. Oncol. Biol. Phys. 2000; 48:1489–1495.CrossRefGoogle Scholar
Sutow, W. W., Sullivan, M. P., Ried, H. G., et al.Prognosis in childhood rhabdomyosarcoma. Cancer 1970; 25:1386–1390.3.0.CO;2-T>CrossRefGoogle ScholarPubMed
Maurer, H. M., Beltangady, M., Gehan, E. A., et al.The Intergroup Rhabdomyosarcoma Study-I: A final report. Cancer 1988; 61:209–220.3.0.CO;2-L>CrossRefGoogle ScholarPubMed
Newton, W. A., Soule, E. H., Hamoudi, A. B., et al.Histopathology of childhood sarcomas: Intergroup Rhabdomyosarcoma studies I andII: clinicopathologic correlation. J. Clin. Oncol. 1988; 6:67–75.CrossRefGoogle ScholarPubMed
Raney, R. B., Toffer, M., Hays, D. M., & Triche, T. J. Rhabdomyosarcoma and the undifferentiated sarcomas. In Pizzo, P. A., & Poplack, D. G. (eds), Principles and Practices of Pediatric Oncology, 2nd edn. Philadelphia: J. B. Lippincott, 1993.Google Scholar
Sutow, W. W., Lindberg, R. D., Gehan, E. A.et al.Three-year relapse-free survival rates in childhood rhabdomyosarcoma of the head and neck: report from the Intergroup Rhabdomyosarcoma study. Cancer 1982; 49:2217–2221.3.0.CO;2-V>CrossRefGoogle ScholarPubMed
Oberlin, O., Rey, A., Anderson, J.et al.Treatment of orbital rhabdomyosarcoma: survival and late effects of treatment – results of an international workshop. J. Clin. Oncol. 2001; 19:197–204.CrossRefGoogle ScholarPubMed
Andrassy, R. J.Advances in the surgical management of sarcomas in children. Am. J. Surg. 2002; 184:484–491.CrossRefGoogle ScholarPubMed
Wharman, M. D., Beltangady, M. S., Heyn, R. M.et al.Pediatric orofacial and laryngopharyngeal rhabdomyosarcomas: an Intergroup Rhabdomyosarcoma study report. Arch. Otolaryngol. Head Neck Surg. 1987; 113:1225–1227.Google Scholar
Liebert, P. S. & Stool, S. E.Rhabdomyosarcoma of the tongue in an infant: results of combined radiation and chemotherapy. Ann. Surg. 1973; 178:621–624.Google Scholar
Lawrence, W., Hays, D. M., Heyn, R. M.et al.Lymphatic metastases with childhood rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma study. Cancer 1987; 60:910–915.3.0.CO;2-8>CrossRefGoogle ScholarPubMed
UICC Manual of Clinical Oncology 7th edn, 1999, Wiley-Liss.
