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Chapter 13 - Childhood Myelodysplastic Syndromes (MDSs)

from Section IV - Neoplastic Disorders of Bone Marrow

Published online by Cambridge University Press:  25 January 2024

By
Bradford Siegele
Edited by
Xiayuan Liang ,
Bradford Siegele  and
Jennifer Picarsic
Xiayuan Liang
Affiliation:
Children’s Hospital of Colorado
Bradford Siegele
Affiliation:
Children’s Hospital of Colorado
Jennifer Picarsic
Affiliation:
Cincinnati Childrens Hospital Medicine Center
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Summary

Childhood myelodysplastic syndromes (MDSs) are clonal myeloid neoplasms characterized by impaired production of circulating hematopoietic elements (generally, hemoglobin concentration < 10 g/dL, platelet count < 100 × 109/L, or absolute neutrophil count < 1.8 × 109/L), frequently accompanied by morphologic dysplasia and recurrent genetic abnormalities and lacking features of overproduction of additional hematopoietic lineage elements. In light of its rarity in comparison to its clinicopathologic mimics, minimal diagnostic criteria have been proposed (see Table 13.1).

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Chapter
Information
Pediatric Pathology of Hematopoietic and Histiocytic Disorders , pp. 148 - 154
Publisher: Cambridge University Press
Print publication year: 2024

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References

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