Crist, W. M., Anderson, J. R., Meza, J. L.et al.Intergroup rhabdomyosarcoma study –IV: results for patients with nonmetastatic disease. J. Clin. Oncol. 2001; 19:3091–3102.CrossRefGoogle ScholarPubMed
Hawkins, D. S., Rajendran, J. G., Conrad, E. U., Bruckner, J. D., & Eary, J. F.Evaluation of chemotherapy response in pediatric bone sarcomas by [F-18]-fluorodeoxy-D-glucose positron emission tomography. Cancer 2002; 94:3277–3284.CrossRefGoogle Scholar
Mandell, L. R., Massey, V., & Ghaviri, F.The influence of extensive bone erosion on local control in non-orbital rhabdomyosarcoma of the head and neck. Int. J. Radiat. Oncol. Biol. Phys. 1989; 17:649–653.CrossRefGoogle ScholarPubMed
Lyos, A. T., Goepfert, H., Luna, M. A.et al.Soft tissue sarcoma of the head and neck in children and adolescents. Cancer 1996; 17:193–200.3.0.CO;2-Z>CrossRefGoogle Scholar
Ron, E., Modan, B., Boice J. D.et al.Tumors of the brain and nervous system after radiotherapy in childhood. N. Engl. J. Med. 1988; 319:1033–1039.CrossRefGoogle ScholarPubMed
Raney, R. B., Anderson, J. R., Kollath, J.et al.Late effects of therapy in 94 patients with localized rhabdomyosarcoma of the orbit: report from the intergroup rhabdomyosarcoma study (IRS)-III, 1984–1991. Med. Pediatr. Oncol. 2000; 34:413–420.3.0.CO;2-4>CrossRefGoogle ScholarPubMed
Raney, R. B., Tefft, M., Maurer, M. M.et al.Improved prognosis with intensive treatment of children with cranial soft tissue sarcomas arising in non-orbital parameningeal sites: a report from the Intergroup Rhabdomyosarcoma study. Cancer 1987; 59:147–155.3.0.CO;2-8>CrossRefGoogle Scholar
Wolden, S. L., Anderson, J. R., Crist, W. M.et al.Indications for radiotherapy and chemotherapy after complete resection in rhabdomyosarcoma: a report from the intergroup rhabdomyosarcoma studies I toIII. J. Clin. Oncol. 1999; 17:3468–3475.CrossRefGoogle ScholarPubMed
Donaldson, S. S., Meza, J., Breneman, J. C.et al.Results from the ISR- IV randomized trial of hyperfractionated radiotherapy in children with rhabdomyosarcoma – a report from the IRSG. Int. J. Radiat. Oncol. Biol. Phys. 2001; 51:718–728.CrossRefGoogle Scholar
McGill, T.Rhabdomyosarcoma of the head and neck: an update. Otolaryngol. Clin. N. Amer. 1989; 22:631–636.Google ScholarPubMed
Moore, O. & Grossi, C.Embryonal rhabdomyosarcoma of the head and neck. Cancer 1959; 12:69–73.3.0.CO;2-C>CrossRefGoogle Scholar
Masson, J. K. & Soule, E. M.Embryonal rhabdomyosarcoma of the head and neck: report of 88 cases. Am. J. Surg. 1965; 110:585–591.CrossRefGoogle Scholar
Heyn, R. M., Holland, R., Newton, W. A.et al.The role of combined chemotherapy in the treatment of rhabdomyosarcoma in children. Cancer 1974; 34:2128–2142.3.0.CO;2-M>CrossRefGoogle ScholarPubMed
Flamant, F. & Hill, C.The improvement in survival associated with combined chemotherapy in children rhabdomyosarcoma: a historical comparison of 345 patients in the same center. Cancer 1834; 53:2417–2421.3.0.CO;2-#>CrossRefGoogle Scholar
Crist, W. M., Garnsey, L., Beltangady, M. S.et al.Prognosis in children with rhabdomyosarcoma: a report of the Intergroup Rhabdomyosarcoma studies I and II. J. Clin. Oncol. 1990; 8:447–448.CrossRefGoogle ScholarPubMed
Rao, B. N., Santana, V. M., Flemming, J. D.et al.Management and prognosis of head and neck sarcomas. Am. J. Surg. 1989; 158:373–377.CrossRefGoogle ScholarPubMed
Wharam, M. D., Foulkes, M. A., Lawrence, W.et al.Soft tissue sarcoma of the head and neck in children: non-orbital and non-parameningeal sites: a report of the Intergroup Rhabdomyosarcoma study IRS-I. Cancer 53:1016–1019.3.0.CO;2-2>CrossRef
Raney, J. B., Crist, W. M., Maurer, H. M.et al.Prognosis of children with soft tissue sarcoma who relapse after achieving a complete response: a report from the Intergroup Rhabdomyosarcoma study I. Cancer 1983; 52:444–450.Google ScholarPubMed
Sutow, W. W., Fugimoto, T., Wilbur, J. R.et al.Long-term evaluation of VAC-chemotherapy in childhood rhabdomyosarcoma. Proc. AACR, ASCO 1977; 18:291 (abstract).Google Scholar
Sutton, W. W., Lindberg, R. D., Gehan, A. E.et al.Three-year relapse-free survival rates in childhood rhabdomyosarcoma of the head and neck: report from the Intergroup Rhabdomyosarcoma study. Cancer 1982; 49:2217–2221.Google Scholar
Young, J. L. & Miller, R. W.Incidence of malignant tumors in US children. J. Pediatr. 1975; 86:254–258.CrossRefGoogle Scholar
Stark, A., Kreicberg, S. A., & Silfersward, C.The age of osteosarcoma patients is increasing: an epidemiological study of osteosarcomas in Sweden, 1971 to 1984. J. Bone Joint Surg. 1990; 72B:89–93.CrossRefGoogle Scholar
Clark, J. L., Unni, K. K., Dahlin, D. C.et al.Osteosarcoma of the jaw. Cancer 1983; 51:2311–2316.3.0.CO;2-Z>CrossRefGoogle ScholarPubMed
Tabone, M. D., Terrier, P., Pacquement, H.et al.Outcome of radiation-related osteosarcoma after treatment of childhood and adolescent cancer: a study of 23 cases. J. Clin. Oncol. 1999; 17:2789–2795.CrossRefGoogle ScholarPubMed
Marcus, R. B., Post, J. C., & Mancuso, A. A. Pediatric tumors of the head and neck. In Million, R. R. & Cassisi, N. J. (eds), Management of Head and Neck Cancer: A Multidisciplinary Approach, 2nd edn. Philadelphia: J. P. Lippincott, 1994.Google Scholar
Dahlin, D. C.Osteosarcoma of bone and a consideration of prognostic variables. Cancer Treat. Rep. 1978; 62:189–192.Google Scholar
Smeele, L. E., Kostense, P. J., Waal, I.et al.Effects of chemotherapy on survival of craniofacial osteosarcoma: a systematic review of 201 patients. J. Clin. Oncol. 1997; 15:363–367.CrossRefGoogle Scholar
Regizi, J. A. & Sciubba, J. W. Oral pathology. In Regizi, J. A., Sciubba, J. (eds), Clinical–Pathological Correlations, 2nd edn. Philadelphia: W. B. Saunders, 1993: 442.Google Scholar
Fechner, R. E. & Mills, S. E. (eds). Tumors of the bones and joints, In Atlas of Tumor Pathology, 3rd series, fascicle 8. Washington, DC: Armed Forces Institute of Pathology, 1993: 14–15.Google Scholar
Gardener, D. G. & Mills, D. M.The widened periodontal ligament of osteosarcoma of the jaws. Oral. Surg. 1976; 41:652–656.CrossRefGoogle Scholar
Garrington, G. E., Scofield, H. H., Cornyn, J., & Hooker, S. P.Osteosarcoma of the Jaws: analysis of 56 cases. Cancer 1967; 20:377–391.3.0.CO;2-T>CrossRefGoogle ScholarPubMed
Smeele, L. E., Wal, J. E., Van, Diest P. J.et al.Radical surgical treatment in craniofacial osteosarcoma gives excellent survival: a retrospective cohort study of 14 patients. Oral Oncol. Eur. J. Cancer. 1994; 30B:374–376.CrossRefGoogle ScholarPubMed
Friedman, M. A. & Carter, S. K.The therapy of osteogenic sarcoma: current status and thoughts for the future. J. Surg. Oncol. 1972; 4:482–510.CrossRefGoogle ScholarPubMed
Goepfert, H., Raymond, A. K., Spires, J. R.et al.Osteosarcoma of the head and neck. Cancer. Bull. 1990; 42:347–354.Google Scholar
Delgardo, R., Maafs, E., Alfeiran, A.et al.Osteosarcoma of the jaw. Head Neck 1994; 16:246–252.CrossRefGoogle Scholar
Link, M. P. & Eilber, F. Osteosarcoma. In Pizza, P. A. & Poplack, D. G. (eds), Principles and Practice of Pediatric Oncology, 2nd edn. Philadelphia: J. B. Lippincott, 1993.Google Scholar
Suit, D. G.Radiotherapy in osteosarcoma. Clin. Orthop. 1975; 111:71–75.CrossRefGoogle Scholar
Goorin, A. M., Schwartzentruber, D. J., Devidas, M.et al.Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: pediatric oncology group study POG-8651. J. Clin. Oncol. 2003; 21:1574–1580.CrossRefGoogle ScholarPubMed
Veges, D. S., Borges, A. M., Aggrawal, K.et al.Osteosarcoma of the craniofacial bones: a clinico-pathological study. J. Craniomaxillofac. Surg. 1991; 19:90–93.CrossRefGoogle Scholar
Meyers, P. A., Hiller, G., Healey, J.et al.Chemotherapy for non-metastatic osteogenic sarcoma: the Memorial Sloan–Kettering experience. J. Clin. Oncol. 1992; 10:5–15.CrossRefGoogle Scholar
Horowitz, M. E., Malower, M. M., Delaney, T. F., & Tsakos, M. G. Ewing's sarcoma family of tumors: Ewing's sarcoma of bone and soft tissue and the peripheral primitive neuroectodermal tumors. In Pizzo, P. A. & Poplack, D. G. (eds.), Principles and Practice of Pediatric Oncology, 2nd edn. Philadelphia: J. B. Lippincott, 1993.Google Scholar
Burdach, S. & Jurgens, H.High-dose chemotherapy (HDC) in the Ewing family of tumors (EFT). Crit. Rev. Oncol. Hemat. 2002; 41:169–189.CrossRefGoogle Scholar
Posnick, J. C., Louie, G., Zucker, R. M.et al.Ewing's sarcoma primary involvement of the zygoma undergoing resection and immediate reconstruction. Plast. Reconst. Surg. 1992; 89:956–961.CrossRefGoogle Scholar
Berstein, P. E., Bone, R. C., & Feldman, P. S.Ewing's sarcoma of the mandible. Ann. Otol. Rhinol. Laryngeal. 1979; 88:105–108.CrossRefGoogle Scholar
Siegal, G. P., Oliver, W. R., Reinus, W. R.et al.Primary Ewing's sarcoma involving the bones of the head and neck. Cancer 1987; 60:2829–2840.3.0.CO;2-S>CrossRefGoogle ScholarPubMed
Crowe, W. W. & Harper, J. C.Ewing's sarcoma with primary lesion in the mandible: report of a case. J. Oral. Surg. 1965; 23:156–161.Google Scholar
Berk, R., Heller, A., Heller, D.et al.Ewing's sarcoma of the mandible. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 1995; 79:159–162.CrossRefGoogle ScholarPubMed
Pottlar, G. G.Ewing's sarcoma of the jaws. Oral Surg. Oral Med. Oral Pathol. 1970; 29:505–512.Google Scholar
Rapoport, A., Sobrinho, J., Carvalho, M.et al.Ewing's sarcoma of the mandible. Oral Surg. Oral Med. Oral Pathol. 1977; 44:89–94.CrossRefGoogle ScholarPubMed
Wood, R. E., Nortje, C. J., Messeling, P.et al.Ewing's tumor of the jaw. Oral Surg. 1990; 69:120–127.CrossRefGoogle ScholarPubMed
Miser, J. S., Kirsella, T. J., Triche, T. J.et al.Preliminary results of treatments of Ewing's sarcoma of bone in children and young adults: six months of intensive combined modality therapy without maintenance. J. Clin. Oncol. 1988; 6:686–690.CrossRefGoogle Scholar
Posnick, J. C. Pediatric craniomaxillofacial tumors in oral and maxillofacial surgery. In Kahan, L. B. (ed.), Clinics of North America, vol. 6:1. Philadelphia: W. B. Saunders, 1996.Google Scholar
Bacci, G., Forni, C., Longhi, A.et al.Lont-term outcome for patients with non-metastatic Ewing's sarcoma treated with adjuvant and neoadjuvant chemotherapies. 402 patients treated at Rizzoli between 1972 and 1992. Eur. J. Cancer. 2004; 40:73–83.CrossRefGoogle ScholarPubMed
Nesbit, M. E., Gehan, E. A., Burgert, E. O.et al.Multimodal therapy for the management of primary non-metastatic Ewing's sarcoma of bone: a long-term follow-up of the first intergroup study. J. Clin. Oncol. 1990; 8:1664–1672.CrossRefGoogle Scholar
Burgert, E. O., Nesbit, M. E., Garnsey, L. A.et al.Multimodal therapy for the management of non-pelvic, localized Ewing's sarcoma of bone: Intergroup study IESS-II. J. Clin. Oncol. 1990; 8:1514–1521.CrossRefGoogle Scholar
Marcus, R. B., Cantor, A., Heare, T. C.et al.Local control and function after twice-a-day radiotherapy for Ewing's sarcoma of bone. Int. J. Radiat. Oncol. Biol. Phys. 1988; 15:53–59.CrossRefGoogle Scholar
Duns, J., Sauer, R., Burgers, J. M.et al.Radiation therapy as local treatment in Ewing's sarcoma: results of the Cooperative Ewing's Sarcoma Studies CESS 81 and CESS 86. Cancer 1991; 67:2828–2825.Google Scholar
Sailer, S. J., Harmon, D. C., Mankin, H. J.et al.Ewing's sarcoma: surgical resection as a prognostic factor. Int. J. Radiat. Oncol. Biol. Phys. 1988; 15:43–48.CrossRefGoogle ScholarPubMed
Hayes, F. A., Thompson, E. l., Meyer, W. H.et al.Therapy for localized Ewing's sarcoma of bone. J. Clin. Oncol. 1989; 7:208–212.CrossRefGoogle ScholarPubMed
Cangir, A., Vietti, T. J., Gehan, E. A., et al.Ewing's sarcoma metastatic at diagnosis. Results and comparisons of two intergroups: Ewing's sarcoma studies. Cancer 1990; 66:887–893.3.0.CO;2-R>CrossRefGoogle Scholar
Fuchs, B., Valenzuela, R. G., Inwards, C., Sim, F. H., & Rock, M. G.Complications in longterm survivors of Ewing sarcoma. Cancer 2003; 98:2687–2692.CrossRefGoogle Scholar
Sonis, A. L., Tarbell, N., Valachovic, R. W.et al.Dentofacial development in longterm survivors of acute lymphoblastic leukemia: a comparison of three treatment modalities. Cancer 1990; 66:2645–2652.3.0.CO;2-S>CrossRefGoogle Scholar
Perrott, D. H., Sharma, A. B. & Vargervik, K.Endosseous implants for pediatric patients: unknown factors, indications, contra-indications and special considerations. Oral Maxillofac. Surg. Clin. N. Amer. 1994; 6:79–88.Google Scholar
Chuong, R. & Kaban, L. B.Diagnosis and treatment of jaw tumors in children. J. Oral Maxillofac. Surg. 1985; 43:323–332.CrossRefGoogle ScholarPubMed
Topazian, R. B.Ameloblastoma in a 4-year-old child. Oral Surg. 1964; 17:581–583.CrossRefGoogle Scholar
Dresser, W. J. & Segal, W.Ameloblastoma associated with a dentigerous cyst in a 6-year-old child. Oral Surg. 1967; 24:388–391.CrossRefGoogle Scholar
Young, D. R. & Robinson, M.Ameloblastomas in children. Oral Surg. 1962; 15:1155–1159.CrossRefGoogle ScholarPubMed
Ord, R. A., Blanchaert, R. H., Nikitakis, N. G., & Sauk, J. J.Ameloblastoma in children. J. Oral Maxillofac. Surg. 2002; 60:762–770.CrossRefGoogle ScholarPubMed

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